Mirizzi 증후군의 변형된 분류와 치료

김형철,강길호,채만규,김성용,백무준,이문수,박상흠,이문호,김창호,송옥평,조무식,박희주 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Purpose : The Mirizzi syndrome is relatively rare and preoperative diagnosis of this disease is difficult. In 1978, Morelli suggested the subclassification of the Mirizzi syndrome into acute or chronic form. We experienced 5 cases of acute form. We analysed clinical features, preoperative radiologic findings and operative findings of 18 cases including acute forms which were diagnosed as Mirizzi syndrome and should suggest the modified classification of Mirizzi syndrome for choice of appropriate treatment. Method : From January 1995 to December 1998, 18 cases, of which 8 cases were diagnosed at Soonchunhyang University Chunan Hospital, and 10 cases were reported in the Korean Journal were retrospectively analysed with regard to clinical features, preoperative radiologic findings and operative findings. According to the clinical features, whole cases were divided into type Ⅰ(acute form) and type Ⅱ(chronic form) and then each type of cases were subclassified according to preoperative radiologic findings and operative findings. Results : Of 18 cases there were 5 cases in type Ⅰ(27.8%), 13 cases in type Ⅱ(72.2%). Type Ⅱb was most common. Type Ⅰa cases were treated only with cholecystectomy. We applied cholecystectomy, T-tube choledochostomy and patch technique in type Ⅰb and thpe Ⅰc cases. Cholectystectomies including removal of gallstones and internal drainage procedures were done in type Ⅱ chronic forms. Conclusion : The acute form(Type Ⅰ) of Mirizzi syndrome was suggested by Morelli might be subclassified into typeⅠa,Ⅰb and Ⅰc following the presence of the necrotic defect in common hepatic duct. Through the modified classification of Mirizzi syndrome based on clinical feature, preoperative radiologic findings and operative findings, we can choice appropriate treatment.

Identification of Genes Modulated by High Extracellular Calcium in Coculture of Mouse Osteoblasts and Bone Marrow Cells by Oligo Chip Assay

Kim, Hyung-Keun,Song, Mina,Jun, ji-Hae,Woo, Kyung-Mi,Kim, Gwan-Shik,Baek, Jeong-Hwa The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Calcium concentration in the bone resorption lacunae is high and is in the mM concentration range. Both osteoblast and osteoclast have calcium sensing receptor in the cell surface, suggesting the regulatory role of high extracellular calcium in bone merabolism. In vitro, high extracellular calcium stimulated osteoclastogenesis in coculture of mouse osteoblasts and bone marrow cells. Therefore we examined the genes that were commonly regulated by both high extracellular calcium and 1,25(OH)_(2)vitaminD_(3)(VD3) by using mouse oligo 11 K gene chip. In the presence of 10 mM[Ca^(2+)]e or 10 nM VD3, mouse calvarial osteoblasts and bone marrow cells were co-cultured for 4 days when tartrate resistant acid phosphatase-positive multinucleated cells start to appear. Of 11,000 genes examined, the genes commonly regulated both by high extracellular calcium and by VD3 were as follows; 1) the expressions of genes which were osteoclast differentiation markers or were associated with osteoclastogenesis were up-regulated both by high extracellular calcium and by VD3; trap, mmp9, car2, ctsk, ckb, atp6b2, tm7sf4, rab7, 2) several chemokine and chemokine receptor genes such as sdf1, scya2, scyb5, scya6, scya8, scya9, and ccr1 were up-regulated both by high ectracellular calcium and by VD3, 3) the genes such as mmp1b, mmp3 and c3 which possibly stimulate bone resorption by osteoclast, were commonly up-regulated, 4) the gene such as c1q and msr2 which were related with macrophage function, were commonly down-regulated, 5) the genes which possibly stimulate osteoblast differentiation and/or mineralization of extracellular matrix, were commonly down-regulated;slc8a1, admr, plod2, lox, fosb, 6) the genes which possibly suppress osteoblast differentiation and/or mineralization of extracellular matrix, were commonly up-regulated;s100a4, npr3, mme, 7) the genes such as calponin 1 and tgfbi which possibly suppress osteoblast differentiation and/or mineralization of extracellular matrix, were up-regulated by high extracelluar calcium but were down-regulated by VD3. These results suggest that in coculture condition, both high extracellular calcium and VD3 commonly induce osteoclastogenesis but suppress osteoblast differentiation/mineralization by regulating the expression of related genes.

항균 활성을 가진 천연약재의 검색

송형석,이지연,오성준,백남인,김해영 경희대학교 생명자원과학연구원 2000 硏究論文集 Vol.21 No.-

We investigated the antimicrobial activity of the hot-water extracts and methanol extracts from medicinal plants. Sixty-two samples were tested by disk diffusion method at concentrations of 5,000ppm and 10,000ppm. Seven species of medicinal plants showed a significant antimicrobial activity against various food-borne microorganisms.

직무스트레스와 뇌 · 심혈관계질환의 관련성

황창국,고상백,장세진,박종연,차봉석,현숙정,박준호,이강명,차경태,박우진,전형준 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.2

연장 가골에 골 이식 대체물 투여가 골 경화에 미치는 영향 : 가토 경골에서의 방사선 및 골 밀도의 변화 Changes of Radiography & Bone Mineral Density in the Tibia of Rabbits

오창욱,김풍택,박병철,송해룡,박일형,백준호,박형진 경북대학교 병원 2003 경북대학교병원의학연구소논문집 Vol.7 No.1

목적 : 골 연장술 후 생기는 연장 가골에 황화 칼슘과 이종 이식골을 투여하여 골 경화 속도에 대한 영향을 알아보기 위한 실험이었다. 연구대상 및 방법 : 성장중인 뉴질랜드 화이트 토끼(2.0-2.5㎏)의 경골 간부에 골막을 보호하고, 절골술을 시행하고, 5일간의 휴지기후 외고정 장치를 이용하여 1주일 동안 7㎜가 연장될 때까지 하루 1㎜씩 2회의 리듬을 가지고 골 연장을 실시하였다. 제1 실험 군 7마리에는 연장이 끝난 직후 황화 칼슘(Osteoset^(ⓡ), Wright medical USA) 1정, 제 2 실험 군 7마리에는 이종 이식골의 일종인 Lubboc 5㎟을 각각 연장된 가골 부에 주입하고, 단순 연장한 대조군 7마리와 함께, 방사선 및 골 밀도비를 측정하고 추시하여, 골 경화의 진행속도를 비교하였다. 방사선 촬영은 전후면 및 측면사진을 1주 간격으로 촬영하였고, 골밀도 측정은 DEXA(dual energy X-ray absorptionmetry, Lunar^(ⓡ)) 장치를 2주일 간격으로 시행하였다. 결과 : 방사선 소견상, 제 1실험군의 연장가골의 완전 경화시간은 평균 14주, 제 2실험군은 154 주로 각각 대조군의 16.9주보다 단축되었으며, 골 밀도 비에서도, 두 실험군에서 최고치가 대조군의 값보다 높고, 최고치까지의 경과기간도 빨랐다. 결론 : 본 연구에서 연장 가골에 황화칼슘 및 이종 이식골의 투여가 골 경화의 기간을 단축시킬 수 있고, 외고정 장치의 빠른 제거에 도움이 될 수 있음을 알았다. Purpose : This study was designed to know the effect of calcium-sulfate and xenograft on the distracted callus after lengthening. Materials & Methods : We had operation of subperiosteal osteotomy and external fixation on the tibial diaphysis of young New Zealand White rabbits(2.0-2.5㎏); after 5 days of latency period, 7㎜(1㎜/day, 2times/day) of tibial lengthening was reached in a week. At 1 week after lengthening, the 1st experimental group of 7 rabbits received a pellet of calcium sulfate(Osteoset, Wright medical, USA) in the distraction gap, and the 2nd experimental group of 7 rabbits received 5㎜ 2 of xenogrfat(Lubboc) in the distraction gap. But, the control group of 7 rabbits did not receive any of above materials. We compared three groups with the changes of radiographic findings at every week and bone mineral ratio(DEXA) at every two weeks. Results : The time to complete consolidation of distraction callus of both experimental group(calcium sulfate;14 weeks, xenograft; 15.4 weeks) was shorter than that of control group(16.9 weeks) in radiographic findings. Maximum value of bone mineral ratio of distraction callus was higher and the time to reach the highest value was also shortened in the both experimental group compared to control group. Conclusion : By use of bone substitutes as like calcium sulfate or xenograft in the distraction callus with external fixator, it may be possible to shorten the consolidation period and the fixator-wearing period.

간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의

김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.

노인 인구에서 신경인지기능저하와 혈청 지질농도와의 상관성

유영선,최석주,정성수,김지은,윤성욱,전동욱,백준형,박성우,이정구,추일한,김영훈 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.6

Objectives : In this study, the authors evaluated the correlation between eurocognitive impairments and serum lipids levels among Korean elderly over the age of 65. Methods : A total of 609 elderly individuals participated in this study. Screening for cognitive impairments were carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). There were 197 subjects above 1.5SD Of MMSE- KC and they were evaluated using the Korean versions of the Consortium to Establish a Registry for Alzheimer's Disease (AD) (CERAD-KC) and Geriatric Depression Scale (GDS-K). Results : There was a correlation between old age/low levels of education and AD (p<0.05, P<0.01). There was an inverse correlation between the serum level of total cholesterol and the word list recognition test scores. The serum levels of LDL cholesterol were inversely correlated with the scores on the constructional praxis test, word list recall test and word list recognition test. Inverse correlations between the serum level of triglyceride and scores on the word list recall test and word list recognition test were also observed. Conclusion : There were inverse correlations between the serum levels of lipids and language/memory function in subjects with AD.

Perceptions of American and Korean Parents of the Effects of Taekwondo Training on Behavior Changes of Taekwondo Trainees

Jun-Hyung Baek 세계태권도문화학회 2018 세계태권도문화학회지 Vol.9 No.3

Abstract : 이 연구의 목적은 태권도교육이 태권도 수련생들의 정서적, 사회 관계적, 그리고 총체적 영역 행동변화에 대한 한국과 미국의 태권도 수련생들의 학부모들의 인식을 이해하고, 두 국가간의 학부모들의 인식에 차이가 있는지 조사하는 것이다. 300명의 태권도수련생들의 학부모들은 태권도 수련이 미치는 영향에 대한 설문지 (Effects of Taekwondo Education Survey) 에 응답하도록 요청되었 다. 그 중 88 명의 한국인 태권도수련생 학부모와 91명의 미국인 태권도 수련생학부모, 총 179명의 태권도수련생들의 학부모가 설문지에 응답하였다. 작성된 설문지는 기술적통계와 Chi-square에 의해 분석되었다. 연구를 분석한 결과 한국과 미국 학부모들의 응답들은 척도에서 유사한 차이들을 보였지만, 두 국가의 학부모 모두 태권도수련이 자녀들의 행동변화에 긍정적인 영향을 주었다고 응답하였다. 이 연구의 흥미로운 발견은 약 27.5%의 미국인 학부모들이 태권도교육이 자녀들의 강인한 정신력에 긍정적인 영향을 주지는 못했다고 응답한 반면, 상당히 높은 비율의 한국인 학부모 들은 (50%) 태권도교육이 자녀들의 강인한 정신력을 기르는데 도움을 주지못했다고 응답하였다. 또한, 높은 비율의 미국의 학부모들은 (50.6%) 태권도교육이 자녀들의 자제력을 기르는데 긍정적인 영향을 미쳤다고 응답한 반면, 미국학부모보다 낮은 비율의 한국 학부모들은 (35.2%) 태권도교육이 자녀들의 자제력 형성에 긍정적인 영향을 주었다고 응답하였다. 이것은 한국과 미국의 다른 교육철 학과 방침 때문일 것 이다. 비록 두 국가간의 학부모들안에서 태권도교육이 자녀들의 행동변화에 미친 영향에 대한 인식들은 유사한 차이를 보였지만, 두 국가의 학부모들의 태권도에 대한 긍정적인 인식을 내비치었다. 이러한 긍정적인 영향을 고려한다면 좀더 많은 태권도기회가 어린이들에게 주어져야 한다.

The Effects of Physical Education Classes on 4<SUP>th</SUP> Grade Children’s Health-Related Physical Fitness Levels

Baek, Jun-Hyung(백준형),Kim, Ha-Young(김하영) 한국체육과학회 2013 한국체육과학회지 Vol.22 No.2

The purpose of this study was to examine how the frequency and duration of physical education classes influence children’s health-related physical fitness levels. One hundred and fourteen 4<SUP>th</SUP>grade students from two elementary schools providing different frequency and duration of PE classes in Northern region of illinois participated in the study. Data were collected by using FITNESSGRAM test and after-school sport participation questionnaire during their regular PE classes. Data were analyzed by gender using descriptive analysis and statistical analysis (ANOVA). No significant differences in health-related physical fitness levels were found between students of the two elementary schools. This result may be because there was significant difference in after-school sports participation of students. In fact, students from school A attended the after-school program more often and spent significantly more time in the after-school programs than students in school B.

Effects of Attentional Focus on Reaction Time in Sprint

( Jun Hyung Baek ) 한국체육학회 2019 International journal of human movement science Vol.13 No.3

Reaction time (RT) is one of the most important factors when looking at successful performance in multiple sports. Sports, such as track and field, swimming, tennis, and football, require good RT because it determines the overall performance of the athlete. Of the number of factors influencing RT, researchers have paid attention to the focus of attention provided by the instructor in the form of instruction or feedback. Collective study regarding attentional focus have suggested that manipulating focus of attention can have a great impact on motor skill learning and performance. In this current study, the effectiveness of different types of attentional focus on RT of sprint performance was examined. Thirty college students participated in this study. They were divided into two groups instructing with two different attentional focus conditions. The results found that participants in the external focus of attention group improved their RT. Although the sample size of this study is small, this study showed the evidence that the use of external attentional focus would decrease RT even for college students.