혈액투석 환자의 가성 고칼륨혈증

최창렬,조형도,강태영,이준수,한호,정청일,이동규,유준호,한상웅,김호중 대한신장학회 2001 대한신장학회잡지 Vol.20 No.5

Protective Effects of Hyperoside against Carbon Tetrachloride-Induced Liver Damage in Mice

Choi, Jun-Ho,Kim, Dong-Wook,Yun, Nari,Choi, Jae-Sue,Islam, Md. Nurul,Kim, Yeong-Shik,Lee, Sun-Mee American Chemical Society and American Society of 2011 Journal of natural products Vol.74 No.5

<P>In this study, the hepatoprotective effects of hyperoside (<B>1</B>), a flavonoid glycoside isolated from <I>Artemisia capillaris</I>, have been examined against carbon tetrachloride (CCl<SUB>4</SUB>)-induced liver injury. Mice were treated intraperitoneally with vehicle or <B>1</B> (50, 100, and 200 mg·kg<SUP>−1</SUP>) 30 min before and 2 h after CCl<SUB>4</SUB> (20 μL·kg<SUP>−1</SUP>) injection. Levels of serum aminotransferases were increased 24 h after CCl<SUB>4</SUB> injection, and these increases were attenuated by <B>1</B>. Histological analysis showed that <B>1</B> prevented portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia. Lipid peroxidation was increased and hepatic glutathione content was decreased significantly after CCl<SUB>4</SUB> treatment, and these changes were reduced by administration of <B>1</B>. Protein and mRNA expression of tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1) and nuclear protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2) significantly increased after CCl<SUB>4</SUB> injection. Compound <B>1</B> suppressed TNF-α, iNOS, and COX-2 protein and mRNA expression and augmented HO-1 protein and mRNA expression and Nrf2 nuclear protein expression. These results suggest that <B>1</B> has protective effects against CCl<SUB>4</SUB>-induced acute liver injury, and this protection is likely due to enhancement of the antioxidative defense system and suppression of the inflammatory response.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2011/jnprdf.2011.74.issue-5/np200001x/production/images/medium/np-2011-00001x_0006.gif'></P>

7두의 개에서 배설성 요로조영술을 통한 신장 기능 평가

최윤정,이기자,최형준,이용진,박성준,송근호,정성목,최호정,이영원 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-

Excretory urography is a type of contrast study used to verify and localize upper urinary tract disease. It is an inexpensive and easy way to visualize of anatomic and functional status of the kidney and has been used as a primary imaging modality for the evaluation of urinary tract abnormalities. We describe urological signs of 7 dogs who examined with excretory urography and ultrasonography. Six cases were referred to veterinary medical teaching hospital. Chungnam national university (VMTH, CNU) to evaluate renal function after the treatment for renal failure and one case was referred showing hematuria. In case 1, 2 and 4, blood test and urinalysis was normal and the results of excretory urography presented that renal function were normal range. In case 3, the results of urinalysis, ultrasonography, and excretory urography except blood test presented abnormal kidney and hydronephrosis was diagnosed. In case 5 and 6, blood test, urinalysis, ultrasonography and excretory urography indicated renal failure. In case 7, blood test, urinalysis and ultrasonography presented partially abnormal signs, however, the results of excretory urography was normal range.

단기간의 금연과 일회성 유산소 운동이 흡연자의 심혈관 반응에 미치는 영향

송준경(Jun Kyung·choi),최현민(Hyun Min Choi),김종경(Jong Kyung Kim),노호성(Ho Sung Nho) 한국사회체육학회 2012 한국사회체육학회지 Vol.0 No.48

The purpose of this study was to investigate cardiovascular responses to a bout of aerobic exercise and acute smoking cessation in smoker. nine collegiate male smoker who have been smoking(duration of smoking: 7.5 ± 0.9yrs; number of cigarettes per day: 15.5 ± 1.5) participated in this study. All subjects performed PEI to stimulate Group IV metaboreceptor at immediately after smoking, 24hours after smoking cessation and smoking after a bout of aerobic exercise. they were measured SBP, DBP, HR, SV, CO, TVC using by finometer(FMS co, Netherland). As a result, compared to immediately after smoking, SBP, DBP, and MAP were significantly decreased 24-hours after smoking cessation at rest and PEI(p<0.05). In addition, smoking after a bout of aerobic exercise caused by post-exercise hypotension indicated that SBP was significantly decreased compared to immediately after smoking(p<0.05). also, the changes in DBP and MAP at rest and handgrip exercise were significantly smaller compared to immediately after smoking(p<0.05). Thus, the results showed that smoking cessation during 24-hours and a bout of aerobic exercise relieve excess blood pressure response and enhanced arterial baroreflex in collegiate male smoker. It is concluded that caused exercise pressor reflex by stimulated Group IV may be effective to improve excess blood pressure responses.

간 이식 환자에서 발생한 파종성 Scedosporium apiospermum 감염 1예

박현구,최성호,강호석,송주형,정지훈,소민욱,최상호,김양수,우준희 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

저자들은 다발성 뇌 농양을 동반한 치명적인 파종성 S. apiospermum 감염이 발생한 간 이식 환자를 경험하였다. 본 증례의 환자는 voriconazole로 치료하는 호전경과를 보이다가 진균성 뇌 동맥류 파열로 사망하였다. S. apio-spermum은 비교적 드문 진균으로 병리학적으로 Aspergillus spp.와 매우 유사하고 amphotericin B에 내성을 나타내므로 진단과 치료가 적절하게 이루어지지 못할 가능성이 많고 면역 기능 저하 환자에서 혈행성 전파를 통한 파종성 감염이 용이하게 발생하므로 높은 사망률을 나타낸다. 이식 환자를 비롯한 면역 기능 저하 환자에서 진균감염이 의심될 때 S. apiospermum과 같은 드문 진균에 의한 감염증도 감별진단에 포함해야 하겠다. Sedosporium apiospermum is a saprophytic fungus commonly found in soil and polluted water. This organism is known as a cause of mycetoma, which may occur in immunocompetent hosts following trauma. However, in immunocompromised patients, S. apiospermum can also cause life-threatening invasive disease, including central nervous system infection or disseminated infection. We report a fatal case of disseminated S. apiospermum infection in a 46-year-old woman after liver transplantation. Eight days postoperatively, she developed pneumonia, followed by altered mentality in the 15 days. A head CT demonstrated multiple brain abscesses. Sputum and stereotactic-aspirated brain abscess culture yielded S. apiospermum. Despite treatment with voriconazole, the patient died of intracranial hemorrhage.

학교 경제교육 방향 탐색을 위한 델파이 조사 연구

최병모,김정호,이준혁 한국경제교육학회 2005 경제교육연구 Vol.12 No.1

연세대학교 치과병원에 내원한 어린이에서의 영구치 맹출 시기 및 순서

강태성,최병재,권호근,손홍규,최형준 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.4

치아의 정확한 맹출 시기와 그 순서는 어린이의 발육 성숙도의 지표로서 소아치과 임상 및 예방 교정치료에 있어서 매우 중요하다. 이에 2001~2003년에 연세대학교 치과대학병원 소아치과에 내원한 어린이중 만 5세부터 만 14세까지의 남자 654명, 여자 542명, 총 1,196명의 자료를 수집하여 영구치의 맹출 시기 및 순서에 대한 연구 결과 다음과 같은 결론을 얻었다. 1. 상악 영구치의 맹출 시기는 중절치 남 만6.81세, 여 만6.78세, 측절치 남 만8.30세, 여 만7.98세, 견치 남 만10.28세, 여 만10.04세, 제1소구치 남 만9.74세, 여 만9.90세, 제2소구치 남 만10.87세, 여 만10.41세, 제1대구치 남 만6.25세, 여 만6.54세, 제2대구치 남 만12.21세, 여 만12.03세, 여 만12.03세였다. 2. 하악 영구치의 맹출 시기는 중절치 남 만6.00세, 여 만6.06세, 측절치 남 만6.99세, 여 만6.74세, 견치 남 만9.83세, 여 만9.17세, 제1소구치 남 만9.92세, 여 만9.75세, 제2소구치 남 만10.66세, 여 만10.39세, 제1대구치 남 만5.99세, 여 만5.75세, 제2대구치 남 만11.92세, 여 만12.17세였다. 3. 영구치의 맹출 순서는 상악에서 제1대구치, 중절치, 측절치, 제1소구치, 견치, 제2소구치, 제2대구치의 순이었고, 하악에서 제1대구치, 중절치, 측절치, 견치, 제1소구치, 제2소구치, 제2대구치의 순이었다. Accurate timing and sequence of eruption of permanent teeth are indicies of growth and essential for pediatric dentistry and pediatric clinical orthodontics. From the children brought to the Yonsei Dental Hospital during 2001 to 2003, 654 boys and 542 girls, ranging in age from five to fourteen years, were selected and analysed. The following was concluded. 1. Eruption time of maxillary teeth is 6.81 years in boys, 6.78 years in girls for central incisor, 8.30 years in boys, 7.98 years in girls for lateral incisor, 10.28 years in boys, 10.04years in girls for canine, 9.74 years in boys, 9.90 years in girls for first premolar, 10.87 years in boys, 10.41 years in girls for second premolar, 6.25 years in boys, 6.54 years in girls for first permanent molar, 12.21 years in boys, 12.03 years in girls for second permanent molar. 2. Eruption time of mandibular teeth is 6.00 years in boys, 6.06 years in girls for central incisor, 6.99 years in boys, 6.74 years in girls for lateral incisor, 9.83 years in boys, 9.17 years in girls for canine, 9.92 years in boys, 9.75 years in girls for first premolar, 10.66 years in boys, 10.39 years in girls for second premolar, 5.99 years in boys, 5.75 years in girls for first permanent molar, 11.92 years in boys, 12.17 years in girls for second permanent molar. 3. The following eruption sequence was observed: the first permanent molar erupted first, followed by the central incisor, the lateral incisor, the first premolar, the canine, the second premolar and the second permanent molar in the maxilla. The first permanent molar erupted first, followed by the central incisor, the lateral incisor, the canine, the first premolar, the second premolar and the second permanent molar in the mandible.

<i>Toxoplasma gondii</i> protects against H₂O₂‐induced apoptosis in ARPE‐19 cells through the transcriptional regulation of apoptotic elements and downregulation of the p38 MAPK pathway

Choi, Si‐,Hwan,Park, Sung Jun,Cha, Guang‐,Ho,Quan, Juan Hua,Chang, Nam‐,Sik,Ahn, Myoung‐,Hee,Shin, Dae‐,Whan,Lee, Young‐,Ha Blackwell Publishing Ltd 2011 Acta ophthalmologica Vol.89 No.4

<P><B>Abstract.</B></P><P><B>Purpose: </B> Toxoplasmosis, which is caused by the protozoan parasite <I>Toxoplasma gondii</I>, can lead to severe visual impairment. <I>T.?gondii</I> inhibits or delays programmed cell death caused by various apoptotic triggers; however, the mechanisms involved in the <I>T</I>.?<I>gondii</I>‐induced suppression of apoptosis in retinal cells have not been analysed in detail.</P><P><B>Methods: </B> We investigated the role of <I>T</I>.<I>?gondii</I> infection in H<SUB>2</SUB>O<SUB>2</SUB>‐induced apoptosis in human retinal pigment epithelial cells (ARPE‐19) by monitoring the activities of apoptosis‐regulating molecules and mitogen‐activated protein kinases (MAPKs), including p38 MAPK. We also examined the gene downstream from p38 MAPK.</P><P><B>Results: </B> <I>T.?gondii</I> infection significantly inhibited the cellular toxicity of H<SUB>2</SUB>O<SUB>2</SUB> (500 μ<SMALL>m</SMALL>) and increased cell viability in a multiplicity of infection (MOI)‐dependent manner by reducing DNA fragmentation and reactive oxygen species (ROS) generation in ARPE‐19 cells. Western blot analysis also showed that <I>T</I>.?<I>gondii</I> infection prevented the host cell expression of pro‐apoptotic factors, such as Bad and Bax, and the activation of caspase‐3. Infection with <I>T</I>.?<I>gondii</I> increased the expression of the anti‐apoptotic factor Bcl‐2 in ARPE‐19 cells under oxidative stress. In accordance with these findings, <I>Toxoplasma</I> infection was protective enough to suppress the phosphorylation of p38 MAPK following H<SUB>2</SUB>O<SUB>2</SUB> treatment. Exposure to H<SUB>2</SUB>O<SUB>2</SUB> increased the expression of heme oxygenase‐1 (HO‐1) in ARPE‐19 cells, and its expression was significantly inhibited in H<SUB>2</SUB>O<SUB>2</SUB>‐treated infected cells.</P><P><B>Conclusion: </B> The protective function of <I>T</I>.?<I>gondii</I> infection against ROS‐induced apoptosis results from changes in the expression of apoptotic molecules and the downregulation of stress‐induced intracellular signalling.</P>

중국ㆍASEAN FTA에 따른 관세인하의 영향과 시사점

최준호,홍승린 한국관세학회 2007 관세학회지 Vol.8 No.1

This paper inspects beforehand China, ASEAN FTA begun substantially according to China, ASEAN sign trade in services agreement between FTA, and customs brokers who is taking charge of 97% of import and export customs clearance of our country wishes to investigate about segment to correspond hereafter according to role enlargement with China and ASEAN. Main result of this paper is as following. First, will have to grasp change circumstance strictly market environment that follow to China-ASEAN FTA as for our enterprise, and propel market extension for these area at the same time through strategic investment about China-ASEAN. Second, role which registered customs brokers of our country prepare FTA and first of all, are important with China-ASEAN is achievement of consulting business by FTA conclusion including certificate of origin. Third, Our government should prepare Korea-ASEAN ETA for early tariff reduction realization of ASEAN interest item.

Van der Woude 증후군 1예

최홍식,임재열,박준호,남지인 대한이비인후과학회 2001 대한이비인후과학회지 두경부외과학 Vol.44 No.11