과학탐구 자료 및 방법 개발을 위한 컴퓨터 저작도구 탐색

임정규 강원과학교육연구회 1998 강원과학교육연구회지 Vol.3 No.2

Oxantel pamoate의 편충에 대한 구충효과

임정규 大韓藥理學會 1974 대한약리학잡지 Vol.10 No.2

The present clinical trial was performed to evaluate the anthelminthic effect and tolerance of Oxantel pamoate, a new antiwhipworm agent, in the treatment of T. trichiurus infection. Oxantel pamoate oral suspension was administered as a sing1e dose of 10 mg per kg. body weight to a total of 46 T. trichiurus infected cases selected out of 64 positives, by examining 89 fecal specimens collected from the soldiers and in-patients of xx Armed Forces General Hospital. For the evaluation, the negative conversion rate (cure rate) and the egg reduction rate were assessed 22 days after the treatment. The result obtained were as follows: 1. The prevalence rate of T. trichiurus infection in this study was 71.9%, while the mean E.P.G. of 46 treated cases was 126. 2. The egg negative conversion rate was 91.3%, and 98.4% of egg reduction rate was obtained. 3. From the observation of 107 worms expelled during 3 consecutive days after the treatment, it was known that sex ratio of male and female was about 1 : 2 and that average worm burden per capita was 2.3. 4. In all treated cases, the medication was readily accepted and well tolerated. On the hemograms, urinalysis and liver function tests, no significant differences were noted before and after the drug administration. There was also no detectable objective and subjective side effect.

Oxytetracycline과 Erythromycin Stearate의 생체유용성 검토

임정규,정명희,신상구,차인준,Lim J.K.,Chung M.H.,Shin S.G.,Cha I.J. 대한약리학회 1977 대한약리학잡지 Vol.13 No.1

The physicochemical equivalencies of drugs are not usually correlate to the generic equivalencies of drugs and the generic equivalencies of drugs produced by different manufacturers or different formulations are being called in question frequently. The bioabailability of two formulations of oxytetracycline and erythromycin stearate were performed in healthy human volunteers. At the same time, the disintegration testes were performed with randomly sampled materials in question. For the biological evaluation of new oxytetracycline formulation; tablet(250mg), two-way cross over study in 10 healthy young volunteers was performed using oxytetracycline capsule (250mg) as reference, Erythromycin stearate (250mg) tablets and capsules produced by different manufacturers were compared in a two-way cross over study in 12 subjects with same manner of oxytetracyclines. oxytetracycline tablets showed somewhat slow disintegration rate, but appeared not statistical differences in serum concentrations from the reference, up to six hours after ingestion. Erythromycin stearate capsules disintegrated more rapidly than enteric coated tablets. Serum concentrations of capsules were more variable and markedly lower (P<.005 after 2hrs) than the enteric coated tablets. Rapid disintegration of capsules may result in destruction of active chemicals owing to the interaction with gastric acid and the above factor may contribute mainly to the low serum level after ingestion of capsules.

도로포장에서 표면조직깊이 측정에 대한 통계적 게이지 R&R 분석

임정규,김성준,최돈화,이승우 한국도로학회 2010 한국도로학회 학술발표회 논문집 Vol.2010 No.3

경구용 Amoxicillin 캡슐의 약력학적 검토

임정규,신상구,차인준,이광호 대한화학요법학회 1984 대한화학요법학회지 Vol.2 No.1

Azxxicillin capsdes cf two diiferect proctucers were testec! in 8 Eealthy adalt suE.ects in 2 Cross-CT-er design after or21 adrinistration of 2jOng loses. Serun: dr;g levels 4 ere acalj -Zed a one-compartmental open rrodel, as nei? as area urder the curves (AT3Cj. TLcxgL s:atisticaliS- ins:giifics.nt, the Eean peak serum level, tirce to Feak and absorption of erx~xicillin of ''I?*' FrGducer were higher, shorter arid more rarid thar, tkose of prci-xcer. Otker kinetic parameters for Loth of icradations were nearly identical. Rclatix e kiczl-azk- of arroxicillin capule of ''P'' producer to that of "B" prohcer --as 1.15. Ecxever, cx-eral~ pharmacokinetic paraneters of both formulatiors were ccrrFaraLle t o those cf a:-ox,cilliz prodccts officially apprm-ed. So it was considered that the both amoxicillin products tested are suitable t o clinical purposes.

비흡습성 Oxyteracycline 제형의 약력학적 검토

임정규,정명희,신상구,차인준,김용식 대한화학요법학회 1984 대한화학요법학회지 Vol.2 No.1

For the development of Terramycin bulk refinery processing, the pharmacokinetic comparison of a new non-hygroscopic product (NERTB) is. required. Single usual oral doses of Terramycin (250㎎) and NHRTB (250㎎) capsules were given to 12 healthy male subjects on a cross-over randomized basis. Data were d y s e d in terms of a single compartmental open model. There were no differences in serum oxytetracycljne l e d s of the both formulations for 6 hr experimental periods. The apparant lag-time of NHRTB formulation before absorption wa5 shorter than Terramycin capsule but was slightly lower in absorption rate, yealding no differences in peak serum l e d and time to peak Bioavailability of NKRTB formulation measured by the area under the serum level of curves was equivalent to of the Terramycin capsules.

비뇨기과 영역에서의 Vibramycin Precon PT-122M의 효과

임정규,신상구,박찬웅,장대수 大韓藥理學會 1977 대한약리학잡지 Vol.13 No.1

To investigate the efficacy, tolerance of Vibramycin Precon PT-122 M and to determine the nature, incidence and severity of side effects of this formulation, 19 patients with urogenital infections were studied. 1. Vibramycin Precon PT-122 M reduced the signs and symptoms of various urogenital infections so as to determine the overall efficacy as good or satisfactory. 2. Intravenous injection of PT-122 M was generally well tolerated in all patients except 2 case of discontinuation because of adverse effect. 3. PT-122 M showed mild to moderate side effects but clinical features ana response to therapy were not influencea by those side effects.

Cefoperazone(T-1551)의 약리학적 연구

임정규,홍사악,박찬웅,김명석,서유헌,신상구,김용식,김혜원,이정수,장기철,이상국,장우현,김익상,Lim J.K.,Hong S.A.,Park C.W.,Kim M.S.,Suh Y.H.,Shin S.G.,Kim Y.S.,Kim H.W.,Lee J.S.,Chang K.C.,Lee S.K.,Chang K.C.,Kim I.S. 대한약리학회 1980 대한약리학잡지 Vol.16 No.2

The pharmacological and microbiological studies of Cefoperazone (T-1551, Toyama Chemical Co., Japan) were conducted in vitro and in vivo. The studies included stability and physicochemical characteristics, antimicrobial activity, animal and human pharmacokinetics, animal pharmacodynamics and safety evaluation of Cefoperazone sodium for injection. 1) Stability and physicochemical characteristics. Sodium salt of cefoperazone for injection had a general appearance of white crystalline powder which contained 0.5% water, and of which melting point was $187.2^{\circ}C$. The pH's of 10% and 25% aqueous solutions were 5.03 ana 5.16 at $25^{\circ}C$. The preparations of cefoperazone did not contain any pyrogenic substances and did not liberate histamine in cats. The drug was highly compatible with common infusion solutions including 5% Dextrose solution and no significant potency decrease was observed in 5 hours after mixing. Powdered cefoperazone sodium contained in hermetically sealed and ligt-shielded container was highly stable at $4^circ}C{\sim}37^{\circ}C$ for 12 weeks. When stored at $4^{\circ}C$ the potency was retained almost completely for up to one year. 2) Antimicrobial activity against clinical isolates. Among the 230 clinical isolates included, Salmonella typhi was the most susceptible to cefoperazone, with 100% inhibition at MIC of ${\leq}0.5{\mu}g/ml$. Cefoperazone was also highly active against Streptococcus pyogenes(group A), Kletsiella pneumoniae, Staphylococcus aureus and Shigella flexneri, with 100% inhibition at $16{\mu}g/ml$ or less. More than 80% of Escherichia coli, Enterobacter aerogenes and Salmonella paratyphi was inhibited at ${\leq}16{\mu}/ml$, while Enterobacter cloaceae, Serratia marcescens and Pseudomonas aerogenosa were somewhat less sensitive to cefoperagone, with inhibitions of 60%, 55% and 35% respectively at the same MIC. 3) Animal pharmacokinetics Serum concentration, organ distritution and excretion of cefoperazone in rats were observed after single intramuscular injections at doses of 20 mg/kg and 50 mg/kg. The extent of protein binding to human plasma protein was also measured in vitro br equilibrium dialysis method. The mean Peak serum concentrations of $7.4{\mu}g/ml$ and $16.4{\mu}/ml$ were obtained at 30 min. after administration of cefoperazone at doses of 20 mg/kg and 50 mg/kg respectively. The tissue concentrations of cefoperazone measured at 30 and 60 min. were highest in kidney. And the concentrations of the drug in kidney, liver and small intestine were much higher than in blood. Urinary and fecal excretion over 24 hours after injetcion ranged form 12.5% to 15.0% in urine and from 19.6% to 25.0% in feces, indicating that the gastrointestinal system is more important than renal system for the excretion of cefoperazone. The extent of binding to human plasma protein measured by equilibrium dialysis was $76.3%{\sim}76.9%$, which was somewhat lower than the others utilizing centrifugal ultrafiltration method. 4) Animal pharmacodynamics Central nervous system : Effects of cefoperazone on the spontaneous movement and general behavioral patterns of rats, the pentobarbital sleeping time in mice and the body temperature in rabbits were observed. Single intraperitoneal injections at doses of $500{\sim}2,000mg/kg$ in rats did not affect the spontaneous movement ana the general behavioral patterns of the animal. Doses of $125{\sim}500mg/kg$ of cefoperazone injected intraperitonealy in mice neither increased nor decreased the pentobarbital-induced sleeping time. In rabbits the normal body temperature was maintained following the single intravenous injections of $125{\sim}2,000mg/kg$ dose. Respiratory and circulatory system: Respiration rate, blood pressure, heart rate and ECG of anesthetized rabbits were monitored for 3 hours following single intravenous inje

주조용(鑄造用) 합금(合金)의 조직반응(組織反應)에 관(關)한 실험적(實驗的) 연구(硏究)

임정규,Lim, Jeong-Kyu 대한치과보철학회 1976 대한치과보철학회지 Vol.14 No.1

The author studied the effects of some dental gold alloys and dental nonprecious metals on muscle. The metal specimens were cast in the size of $1.0mm.{\times}5.0mm.{\times}3.0mm.$ and implanted in the gluteus maximus musculus of the two dogs. The subjects were sacrificed at 3 weeks and 5 weeks respectively after implantation. The tissue was examined his to-pathologically. The findings were as follows. 1. The more the alloy contains gold, the less the tissue response to the alloy and the less the connective tissue layer around the specimens. 2. The recovery of connective tissue layer in gold specimens was markedly observed. 3. There were very thick connective layers around nonprecious specimens.

연 작업자들의 업종별 보건관리에 의한 건강수준의 변화

임정규,안규동,이병국 순천향대학교 산업의학연구소 1996 순천향산업의학 Vol.2 No.1

In order to evaluate the effect of industry type specific occupational health service on the health status of lead workers, total 39,203 record of 5 year accumulated data of workers from 1989 to 1993 in lead using industries which made special contract of group occupational health service with Soonchunhyang university, institute of industrial medicine were studied. Blood zinc protoporphyrin (ZPP) and 15 lead related symptoms were selected as a health indices and air concentration of lead (PbA) was selected as a environmental index of lead industries. Blood ZPP and symptoms survey were carried out twice a year for lead workers and once a year for non-lead office workers. Environmental measurements of lead in air were done twice a year in every lead using industries. Lead industries were divided into 4 group of lead industries arbitrarily such as storage battery industries for group I, secondary smelting, litharge making and related operation for group II, telecommunication for group III and primary smelting and crystal glass making for group IV. Data for group III only available for 3.5 years from 1990 to first half of 1993. Blood ZPP was measured with hematoflurometer (Aviv model 206). Fifteen questionnaire of lead related symptoms were provided to all workers and filled by themselves and confirmed by interview doctor at the site. The results obtained were as follows: 1. While the geometric means of lead in air of group I, II, IV in 1989 were 0.333, 0.353 and 0.113 ㎎/㎥, those in 1993 were decreased to 0.081, 0.162 and 0.037 ㎎/㎥ respectively. On the other hand the geometric means of lead in air of group III were always below 0.020 ㎎/㎥ throughout the study period. 2. While the geometric mean of lead in air in medium/large storage battery industries was 0.313 ㎎/㎥ in 1989, it was decreased to below 0.05 ㎎/㎥ since 1992, that in small storage battery industries was 0.395 ㎎/㎥ and it was still 0.101 ㎎/㎥ in 1993. This data suggested that the effect of group occupational health service were more effective in medium/large storage battery industries. 3. The overall percent of distribution of lead in air of below 0.05, 0.05-0.15 and over 0.15 ㎎/㎥ in group I for 5 years were 87.54%, 9.29% and 3.16% respectively. On the other hand, for group II and III, those were 77.19%, 15.21%, 7.6% and 92.78%, 3.72%, 3.5% respectively. The overall percent of distribution of lead in air of above three category in medium/large and small storage battery industries were 90.42%, 7.32%,2.25% and 79.96% 14.47%, 5.57% respectively. 4. The mean blood ZPP of male lead workers decreased from 52.61±68.67 ㎍/100ml in 1989 to 33.31±34.62 ㎍/100ml and those of female lead workers decreased from 84.01±79.06 ㎍/100ml in 1989 to 58.35±47.30 ㎍/100ml. While the mean blood ZPP of male lead workers for group I, II and IV in 1989 was 39.65±40.41, 132.9±121.1 and 32.9±55.51 ㎍/100ml, those in 1993 were 29.75±28.38, 77.35±64.48 and 31.41±21.35 respectively. The mean blood ZPP for group III were ranged from 13.11±8.53 to 26.43±8.83 ㎍/100ml for 3 and half years period. 5. The mean blood ZPP of male lead workers in medium/large and small storage battery industries in 1989 were 32.16, 82.53 ㎍/100ml in 1989 and those in 1993 were decreased to 25.69 and 76.22 ㎍/100ml respectively. Those of female lead workers in both industries in 1989 were 53.36, 126.3 ㎍/100ml and 43.68, 90.17 ㎍/100ml respectively. 6. The overall percent of distribution of blood ZPP of below 50, 50-99, 100-149 and over 150 for 5 years were 72.83% (male: 76.63%, female: 44.59%), 16.97% (male:15.23, femlae: 29.93%), 5.23% (male: 4.18%, female: 13.04%) and 4.96% (male: 3.96%, female: 12.44%) respectively. Among 4 groups, the percent of workers whose blood ZPP over 50 ㎍/100ml was highest in group II. 7. The mean of overall symptoms of male and female lead workers in 1989 were 5.2 and 4.9 and decreased to 4.6 and 4.3 in 1993 respectively. The mean of overall symptoms of male and female lead workers in medium/large storage battery industries in 1989 were 5.7, 5.9 and decreased to 4.8, 5.2 in 1993. Those in small storage battery industries in 1989 werer 4.8, 5.2 and 3.8, 3.2 respectively. 8. The most frequent symptom among 15 lead related symptom questionnaires for 5 year duration was 'generally fatigue' (male: 63%, female: 53%) and the least frequent symptom was 'acute abdominal pain around umbilicus' (male: 12%, femlae: 9%). Among male lead workers of 4 groups the prevalence of lead related symptoms was highest in group 4 and followed by group 3, 1 and 2 in descending order. Among female lead workers it was highest in group 3 and followed by group 1, 2, and 4 in descending order. 9. The prevalence of lead related symptoms were high in group whose blood ZPP below 100㎍/100ml than those with blood ZPP over 100 ㎍/100ml. The prevalence of lead related symptoms of male lead exposed workers were higher or same with male non-lead exposed workers in every symptoms except questionnaire 11. But for female workers the prevalence of lead related symptoms of lead exposed workers were lower than non-exposed lead workers except questionnaire 1, 4, 5, 6, 7, 8, 12, 15. 10. There was very similar pattern of symptom prevalence over the 5 years in lead exposed and non-exposed workers for both sex. 11. The prevalence of lead related symptoms was higher in young age group than old age group and there was no big difference of prevalence according to the work duration. With above results, group occupational health service for lead workers improved working condition of lead industries under special contract with Soonchunhyang university, institute of industrial medicine in term of decrease of lead in air, particularly more effective in medium/large storage battery industries. It also brought out the the decrease of lead burden of most lead workers in terms of blood ZPP of lead workers which is a good index of lead intoxication. But symptom servery did not give any clue of dose-response relationship between lead exposure and lead related symptoms with current symptom questionnaire. It is recommended to revise the way of questioning lead related symptoms from lead workers. On the other hand, for group II and III, those were 77.19%, 15.21%, 7.6% and 92.78%, 3.72%, 3.5% respectively. The overall percent of distribution of lead in air of above three category in medium/large and small storage battery industries were 90.42%, 7.32%,2.25% and 79.96%, 14.47%, 5.57% respectively.