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전범중 대신대학 1990 논문집 Vol.10 No.-
화자의 의식과 매개로서의 기호가 연합됨으로써 하나의 의미가 형성된다. 화자의 의식은 의식대로 매개인 기호는 기호대로 시간·공간적으로 변화 무쌍하며, 복잡 다양하다. 이같은 의식과 매개로서의 기호의 연합은 두 가지 형식에 의하여 연합된다고 생각된다. 하나는 기연(機緣)이고, 하나는 일치의 원리이다. 화자와 청자간의 전달에 있어서도 이와 마찬가지이다. 의미의 심화, 확장 과정에 있어서도 위와 같은 형식을 취한다고 생각된다.
전범중 대신대학 1991 논문집 Vol.11 No.-
의태어는 의성어와 같은 맥락의 상징어가 아니다. 의태어는 본질적으로 의성어와는 다른 구조를 가졌기 때문이다. 언어에, 그것을 사용하는 민족의 얼이 들어 있다는 것을 주장하면서 한편으로는 언어의 필연성을 부정하고 자의성을 수용하는 것은 자기 모순에 빠진 현상이다. 의태어가 다른 비상징어와 같은 구조를 가졌다는 것을 서술하는 것이 보고의 의도이다.
유한요소해석을 이용한 LED 프레임의 열전달 특성에 관한 연구
손인수,강성중,전범식,안성진,Son, In-Soo,Kang, Sung-Jung,Jeon, Bun-Sik,Ahn, Sung-Jin 한국산업융합학회 2020 한국산업융합학회 논문집 Vol.23 No.6
In this study, the effect of different shapes on the heat dissipation characteristics of other porous frames on LED lighting frames was studied using finite element analysis. In addition, the heat transfer characteristics of LED frames were tested using a thermal imaging camera and the results of finite element analysis were compared to derive the optimal hole shape. According to the study, the heat dissipation effect was better for frames with hole compared to existing ones without holes. In particular, the heat dissipation characteristics test showed that for frames with holes, the rise time to the maximum temperature is fast and the maximum temperature is significantly lower. Also, we could see that the square and diamond shapes were smaller than the circular pores, but had a greater heat dissipation effect. Through this study, we have concluded that there is a limit to increasing the heat dissipation effect of the frame with a perforated shape, and it is necessary to conduct further research on the change in the shape of the frame in order to achieve a better heat dissipation effect in the future.
김성익,전범석,배정모,원재경,김한준,임지민,김윤중,박성혜 한국뇌신경과학회 2019 Experimental Neurobiology Vol.28 No.1
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive degenerative white matter disorder caused by mutations in the tyrosine kinase domain of the CSF1R gene. ALSP is often misdiagnosed as other diseases due to its rarity and various clinical presentations such as Parkinsonism, pyramidal signs, cognitive impairment and/or psychiatric symptoms. We describe an autopsy case of ALSP with a CSF1R mutation. A 61-year-old woman presented insidious-onset gait difficulty for 12 years since her age of 49, and premature ovarian failure since her age of 35. At initial hospital visit, brain magnetic resonance imaging revealed hydrocephalus. Initially, Parkinson’s syndrome was diagnosed, and she was prescribed L-dopa/carbidopa because of spasticity and rigidity of extremities, which had worsened. Subsequently, severe neuropsychiatric symptoms and cognitive impairment developed and radiologically, features of leukoencephalopathy or leukodystrophy were detected. She showed a down-hill course and died, 12 years after initial diagnosis. At autopsy, the brain showed severe symmetric atrophy of bilateral white matter, paper-thin corpus callosum, thin internal capsule, and marked hydrocephalus. Microscopically, diffuse loss of white matter, relatively preserved subcortical U-fibers, and many eosinophilic bulbous neuroaxonal spheroids were noted, but there was no calcification. Pigmented glia with brown cytoplasmic pigmentation were readily found in the white matter, which were positive for Periodic acid-Schiff, p62, and CD163 stains, but almost negative for CD68. Whole-exome and Sanger sequencing revealed a CSF1R mutation (c.2539G>A, p.Glu847Lys) which was reported in prior one ALSP case. This example demonstrates that ALSP could be associated with premature ovarian failure.
Clinical Heterogeneity of Atypical Pantothenate Kinase-Associated Neurodegeneration in Koreans
이재혁,박종규,유호성,박혜영,김영은,홍진용,남상욱,성영희,이승환,이지영,이명준,김태형,류철형,정선주,고성범,이필휴,조진환,박미영,김윤중,손영호,전범석,이명식 대한파킨슨병및이상운동질환학회 2016 Journal Of Movement Disorders Vol.9 No.1
Objective Neurodegeneration with brain iron accumulation (NBIA) represents a group of inherited movement disorders characterized by iron accumulation in the basal ganglia. Recent advances have included the identification of new causative genes and highlighted the wide phenotypic variation between and within the specific NBIA subtypes. This study aimed to investigate the current status of NBIA in Korea. Methods We collected genetically confirmed NBIA patients from twelve nationwide referral hospitals and from a review of the literature. We conducted a study to describe the phenotypic and genotypic characteristics of Korean adults with atypical pantothenate kinase-associated neurodegeneration (PKAN). Results Four subtypes of NBIA including PKAN (n = 30), PLA2G6-related neurodegeneration (n = 2), beta-propeller protein-associated neurodegeneration (n = 1), and aceruloplasminemia (n = 1) have been identified in the Korean population. The clinical features of fifteen adults with atypical PKAN included early focal limb dystonia, parkinsonism-predominant feature, oromandibular dystonia, and isolated freezing of gait (FOG). Patients with a higher age of onset tended to present with parkinsonism and FOG. The p.R440P and p.D378G mutations are two major mutations that represent approximately 50% of the mutated alleles. Although there were no specific genotype-phenotype correlations, most patients carrying the p.D378G mutation had a late-onset, atypical form of PKAN. Conclusions We found considerable phenotypic heterogeneity in Korean adults with atypical PKAN. The age of onset may influence the presentation of extrapyramidal symptoms.