Systemic Sclerosis Sine Scleroderma

김채기 ( Chae Gi Kim ),류헌모 ( Hun Mo Rhoo ),권중구 ( Joong Goo Kwon ),이창형 ( Chang Hyeong Lee ),송용호 ( Yong Ho Song ),최정윤 ( Jung Yoon Choe ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.3

Systemic sclerosis (SSc) is a generalized connective tissue disorder of unknown etiology. Clinically, there is a broad spectrum of disease ranging from widespread severe skin thickening to skin thickening limited to the distal extremities. In rare cases of systemic sclerosis, no cutaneous change only with internal organ involvement has been reported, which is called `systemic sclerosis sine scleroderma (ssSSc)`. We describe a patient with Raynaud`s phenomenon, who showed intestinal pseudoobstruction as a presenting symptom but did not show any skin change. She had also an esophageal motility disorder, but other organ involvement was not evident. Antinuclear antibody was positive. Her obstruction symptoms were improved by decompression by nasogastric tube and pharmaceutical treatment with erythromycin and octreotide.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

土性에 따른 煙草植物의 養分吸收의 變化

陸昌洙,洪淳達,金雄柱,鄭勳采 충북대학교 엽연초연구소 1983 煙草硏究 Vol.10 No.-

Experiment was conducted to investigate the relation of growth characteristics, nutrient amount absorbed by tobacco plant, chemical components, changes of NH4 -N and NO3-N in the soil, yield, quality and price per 10a. Nc2326 and Burley 21-tobacco plant grew in sandy loam and clay loam by treated different levels of nitrogen, phosphorous and potassium fertilizers. the results were summarized as follows. 1.The plant height, length and width of the largest leaf, fresh weight and dry weight of tobacco leaves and stem of NC2326 and Burley21 were greater in clay loam than those in the sandy loam during growing. 2.The amount of nitrogen and phosphorous in tobacco leaves and stem absorbed by NC 2326 grown in clay loam were increased by 60days after transplanting, and then decreased, and amount absorbed by Burley 21 increased continuously in sandy loam and clay loam till the harvesting time. 3.The contents of potassium, calsium and magnesium in the leaves of NC 2326 and Burley 21 were increased continously during growing period and the amount of patassium uptake was greatest. 4.Total nitrogen, total alkaloid and reducing sugar in the dry leaves of NC 2326 and Burley 21 showed no differences between the plot of sandy loam and clay, but Burley 21 showed higher content of total nitrogen and alkaloid than NC2326. 5.Changes of NH4-N and NO3 -N in soil decreased gradually during growing period. Amount of NH4 -N in the plot of Burley 21 was higher than that in NC 2326 during glowing period. 6.The best yield was shown in the NC 2326 glowing in clay loam soil and quality was highest in the sandy loam. The highest price per 10a, 590, 400, was shown in clay loam with 10-10-20kg/10a fertilization.

A preliminary study in melasma following INMODE forma procedure

( Soon-hyo Kwon ),( Je-byeong Chae ),( Jung-won Shin ),( Jung-im Na ),( Chang-hun Huh ),( Kyoung-chan Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Melasma is a common hypermelanosis that frequently appears on the face. In recent studies, it is suggested that dermal structural alteration, including solar elastosis and basement membrane disruption, may have an important role in the pathogenesis of melasma. Forma device (InMode Inc, Richmond Hill, ON, Canada, North America) is a radiofrequency dermal heating device used on facial wrinkles and rhytides. Objectives: The aim of this study was to evaluate the effects of Forma device on melasma in a small group of volunteers. Methods: All volunteers were treated 4 times at 3 weeks intervals. Every visit, melanin index and erythema index was measured to assess the improvement in hyperpigmentation and erythema. Clinical photos were evaluated to estimate the degree of skin changes. Results: Clinical and instrumental evaluation showed that melasma improved after INMODE forma treatment. Conclusion: We suggest that treatment with Forma device may have beneficial effects on melasma by dermal remodeling and direct heat delivery on melanocytes.

급성충수돌기염으로 발현된 방선균증 2예

조진원,송진영,김창억,민영훈,최창순,우흥정,현인규,김종현,유기철,채승완,손진희 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

The Actinomyces species are normal flora of oral cavity and upper intestine characterized as gram-positive, non-spore-forming anaerobic or mjcroaerophilic rods. Actinomycosis is a chronic suppurative and granulomatous disease characterized by abscess, sinus, abundant granulation and mass. The appendix is the commonly involved site among abdominal actinomycosis. Abdominal actinomycosis is often difficult to diagnose before operation because of no reliable clinical features and infrequency of the disease. We report two cases of abdominal actinomycosis which were manifested as acute appendicitis. Those were detected Incidentally tv the pathologist after routine appendectomy. Both patients were successfully treated with appendectomy followed by proper antibiotics use.

규칙적인 수영운동과 taurine 섭취가 Seizure 유발 마우스의 해마에서 항산화 효소 및 caspase-3, 8 발현에 미치는 영향

채창훈(Chae Chang-Hun),노종철(Noh Jong-Cheol),이진경(Lee Jin-Kyung),강성환(Kang Sung-Hwan),박석(Park Sok),김현태(Kim Hyun-Tae),박종명(Park Jong-Myoung),안응남(An Eung-Nam),김지연(Kim Ji-Youn) 한국체육과학회 2010 한국체육과학회지 Vol.19 No.2

We investigated changes in the activity of inducing epileptic seizures with PTZ, changes in apoptosis-related factors and the antioxidant defense system in mice. The mice were divided into 4 groups (n=8 for each group) such as the control (PTZ) group, the carnosine-administered (Ca+PTZ) group, the exercise (Ex+PTZ) group and the mixed treatment (Ca+Ex+PTZ) group. The expression of caspase-3, 8 protein was a significant difference in the changes of protein expression between all groups. But the changes in the activity of antioxidant enzymes were significantly different only for SOD. Based on the results above, pretreatment of carnosine and exercise was found to have a positive effect on protection against oxidative damages and excitatory toxicity which is produced in large amounts in epileptic seizures. This study reported that especially the mixed treatment of regular aerobic exercises and carnosine administration reduced the level of seizure activities and mortality by reducing the protein level of caspase-3, 8 as well as increasing antioxidant enzyme activity.

수중운동프로그램이 비만 지적장애여성의 CRP, Fibrinogen 및 Adiponectin에 미치는 영향

송채훈(Song, Chae-Hun),박승수(Park, Seung-Soo),손창욱(Son, Chang-Wook) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.4

This study conducted an aquatic exercise program with obese women with intellectual disabilities for 12 weeks and examined its effects on CRP, fibrinogen, and adiponectin. The results are as follows. First, for a change in CRP, the exercise group showed a significant difference in CRP(p〈.001). It suggested that the aquatic exercise program had a positive effect on the change of a CRP level in obese women with intellectual disabilities. Second, for a change in fibrinogen, the exercise group showed a significant difference in fibrinogen(p〈.001). It suggested that the aquatic exercise program had a positive effect on the change of a fibrinogen level in obese women with intellectual disabilities. Third, for a change in adiponectin, the exercise group showed a significant difference in adiponectin(p〈.001). It suggested that the aquatic exercise program had a positive effect on the change of a adiponectin level in obese women with intellectual disabilities. Based on the findings, it was confirmed that the aquatic exercise program applied to obese women with intellectual disabilities was effective to decrease weight and body fat and the onset of metabolic syndrome and cardiovascular diseases in people with intellectual disabilities who can be easily obese due to restrictive body activity and social involvement and imprudent dietary habits. Moreover, the aquatic exercise program had a positive effect on prevention against obesity, cardiovascular diseases, and life-style related diseases in obese women with intellectual disabilities by decreasing CRP and fibrinogen which is a vascular inflammation marker, and increasing adiponectin which is an inflammation marker manifested in obese cells. The effects of exercise can be increased with people’s active interest and encouragement. Further study should develop exercise programs useful for people with intellectual disabilities. If professional coaches are trained and institutional supports are made for their easy participation in exercise, they can not only enjoy doing exercise, but also undergo mental treatment through the exercise.

Development of Physics-Based Virtual Training Simulator for Inspections of Steel Transmission Towers

Chae Chang-Hun,Ko Kwang-Hee 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.3

Industrial drones are widely used for the inspection of power transmission lines of steel transmission towers for the safety of workers, reduced inspection time and cost. However, mistakes in drone operations by unskilled operators may lead to major accidents, resulting in a lot of time and cost to recover from the accidents. Therefore, the education and training of drone operators in this inspection job are essential. Training using physical drones is quite limited. First, a large space is needed where drones are controlled. Second, a sufcient amount of time for training cannot be provided due to the capacity of batteries that may only last approximately ten minutes. Moreover, the education and training for the power transmission line inspection task are much more dangerous and complicated because it is difcult to train near the steel transmission towers. We develop a training simulator using virtual reality technology to overcome these difculties. The virtual training simulator provides an immersive training environment by incorporating into the simulator various physical factors such as the weight, movement direction, and velocity of the drone, and the direction and speed of the wind. Also, it allows multiple users to operate drones and camera gimbals at the same time for efective training. The simulator was tested using a simulation scenario. Actual users evaluated its efectiveness in the training of the inspection task.

Treatment Efficacy of Nucleos(t)ide analogues in Treatment- Naive Chronic Hepatitis B Patients with Liver Cirrhosis

( Chang Hun Lee ),( Yun Chae Lee ),( Yeon Soo Lee ),( So Min Jeong ),( Jong Oh Park ),( Ji Hun Lee ),( Han Eum Ju ),( Seung Young Seo ),( Seong-hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1

Early Percutaneous Catheter Drainage Reduces Hospital Stay but Not Mortality in Patients with Pyogenic Liver Abscess

( Chang Hun Lee ),( Yun Chae Lee ),( Jaehee Park ),( Song Yi Yu ),( Hun Gil Jo ),( Jae Sun Song ),( Gum Mo Jung ),( Yong Keun Cho ),( Eun Young Cho ),( In Hee Kim ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: To investigate the factors associated with prolonged hospital stay and mortality among patients with pyogenic liver abscess (PLA) who underwent percutaneous drainage (PCD). Methods: We retrospectively reviewed data from PLA patients admitted from 2005 to 2018 at three tertiary hospitals in Jeonbuk province. We selected patients who underwent PCD during the admission period and early PCD was defined whether the procedure was done within 3 days of admission. Results: Among 655 patients diagnosed with PLA, 366 patients who underwent PCD were enrolled for the study. The patients had a mean age of 65.5 ± 14.7 years, and mean maximal diameter of the hepatic abscess was 6.1 ± 2.6 cm and 71.9% of the lesion was single. Next, two groups were divided depending on the time period of PCD and 269 patients (73.5%) underwent PCD within 3 days of hospitalization. In baseline characteristics, early PCD group was significantly higher in the number of abscess as well as the maximal abscess diameter. However, hospitalization period was significantly lower in the early PCD group though in-hospital mortality was not different. We checked laboratory results at 1 week after the admission and CRP levels were significantly lower in the early PCD group. We further analyzed the factors related to the long-term hospitalization more than 14 days. In multivariate analysis, underlying diabetes, lower albumin levels, and PCD inserted after 3 days of admission were independent factors associated with prolonged hospital stay. Conclusions: Early PCD facilitated improvement of inflammatory laboratory markers and shortened the hospital stay. Early PCD may be beneficial in patients with PLA.