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정해원,최진영,이원영 대한보건협회 1988 대한보건연구 Vol.14 No.1
Drug resistance of P 815 mouse tumor cells after various drug treatment were studied "by scoring the changes of cell sizes. Percent of cells with abnormal large cell size (larger than 15㎛. in diameter) increased by treatment of anticancer drugs. When the cells were treated with adriamycin, cells larger than 15㎛ in diameter were observed at second day post-treatment and the percent of larger cells reached maximum at 9th day post-treatment. Similar trends were observed following the treatment with cisplatin, 5-Fu, or methotrexate. Inverse relationship between survival of tumor cell population and percent distribution of large cells was observed when cisplatin was treated. Thus it was suggested that co-existence of abnormal large cells and cells in original size in the tumor cell population after drug treatment might be a key to determine that the cell line is resistant which thereby indication for next drug of choice.
정해원,이미진,조재완,안재윤,김창호 대한임상독성학회 2019 대한임상독성학회지 Vol.17 No.2
Purpose: Osmolar gap (OG) has been used for decades to screen for toxic alcohol levels. However, its reliability may vary due to several reasons. We validated the estimated ethanol concentration formula for patients with suspected poisoning and who visited the emergency department. We examined discrepancies in the ethanol level and patient characteristics by applying this formula when it was used to screen for intoxication due to toxic levels of alcohol. Methods: We retrospectively reviewed 153 emergency department cases to determine the measured levels of toxic ethanol ingestion and we calculated alcohol ingestion using a formula based on serum osmolality. Those patients who were subjected to simultaneous measurements of osmolality, sodium, urea, glucose, and ethanol were included in this study. Patients with exposure to other toxic alcohols (methanol, ethylene glycol, or isopropanol) or poisons that affect osmolality were excluded. OG (the measured-calculated serum osmolality) was used to determine the calculated ethanol concentration. Results: Among the 153 included cases, 114 had normal OGs (OG≤14 mOsm/kg), and 39 cases had elevated OGs (OG>14). The mean difference between the measured and estimated (calculated ethanol using OG) ethanol concentration was -9.8 mg/dL. The 95% limits of agreement were -121.1 and 101.5 mg/dL, and the correlation coefficient R was 0.7037. For the four subgroups stratified by comorbidities and poisoning, the correlation coefficients R were 0.692, 0.588, 0.835, and 0.412, respectively, and the mean differences in measurement between the measured and calculated ethanol levels were -2.4 mg/dL, -48.8 mg/dL, 9.4 mg/dL, and -4.7 mg/dL, respectively. The equation plots had wide limits of agreement. Conclusion: We found that there were some discrepancies between OGs and the calculated ethanol concentrations. Addition of a correction factor for unmeasured osmoles to the equation of the calculated serum osmolality would help mitigate these discrepancies.
말티즈견에서 발생한 파종성혈관내응고를 동반한 거미막하 출혈 증례
정해원,이희천,문종현,정동인 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.4
An 11-year-old male Maltese dog was presented with sudden onset of convulsion and right sided circling. On neurological examination, left side proprioception and menace reflexes were delayed. Blood examinations indicatedsevere thrombocytopenia and increased hepatic enzymes. On brain magnetic resonance imaging, lesions were foundedon the left lateral subarachnoid space area. Those lesions showed hyperintense on T1-weighted images, hyperintenseon T2-weighted images and hyperintense on fluid attenuated inversion recovery images. Cerebrospinal fluid analysisrevealed xanthochromia and erythrophagocytosis. Coagulation test results demonstrated that fibrin degradation productand D-dimer concentrations were higher than normal range. The patient expired few hours after presentation. Thiscase report demonstrates intracranial hemorrhage with disseminated intravascular coagulation in a dog.
부산시 세븐브리지 브랜드 캠페인 사례연구 - 디지털 스토리텔링을 중심으로
정해원,유현중,Chung, Hae Won,Yu, Hyun Joong 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.6
This study was conducted as a case study to examine the characteristics and differences from the storytelling defined in the previous research through an analysis of the storytelling of brand campaigns appearing on the digital platform and to explore them. The results of the Seven Bridges brand campaign conducted by Busan City for eight months from September 2021 to May 2022 were as follows. First, storytelling that can be interpreted in various ways for individual users was conducted. Second, storytelling was composed of four stages based on social media marketing. Third, it was possible to establish a storytelling hierarchy that exposes the story in consideration of the marketing funnel. Through the case, it was possible to examine the recent brand campaign's storytelling as a framework that can be interpreted in various ways, focusing on social media.
정해원,남궁준,김형윤 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Congenital coronary artery anomalies have an incidence of 1-2% in patients undergoing coronary artery catheterization and it has received much attention due to its association with sudden cardiac death (SCD). Besides, researchers have related angina, dyspnea, syncope, acute myocardial infarction and sudden cardiac death to coronary anomalies. But the diagnosis and pathophysiology for coronary anomalies are not well understood, treatment guideline and prognosis of abnormal coronary anatomy also tend to be unsubstantiated. There were debates on conservative medical treatment and surgical management. Currently, Surgery as the primary treatment strategy has been promising. Case: We recently treated three patients who were found to be carriers of Anomalous origination of a right coronary artery from the opposite sinus (ACAOS) and presented with severe clinical manifestations such as exertional typical chest pain. In the catheterization laboratory, we found coronary anomaly and additional cardiac 3DCT was taken before surgical management. Bypass grafting surgery was performed promptly. Post-operative prognosis was good without any clinical presentation or complications.