Renca 마우스 종양모델에서 지구성운동이 종양형성에 미치는 영향

조정제,안현종,김성수,김창주 대한스포츠의학회 2003 대한스포츠의학회지 Vol.21 No.1

Subcutaneous injection of cells from renal adenocarcinoma line, renca, into Balb/c mice induces fast growing solid tumors. This method has been used to speculate the efficacy of cytokine treatment for tumor regression. The present study was designed to investigate the effect of treadmill exercise on tumor growth using renca mouse tumor model. We also examined the expression pattern of several genes related to immune response after exercise training for 4 weeks. Exercise training reduced the size of tumor mass compared to that of non-exercised group in tumor cell recipient mice. Natural killer(NK) cell activity showed no significant difference between exercised and non-exercised groups in tumor cell non-recipient mice. Although NK cell activity of non-recipients was higher than tumor cell recipients, NK cell activity of exercised group was significantly lower than non-exercised group among tumor cell recipients. There were no significant differences in mRNA expressions of cytokines. scavenger receptors, and neuropeptieds which are related to immune response, while mRNA expression of TGF-beta was significantly reduced both in spleen and in tumor mass by treadmill exercise. Based on the results presented in this study, endurance exercise has shown the possibility to suppress tumor formation.

노인에서 넘어짐의 원인과 예방

조상현,이현주 연세대학교 보건과학연구소 2002 보건과학논집 Vol.12 No.-

우울증 관련 평가도구의 개관

조현주,채정호,전태연 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.2

Objective : Since a lot of assessment tools for depression have been developed and used, it is difficult to choose the proper and optimal instruments for the purpose of their usage, In order to maximize the effectiveness of assessment for depression, this paper reviewed the characteristics and specific features of currently using tools. Method : The domestically and internationally using assessment tools for depression were reviewed and classified by litera-hire search and clinical experience. Results : Methods of assessment, selecting guides and characteristics of assessment tools for depression were presented. Conclusion : This paper would provide helpful guidelines for selecting the assessment tools. We suggest that it is needed to develop the assessment tools for depression that reflects Korean specific culture and custom.

가정과 교사들의 다문화 교육에 대한 인식 및 다문화 교육 실천 효능감 분석

조현주,육경민 이화여자대학교 교과교육연구소 2015 교과교육학연구 Vol.19 No.2

본 연구의 목적은 중등 가정과 교사들의 다문화적 태도, 다문화 교육 실천 효능감, 다문화 교육 목표 관점에 대한 인식을 조사하고, 세 하위척도가 각각 어떠한 상관관계가 있는지 알아본 것이다. 연구 대상은 중등 가정과 교사들 130명이며, 양적 연구를 통해 분석한 결과는 다음과 같다. 첫째, 중등 가정과 교사들은 현행 교육과정에서 다문화주의와 다양성을 미흡하게 다루고 있다 고 인식하고 있었으나, 다문화 관련 학부 수강 경험이 거의 없거나 연수를 받지 않은 것으로 나타났다. 이에 다문화 교육을 위한 교사 교육의 강화가 시급하다. 둘째, 중등 가정과 교사들은 다문화 교육 실천 효능감에 대한 인식들 중에서 다문화 교실에 적합한 학습 자료의 개발과 수업방법 적용 측면에서 특히 낮은 효능감을 나타내었으며, 이에 대한 교사 의 자발적인 노력과 행정적인 지원이 수반 되어야 할 것이다. 셋째, 중등 가정과 교사들의 다문화 교육 목표에 대한 관점은 사회적 행동 지향적, 배려중심 지 향적 목표를 중점적으로 동의하는 것으로 나타났다. 넷째, 다문화적 태도, 다문화 교육 실천 효능감, 다문화 교육 목표에 대한 관점의 상관관계를 살 펴본 결과, 사회적 행동 지향적 목표는 다문화적 태도에, 배려중심 지향적 목표는 다문화교육 실천 효능감에 영향을 주는 예측변인으로 나타났고, 다문화적 태도와 다문화 교육 실천 효능감이 사회 적 행동 지향적 목표와 배려 중심 지향적 목표에 영향을 주는 예측변인으로 나타났다. 그러므로 교 사들이 추구해야 할 목표는 현상유지의 관점을 공유하는 것이 아닌 변혁적인 교실 수업을 지향하는 관점을 추구해야 할 것이다. This study is intended to investigate Homes Economics teachers' multicultural attitudes and teaching practice self-efficacy, and their awareness of the objectives of multi-cultural education. The study also aims to find how these three elements are correlated with each other. For these purposes, one hundred thirty Homes Economics teachers were surveyed employing a questionnaire and the data obtained were analyzed quantitatively. The main findings are as follows. First, Homes Economics teachers perceived that the current curriculum does not deal with multiculturalism and diversity sufficiently. However, they took few courses related to multiculturalism in their undergraduate courses. They also had few opportunities of being trained on multiculturalism since they started to work as teachers. Thus, it is urgent for teachers to be educated or trained in multiculturalism. Second, as for their perception of teaching practice self efficacy of multiculturalism, Homes Economics teachers showed a low level of self efficacy especially in developing and applying teaching materials and methods suitable for multicultural classes. Therefore, Homes Economics teachers are required to make voluntary efforts to create and practice multicultural teaching materials and methods. In addition, administrative support is urgently needed to promote their efforts. Third, as for Homes Economics teachers' perspectives on the objectives of multicultural education, theyprimarily agreed to objectives oriented toward social behaviors and considerateness. Finally, an examination of the correlation between Homes Economics teachers' multicultural attitudes, their multicultural teaching efficacy and their perspectives of objectives for multicultural education led to the following: the objective oriented toward social behaviors was found to be a prediction variable of multicultural attitudes, and the objective oriented to considerateness was shown to be a prediction variable of multicultural efficacy. Therefore, Homes Economics teachers are required to have the perspective of seeking innovative classes instead of sharing the perspective of maintaining the current status.

유전체가 입혀진 금속거울을 사용한 3중반사 위상지연계 설계

趙顯柱,玄在慶 慶熙大學校 1990 論文集 Vol.19 No.-

Triple-reflection system of the dielectric coated metallic mirror acts as retarder, by proper selection of film refractive index, film thickness, and angle of incidence, that maintains collinearity of the input and output beams. If the film refractive index and angle of incidence are given, then the design procedure is described to determine the film thickness at design wavelength. Example is presented of quarterwave retarder that uses a ZnS-Ag film substrate system at the CO_2 laser wavelength. The equal net reflectances for p and s polarizations are computed and found to be high. Also the useful operation over a small wavelength range is demonstrated.

가정학 정의의 도식적 접근

조현주 경북대학교 사범대학 부속 중등교육연구소 2005 중등교육연구 Vol.53 No.2

본 연구의 목적은 바람직한 가정학의 정의를 내리기 위한 것이다. 먼저 정의의 논리학적인 진술 형식에 관해서 알아보고, 진술형식들을 도식화하여 이 형식에 따른 정의를 내릴 때의 준수 사항들을 제시하였다. 다음으로 선행 학자들이 내린 정의들이 거의 설명적 진술 형식을 취하고 있으므로 이 두 진술 양식을 비교해 보고, 앞으로의 가정학의 발전을 위해 그 정의에 관한 문제들을 제시하였다. 마지막으로 두 가지 정의의 진술 형식을 바탕으로 한 새로운 가정학의 정의를 내려보았다. The purpose of this paper is to make a desirable definition of home economics, For this purpose, the study has surveyed the two modes of statement about the definition of home economics: explanatory and logical. The literary survey has shown that most preceding scholars of home economics used the mode of explanatory statement in defining home economics. So it has diagrammed the way of logical statement and presented articles of observance in making a definition of home economics. Next the two modes of statement have been compared with each other. And some problems of defining home economics have been found out Finally, based on the mode of logical statement, some new definitions of home economics have been suggested for future growth of home economics.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

제주 지역의 B형 간염 바이러스 유전자형

조지현,박도심,김태현,염주진,김학철,문주현,양재식 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.1

목적: HBV 감염이 무증상의 자연 회복부터 간경변 혹은 간세포성 간암까지 다양하게 나타나는 요인들로 숙주의 요인과 바이러스의 요인으로 구분되어 제시되는데, 바이러스 요인으로는 감염된 바이러스이 유형이나 염기 변이들이 논의된다. HBV 유형을 구분하는 데는 혈청형과 유전자형이 이용되는데 근자에는 주로 유전자형이 이용된다. 이러한 HBV의 분포는 지역적으로 다르나 지역에 따라서 다른 유형들이 혼재되어 있다. 동남아시아는 B형이지만 극동아시아는 C형으로 알려져 있으며, 대만과 오키나와에서는 B와 C형이 혼재되어 나타난다. 이러한 결과로 미루어 보아 우리 나라의 남부지역에서는 B과 C형이 혼재되어 있을 가능성이 있다. 이에 본 연구는 제주 지역에서 HBV의 유전자형을 조사하고자 하였다. 대상과 방법: 원적지가 제주도이면사, HBsAg가 양성이었던 107명(평균 연령: 46.5세)을 대상으로 하였다. 이들의 혈청으로부터 HBsAg/antiHBe를 분석하고, DNA를 추출하여 7개의 유전자형에 따라 특이성을 갖는 시발체(genotype specific primer)들을 이용하여 PCR로 증폭한 후 이를 분석하였다. 주된 유전자형의 일부와 다른 유형에서 증폭에 이용되었던 시발체를 다르게 이용하여 hemi nested PCR로 증폭한 후 염기를 분석하여 계통발생학적 분석법을 이용하였다. 결과: 1. PCR에 의한 HBV DNA 양성은 107명 중 59명(55.1%)이 양성이었다. HBeAg/anti HBe의 발현 양태에 따라 음성/음성에서 2명(66.7%), 음성/양성에서 30명(41.1%), 양성/음성에서 24명(85.7%), 양성/양성에서는 3명(100%)에서 증폭되었다. 2. Multiplex PCR에서는 58명의 유전자형이 C형, 1명에서는 B형과 C형이 동반 출현하였다. 3. Genotype specific primer를 이용하여 각각 따로 PCR을 시행한 경우에 A형에 의하여 증폭된 예가 1예, B형에 의하여 증폭된 예가 1예, C형에 의하여 증폭된 예가 59예로 A형과 B형 모두가 C형에서 증폭된 예였다. 4. 한 쌍의 시발체에 의하여 증폭되었던 A형과 B형 및 C형의 일부에서 염기를 분석한 결과 모두 C 유전자형이었다. 결론: HBsAg이 양성인 제주 지역 주민의 HBV의 유전자형은 C형일 것으로 생각된다. Background/Aims: Hepatitis B virus (HBV) was classified into 8 genotypes by a sequence divergence in the entire genome designated from A o H. HBV genotypes have distinct geographic distributions. Recently, HBV genotypes have been partially found as influencing the clinical manifestation of chronic liver disease in hosts. In Korea, the distribution of HBV genotypes remains unclear. The aim of this study was to evaluate the prevalence of the HBV genotype on Jeju Island. Methods: Hepatitis B virus genotypes were evaluated among 107 hepatitis B carriers residing on Jeju Island. We used single PCR and multiplex-PCR assay with genotype-specific primer pairs for HBV genotypes A-F for the genotyping. Results: 1. Fifty nine samples (55%) were positive for HBV DNA. The positivity was different according to the pattern of HBeAg/anti-HBe expression, as -/-; 2/3 (66.7%), -/+; 30/73 (30%), +/-; 24/28 (85.7%) and +/+; 3/3 (100%). 2. In the single primer set of genotype-specific PCR, 59 samples (100%) were detected as genotype C and 2 (3%) were also detected as genotype A and B. 3. In multiplex-PCR, 58 samples (98%) were detected as genotype C and only one (2%) as a mixed pattern of genotype B and C. 4. When the PCR products were amplified with universal sense and genotype specific anti-sense from one genotype A, one B, and 2 C, all were included in genotype C. Conclusions: These results suggest that on Juju Island, almost all HBV genotypes are C.(Korean J Hepatol 2004;10:42-50)

전해 인프로세스 드레싱을 이용한 Optical glass계의 경면연삭에 관한 연구

조주현,원종호,박원규,이진오,김민수,김성수 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

Electrolytic In-process Dressing (ELID) technique for metal bonded diamond grinding wheel has been developed for mirror surface grinding of hard and brittle materials. This study process optical glass in using Electrolytic In-process Dressing. In using to main variable wheel speed(400 rpm ~ 2000 rpm), feed rate(5 μm/min ~ 25 μm/min), depth of cut (3 μm - 15 μm), dressing and spray. we measured surface roughness by Form Talysurf series2. we finded optimum grinding condition to obtain confident surface roughness in representative brittle materials.

계단상승 시 몸통각도에 따른 운동학적 요인과 지면반력 변화

조현영,정남주 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

The purpose of this study was to investigate the kinematical and ground reaction force variables according to the trunk lean[type A : 0~4deg., type B : 6~12deg.) during the stair ascent. For thi experiment, the stair structure was made and AMTI force plate was installed on the second and third stepping. Each motion was videotaped and digitalized with five video cameras to calculated the kinematical variables, and at the same time collected the ground reaction force. As a result, the following findings were obtained: 1. It was found that gait cycle of the type A was longer than type B, but ratio of the stance and swing to the gait cycle was similar to each other. Also it was found that stair ascent of the type A was more effective than that type B in the lower extremity motion. 2. It was found that stair ascent of the type A in the vertical and antero-posterior ground reaction force variables was more effective than that type B in that ascending the body weight.