Transcatheter Closure of a Residual Shunt after Surgical Repair of Traumatic Ventricular Septal Defect

정희정,임한혁,유재현,이재환,길홍량,Jeong, Hee Jeong,Lim, Han Hyuk,Yu, Jae Hyun,Lee, Jae Hwan,Kil, Hong Ryang The Korean Pediatric Society 2005 Clinical and Experimental Pediatrics (CEP) Vol.48 No.10

The traumatic ventricular septal defect (VSD) is a rare but potentially life threatening complication of chest wall injury. The traumatic VSD occurs in up to 4.5% of penetrating cardiac trauma. Most of the patients are usually operated on because of heart failure and/or significant left-to-right shunt. The feasibility of surgical repair under cardiopulmonary bypass may be affected by coexisting pulmonary, cerebral or other vascular injuries. Transcatheter closure of VSD is being considered as an alternative therapeutic modality to surgery in order to avoid the potential risk of cardiopulmonary bypass. We report a patient who underwent a successful transcatheter closure of VSD with an $Amplatzer^{(R)}$ VSD occluder. The patient had a residual VSD with significant left-to-right shunt after surgical repair of post-traumatic VSD using cardiopulmonary bypass. 흉부 관통상에 의해 심실중격결손이 동반된 대부분의 환자들은 내원 시 활력징후가 불안정하여 심폐소생술 및 응급 개흉술을 시행받게 되는데, 이러한 경우 심장과 흉부 손상의 위치 및 정도에 대한 자세한 검사가 이루어지지 않은 상태이므로 발견되지 않았거나 잔존하는 이상 소견들이 수술 후 검사에서 발견될 수 있고 이에 대한 재수술을 필요로 하는 경우도 있다. 심실중격결손의 심도자술을 통한 폐쇄는 수술을 대처할 수 있는 방법으로서, 특히 수술 후 잔존하는 단락의 경우 이차 수술의 위험을 피할 수 있다. 저자들은 흉부 자상에 의한 심실벽의 열창 및 심실중격결손을 수술적 방법으로 봉합한 후 잔존하는 심실중격결손을 기구($Amplatzer^{(R)}$ VSD occluder)를 이용한 중재적 심도자술로 치료한 증례를 문헌 고찰과 함께 보고한다. 심도자술 6개월 후 시행한 심초음파검사에서 잔존하는 심실 좌우 단락은 없었고, 심실 크기와 기능도 정상이었고, 현재 상태는 양호하여 정상적으로 학교생활을 하고 있다.

새로운 우울증 치료 약물

정희정,문은수,Jeong, Hee Jeong,Moon, Eunsoo 대한생물정신의학회 2016 생물정신의학 Vol.23 No.1

Development of various antidepressants such as monoamine oxidase inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and noradrenergic and specific serotonergic antidepressant has led to a tremendous progression of pharmaceutical treatment for depression, but still there are some limitations of current antidepressants, such as treatment-resistant depression and delayed onset of antidepressants. The pathogenesis of depression is unclear because depression is a heterogeneous disease state, and the mechanisms of antidepressants remain uncertain as well. Nevertheless, in an attempt to develop novel antidepressants, some trials have been conducted based on the potential biological mechanism discovered in the numerous research results. This review will provide information about the potential novel antidepressants and the current states of clinical studies using them. In particular, some potential novel antidepressants anti-inflammatory agents, antioxidants, anticholinergics, modulators of Hypothalamic Pituitary Adrenal Axis, glutamate, and opioid systems, as well as some neuropeptides such as susbstance P, neuropeptide Y, and galanin will be discussed.

HL-60 세포주, 제대혈 및 골수 단핵구 세포의 interferon-gamma에 대한 감수성에 관한 연구

정희정,홍대식,김숙자,정재화,이주영,이남수,박성규,원종호,박희숙,김성일,Cheong, Hee Jeong,Hong, Dae Sik,Kim, Sook Ja,Cheong, Jae Hwa,Lee, Joo Young,Lee, Nam Su,Park, Sung Kyu,Won, Jong Ho,Park, Hee Sook,Kim, Sung Il 대한면역학회 2001 Immune Network Vol.1 No.3

Background: Finding of the regulation of various gene expression by cytokine including $IFN-{\gamma}$ in hematopoietic stem cell will light up the understanding of pathogenesis of aplastic anemia in various aspects. To study on aplastic anemia, however, we have to circumvent the difficulty of directly obtaining bone marrow stem cells from the patient. Therefore, we tried to find out a cell can replace the bone marrow stem cells for study on cell signaling pathway and regulation of gene expression by $IFN-{\gamma}$. Materials and Methods: HL-60 cells, of 20 ng/mL of $IFN-{\gamma}$. Total RNA was isolated from the cells and RT-PCR of the indoleamine 2,3-dioxygenase (IDO), $IFN-{\gamma}$, TNF-${\alpha}$, $MIP-1{\alpha}$, and $TGF-{\beta}2$ was carried out for the estimation of the gene expression. Results: $IFN-{\gamma}$ induced IDO gene expression of mononuclear cells from umbilical cord blood showed similar pattern as compared to that of bone marrow. Whether $INF-{\gamma}$ was treated or not, $TNF-{\alpha}$ was expressed in both mononuclear cells from umbilical cord blood and bone marrow. However, HL-60 cells showed different expression patterns. HL-60 cells would express neither IDO nor $TNF-{\alpha}$ even under the culture with 20ng/mL of $IFN-{\gamma}$. Conclusion: Our results showed bone marrow can be replaced with mononuclear cells from umbilical cord blood in the study on the relation between aplastic anemia and $IFN-{\gamma}$ including $IFN-{\gamma}$ cell signaling pathway.

우리나라도 지진 안전지대 아니다

정희정,Jeong, Hui-Jeong 한국과학기술단체총연합회 2005 과학과 기술 Vol.38 No.4

World Tour of Public Design with Dr. Jeong, Hee-jeong - 공중화장실

정희정(Jeong Hee-jeong) 현대건축사 2010 (월간)Maru Vol.- No.100

국가 옥외광고물 표준 가이드라인 수립을 위한 기초자료 조사 연구

정희정(Hee Jeong Jeong) 한국디자인문화학회 2013 한국디자인문화학회지 Vol.19 No.4

도시와 마을마다 아름다운 가로환경을 위한 생활형간판개선사업들이 실행되고 있으나 유사한 조건을 갖춘 지방자치단체마저도 상호 교류와 소통이 원활치 않아 정보와 지식 등의 축척이 어려운 게 현실이다. 이에 전국 지방자치단체의 유사·중복적인 간판개선 사업들을 아우르는 컨트롤 타워로써 국가 차원에서의 옥외광고물 표준가이드라인 수립을 위한 기초자료 조사를 목적으로 본 연구는 진행 되었다. 연구의 방범과 범위는 다음과 같다. 2012년 9월부터 10월까지 현업종사자인 한국옥외광고협회 등록 회원 중 6, 040명을 전문가집단으로 하여 조건충족 답변자 380명을 유효 표본으로 설정하고 비전문가집단은 간판개선사업 또는 시범사업의 실시 경험이 있거나 예정되어있는 전국 15개 지역의 옥외광고 수요대상자(건물주, 업주)를 대상으로 하였다. 지역별 각각 1, 218명인 18, 262명중 조건충족 답변자699명을 유효 표본으로 선정하여 연구 분석하였으며 전문가집단의 심층면접 설문조사를 통하여 구조화된 설문지에 따라 ARS전화조사 방식으로 진행 하였다. 수집된 자료의 분석은 사회과학 전산통계프로그램인 SPSS WIN 12.OK를 통하여 분석하였고 조사대상자의 일반적인 특성과 기초통계자료의 분석을 위하여 빈도분석을 중심으로 실시하였으며 조사대상자의 경향차이를 분석하기 위하여 필요항목별 교차분석 및 비교분석을 실시하여 전문가집단과 비전문가집단의 경향을 분석하였다. 연구결과 옥외광고물의 통제 및 사용절차를 간단명료하게 일반화 할 수 있는 국가차원의 옥외광고물 표준 가이드라인의 필요성이 절실히 요구되고 있다는 것을 알 수 있었다. 국가 옥외광고물 표준가이드라인은 중앙정부와 지방자치단체의 예산을 절감하여 창조경제에 기여할 수 있으며 더 나아가 온라인시스템 등을 활용한 옥외광고물을 위한 스마트정부와 같은 사이트개발을 위하여 다양한 분야에서의 다각적인 후속 연구가 이루어 져야 할 것이다. Even though many projects related to theimprovement of signboards are underway to establisha better street environment in every city and village, it is hard to accumulate relevant information andknowledge due to lack of interaction and communicationeven among local governments in similar condition. This study was conducted for the purpose ofpresenting the base data to establish the guideline onoutdoor signboards at the national level as a controltower that encompasses similar and duplicate signboardimprovement projects led by local governments acrossthe nation. The method and scope of this study are asfollows. The survey was conducted from September toOctober in 2012 targeting 6, 040 registered members ofthe Korea Outdoor Advertising Association as an expertgroup and establishing 380 respondents who meet thecondition as effective sample. In addition, the survey alsotargeted those in demand of outdoor advertising(ownerof a building or store) in 15 regions which have anexperience or a plan of signboard improvement projector pilot project as a non-expert group. The study and analysis were conducted byselecting 699 respondents as effective sample from18, 262 respondents(1, 218 respondents per region)meeting the condition and the study was conductedusing ARS telephone calling method with questionnairestructured through in-depth interview survey with theexpert group. The analysis on the collected data was done bySPSS WIN 12.OK, which is social science computerstatistics program and frequency analysis was thefocus to analyze the general characteristics of surveytargets and basic statistical data. Cross analysis andcomparative analysis on each required item wereconducted to analyze the differences between an expertgroup and a non-expert group. The result of the study found that the standardguideline on outdoor advertisement at the national level, which gives a simple and clear description on thecontrol and usage procedure of outdoor signboard isdesperately required. Diversified follow-up studies on the nationalstandard guideline on outdoor advertisement should beconducted not only to contribute to the creativeeconomy by reducing the cost for the central andregional governments but also to develop sites includingsmart government for outdoor advertisement usingonline system.

『파수록』에 나타난 여성 삶의 표상화

정희정 ( Hee Jeong Jeong ) 한국고전여성문학회 2002 한국고전여성문학연구 Vol.0 No.4

계룡산 설화에 나타난 민중 정서

정희정(Jeong, Hee-Jeong) 한국역사민속학회 2005 역사민속학 Vol.- No.20

알츠하이머병 환자에서 해마 위축과 정신병적 증상

정희정(Hee Jeong Jeong)이영민(Young Min Lee),박제민(Je Min Park),이병대(Byung Dae Lee),문은수(Eun Soo Moon),김수연(Soo Yeon Kim),이강윤(Kang Yoon Lee),김지훈(Ji-Hoon Kim),정영인(Young-In Chung) 대한신경정신의학회 2018 신경정신의학 Vol.57 No.3

Objectives This study examined the difference in the volume or thickness of the medial temporal lobe between Alzheimer’s disease patients with psychosis (AD+P) and those without psychosis (AD-P). Methods Overall, 31 AD+P patients and 29 AD-P patients were included from the Memory impairment clinics of Pusan National University Hospital in Korea. AD+P was diagnosed according to Jeste and Finkel’s proposed diagnostic criteria for psychosis of Alzheimer’s disease. AD-P included AD patients with no psychotic symptoms during a 5-year follow-up period. Medial temporal volume or thickness was measured by 3-tesla MRI and freesufer analysis. Analysis of variance was used to examine the difference in the volume or thickness of medial temporal lobe between AP+P and AD-P after controlling for age, gender, education years, Clinical Dementia Rating scale-Sum of Box, and total intracranial volume. Results The hippocampal volume in AD+P was smaller than that in AD-P. Conclusion These findings suggest that AD+P is associated with a reduced hippocampal volume.

국가 옥외광고물 표준 가이드라인 수립의 당위성에 관한 연구

정희정(Hee Jeong Jeong) 한국디자인문화학회 2013 한국디자인문화학회지 Vol.19 No.3

지방자치단체별로 옥외광고물 가이드라인을 만들고 가로환경 개선을 위한 간판개선 사업을 실천하고 있으나 유사 지형과 지세 면적과 여러 구성요소가 비슷한 지방자치단체마저도 상호 교류와 소통이 원활치않아 정보와 지식 등의 축척이 어려우며 행정과 행정간 행정과 정책 그리고 관과 민의 원활한 소통이 이루어지지 않는 게 현실이다. 옥외광고물 민원절차의 오류를 없애고 체계적이며간소화 할 수 있는 방안을 모색하기 위함에 목적을 두고 가로환경 간판개선 사업을 시행한 지역을 대상으로 옥외광고물의 동향과 매체별 환경을 살펴보고 옥외광고물의 중요성과 수준 디자인개선 방향에 대하여 전문가집단과 비전문가 집단의 직접면접 설문조사를 실시하고 이를 분석하였다. 연구결과 통합적 관리 시스템을 구축하여 정확한 가이드라인을 적용함으로써 법규의 정확한 실천과 광고관련부서의 디자인과 간판의 안전도에 보다 체계적이며 효율적으로 관리할 수 있는 국가차원의 옥외광고물 표준 가이드라인의 수립이 요구되었다. 전국 지방자치단체의 유사ㆍ중복적인 간판사업들의 가이드라인 및 시범사업들을 아우르는 컨트롤 타워로써 중앙정부와 지방자치단체의 예산을 절감하여 창조경제에 기여할 수 있으므로 국가차원의 옥외광고물 가이드라인에 대하여 다양한 분야에서의 다각적인 후속 연구가 이루어져야 할 것이다. Each Municipality Has Its Own Guidelines for Outdoor Advertisements and Is Promoting Signboard Improvement Projects to Improve Street Environments. However, as Even Municipalities that Are Similar in Geographical Features, Sizes and Other Features Do Not Effectively Communicate with Each Other to Share Information, It Is Difficult to Accumulate Relevant Knowledge and Information and There Is Lack of Smooth Communication Between Administrations, Between Administrations and Policies and Between the Public and Private Sectors. With a Purpose to Identify a Measure to Eliminate Errors in and Simplify Licensing and Approval Processes, the Author Has Investigated the Trends of Outdoor Advertisements and Environments by Medium in Municipalities that Have Promoted Street Environment and Signboard Improvement Projects, Conducted Interviews with Expert and Non-expert Groups on the Importance of Outdoor Advertisements and Orientations for Improving Their Design, and Analyzed the Results. The Results of This Study Showed that It Is Required to Establish a National Standard Guideline for Outdoor Advertisements that Will Develop an Integrative Management System and Apply Correct Guidelines, Thereby Ensuring the Proper Enforcement of Laws and Regulations and the Systemic and Efficient Management of Advertisement Design and Signboards Safety by Relevant Departments. In Doing So, Having a Control Tower that Integrates Similar, Overlapped Guidelines and Pilot Projects of Many Local Municipalities Will Contribute to the Creative Economy by Helping both the Central and Local Governments Save Their Budgets, which Calls for Follow-up Studies in Diverse Fields.