주의력 결핍 - 과잉운동장애의 deanol치료 사례보고

이혜련,오경자 최신의학사 1988 最新醫學 Vol.31 No.7

컨벤션참가자의 개최지서비스에 대한 인식: 중요도와 성취도

이혜련,김정만 대한관광경영학회 2003 觀光硏究 Vol.18 No.1

The purposes of this study were to examine convention attendees' perception of services provided by the convention destination in terms of importance and performance. Data were collected from the self-administered questionnaires of 150 overseas attendees in the four international conventions held in Seoul, Korea from September to October 2001. The 40 items for measuring convention destination service were developed and grouped into seven dimensions of physical environments, accessibility & communications, service encounter, safety & security, conference programs, special activities, convention management & networking. The major findings were that there are significant differences between importance and performance in accessibility & communications and conference program dimensions. The I-P matrix for Seoul as a convention destination shows major strengths and weaknesses. Among its major strengths are safety & security, service encounter, and physical environments dimensions. Accessibility & communications, conference program dimensions are its major weaknesses. It is important for the convention destination that weaknesses are addressed and strengths are emphasized in promotional efforts. The results of this study could be used to improve the destination's competitiveness.

The Effect of Umbilical Cord Blood Derived Mesenchymal Stem Cells in Monocrotaline-induced Pulmonary Artery Hypertension Rats

이혜련,이재철,권정현,김관창,조민선,양윤선,오원일,최수진,서은석,이상준,왕태준,홍영미 대한의학회 2015 Journal of Korean medical science Vol.30 No.5

Pulmonary arterial hypertension (PAH) causes right ventricular failure due to a gradual increase in pulmonary vascular resistance. The purposes of this study were to confirm the engraftment of human umbilical cord blood-mesenchymal stem cells (hUCB-MSCs) placed in the correct place in the lung and research on changes of hemodynamics, pulmonary pathology, immunomodulation and several gene expressions in monocrotaline (MCT)- induced PAH rat models after hUCB-MSCs transfusion. The rats were grouped as follows: the control (C) group; the M group (MCT 60 mg/kg); the U group (hUCB-MSCs transfusion). They received transfusions via the external jugular vein a week after MCT injection. The mean right ventricular pressure (RVP) was significantly reduced in the U group after the 2 week. The indicators of RV hypertrophy were significantly reduced in the U group at week 4. Reduced medial wall thickness in the pulmonary arteriole was noted in the U group at week 4. Reduced number of intra-acinar muscular pulmonary arteries was observed in the U group after 2 week. Protein expressions such as endothelin (ET)-1, endothelin receptor A (ERA), endothelial nitric oxide synthase (eNOS) and matrix metalloproteinase (MMP)-2 significantly decreased at week 4. The decreased levels of ERA, eNOS and MMP-2 immunoreactivity were noted by immnohistochemical staining. After hUCB-MSCs were administered, there were the improvement of RVH and mean RVP. Reductions in several protein expressions and immunomodulation were also detected. It is suggested that hUCB-MSCs may be a promising therapeutic option for PAH.

간호사의 직장폭력 경험에 따른 분노 및 외상 후 스트레스 장애

이혜련,신미경,문현숙 한국직업건강간호학회 2013 한국직업건강간호학회지 Vol.22 No.3

음악교육용 사이트의 활용실태와 특성 비교 분석 : 초등학교 4학년을 중심으로

이혜련 한국유초등음악교육학회 2007 음악교육 Vol.7 No.-

A Comparative Study of International Convention Attendees' Motivation and Perceived Destination Image : Focusing on Asian and Non-Asian Attendees

이혜련,윤유식,김은진 한국자료분석학회 2015 Journal of the Korean Data Analysis Society Vol.17 No.4

This study aims to identify differences in international convention attendees' motivation and perceived destination image between Asian and non-Asian attendees. Despite ample amount of literature, a comparison study of convention motivation and the perceived destination image among international convention attendees has yet to emerge. The study explores whether any differences exist concerning the relationship of motivation and destination image. Especially this study incorporates both cognitive and affective components of destination image. Data were gathered from 450 overseas attendees who participated international conventions and a corporate meeting held in Seoul, Korea. The findings of the study indicate that attendees with different cultural backgrounds have differences in their motivation and perceived cognitive and affective image of the convention destination. It reveals that the cognitive image fully mediates the relationship between motivation and affective image for all attendees. However, the result of relationship between motivation, cognitive and affective destination image provides no difference between Asian and non-Asian attendees.

기증된 한국인 신생아 제대혈의 전혈구 수(complete blood count) 참고치

이혜련,신수,윤종현,김진주,김병재,황규리,노은연 대한진단검사의학회 2009 Annals of Laboratory Medicine Vol.29 No.3

배경 : 공여제대혈은행에서는 세포 수가 충분하고 안전한 제 대혈에 대해서만 저장 처리를 시행하는데 제대혈 전혈구 수 검사 는 제대혈의 총 유핵세포 수를 산정하고 혈액학적 이상이 없는 이식적합 제대혈을 선별하는데 중요한 검사이다. 본 연구에서는 공여제대혈은행에 기증 및 저장된 제대혈 검체를 대상으로 건강 한 한국인 신생아 제대혈의 전혈구 수에 대한 참고치를 설정하 고자 하였다. 방법 : 2007년 8월 1일부터 12월 31일까지 기증 후 저장 처리 된 제대혈 검체 2,129단위를 대상으로 XE-2100 자동혈구분석 기(Sysmex, Japan)를 이용하여 혈색소, 백혈구 수, 백혈구 감별계수, 혈소판 수 및 유핵적혈구 수를 측정하고. 각 항목별로 모수법(Mean±2SD) 또는 비모수법(2.5-97.5 백분위수)으로 참고치를 설정하였다. 이와 함께, 신생아 성별 및 분만 방법에 따른 전혈구 수 항목별 측정값을 비교하였다. 결과 : 하위 그룹 간 전혈구 수 결과의 차이가 근소하여 그룹 별 참고치 구분은 필요하지 않았으며, 제대혈 전혈구 수 참고치 를 다음과 같이 설정하였다: 혈색소, 9.0-14.4 g/dL; 백혈구 수, 5.6-18.5×103/μL; 백혈구 감별계수(호중구, 40.8-72.4%; 림 프구, 17.2-46.7%; 단구, 4.9-12.8%; 호산구, 0.7-7.0%; 호염구, 0.0-1.6%); 혈소판 수, 130-287×103/μL; 유핵적혈구 수, 0.0- 13.1/100 WBCs. 결론 : 저자들은 대단위의 제대혈 검체를 대상으로 정상 한국 인 신생아의 제대혈 전혈구 수 참고치를 설정하였으며, 본 연구 를 통해 설정된 참고치는 향후 제대혈은행에 기증되는 제대혈의 검사 결과 해석과 저장 적합성 평가에 있어서 기초 자료로 유용 하게 이용될 것이다. Background : In the public cord blood (CB) banks, only safe CB units with adequate cell doses are processed and stored. Complete blood count (CBC) of CB is crucial for estimating total nucleated cells (TNC) and screening suitable CB units without hematologic abnormalities. We analyzed CBC parameters of the donated CB from healthy Korean neonates to establish CBC reference values. Methods : A total of 2,129 Korean CB units, donated and processed during the period from August 2007 to December 2007, were enrolled. We measured hemoglobin (Hb), white blood cell (WBC) count, differential count of WBC, platelets and nucleated red blood cell (nRBC) count by XE-2100 automated hematology analyzer (Sysmex, Japan), and estimated reference value of each parameter by using parametric (Mean±2SD) and/or non-parametric methods (2.5-97.5 percentile). And also, we compared the result of each parameter in relation to sex of neonates and delivery method. Results : Because the differences of CBC values among different subgroups were not remarkable, we established the reference intervals as follows without subgroup division: Hb, 9.0-14.4 g/dL; WBC count, 5.6-18.5×103/μL; differential count of WBC (neutrophils, 40.8-72.4%; lymphocytes, 17.2-46.7%; monocytes, 4.9-12.8%; eosinophils, 0.7-7.0%; basophils, 0.0-1.6%); platelet, 130-287×103/μL; nRBCs, 0.0-13.1/100 WBC. Conclusions : We established cord blood CBC reference values of healthy Korean neonates using a large-scale CB units. The established CBC reference values from our study will be useful as basic data for CBC interpretation and assessment of transplant suitability of donated CB.

Optimal Dose and Timing of Umbilical Stem Cells Treatment in Pulmonary Arterial Hypertensive Rats

이혜련,홍영미,김관창,최수진 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.3

Purpose: Pulmonary arterial hypertension (PAH) is a fatal disease which is characterized by an increase in pulmonary arterial pressureleading to increases in right ventricular afterload. Human umbilical cord blood derived-mesenchymal stem cells (hUCB-MSCs) administered via the jugular vein have been previously shown to improve PAH by reversal treatment. However, the effect of low dosageand transfusion timing of hUCB-MSCs on PAH has not yet been clearly established. Obviously, low dosage treatment can lead to a reduction in costs. This is the first study on early transfusion effect. Materials and Methods: This study was divided into two parts. The first part is an investigation of dose-dependent effect. hUCB-MSCs were administered into 3 groups of rats (UA: 3×106 cells, UB: 1.5×106 cells, UC: 3×105 cells) via the external jugular vein at week 1 after monocrotaline (MCT) injection. The second part is a search for optimal treatment timing in 3×105 cells dose of hUCB-MSCs administered at day 1 for UD group (low dose of hUCB-MSCs at day 1), at day 1 and week 1 for the UE group (dual transfusionof low dose of hUCB-MSCs at day 1 and week 1) and at 1 week for the UF group (reversal treatment of low dose hUCB-MSC at week 1) after MCT injection. Results: The administration of 3×105 hUCB-MSCs was as effective as the 3×106 dose in decreasing mean right ventricle (RV) pressureand pulmonary pathological changes. Early treatment with hUCB-MSCs improved mean RV pressure, pulmonary pathologicalchanges and heart collagen 3 protein expression levels in PAH. Conclusion: Low-dose early treatment of hUCB-MSCs is as effective as a high dose treatment of hUCB-MSCs in improving PAH although dual or reversal treatment is still more effective.

세라믹 멤브레인의 나노구조 제어 및 응용

이혜련,서봉국,최용진 한국막학회 2012 멤브레인 Vol.22 No.2

내열성, 용매 저항성의 특징을 갖는 다공성 세라믹 소재를 이용한 무기 멤브레인이 기체분리(수소 분리, 이산화탄소 분리 등), 액체 분리(수처리, 폐수처리, 유기용매 분리 등) 등 여러 가지 분야로 그 응용이 확대되고 있다. 본 논문에서는 다공성 세라믹 멤브레인의 소재, 제조 방법에 따른 멤브레인의 구조 제어 및 성능 평가에 관한 연구를 소개하고, 멤브레인의 세공 크기에 따른 구조, 멤브레인의 특성을 이용한 여러 가지 기체 분리 및 액체 분리에 관한 연구 동향을 정리하였다. Amorphous ceramic membranes have been developed for gas phase separation and liquid phase separation (water treatment, wastewater treatment and separation of organic solvent or compounds) because of their thermal stability and solvent resistance. In this paper, ceramic membranes were categorized by membrane pore size and materials, and summarized for hydrogen separation, carbon dioxide separation, membrane reactor, pervaporation and water treatment with membrane structure and properties.

컨벤션 참가동기와 관광활동 선호에 관한 비교연구-아시아와 서구 참가자를 중심으로

이혜련 한국관광연구학회 2006 관광연구저널 Vol.20 No.3

The purpose of this study is to make a comparison of international convention attendee motivations and preferred tourism activities between Asian and Western attendees. This study collected data from overseas convention attendees to the international convention held in Seoul, Korea in 2006. Factor analysis of 12 motivation items resulted in three underlying dimensions: 'self development', 'sightseeing', and 'convention activities'. The results show that significant differences between Asian and Western attendees existed with respect to 'self development'. And the mean scores indicate that Asian attendees tended to have higher motivations than Western attendees. Significant differences were also found with respect to four items among seven preferred tourism activities.