정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

보건간호활동으로 추진한 노인건강증진 프로그램

유인영(In-Young Yoo),조정민(Chung0Min Cho),최영숙(Young-Sook Choi),정문희(Moon-Hee Jung),김미혜(Mi-Hye Kim),유광수(Kwang-Soo You),윤숙례(Suk-Rye Yoon),한명화(Myung-Hwa Han),최선하(Sun-Ha Choi),하영(Young Ha),김규성(Kyu-Sung Kim),이현주 한국보건간호학회 1997 韓國保健看護學會誌 Vol.11 No.1

q진 LCZ 수열군의 일반화된 확장 생성 방법

정정수(Jung-Soo Chung),김영식(Young-Sik Kim),장지웅(Ji-Woong Jang),노종선(Jong-Seon No),정하봉(Ha-Bong Chung) 한국통신학회 2008 韓國通信學會論文誌 Vol.33 No.11C

[1]에서 LCZ 수열군의 2배 확장을 제안하였다. 본 논문에서는 [1]에서의 2배 확장방법을 일반화하는 새로운 확장방법을 제안한다. 이 생성방법을 사용하면 인수가 (N,M,L,ε)인 q진 LCZ 수열군은 인수가(pN,pM,p「(L+1)/p」-,pε)인 q진 LCZ 수열군이 된다. 이 때, p는 소수이고 p는 q의 약수다. 특히 L≡p-1modp 일 때, 확장된 q진 LCZ 수열군의 인수는 (pN,pM,L,pε)이 된다. In this paper, a new extending method of q-ary low correlation zone(LCZ) sequence sets is proposed, which is a generalization of binary LCZ sequence set by Kim, Jang, No, and Chung. Using this method, q-ary LCZ sequence set with parameters (N,M,L,ε) is extended as a q-ary LCZ sequence set with parameters (pN,pM,p「(L+1)/p」-1,pε), where p is prime and p|q.

直憤式 디이젤機關의 出力性能 및 排出微粒子에 미치는 吸氣 濕度의 影響에 관한 硏究

하종률,탁영조,정대간 동아대학교 환경문제연구소 1988 硏究報告 Vol.11 No.1

The engine output and particulate emission are influenced by inlet air humidity. This study is concerned with the engine output and particulate emission on the inlet air humidity. The engine performance was analized to P-θ diagram, the rate of pressure rised, the rate of heat release, and the rate of mass burned by means of combustion analysis system. The particulate emission measurement is made by mini-dilution tunnel system. Consequently, this study showes the qualitative relationship between the engine output or particulate emission and the inlet air humidity.

응급의학과 의사가 시행한 상복부 초음파의 정확성

하영록,김훈,유승,정성필,김승환,유인술 대한응급의학회 2002 대한응급의학회지 Vol.13 No.4

Purpose: The purpose of this study is to determine for upper abdominal pain, the accuracy of emergency abdominal ultrasonography (EAU) performed by emergency physicians with limited training. Methods: Two PGY-3 emergency physicians, who had received 2 hours of hands-on training, including the normal anatomy of a biliary system, liver, kindney, spleen, and pancreas, and who had studied the pathologic findings for another month were the subjects of this study. They used a Sonosite 180? to perform EAU on patients with upper abdominal pain within 2 months after training. We determined the agreement between the radiologist’s abdominal ultrasonography(RAU) and EAU by using Kappa statistics. Results: A total of 59 patients were enrolled. The agreement between the EAU and the RAU findings was 0.97, 0.88, 0.79, 0.73, 0.62, and 0.57 for gall bladder (GB) distension, cholelithiasis, GB wall thickening, duct dilatation, choledocholithiasis, and pericholecystic fluid, respectively (p<0.05). Conclusion: The results of EAU, performed by emergency physician with limited training on patients suffering from upper abdominal pain had a significant agreement with the RAU. However, more educations and cautions are warranted for diagnosing pericholecystic fluid and choledocholithiasis.

우리나라와 일본의 중학교 가정과 교육과정의 비교연구

정옥님,김영숙,전옥하 조선대학교 교육연구소 1986 교과교육연구 Vol.9 No.-

Every country in the world has unique curriculums. This is because the expectation of individuals differs with each country's situation, social environment and social needs. Since our country is no exception, in legal limitation the educational curriculum is organized and restricted directly by the goverment. That is, the educational curriculum is organized to embody the national educational ideals. In this respect it is possible to explain the organization of the educational curriculum with respect to the socio-cultural background. The content of educational curriculums, receiving social influence, is determined in the of viewpoint sociology of knowledge through social analysis of the ideological and cultural background and organization process for the selection of content. From this point of view the middle school home economics curricums in Korea and Japan have been comparatively analyzed. Viewing the educational curriculum as being related to political ideology, national political ideology is to build an ideal society with the aid of educational activities to cultivate the ideal individual. In order to do this, political ideology is taken into account in the selection of content that is realizable as having political pursuable value by applying tactical and systematic restrictions on the educational curriculum. The organization of Korean and Japanese educational curriculums are formed in this context. Therefore, the educational ideals, educational laws, and educational objectives have been compared and their relationships surveyed. As a result, it has been found that the educational curriculum has been organized with the purpose of individual happiness and citizenship in Japan and individual character-building and social development in Korea. It has also been found that the objective of home economics education in Korea is a search of one's role and direction in society, and in Japan emphasis is placed on individual personality development and social adjustment. It can be said that this comes from the differences in the socio-cultural environments that the two countries have. So far the Korean educational curriculum has been revised four times and problems have always arisen in the adaptability of the curriculum. But, because our educational curriculum is formed under policy and systematic restrictions, before evaluating adaptability it is more desirable to reflect on the necessary content in preparation for life in society in order to meet changes and the future by finding adaptability in our present situation.

두경부 악성종양 절제술 후 유리피판을 이용한 재건술 40예의 고찰

백정환,손영익,김성민,추광철,하범준,심영목 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7

유아에서의 메타콜린 유발 검사의 의의

정용헌,이하룡 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

A study was performed to evaluate the usefulness of methacholine challenge test in preschool children unable to perform the spirometry 45 cases were selected from patients complaining frequent respiratory illness, seen in ourpatient clinic of pediatric department, Chungnam University hospital during the period of Aug. 1994 to July 1996. The results were summarized as follows: 1. The values of methacholine concentration showing PC20 were widely distributed as reange of 0.3mg/ml to 25 mg/ml, not 50 mg/ml. 2. Methacholine mean value inducing cough was 1.25mg/ml in under 6 year of age, 2.5mg/ml in over 6 year of age. 3. Methacholine mean value inducing wheezing was 5 mg/dl in under 6 year of age, 10mg/ml. in over 6 year of age. 4. Methacholine concentrations showing PC20 values induced by methacholine challenge were more compatible with those of wheezing than cough. 5. Wheezing and cough were not correlated in methacholine challenge test With the results, a significant association was found between bronchial responseiveness to methacholine and wheezing checked by ausculation. Clinical manifestation, as wheezing, by methacholine challenge, can be predictable for pulmonary function value in preschool children without spirometry.

실내사무환경의 환경성담배연기(ETS)의 지표물질에 관한 연구

하권철,백남원,박동욱,윤충식,김원,최상준,박지영,최인자,김신범,강태선 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

The purpose of this research is to evaluate indoor office environment using the concentrations of nicotine, 3-enthenyl-pyridine(3-EP), and respirable suspended particulate(RSP), which are indicators for environmental tobacco smoke(ETS) and the correlations between indicators and environmental conditions(smoking density, smoking index). The mean air charge per hour (ACH) in smoking rooms was 10.4 and most of the smoking rooms showed non-compliance withe ASHRAE standard value except only one smoking rooms. The concentrations of RSP, 3-EP, nicotine showed log=normal distributions, and became different statistically depending on smoking condition(p〈0.01). The geometric mean concentration of RSP in smoking room was 441.7 ug/㎡ that is far exceeded environmental standard(150 ug/㎡). This implies that fine particulate in smoking room should be carefully controlled considering smoking density and ventilation fate. The mean concentrations of nicotine and 3-EP were 93.4 ug/㎥, respectively. The correlation coefficients between RSP and SI, 3-EP and SI, and Nicotine and SI were 0.67, 0.84 and 0.74, respectively. The correlation coefficient between nicotine and 3-EP, nicotine and RSP, and RSP and 3-EP were 0.76,0.78 and 0.57 respectively.

급성 심근경색증에 동반된 승모판 폐쇄부전증의 임상적 특징

정상만,조영일,조화상,유광하,송기호,인행환 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-

The early detection and proper management of mitral regurgitation(MR) associated with acute myocardial infarction(MI) is very important to improve the clinical course and outcome of disease. The change of left ventricular shape and regional function, papillary muscle rupture are major determinant of the existence and severity of MR. We performed 2D and M mode echocardiography of 28 patients at the early stage of acute MI to evaluate the existance and degree of MR and its pathogenetic factor. Significant MR occured in 12 (42.9%) patients. In the group of MI with MR, the inferior MI was frequent (7 case) than anterior MI (5 case) comparing to the patient group of MI without MR (inferior MI : 6 case, anterior MI : 10 case) (p<0.01).The left ventricular end diastolic dimension(LVEDD), end systolic dimension (LVESD) and left atrial dimension (LAD) were significantly increased in MI with MR than MI without MR (LVEDD : 57.3 ±8.6 vs 46.4 ±9.2, p<0.05 ; LVESD : 52.9 ±9.2 vs 38.3 ±7.4, p<0.01 ; LAD : 45.4 ±3.8 vs 37.7 ±3.7, p<0.05).However, the ejection fraction was not different between two group two groups. These datas showed that MR was more frequent in inferior MI and the hemodynamic derangement was more serious in acute MI with MR.