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이병국,맹광호,이광묵 최신의학사 1975 最新醫學 Vol.18 No.2
An Environmental and santiary survey was carried out on 585 houses and 36 wells in Gunseo Area, Okcheon-Gun, Choongbook Province. As a survey on sanitary environments of houses, number of rooms they were using, artificial lightening method, house heating method and sanitary measures in the kitchen were checked. Sanitary environments of drinking water sources were also investigated. Other tested items with water samples were hardness, pH, and chloride ion, and the results were summarized as follows: 1. 38.1 % of all subjected households were using 2 rooms and 29.4%, 3 rooms. 97.0% of all households were lightening their houses with oil lantern and those who were using elec tric lights were 1.7%. Those who were using coal briquett for their house heating were 12 households (2.0%). 7.4% of all households did not have any cupboard in their kitchens and those who were using dry wiping cloth were only 30.3% among all subjected housholds. 2. Main drinking water source was well (78.3%) and the pump was next (15.0%). 33.3% of all drinking water sources were beeing used by more than 6 househods. 96.1% of all drinking sourees (except pumps) were not covered and the drainage was bad in 30.0% of all drinking sources. 3. 47.0% of all households were disposing sewage unsanitarily and most of the rubbishes (93.2%) were beeing used for a compost. 4. 1% of the households were throw them away around their houses. Excrements were beeing used for fertilizer among 97.9% of all households. 4. The average hardness of 36 sampled well water was 188 ppm and the hardness of 7 samples(19.5 %) were over 300 ppm. 5. The average pH of 36 well surveyed were 6.48. Two samples were below 5.5 and 4 were over 7.1. 6. The average chloride ion of all samples were 75.2 ppm. The chloide ion of 4 samples were over 150 pPm, the international standard for drinking water.
이병국,이은규 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.1
Interferon (IFN) alpha 2a plays an essential role in the treatment of chronic hepatitis C. To improve its serum circulation stability, IFN is conjugated with PEG (polyethylene glycol) moiety. For Nterminally site-specific modification, we developed a solid-phase PEGylation process based on reductive alkylation in which aldehyde mPEG of 5, 10, or 20 kDa was conjugated to the IFN immobilized to a cation exchange resin (CM-Sepharose). From this preparation the IFN mono- PEGylate was easily purified by a single chromatographic step. N-terminal amino acid sequencing and MALDI-TOF MS confirmed the N-terminal, mono-PEGylation. The PEGylate showed the reduced anti-viral activity (by cell proliferation assay) and immunogenicity (by antibody binding assay). However, the proteolytic resistance as well as thermal stability was considerably improved. The solid-phase PEGylation process was highly reproducible in site specificity. This novel conjugation method may find other applications in improving biopharmaceutical proteins`` characteristics by site-specific chemical modification.
비심인성 폐부종과 정맥공기색전증으로 나타난 폐감압병 1례
이병국,문정미,류현호,정경운 대한응급의학회 2009 대한응급의학회지 Vol.20 No.3
Pulmonary decompression sickness (DCS) is a relatively uncommon form of type II DCS, with a frequency of only 2.4% as averaged from several studies. The deposition of venous gas emboli in the pulmonary arterial circulation produces progressive dyspnea, cough, chest pain and the physical findings of increased central venous pressure and pulmonary arterial pressure, and right-sided strain on an electrocardiogram. We recently experienced a case of pulmonary DCS presenting as interstitial pulmonary edema combined with low central venous pressure. In this case, air bubbles that were trapped in the most nondependent part of the femoral vein were discovered incidentally, on abdominal computed tomography scan, which may mean that the buoyancy of gas bubbles was sufficient to counteract the venous blood flow propelling such bubbles in the direction of blood flow. In addition, we discuss the current availability of recompression facilities in South Korea since some difficulties are anticipated in treating an unstable patient with a monoplace hyperbaric chamber, which is typically the only available type of hyperbaric chamber in South Korea.
이병국 대한에이즈예방협회 2003 레드리본 Vol.53 No.-
에이즈전파는 주로 성관계로 이루어진다. 그러므로 에이즈예방교육은 청소년기때부터 습득할 필요가 있다. 선진국의 경우 청소년들에게 어떤 예방교육을 실시하고 있는지 살펴보자.