정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

5-〔3-(N-Substituted Piperazinyl)Propoxy〕Indan類의 合成과 中樞神經抑制效果

黃熙喆,閔庚鎭,文勝煜,李萬佶,徐丙天 嶺南大學校附設 基礎科學硏究所 1985 基礎科學硏究 Vol.5 No.-

Five new indans, 5-[3-(N-substitued piperaziny) propxy]indans, were synthesized by condensation of 5-(3-bromopropoxy)indan, the intermediate, and N-substituted piperazines. The structure of the compunds were determined by means of IR, NMR spectoscopy along with elemental analysis. Each compound was tested for antimorphine and antiamphetamine effects as part of CNS depressant effects and for muscle relaxant action in mice. Thes compound exhibited less potent activity compared to chlordiazepoxide on CNS depressant effect. Muscle reaxant action of the compounds, the side effect of tranquilizer, however, was much weaker than that of chlordiazepoxide.

Paraquat 투여 백서에서 Cyclophosphamide와 Dexamethasone의 치료 효과

신정철,신양수,유병전,임현성,정태흥,박찬국,오금탁,이병래 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

Paraquat (N,N'-dimethy 1-4,4'bipyrydinium : Gramoxone^(R), a widely used herbicide, is extremely toxic to all green plants and many eukaryotic organisms. In human, paraquat intoxication leads to multiple organ failure, it preferentially damages the lung, kidney and liver and may result in death. The participation of superoxide in initiating tissue damage by administration of paraquat is well known in which one electron reduction of paraquat leads to the formation of radical species which react with molecular oxygen to give superoxide. This process initiates immunological changes with the activation of neutrophilic leukocytes, which is related to further production of superoxide. In this experiment, therapeutic effects of cyclophosphamide and dexamethasone on blood cell count, malondialdehyde as a indicator of lipid peroxidation, and antioxidant enzymes levels in the lung, liver and kidney of paraquat intoxicated rats were inbestigated. The WBC count were significantly decreased by combined treatment of cyclophosphamide and dexamethasone in paraquat intoxicated rats at 3 and 5 days but RBC count were not changed. The contents of malondialdehyde were significantly decreased in the lung and Kidney by combined treatment at 10 days after paraquat intoxication. The catalase acitvities were markedly increased in the lung and liver of rats at 10 days after paraquat intoxication, and superoxide dismutase activities showed minimal changes in the lung, liver and kidney of rats by combined treatment. These results suggest that paraquat induced tissue damage in rats can be redeced by combined administration of cyclophosphamide and dexamethasone.

HL-60 세포의 성장에 대한 제주자생 해조류의 효과

김상철,박수영,김병석,강지훈,김세재 제주대학교 생명과학기술혁신센터 2002 제주생명과학연구 Vol.5 No.-

The purpose of the present study is to examine the inhibitory effect of extracts of marine algae growing in Jeju on the growth of HL-60 leukemia cells. The effect was observed by measurement of metabolic activity and counting of viable cells. The methanol extracts on 36 species of marine algae growing in Jeju were screened for cytotoxic effect at the concentration of 100㎍/㎖. In results, the inhibitory effect on the growth was observed in the treatment of crude extracts on 7 species of marine algae. In particular, Dictyota dichotoma, Myelophycus simplex, Laurencia okamurae, Plocamium telfairiae, Petalonia binghamiae, Codium minus marketdly inhibited the growth of HL-60 cells.

CybexⅡ를 이용한 여자 태권도 선수와 유도 선수들의 등속성 근력에 관한 연구

조용철,류병관 龍仁大學校 體育科學硏究所 1995 體育科學硏究論叢 Vol.5 No.1

The purpose of this study was to assess isokinetic factors between female taekwondo and judo players. Fourteen female subjects employed for this study were all national team levels. They were all university students and average age were 21 years old. The main findings as follows: 1) Taekwondo players were significantly higher than Judo players in Peak Torque. 2) Taekwondo players were significantly wider than Judo players in angle of Peak Torque. 3) Taekwondo players were significantly faster than Judo players in Accel Time. 4) Taekwondo players were significantly higher than Judo players in Total Work. 5) Taekwondo players were significantly higher than Judo players in Average Power. 6) Taekwondo players were significantly higher than Judo players in TAE. 7) Taekwondo players were significantly higher than Judo players in Set Total Work. 8) There was no significant differences exist in endurance rate between female Taekwondo and Judo players.

제주자생 해조류의 세포성장 억제효과

김상철,박수영,김병석,강희경 제주대학교 생명과학연구소 2002 제주생명과학연구 Vol.5 No.6

The purpose of the present study is to examine the inhibitory effect of extracts of marine algae growing in Jeju on the growth of leukemia cells, adenocarcinoma cells, normal cell. The effect was observed by measurement of metabolic activity using colorimetric MTT assay. The methanol extracts on 36 species of marine algae growing in Jeju were screened for cytotoxic activity against HL-60 cells was found in 5 specices of Marine algae. In particular, Scytosiphon lomentaria, Lithophyllum okamurae. Hydroclathrus clathratus, Dictyopteris undulata, also showing similar cytotoxity to KG-1 cells. But, they did not show similar cytotoxicity to SNU-16 cells, HCT-15 cells. Lithophyllum okamurae, Dictyopteris undulata markedly inhibited the growth of CCD-25Lu normal cell.

月經痛에 應用되는 淸熱調血湯의 效能에 對한 實驗的 硏究

金哲源,柳深根,朴炳烈 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

To elucidate the effects of Chungyeoljohyeoltang(淸熱調血湯) being applied to dysmenorrhea, after oral administration Chungyeoljohyeoltang water extract in mice and rats, acute toxicity, analgesic, sedative, hypothermic, estrogenec actions, action on isolated uterine muscle and serum estradiol concentration were measured. The results obtained were as follows ; 1. The yield of water extract of Chungyeoljohyeoltang was 21.8%, minimum lethal dose was 4,000mg/kg, which rarely had the acute toxicity in mice and rats. 2. The analgesic effects of Chungyeoljohyeoltang by acetic acid induced writhing syndrome in mice were not remarkably observed. 3. The relaxant action of Chungyeoljohyeoltang by acetic acid induced uterine muscle in estrogenized rats were not remarkably observed. 4. The hypothermic effects of Chungyeoljohyeoltang in rat's rectus were remarked. 5. The sedative effects of Chungyeoljohyeoltnag by hexobarbital sodium induced sleeping time in mice were remarked. 6. Administration of Chungyeoljohyeoltnag increased serum estradiol consentration in rats but without significance. 7. Administration of Chungyeoljohyeoltnag caused remarkably increase in weight of rat's uterus.

서울시 대기오염과 호흡기 질환 환자와의 관련성에 대한 시계열적 연구

최병철,구정완,박성균,임현우,이강숙,이원철,박정일 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 서울시의 대기오염 수준이 호흡기 질환 외래 환자수에 미치는 단기 영향을 파악하고자 하였다. 방법 : 1997년 7월부터 1998년 6월까지 서울시의 대기오염자료와 호흡기 질환에 대한 의료보험자료를 분석하였다. 추세변동과 기상요인, 요일 및 주별 효과등의 교란요인을 제어하고 관련성을 평가하기 위하여 generalized additive model(GAM)을 이용하였다. 결과 : 교란요인을 제어한 기본모델에 각 대기오염 물질을 포함시켜 분석한 결과, CO는 모든 연령층에서 일정하게 당일 농도가 가장 유의한 영향을 미치는 것으로 나타났고(RR=1.041∼1.051), NO₂역시 3일전의 농도가 모든 연령층에서 가장 유의한 영향을 미쳤다(RR=1.024∼1.050). O₃와 SO₂는 4일전 농도부터 당일 농도까지 지연시간이 길게 나타나는 특징을 보였으며, 15세 이하에서는 3일전 농도가(O₃RR=1.047, 95 % Cl=1.045∼1.049, SO₂RR=1.018, 95 % Cl=1.017∼1.020), 15-64fll (O₃RR=1.035, 95 % Cl=1.032∼1.037, SO₂RR=1.037, 95 % Cl=1.035∼1.039)와 65세 이상 (O₃RR=1.042, 95 % Cl=1.033∼1.051, SO₂RR=1,029, 95 % Cl=1.022∼1.036)에서는 당일 농도가 가장 유의한 결과를 나타냈다. PM□은 유의성이 낮게 나타났는데 15세 이하는 하루 전 농도(RR=1.011, 95 % 71=1.010∼1.013), 15∼64771(RR=1.021, 95 % Cl=1.019∼1.023)와 65세 이상(RR=1.025, 95 % Cl=1.018∼1.032)은 당일 농도가 유의하게 나타났다. 두 포염물질씩을 기본모델에 포함시켜 분석한 결과 CO, NO₂, O₃는 상대위험비가 '단일 오염물질모델'의 값과 거의 일정하게 통계적 유의성을 유지하였으나 SO₂는 15세 이하에서 NO₂와 같이 포함된 모델에서 통계적 유의성을 상실하였다. PM□은 모든 연령층에서 CO와 같이 포함된 모델에서 통계적 유의성을 상실하여 '단일 오염물질모델'에서 나타난 유의성이 CO에 의한 교란작용의 결과임을 알 수 있었다. 또한 15세 이하에서 NO₂, 15∼64세와 65세 이상에서 502와 같이 포함된 모델에서 역시 유의성을 상실하여 본 연구에서 살펴본 호흡기 질환에 미치는 PM□의 영향은 크지 않은 것으로 나타났다. 결론 : 본 연구의 결과는 서울시의 일상적인 대기오염이 여러 호흡기질환의 발생을 증가시킬 수 있음을 보여주었다. 따라서 대기오염의 효율적 규제에 대해 보다 적극적인 대책이 마련되어야 할 것이다. Objectives : This study was conducted to investigate whether air pollution levels in Seoul have short term effects on respiratory disease outpatients. Methods : We analyzed five air pollutants (CO, NO₂, O₃, SO₂, PM□) and daily counts of outpatient for respiratory disease divided by age group ((15yrs, 15-64yrs, 654yrs)during the period of July 1997-June 1998 using Generalized Additive Model (GAM) . Results : After controlling for seasonal trends, day of the week, week of the month, temperature and humidity, CO (RR=1.041 ∼1.051, 0-day lag) and NO₂(RR=1.024∼1.050, 3-day lag) were significantly associated with daily counts for respiratory disease in all age groups. O₃and SO₂were associated, with a 3-day lag in the age group under 15 years (O₃RR=1.047, 95% Cl=1.045-1.049; SO₂RR=1.018, 95% Cl=1.017-1.020) and with a 0-day lag in the age group 15 to 64 years (03 RR=1.035, 95% Cl=1.032-1.037; 502 RR=1.037, 95% Cl=1.035-1.039), in the age group over 65 years (O₃RR=1.042, 95% Cl=1.033-1.051; SO₂RR=1.029, 95% Cl=1.022-1.036). PMlo was weakly associated, with a 1∼day lag In the age group under 15 years (RR=1.011, 95% Cl=1.010-1.013) and with a 0-day lag in the age group 15 to 64 years (RR=1.021, 95% Cl=1.019-1.023), in the age group over 65 years(RR=1.025, 95% Cl=1.018-1.032) . In the' two pollutant model', the magnitudes of the recta alive risk for CO, NO₂nd O₃were maintained, but SO₂was not assoclated with daily counts for respiratory disease in the age group under 15 years after controlling for NO₂-PM□ was not associated in all age groups after controlling for CO, so the association with PM□ in the' single pollutant model' might be confounded by CO. In this study, the impact of PM□ on the respiratory disease was not large as compared with other pollutants. Conclusions : Air pollution in Seoul may Increase the Incidence of the respiratory disease, so more positive attention for the control of air pollution should be paid.

婦人科領域에서 應用된 鍼灸治療에 關한 文獻的 考察

金哲源,柳深根,朴炳烈 圓光大學校 韓醫學硏究所 1991 원광한의학 Vol.1 No.1

Bibliographic study on the acupuncture and moxibustion treatment applied to gynecological diseases divided into 9 Parts. And the results are as follows. 1. Total numbers of meridian-point used in the JO-KYUNG Part(調經門) were 54. Kidney-Meridian, Liver-Meridian, Conception Vessel-Meridian were used with high frequency and Joong-Kuk (CV_3), Sam-Um-Kyo(SP_6), Ki-Hai(CV_6) were frequently used. Also Yin-Meridian was chiefly used. 2. Total numbers of meridian-point used in the BUNG-ROO Part(崩漏門) were 36. Liver-Meridian, Kidney-Meridian, Bladder-Meridian were used with high frequency and Tai-choong(LIV_3), Hyul Hae(SP_10) Um-Gok(K_10) were frequently used. Also Yin-Meridian was chiefly used. 3. Total numbers of meridian-point used in the DE-HA Part(帶下門) were 46. Bladder-Meridian, Conception Vessel-Meridian, Kidney-Meridian were used with high frequency and God-Gol(CV_2), Jook-Kuk(CV_3), Di-Hai(CV_6) were frequently used. Also Yin and Yang-Meridian showed same frequency. 4. Total numbers of meridian-point used in the JING-HA Part(징하문) were 51. Spleen-Meridian, Kidney-Meridian, Conception Vessel-Meridian were used with high frequency and Sa-Man(K_14), Suk-Kwan(K_18), Kok-Chun(LIV_8) were frequently used. Also Yin-Meridian was chiefly used. 5. Total number of meridian-point used in the KOO-SA Part(求嗣門) were 38. Kidney-Meridian, Conception Vessel-Meridian, Bladder-Meridian were used with high frequency and Kwan-Won(CV_4), Joong-Kuk(CV_3), Yeun-Gok(K_2) were used with high frequently used. Also Yin-Meridian was chiefly used. 6. Total numbers of meridian-point used in the IM-SIN Part(姙娠門) were 58. Conception Vessel-Meridian, Spleen-Meridian, Kidney-Meridian were used with high frequency and Sam-Um-Kyo(SP_6), Kwan-Won(CV_4), Kyum Jung(G_21) were frequently used. Also Yin-Meridian was chiefly used. 7. Total numbers of meridian-point used in the SAN-HOO Part(産後門) were 43. Conception Vessel-Meridian, Spleen-Meridian, Liver-Meridian were used with high frequency and Ki-Hai(CV_6), Sam-Um-Kyo(SP_6), Kwan-Won(CV_4) were frequently used. Also Yin-Meridian was chiefly used. 8. Total numbers of meridian-point used in the YOU-BYONG Part(乳病門) were 47. Kidney-Meridian, Stomach-Meridian, Conception Vssel-Meridian were used with high frequency and Jok-Sam-Lee(S_36), Ha-Lyum(S_39), Jun-Jung(CV_17) were frequently used. Also Yin and Yang-Meridian showed same frequency. 9. Total numbers of meridian-point used in the JUN-UM Part(前陰門) were 35. Liver-Meridian, Heart-Meridian, Kidney-Meridian were used with high frequency and Kok-Chun(LIV_8), Sho-Boo(H_8), Dai-Don(LIV_1) were frequently used. Also Yin-Meridian was chiefly used.

정부혁신과 저항관리

안병철 朝鮮大學校 社會科學硏究所 2007 社會科學硏究 Vol.28 No.1