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주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4
Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)
2009년 인플루엔자 대유행 중 인플루엔자 진료소 방문자의 연령 분포 변화
김백남,곽이경,문치숙,김연숙,김의석,배인규,염준섭,이창섭,허지안 대한감염학회 2010 감염과 화학요법 Vol.42 No.2
The pandemic influenza (H1N1 2009) virus, after being introduced in Korea in April, 2009, spread rapidly nationwide in mid-2009. This study was conducted to characterize trend in age distribution of visitors to Flu-clinics during the pandemic. Demographic, clinical and laboratory data of visitors to flu clinic from Week 36 to 52 (August 30 to December 26) of 2009 were retrieved and collected from electronic databases at 9 hospitals. Visitors 0-6, 7-12, 13-18, 19-29, 30-64, and 65 years or more of age were classified into group I to VI, respectively. A total of 107,467 visitors were seen at Flu-clinics for a 17-week study period. Of those, 32,485 were laboratory-confirmed. Antivirals were prescribed for 62,533 visitors. Numbers of visits, prescriptions of antivirals, and laboratory-confirmed cases of the pandemic influenza (H1N1 2009) peaked at Week 44. A large number of visits by group II and III were followed by those of group I and V, especially around the peak. Numbers of visits by group VI were lowest in all hospitals. In some hospitals, higher number of visits lasted longer in children than in adults while vice versa in other hospitals depending on the location. In summary, the pandemic influenza (H1N1 2009) was presumed to peak in late October and involved majorly children and students in Korea. Unique age distribution of visitors to flu clinic was observed in some hospitals.
Baek, Ji Yeon,Kang, Myoung Hee,Hong, Yong Sang,Kim, Tae Won,Kim, Dae Yong,Oh, Jae Hwan,Lee, Seung Hoon,Park, Jin Hong,Kim, Jong Hoon,Kim, Sun Young M. Nijhoff ; Kluwer Academic Publishers 2011 Journal of neuro-oncology Vol.104 No.3
<P>Brain metastases (BM) occur in approximately 20-40% of cancer patients. The present study investigated the clinical outcomes of patients with BM from colorectal cancer (CRC) to assess the benefit of systemic chemotherapy (CT) administered after surgical or radiotherapeutic control of BM and to identify independent prognostic factors associated with survival after BM. Between August 2001 and July 2009, 118 patients with symptomatic BM from CRC received either cranial irradiation or craniotomy at two large cancer centers in South Korea. Retrospective review and statistical analysis of clinical characteristics and outcomes were performed for all patients. Median time from diagnosis of metastatic CRC to detection of BM was 12.2??months (range 0-76.2??months). Thirteen patients (11%) exhibited brain involvement at initial presentation. Median survival after BM development was 4.1??months [95% confidence interval (CI) 3.3-4.9??months]. Forty-six patients (40%) had been treated previously with the chemotherapeutic agents fluoropyrimidine, oxaliplatin, and irinotecan. Patients who received CT after BM exhibited significantly improved survival compared with those who did not (12.4 versus 3.1??months, respectively; P??<??0.001). Multivariate analysis revealed that CT intervention after presentation with BM was significantly associated with survival after BM, and the adjusted hazard ratio was 0.30 (95% CI 0.17-0.51, P??<??0.001). Although BM is a late-stage phenomenon in CRC, approximately two-thirds of patients were still unexposed to irinotecan or oxaliplatin at the development of BM in our study. Thus, additional chemotherapeutic intervention after BM associated with CRC may be beneficial for selected patients.</P>
Baek, Ji Yeon,Morris, Shelli M.,Campbell, Jean,Fausto, Nelson,Yeh, Matthew M.,Grady, William M. Wiley Subscription Services, Inc., A Wiley Company 2010 International journal of cancer: Journal internati Vol.127 No.5
<P>Hepatocellular carcinoma (HCC) results from the cumulative effects of deregulated tumor suppressor genes and oncogenes. The tumor suppressor and oncogenes commonly affected include growth factors, receptors and their downstream signaling pathway components. The overexpression of transforming growth factor alpha (TGF-α) and the inhibition of TGF-β signaling are especially common in human liver cancer. Thus, we assessed whether TGF-α overexpression and TGF-β signaling inactivation cooperate in hepatocarcinogenesis using an in vivo mouse model, MT1/TGFa;AlbCre/Tgfbr2<SUP>flx/flx</SUP> mice (“TGFa;Tgfbr2<SUP>hepko</SUP>”), which overexpresses TGF-α and lacks a TGF-β receptor in the liver. TGF-β signaling inactivation did not alter the frequency or number of cancers in mice with overexpression of TGF-α. However, the tumors in the TGFa;Tgfbr2<SUP>hepko</SUP> mice displayed increased proliferation and increased cdk2, cyclin E and cyclin A expression as well as decreased Cdkn1a/p21 expression compared to normal liver and compared to the cancers arising in the TGF-α overexpressing mice with intact TGF-β receptors. Increased phosphorylated ERK1/2 expression was also present in the tumors from the TGFa;Tgfbr2<SUP>hepko</SUP> mice and correlated with downregulated Raf kinase inhibitor protein expression, which is a common molecular event in human HCC. Thus, TGF-β signaling inactivation appears to cooperate with TGF-α in vivo to promote the formation of liver cancer that recapitulates molecular features of human HCC.</P>
Baek, Ji-Yeon,Rha, Kyeong-Hee 한국중앙영어영문학회 2022 영어영문학연구 Vol.64 No.2
The aim of this study is to investigate how Korean college students perceived hybrid classes, in terms of their social interaction. Also, it aims to examine the relationship among ‘social interaction’, ‘sense of belonging to the class’, and ‘class satisfaction’ throughout the semester. To achieve the aims, the research questions were established as follows; 1) how did Korean college students perceive the hybrid online classes in terms of their ‘social interaction’, ‘sense of belonging to the class’, and ‘class satisfaction’?, 2) Is there a correlation among those three constructs as they took the online classes conducted in a hybrid format? Thirty-nine college students who took hybrid classes responded to the pre- and post-surveys, which were modified from the Rovai’s (2002) Classroom Community Scale (CCS). The t-test and the Pearson correlation efficient were employed. The results of data analysis showed that the hybrid classes had a positive effect on students’ perceptions of ‘social interaction’, ‘sense of belonging to the class’, and ‘class satisfaction’, and that the students’ social interaction in the hybrid classes had a statistically significant correlation with ‘sense of belonging to the class’ and ‘class satisfaction’. Based on the research findings, more suggestions and implications for the non-face-to-face classes are presented.
[P5-51] Development of a Species Specific-PCR Method for Rapid Identification of Bacillus cereus
Ji Yeon Lee,Gun-Hee Kwon,Hwang A Lee,Ji Yeong Park,Chang Un Baek,Hyeon Deok Jo,Kang Wook Lee,Joo Yeon Kim,Chun-Seok Park,Dae Young Kwon,Jinkyu Lim,Jong-Sang Kim,Jeong Hwan Kim 한국식품영양과학회 2009 한국식품영양과학회 학술대회발표집 Vol.2009 No.11
( Ji Yeon Lee ),( Eun Ah Kim ),( Ji Hyon Jang ),( Min Jung Baek ),( Hee Young Cho ),( Young Ran Kim ),( Eun Hee Ahn ),( Sukho Kang ),( Myung Jin Moon ),( Sung Woon Chang ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: To identify factors associated with massive postpartum bleeding in pregnancies complicated by incomplete placenta previa located on the posterior uterine wall 방법: A retrospective cohort study was performed. Of 718 pregnant women with placenta previa who delivered babies after 24 weeks of gestation between January 2006 and April 2016, we identified 210 healthy singleton pregnancies with incomplete (partial or marginal) placenta previa located on the posterior uterine wall. The cases with intraoperative blood loss (>2,000ml) or transfusion of packed red blood cells (pRBC) (>4) or uterine artery embolization or hysterectomy were defined as massive bleeding. A P value <0.05 was considered statistically significant. 결과: Twenty-three women experienced postpartum profuse bleeding (11.0%). After multivariable analysis, four variables were associated with massive bleeding: experience of 2 or more prior uterine curettage (aOR 4.47, 95%CI 1.29-15.48, p=0.018), short cervical length before delivery (< 2.0cm) (aOR 7.13, 95%CI 1.01-50.25, p=0.049), fetal non-cephalic presentation (aOR 12.48, 95%CI 1.29-121.24, p=0.030), and uteroplacental hypervascularity (aOR 6.23, 95%CI 2.30-8.83, p<0.001). 결론: This is the first study of incomplete placenta previa located on the posterior uterine wall with massive postpartum hemorrhage. Our findings might be helpful to guide obstetric management and provide useful information for prediction of massive postpartum bleeding in pregnancies with incomplete placenta previa located on the posterior uterine wall.
Ji Yeon Baek,Eunju Lee,Gahee Oh,박유랑,Heayon Lee,Jihye Lim,Hyungchul Park,Chan Mi Park,Chan Mi Park,Chang Ki Lee,Hee-Won Jung,Il-Young Jang,Dae Hyun Kim 대한노인병학회 2021 Annals of geriatric medicine and research Vol.25 No.3
The Aging Study of Pyeongchang Rural Area (ASPRA) is a population-based, prospective cohort study of older adults in Pyeongchang, South Korea. Since the initial enrollment of 382 participants, the ASPRA has been maintained and has conducted comprehensive geriatric assessments annually, gradually expanding its population and coverage area. As a cohort study of aging-related conditions and their functional consequences, the ASPRA leveraged Pyeongchang’s relatively low annual population movement rate and its healthcare delivery system, which was largely maintained by community health posts. Since its establishment, the ASPRA has reported numerous observational and multicomponent intervention studies on functional decline, geriatric syndrome, and frailty. Here, we discuss the findings and perspectives of ASPRA studies. We hope that the ASPRA enables the further implementation of a longitudinal study design on geriatric parameters and the development of public health strategies targeting aging-related conditions, especially in resource-limited community settings.