한국사상(韓國思想)(철학(哲學)) : 사계(沙溪) 김장생(金長生)의 경학적(經學的) 주역관(周易觀)(1) -『경서변의(經書辯疑)』의 「주역상경(周易上經)」을 중심으로-

김익수 ( Ik Soo Kim ) 한국사상문화학회 2009 韓國思想과 文化 Vol.48 No.-

송대의 성리학이 전래되어 16세기 중반에 이르면서 퇴계(1501-1570)와 율곡(1536-1584)에 의하여 정착되어 갔다. 17세기에 이르면서 禮學이 등장했는데 이는 필연적이다. 본래 성리학과 예학은 표리관계(表裏關係)이며, 성리학이 인간의 內面을 수양(修己)하는데 중점을 두는데 반하여 예학은 외적(外的)인 실천에 비중을 두는 治人에 있기 때문이다. 더구나 임진, 병자 양난을 격고난 뒤에 인간성과 윤리회복이 시급한 국민적 과제였기 때문에 예학은 시대가 요청하는 현실적 학문이었던 것이다. 요컨대 주자학(성리학)과 예학은 내외(內外), 체용적(體用的) 구조로 지배적 이념이 되었는데 이런 때에 소명을 다한 이는 그 시대의 거성(巨星)이었던 김장생(金長生1548-1631)이었다. 선생은 평소에 저술에는 별 의도가 없었고 경전을 읽다가 의심이 나는 곳이 있으면 적어 놓았던 것이 쌓여서 날로 학문이 깊어지고 실행이 겸해졌는데 이를 류(類) 별로 모아 묶으니 여러 책들이 나왔다. 그 중에서 성리학의 바탕이 되고 전문적인 經學 연구서인 『경서변의(經書辨疑)』가 있다. 여기에는 『小學』을 비롯해서 四書와 三經을 변석한 것이 들어 있다. 그 중에서 四書 五經의 우두머리(首)라고 할 수 있는 周易을 연구대상으로 하되 3차에 걸쳐 연구하려고 하나 우선 1차적으로 上經만을 조심스럽게 먼저 연구해 보려고 한다. 經學의 연구는 성인 (聖人)의 가르침을 제대로 배우기 위함이다. 본 연구에서는 『經書辨疑』 『周易』에서 경학사상연구를 통해서 선생의 學問觀도 배우고 人間觀도 배우려는 것이 본연구자의 의도이다. 또 하나의 의도는 인문학의 기반을 원천적으로 세워 보려고 하는 원대한 뜻도 여기에 있다. 그래서 모든 경서의 몸통(體)이 되는 『주역』을 먼저 선정하였다. 부차적으로는 오늘날 학문하는 풍토가 지식의 축적에만 급급한 느낌인데 지도자들을 변화시킬 수 있고 교육을 바로 세울 수 있는 위치에 있는 학자들부터 學行一致로 자세가 달라져야 할 것을 촉구하는 뜻도 여기에 있다. Neo-Confucianism of Sung Dynasty of China established its firm foundation in Korea by the efforts of Toegye(1501-1570) and Yulgok(1536-1584) in the middle of sixteenth century. It was inevitable that the Study of Rites appeared in the seventeenth century. Primarily Neo-Confucianism and the Study of Rites are the two sides of a coin. While Neo-Confucianism emphasizes the study of mind, the Study of Rites mainly deals with the control of behavior of a person with appearance. After the both invasions by Japanese and Manchus, The Study of Rites became the pragmatic study of the time to recover the ethics. For this reason, harmonizing the Neo-Confucianism and the Study of Rites became the major theme of the time to control the mind and behavior of people and Kim Jang-saeng was the leading scholar to create this trend. Kim Jang-saeng was not particularly interested in writing books, but he took notes while he was reading the books. While doing so, Kim understood well on these issues and he practiced what he had learned. Later, his notes became categorized and published as many books. Among them, Gyeongsoebyeonui is the most professional research on the study of Confucian classics for the Neo-Confucianism. In this book, Kim analyzes the fundamental books of Confucianism such as the Study of the Elements of Confucianism, four major books and three classics of Confucianism. This paper aims to study carefully on the first part of Kim`s analysis on the Book of Change. The aim of studying the classics of Confucianism is to learn the teachings of sages in the correct way. The foundation of Neo-Confucianism came from the classics of Confucianism and Neo-Confucianism evolved from the Book of Change. It is urgent to understand the Book of Change, the core of all Confucian classics, correctly at the time of the crisis on the tradition of the study of humanities. This research tries to provide the Kim Jang-saeng`s views on Neo-Confucian study as well as on human nature through the part of the Book of Change in his Gyeongsoebyeonui. Also, this research aims to establish the foundation for the studies of humanities. This is why the Book of Change, the core of Confucianism, is the subject of the paper. In addition, nowadays, scholars in general intend to seek for knowledge. They are the people to change the leaders of society and that`s why scholars need to demonstrate the behavior of not contradicting their knowledge and behaviors.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

유도 '되치기 본'의 개선 방안에 관한 연구

김의환,김도준,김규수,김관현,김종달,최종삼,조용철,박순진,윤익선,안병근,정 훈,김미정,한성철 龍仁大學校 武道硏究所 1999 武道硏究所誌 Vol.10 No.1

The purpose of this study was to reform practically a Korean Judo's Doechigi-Bon(Forms of Counterattack, judo's Gaeshi no Kata, Judo's Uradori no Kata, Judo's Gonosen no Kata) that was established in 1955 Korea, according to changing of techniques by Judo's modernization, in order to have Judo's carefulness and systematic diffusion. Reform procedure of Judo's Doechigi-Bon was 1st stage, Questionnaire survey 303 judokas, 2nd stage, Technical seminar by judo experts(12 judo professor) 4 times, 3rd stage, wording report for reform, 4rd stage, Discussion and judgement of Teaching and Judgement commission of Korean judo Association(KJA), 5th stage, Public hearing for reform in KJA, 6th stage, Report and decision of board of directors in KJA, 7th stage, public publication of Judo News(No.53) in KJA. Basic principle of reform of Judo's Doechigi-Bon were as table 1. Table 1. Basic principle of reform of Judo's Doechigi-Bon ------------------------------------------------------------------------------- Items Reformed Key Points of Judo's Doechigi-Bon ------------------------------------------------------------------------------- 1. Structure 1) Grand classification : Classified by 3 parts(1,2,3Gyo) 2)Medium classification : Te waza, Goshi waza, Ashi waza devided per each part(Gyo) 3)Sub-classification : Classified five techniques per each part(Gyo) 2. Contents 1) Selected established techniques as possible 2) Considered rationalty and overlapping of counterattack techniques 3. Decision of Conterattack techniques 1) Refered to results of Basic Questionnaire survey 2) Priority to decisions of Judo expert technical seminar -------------------------------------------------------------------------------- Reformed Korean Judo's Doechigi-Bon(Forms of Counterattack techniques-KJA, 1999) are as follows: 1. Gyo; ① Uki otoshi -> Uchi mata ② Harai goshi -> Harai goshi gaeshi ③ O soto gari -> O soto gake ④ Ko uchi gari -> Sasae tsurikomi ashi ⑤ O uchi gari -> Ko soto gari 2. Gyo; ① Ippon seoi nage -> Okuri eri jime ② Tsuri domi goshi -> Uki waza ③ Okuri ashi harai -> Okuri ashi harai ④ Ko soto gari -> Tai otoshi ⑤ Hiza guruma -> Hiza guruma 3. Gyo; ① Kata guruma -> Sumi gaeshi ② Tai otoshi -> Ko soto gari ③ Hane goshi -> Harai tsurikomi ashi ④ Uchi mata -> Tai otoshi ⑤ Tomoe nage -> O uchi gari

철학(哲學) : 우암(尤庵) 송시열(宋時烈)의 직철학(直哲學)과 교육문화

김익수 ( Ik Soo Kim ) 한국사상문화학회 2008 韓國思想과 文化 Vol.42 No.-

우암 송시열(1607~1689)은 理學은 율곡이이(李珥 1536~1584)에게서 전수했으나 直哲學은 스승인 金長生(1548~1631)으로부터 전수(傳受)받았는데 조선조에서 直의 哲學은 송익필(1534~1599)로부터 비롯된 것이다. 우암은 孔子, 孟子, 程子, 朱子, 靜庵, 退溪, 栗谷 등의 사상을 貫通할 수 있는 直哲學 하나(一)로 義理之學을 세웠으니 ``大人之學``이라고 칭할만하다. 조선시대의 학문은 性理學이지만 시대를 초월하여 古今이 通貫되는 것이 直哲學이며 교육문화이므로 원천적으로 孔子易學의 直哲學으로 소급해서 연구되어야 한다. 우암의 直哲學은 平生의 生活哲學이었지만 모든 인류를 바르고 곧고(正直) 淸明하고 光明하게 문화민족으로 살아갈 수 있는 교육문화가 꽃필 修養論이기에 時·空을 초월한 永續性을 갖는다. 朱子를 尊信하고 朱子學에 전심한 우암의 春秋大一統思想의 義理는 민족의 주체성과 국가관이 확고하며 나아가서는 平天下, 곧 世界人類 平和思想임이 확실하다. 현대의 우리나라는 정치와 교육이 일치(政·敎一致)되지 않고 있어서 민족의 주체가 확고하지 않고 윤리가 지극히 문란하며 교육의 본연을 잃고 있다. 國史의 正體性이 허약하고 도덕이 부실(不實)한 토대위의 경제건설은 미래지향적이 아니다. 이런 때에 우암의 直哲學과 교육문화로 시대의 철학과 교육문화로 정착하여 世界化할 때 세계속에 우리나라가 도덕종주국으로 찬란한 교육문화가 인류평화사상으로 꽃필 가능성이 높다고 전망한다. 21세기는 문화의 세기라고 한다. 우암의 直哲學의 修養論은 현대 교육문화철학으로서 가치가 절대적이라고 판단되므로 새로운 정립이 시급하다. Uam Song Si-yeol(1607-1689) inherited the study of li from Yulgok Yi I(1536-584) while he succeeded the tradition of the philosophy of Righteousness from his teacher Kim Jang-saeng(1548-1631). The tradition of the philosophy of the Righteousness began with Song Ik-pil(1534-1599) at the early period of Joseon Dynasty. Uam would be considered as a ``Great Man in Neo-Confucianism because he established the philosophy of Righteousness that provide the theory unifying the cores of the teachings of Confucius, Mencius, Ch`engcius, Chu His, Jeongam, Toegye, and Yulgok. The major trend of the scholarly tradition of Joseon was Neo-Confucianism, however, this timeless philosophy of Righteousness is the core as well as the education. That is why Confucius study of Righteousness needs to be the first step to understand the Neo-Confucian tradition of Joseon. Uam`s philosophy of Righteousness was the philosophy of his life itself. At the same time, he emphasized the education to cultivate the all humankind to live with righteousness and wise to live as civilized men. From this his idea of education receives the respect regardless the time and space. Uam`s righteousness from his philosophy of the Great Union of Spring and Autumn, which reflects his dedication and respect for the Chu His is the one to set up sound national and racial self-esteems to achieve the peaceful co-existence of the mankind. There is a gap between politics and education in Korea today and it causes the collapse of education with the lack of identity and moral. Economic development cannot be futuristic when it lacks the identity in national history and collapse of moral standard. This is why the Uam`s philosophy of Righteousness and civilized education need to be reestablished and internationalized to promote the possibility of Korea becomes a leader of world moral and education. Since twenty-first century is the era of culture, Uam`s thoughts and the concept of education has an unchallengeable values.

직업적 연폭로가 일부 신경행동학적 검사수행에 미치는 영향

안익수,안현철,김용배,리갑수,김화성,황규윤,최은,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

In order to investigate that blood lead levels of lead exposed workers is associated with decreased performance in neurobehavioral tests in adults, we investigate 78 workers in a battery industry. Three items among neurobehavioral core test battery of World Health Organization, including digit span, Santa ana dexterity, digit symbol were administered to workers occupationally lead exposed workers by operational guide for the WHO neurobehavioral core test battery. Blood lead (PbB) and zinc protoporphyrin in whole blood (ZZP) were selected as an index of lead exposure. Detailed occupational history such as exposed agent, age, work duration, smoking and drinking habits, were recorded as confounding factors. After controlling age, the results of digit span and digit symbol among the neurobehavioral tests were significant contributed by PbB.

QT연장 증후군 환자에서 Head-Up Tilt Test에 의해 유발된 Torsades De Pointes 1례

전익수,차태준,김길수,김동완,김규종,김찬욱,김성만,주승재,이재우 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

한국사상문화(韓國思想文化) : 퇴계학(退溪學)의 계승과 례안광김(禮安光金)의 가족문화(家族文化) 묘합(妙合)으로 창조적인 선비문화(文化) 형성(形成)

김익수 ( Ik Soo Kim ) 한국사상문화학회 2008 韓國思想과 文化 Vol.45 No.-

혼합 식물추출물에 대한 차응애의 감수성 검정

김창승(Chang Seung Kim),김도익(Do Ik kim),국용인(Yong In Kuk),현규환(Kyu Hwan Hyun),김상수(Sang Soo Kim1) 한국차학회 2016 한국차학회지 Vol.22 No.1

The acaricidal activity of the mixed plant extracts of Gleditsia japonica var. koraien, Camellia sinensis, Cinnamomum cassia, and Lantana camara, toward the tea red spider mite, Tetranychus kanzawai Kishida was evaluated in laboratory bioassays. Treatments with mixtures 1 and 3 were effective against the adult females of T. kanzawai and yielded 87.0 and 85.6% adulticidal activity at 7 days after treatment, respectively. Mixture 3 revealed 78.7% adulticidal activity. However, mixtures 4 and 5 had lower adulticidal activity than the other treatments. The adult females of T. kanzawai treated with mixtures 1 and 3 produced only 22.5-22.8% as many eggs as did the control females. The residue of the plant extracts tested had low adulticidal activity (16.3-27.2%). All of the plant extracts tested were ineffective against the eggs of T. kanzawai. Treatments with mixtures 1 and 3 were effective against the nymphs of T. kanzawai and led to emergence rates of 20.7 and 25.3%, respectively. These results suggest that mixtures 1 and 3 might be used for the control of T. kanzawai.

孔子敎學思想硏究 : 人間學的 考察을 中心으로 Aspects of Anthropology

金益洙 건국대학교 1979 論文集 Vol.10 No.1

1.Preface The centrial idea of confucius is perfect virtue. He considered as the most important element in morality and advocated physiognomy. The essence of humanity is uprightness. He said politics depended on righteousness and emphasized the need to govern the nation by 7eans of virtue purpose of education was to hand down to posterity, he emphatically assorted, and it was the main feints of education through which they tried to bring up a disciple as a true gentleman of goodwill. Confucius placed emphasis on schooling common people and teaching practical philosophy. Moreover he attached much importance to moral education. He judged four teaching (literature, conduct, loyality, confidence) as the main task of education. Confucius was the founder of confucianism and it had a great influence on Korean educational principle. Therefore, we can find confucius, thought is closely related with Korean educational philosophy. The subject of this study is to help both humanize Korean education through confucius' moral philosophy and practical philosophy, and recongnize that education in this country should be based on philosopy 2.The intention of confucius' education Firstly, spooking abstractly, the aim of schooling, said confucius, was to morality. Perfect virtue and master ship are the central principle as well as an ultimate aim of education. Secondly, spooking concretely, a purpose of teaching was to bring up a man of goodwill. A man of goodwill is a typical model of human being whom we consider the subject of education. For that reason, Confucius laid stress on education of one's whole personality. 3.Confucius' method of education Confucius' method of education was very diverse. (1) Reformatory instruction by personality Confucius always attacked great importance to moral education. According to him, a teach who had admirable personality and dignity inspired his disciple by means of practicing morality. He also took a serious view of consistency of speech and action. His education was not a abstract ethics but a practical philosophy. (2) Introspection enlightment. Confucius held individuality and self-exarlination in esteem, and escaped cramming, education and one which is centering around a teacher. (3) self-denial and self-examination In social life, a selfish desire often come into being. It is perfect virtue that overcomes the selfish is desire and goes hack to decorum Self-denial is an ability to suppress a selfish desire and self-examination is examining oneself after a sense of self-interest comes into being. (4) Thought is labour lost ; thought without learning is perilous. We should practice an education accompanied learning and thinking. (5) Endeavour Confucius said one should study gradually in order. And be asked everybody to improve his ability. One's position is settled by one's ability, not by a more accident (6) Individuality adoptation. Confucius practiced an education which adapted individuality and was appropriate to one's talent. (7) The importance of surroundings Confucius stressed the fact that environment influenced one's learning and one's associates was a very import element in pursuing his study. 4.Conclusion It seems unrealistic, unvaluable and backneyed to say about confucius, its influence in education and so on. But, we must recognize that there are boundless educational principle in confucius' thought and his thought is filled will educational philosophy which has no second. Now that the wourld trys to humanize education. Reexamining help establish Korean educational philosophy.

한국인 정신분열병 및 양극성 기분장애와 Catechol-O-Methyltransferase 유전자 다형성(Valine/Methionine)과의 연합연구

김명수,지익성,이선우,선석철,이영호 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : 카테콜라민의 대사장애는 정신분열병과 양극성장애 같은 주요 정신질환에서 중요한 원인적 요인으로 주목받고 있다. Catechol-O-Methyltransferase(COMT)는 카테콜라민의 대사에 중요한 효소인데, COMT 유전자의 다형성(Val/Met)으로 인하여 COMT의 활동도가 달라진다. 본 연구는 COMT 다형성이 저신분열병과 양극성장애 같이 주요 정신질환의 발병에 있어서 유전적 요인으로 작용하는지 알아보기 위하여 시행되었다. 방 법 : 정신분열병 환자 128명과 양극성장애 환자 110명 그리고 정산이 176명 대상으로 중합효소 연쇄반을 이용하여 COMT 유전자의 유전자형과 대립유전자의 빈도를 비교하였다. 결 과 : 1)COMT의 유전자형은 정신분열병 환자군에서 Val/Val 76(59.4%), Val/Met 43(33.6%), Met/Met 9(7.0%)이었고, 양극성장애 환자군에서는 Val/Val 63(57.3%), Val/Met 35(31.8%), Met/Met 12(10.9)이었으며, 정상대조군에서 Val/Val 83(47.2%), Val/Met 79(44.9%), Met/Met 14(8.0%)이었다. 대립유전자의 빈도는 정신분열병 환자군에서는 Val 195(76.3%), Met 61(23.8%)이었고, 양극성장애 환자군에서는 Val 161(73.2%), Met 59(26.8%)이었으며, 정상 대조군에서는 Val 245(69.6%) Met 107(30.4%)이었다. 2)정신분열병 환자군, 양극성장애 환자군, 정상 대조군간의 유전자형(x²=7.541, df=4. P=0.110)이나, 대립유전자 (x²=3.268, df=2. P=0.200)에서 차이가 없었다. 정신분열병 환자군과 정상 대조군과의 비교에서 유전자형(x²=4.553, df=2. P=0.102)과 대립유전자(x²=3.199, df=1. P=0.081)에서 차이가 없었고, 양극성장애 환자군과 정상 대조군과의 비교에서도 유전자형(x²=4.907, df=2. P=0.086)과 대립유전자(x²=0.842, df=1. P=0.394)에서 차이가 없었다. 결 론 : 이러한 연구결과로 COMT 유전자 다형성(Val/Met)이 한국인 정신분열병과 양극성장애의 발병에 있어서 유전적 요인으로 작용할 것이라고 볼 수 없었다. Objective : Catechol-O-methyltransferase(COMT) is an important enzyme that inactivates biologically active or toxic catechols. Abnormal catecholamine transmission has been implicated in the pathogenesis of schizophrenia and bipolar disorder. Polymorphism(Val/Met) of the COMT gene polymorphism and schizophrenia and bipolar disorder in a Korean population. Method : COMT gene were genotyped with polymerase chain reaction and retriction enzyme NlaⅢ in 128 patients with schizophrenia, 110 with bipolar disorder, and 176 controls. Results : 1)The distribution of the COMT genotype in schizophrenic patients with Val/Val, Val/Met, Met/Met were 76(59.4%), 43(33.6%), 9(7.0%), in bipolar disorder patients were 63(57.3%), 35(31.8%), 12(10.9%), and in the controls were 83(47.2%), 79(44.9%), 14(8.0). The allele frequencies of the COMT gene in schizophrenic patients with Val and Met were 195(76.2%), 61(23.8%), in bipolar disoreder patients were 161(73,2%), 59(26.8%), and in the controls were 245(69.6%), 107(30.4%). 2)There were no differences in genotype distribution and allele frequencies of COMT gene polymorphism among the 3 groups. Neither patients with schizophrenia nor bipolar disorder differed in the genotype and allelic frequencies from the controls. Conclusion : These results suggest COMT gene polymorphism is not causally related to the development of schizophrenia and bipolar disorder in a Korean Population.