RAW264.7 세포에서 interferon-r 및 LPS에 의해 유도되는 NO생성에 미치는 TALT-35의 영향

박종일,박경석,김종석,박지훈,윤은진,송경섭,서강식,김훈,윤완희,박승길,임규,황병두 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-

TALP-35 purified from human term placenta is known to increase microtubule polymerization and stabilize the polymerized microtubule. To examine the effect of TALP-35 on immune system this study was performed. MTT assay was performed to investigate the effect of TALP-35 on the proliferation of RAW264.7 cells. TALP-35 dose dependently suppress the proliferation of RAW264.7 cells at high concentration (above 1 μM) in unstimulated cells, in case of 10 μM TALP-35 treated cells the suppression was 25% but in stimulated cells it was only 15%. Cosedimentation assay was carried out to investigate whether TALP-35 can bind to tubulin of RAW264.7, monocyte/macrophage lineage of mouse, and polymerize it. TALP-35 polymerize the tubulin of RAW264.7 cells and sedimented in dose-dependent manner. To investigate the effect of TALP-35 on the expression of iNOS protein western blotting was performed. The expression level of iNOS was decreased dose dependently in high concentration of TALP-35 treatment. To examine the activity of iNOS, secreted NO was determined by method based on Griess reaction. Interferon-γ and LPS-stimulated production of NO from RAW264.7 cells was decreased dose dependently above 0.1 μM concentration of TALP-35 and 50% is decreased at 10μM of it. This study shows TALP-35 can control cytokine induced-iNOS expression therefore it might control inflammatory diseases.

쵸서의 英語에 나타난 强變化 五類動詞의 硏究

朴兜秉 순천대학교 어학연구소 1988 어학연구 Vol.1 No.-

DOO-BYUNG PARK(1988). "A Study on the Strong Verbs of Class V in Chaucer's English", Language Studies, 1, Ⅰ. The purpose of this article is to prove two hypotheses. The first is that the strong verbs of class Ⅴ in chaucer's English did not change to weak verbs as in the other works of the same period and the second is that the forms of the strong verbs are variegated, because Chaucer's english was transitional and the spelling wasn't fixed. The results of the investigation obtained through my reseach and analysis of the 22 strong verbs of class Ⅴ in the Complete Works of Geoffrey Chaucer edited by F.N.Robinson are as follow. 1. In Chaucer's English there were 22 strong verbs of the class Ⅴ of which 21 verbs had strong forms but only one verb weyen had weak forms. Weyen had already become weak verb before 1400 and even though the 3 verbs fret, weve, wreke among 22 strong verbs had weak forms in Chaucer's time, they kept only strong forms in Chaucer's English. 2. In Chaucer's English strong verbs of class Ⅴ had not forms with a mixture of weak and strong form. 3. In Chaucer's English there were 43 infinitive forms, of which 17 forms had final -n, but 26 forms had final -3. There were 68 past participle forms, of which 29 forms had final -e but 39 forms had final -n. Only 20*(30%)of the past partiaple forms had prefix(i-;6, y;14)but the rest of them had no prefix. 4. The strong verbs of class Ⅴ have retained relatively the good ablaut series in Chaucer's English.

백서 간재생중 H2B Histone 유전자 발현에 대한 Octamer Binding Transcription Factor의 역할

임규,방재웅,최두식,손미영,이영철,박청,김태동,김영래,박종일,윤완희,박승길,황병두 한국노화학회 2001 한국노화학회지 Vol.11 No.1

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

쵸서의 英語에 나타난 强變化 三類動詞의 硏究

朴兜秉 順天大學校 1992 論文集 人文社會科學篇 Vol.11 No.-

The purpose of this article is to prove the hypothesis that the strong verbs of class B in Chau- cer's English did not change to weak verbs as in the other works of the same period. The results of investigation obtained through my research and analysis of the 48 strong verbs of class B in The Complete Works of Geoffrey Chaucer edited by F. N. Robinson are as follow. In Chaucer's English there were 48 strong verbs of the class H of which 37 verbs had strong forms, one verb having weak form besides strong form, 4 verbs having weak forms, and 6 verbs having no forms of past or past participle tense. Before Chaucer's time 13 verbs of this class had weak form but in Chaucer's English only 5 verbs had weak form so that these facts showed that the strong verbs of class H have retained relatively the good ablaut series in Chaucer's English.

외국인 이주자의 기본활동 공간에서의 일상생활과 사회적 관계

최병두,박은경 대구대학교 다문화사회정책연구소 2012 현대사회와 다문화 Vol.2 No.1

외국인 이주자들은 경제의 세계화와 교통통신기술의 발달과 같은 거시적 배경 하에서 국제이주를 행하지만, 또한 동시에 자신들이 추구하는 주요한 목적을 실현시키기 위해 수행한다고 할 수 있다. 특히 후자의 입장에서 외국인 이주자들은 자신의 이주 목적을 실현시키기 위해 활동하는 공간, 즉 기본활동 공간에서의 생활과 사회적 관계에 매우 민감할 것으로 간주된다. 이 논문은 외국인 이주자들이 유형별로 이러한 기본활동 공간(즉 결혼이주자의 가정, 단순 및 전문직 이주노동자의 직장, 그리고 외국인 유학생의 학교)에서 어떻게 생활(특히 만족)하는가, 어떻게 사회적 관계를 형성하는가를 설문조사 및 심층면적을 통해 수집된 자료를 분석하고자 한다. 분석 결과를 정리하면 다음과 같다. 첫째, 결혼이주자의 가정생활은 의사소통, 집안일 처리, 가족생활 문화 적응, 가족생활 전반에 대한 적응에 대해서는 ‘보 통’(5점 척도값, 3) 이상의 만족도를 보였으나, 자녀 양육이 가장 큰 어려움으로 지적되었다. 둘째, 이주노동자의 직장생활은 희망직종, 적정한 업무량, 충분한 임금, 직장 유지 등의 활동에서 ‘보통’ 이상의 만족도를 보였지만, 실제 장시간 노동이 많 았고, 이직 욕구도 강한 것으로 조사되었다. 셋째, 전문직 이주자의 직장 생활은 시설의 편리성, 복지제도, 업무시간 및 업무량, 임금, 업무수행능력 등의 사항에서 ‘대체로 만족’(3.5점) 이상의 만족도를 보였으며, 사회적 관계도 대체로 원활한 것으로 나타났다. 끝으로 외국인 유학생의 대학생활은 대학 내 행정기관 및 편의시설, 장학 및 지원제도, 수업 및 학업, 한국어 교육지원, 기숙사 수용, 교우관계 등에서 ‘보통’이상의 만족도를 보였지만, 의사소통과 외국인 배려 부족 등을 어려움 문제로 지적 했고, 또한 일상적으로나 어려움에 봉착한 상황에서 한국인보다 본국인 친구들과 더 밀접한 관계를 가지는 것으로 나타났다. Foreign immigrants have carried out their international migration under a structural and global context of economic globalization and disparity between countreis, and of development of transportation and communication technology, but at the same time they have done such a career activity in order to realize their life-long aims. And hence, they are very keen to daily activities(and satisfaction) and social relationship in what can be called ‘basic activity spaces’ where they try to realize their aims of international migration: home space for marriage immigrants, workplace for simple or professional immigrant workers, and university campus for foreign students. This paper is to understand foreign immigrants’ daily activities and social relationship in such a basic space, analyzing data collected through questionnaire and in-depth interviews

쵸서의 英語에 나타난 重複動詞의 硏究

朴兜秉 순천대학교 어학연구소 1993 어학연구 Vol.5 No.-

The purpose of this article is to study how many reduplicating verbs (the strong verbs of class Ⅶ) in Chaucer's English changed into weak verbs and to study the corelation of this class Ⅶ with other class in Chaucer's English. The results of investigation obtained through my research and analysis of the 39 strong verbs of class Ⅶ in The Complete Works of Geoffrey Chaucer edited by F. N. Robinson are as follow. 1. In Chaucer's English there were 39 strong verbs of the class Ⅶ, of which 20 verbs (51%) had only strong forms and 10 verbs (26%) had weak forms and weak forms and weak forms besides strong forms, but 4 verbs (10%) having no forms of past or past participle tense. 2. The verbs of this class kept more verbs that had only weak forms and weak forms besides strong forms than the other classes. 3. The 6 verbs : beholde, falle, folde, hatte, know, sowe among 20 verbs which kept only strong forms had weak forms besides strong forms before or in Chaucer's time, but they kept only strong forms in chaucer's English. In short these facts showed that the strong verbs class Ⅶ in Chaucer's English had retained relatively the good ablaut series in Middle English.

Pyrazinoisoquinoline류의 合成

朴龍泰,朴丙準,金榮斗 慶北大學校 産業開發硏究所 1982 硏究報告 Vol.10 No.-

2-cyclohexylcarbonyl-1,3,4,6,11, 11a-hexahydro-2H-pyrazino-[1.2-b]-isoquinoline-l-one was synthesized starting from phenylalanine by cyclization with formaldehyde, esterification of the isoquinoline-3-carboxylic acid thus obtained, followed by condensation with ethyleneimine and reaction of cyclohexyl carbonyl chloride.

정신과 입원 환자의 직종별 불안 성향에 관한 연구

박재선,박두병,이길홍 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.4

The present study was to examine the relationship between psychiatric inpatients' occuputions and their anxiety level. The sampling subjects were randomly selected by 3 stage probability proportional culster extraction method among psychiatric who were admitted to the psychiatric clinics and hospitals nationwide. Four hundred and twenty eight subjects including 249 males and 179 females were undergone by questionnaire survey while measurement of anxiety was done by using Zung's self-rating anxiety scale. Collected data were processed by IBM PC AT computer using SPSS program and statistically analyzed by chi-square test and analysis of variance. 1) It was revealed that these psychiatric inpatients showed relatively higher rates of the unemployed (34.6%), single(43.2%), and divorce(5.1%). 2) Patients with higher classes of occupation such as administrative, managerial or clerical workers showed higher rate of divorce. 3) In the occupational distribution of psychiatric disorders, psychotic disorders were more prevalent among high or low occupational classes, neurotic disorders more prevalent among middle occupational classes, while psychoactive substance use disorder more prevalent among farmers and sales workers. 4) Overall the mean anxiety score of the whole subjects is 39.28 ±14.67. The mean anxiety score (39.71±14.89) of the pschiatric inpatients with job is higher than that (36.59±14.20) of the unemployed. 5) In the anxiety tendency according to occupational classification, the unemployed showed less anxiety compared with the employed. Patients with middle occupational classes such as fishing workers and sales workers showed higher levels of the cardiovascular, musculoskeletal, respiratory and skin system anxiety, while patients with higher or lower occupational classes showed lower anxiety. In the relationship between occupational classes and level of anxiety, it showed profiles of inverted V curve. 6) The lower occupational classes such as sales workers showed higher anxiety level, while the higher occupational classes such as clerical workers showed lowest one. Particularly the fishing group exposed in the higher stress situation showed the highest level of anxiety.

물의 光化學的 分解에 依한 水素生成

朴龍泰,金榮斗,朴丙準 慶北大學校 産業開發硏究所 1982 硏究報告 Vol.10 No.-

Photo chemical splitting of water as a means of solar energy storage was studied. Hydrogen was evolved from water by visible light irradiation of the system containing a ruthenium complex or chlorophyll-a as sensitizer, several different types of electron carriers and catalyst such as colliodal Pt. Especially in the system including chlorophyll-a, manganese solution and benzylnicotin amide, hydrogen was produced. Hydrogen generation was more effective in the microscopically heterogeneous systems such as vesicle and microemulsion than in the homogeneous systems. In the microemulsion system containing chlorophyll-a and Mn^ⅡTPPCl, irradiation of that system by visible light resulted in the reduction of Mn^ⅡTPPCl to Mn^ⅡTPPCl and the oxidation of chlorophyll-a, but in the dark Mn^ⅡTPPCl was regenerated.