서부 경남지역 소아의 마이코플라즈마 폐렴에 대한 임상적 고찰

이주석,최완석,한성룡,김정,이상은,성영순,정진아,조경래 대한 소아알레르기 호흡기학회 2004 Allergy Asthma & Respiratory Disease Vol.14 No.3

The Implicit Price of PM2.5 by Using Hedonic Model : The Case of Incheon and Gyunggido

이주석,이영수,양현석 한국자료분석학회 2015 Journal of the Korean Data Analysis Society Vol.17 No.5

Recently, unlike other air pollutants, the level of fine particle matter (PM2.5) levels have been increased radically. However, there has been few studies to estimate the value of PM2.5. Therefore, this study estimated the value of PM2.5 reduction by using Hedonic model and limited the regional scope to Gyunggido and Incheon. Futhermore, this study employed least median of squares which is robust to outlier. According to estimation results, the educational condition, access to convenience facilities, environmental condition and air quality influence the housing price. Furthermore, the increase of PM2.5 emission per 1 ton makes the housing price decreased by 2,040 won per 1㎡. This elasticity can be interpreted as the implicit price of PM2.5 per 1 ton. This study is expected to provide insight for both research and policy-making.

인프라 정보 융합 기반 자율주행버스의 충돌 예측 알고리즘 설계

이주석,박만복 한국ITS학회 2018 한국ITS학회 학술대회 Vol.2018 No.04

A Semi-parametric Approach to Estimate the Income Elasticity for a Car Fuel Price in Korea with Considering to Deal with Zero Expenditure

이주석,최은철 한국자료분석학회 2019 Journal of the Korean Data Analysis Society Vol.21 No.5

The analysis of the income elasticity for the car fuel expenditure is a very important research topic because of the large proportion of car fuel costs in transportation expenditure and the large amount of price fluctuation. Even if there have been many studies in other countries, few studies have been done in Korea. This paper, therefore, estimates the income elasticity for a car fuel expenditure. Furthermore, about 40 percent of all respondents reported zero expenditure on car fuel. This paper, therefore, has two major goals. The first is to estimate the income elasticity for a car fuel expenditure. The second goal is to explore a robust approach to dealing with zero expenditure on car fuel. Especially, instead of the Tobit estimator, based on the maximum likelihood (ML) estimation method, this paper applied symmetrically censored least squares (SCLS) estimation as a robust approach to dealing with zero expenditure on car fuel in Korea. According to the analysis, car fuel expenditure is very inelastic to households’ income.

권두언

이주석 한국지방재정공제회 2011 지방재정과 지방세 Vol.37 No.-

South Koreans’ Willingness to Pay for Korea Unification

이주석 한국자료분석학회 2017 Journal of the Korean Data Analysis Society Vol.19 No.5

Although considerable effort and attention has been made to estimate the costs of unification in academic and some policy research circles, few studies have considered how to raise the necessary financial resources including the unification tax. Therefore, this study analyzed the South Koreans’ willingness to pay (WTP) for Korean unification. To deal with zero WTP responses given by a large number of people, this study adjusted the spike model with one and one half bound dichotomous choice data. The analysis showed that the mean monthly WTP per household and annual aggregate value to South Koreans was estimated to be 15,532 Korean won ($13.51) and 3,196.9 billion Korean won ($2.78 billion), respectively. According to estimation results, even though they were willing to shoulder some financial burden for the unification, the amount would not be large enough to prepare for unification.

흰쥐 악하선 세포에서 gap junction 봉쇄제인 octanol이 타액분비 및 세포내 $Ca^{2+}$ 농도 조절에 미치는 영향

이주석,서정택,이승일,이종갑,손흥규,Lee, Ju-Seok,Seo, Jeong-Taeg,Lee, Syng-Il,Lee, Jong-Gap,Sohn, Heung-Kyu 대한소아치과학회 1999 大韓小兒齒科學會誌 Vol.26 No.2

세포내 유리칼슘(free calcium, $Ca^{2+}$)은 세균에서 고등동물에 이르기까지 거의 모든 세포에서 세포 고유작용을 조절하는 중요한 세포내 신호전달체계(signal transduction system)의 매개체이다. 타액선 세포에서 부교감 신경 자극으로 타액분비가 증가될 때에도 세포내 $Ca^{2+}$ 농도 증가가 가장 중요한 역할을 한다. 그러나 췌장(pancreas)의 경우 세포내 $Ca^{2+}$ 이외에도 인접세포를 전기적 화학적으로 연결해주는 gap junction이 외분비 기능을 직접적으로 조절할 가능설이 제시되었다. 타액선 세포에서도 세포막에 고농도의 gap junction이 존재하고 있으며 gap junction을 통해 인접세포들이 전기적, 화학적으로 연계되어 있어 gap junction이 타액선 세포의 기능을 직접적으로 조절할 가능성을 내포하고 있다. 따라서 gap junction이 타액선의 타액분비 작용에도 중요한 역할을 하며 이러한 작용이 세포내 $Ca^{2+}$ 농도를 조절하여 이루어질 것이라는 가정하에 이를 확인하는 실험을 시행하였다. 흰쥐 악하선에서 유리되는 타액양을 측정하기 위해서 악하선으로 혈액을 공급하는 동맥에 가는 관을 삽입하여 생리 식염수를 관류하면서 타액선관을 통해 타액을 채취하였다. 세포내 $Ca^{2+}$ 농도는 분리한 악하선 acini 내에 $Ca^{2+}$ 농도 변화에 민감하게 반응하는 형광물질인 fura-2를 축적시키고 형광 분석기를 사용하여 형광강도를 측정하여 다음과 같은 결과를 얻었다. 1. CCh 투여로 타액 분비가 증가하였을 때 gap junction을 봉쇄하는 약물인 octanol(1 mM)을 투여하면 타액분비가 봉쇄되었으며 이는 가역적 반응이었다. 2. CCh투여로 세포내 $Ca^{2+}$ 농도가 증가하였을 때 1mM octanol을 투여하면 세포내 $Ca^{2+}$ 농도가 CCh 투여전의 상태로 감소되었다. 3. Octanol은 CCh에 의하여 유발된 초기 $Ca^{2+}$ 증가를 억제하지는 못한 반면에 후기 $Ca^{2+}$ 농도를 감소시켰다. 4. 세포막 $Ca^{2+}$ 통로를 열어주는 약물인 thapsigargin($1{\mu}M$)을 투여하여 세포내 $Ca^{2+}$ 농도를 증가시킨 후 1mM octanol을 투여하면 세포내 $Ca^{2+}$ 농도가 thapsigargin 투여 전의 상태로 감소하였다. 5. 2,5-di-tert-butyl-1,4-benzohydroquinone(TBQ)의 투여로 세포막을 통한 $Ca^{2+}$ 농도의 주기적 변동인 $Ca^{2+}$의 oscillation이 유발되었는데, 이때 1mM octanol을 투여한 경우에 $Ca^{2+}$농도의 oscillation이 정지하여 역시 gap junction을 봉쇄하면 TBQ에 의해서 유발된 세포내 $Ca^{2+}$ 농도의 주기적 변동이 사라지고 $Ca^{2+}$ 농도의 감소가 나타남을 확인하였다. 6. Gap junction을 봉쇄하는 또 다른 약물인 glycyrrhetinic acid($100{\mu}M$)도 CCh 자극으로 인한 타액분비를 억제하였다. 이상의 결과로 미루어 gap junction은 흰쥐 악하선 세포로부터의 타액분비 조절에 중요한 역할을 하는데, 이는 gap junction이 세포막 $Ca^{2+}$ 통로를 조절함으로써 수용체 자극으로 유발된 세포내 $Ca^{2+}$ 농도 변화에 영향을 미친 결과인 것으로 추측된다. From bacteria to mammalian cells, one of the most important mediators of intracellular signal transduction mechanisms which regulate a variety of intracellular processes is free calcium. In salivary acinar cells, elevation of intracellular calcium concentration ($[Ca^{2+}]_i$) is essential for the salivary secretion induced by parasympathetic stimulation. However, in addition to $[Ca^{2+}]_i$, gap junctions which couple individual cells electrically and chemically have also been reported to regulate enzyme secretion in pancreatic acinar cells. Since the plasma membrane of salivary acinar cells has a high density of gap junctions, and these cells are electrically and chemically coupled with each other, gap junctions may modulate the secretory function of salivary glands. In this respect, I planned to investigate the role of gap junctions in the modulation of salivary secretion and $[Ca^{2+}]_i$, using mandibular salivary glands of rats. In order to measure the salivary flow rate, fluid was collected from the cannulated duct of the isolated perfused rat mandibular glands at 2 min intervals. $[Ca^{2+}]_i$, was measured from the cells loaded with fura-2 by spectrofluorometry. The results obtained were as follows: 1. CCh-induced salivary secretion was reversibly inhibited by 1 mM octanol, a gap junction blocker. 2. CCh-induced increase in $[Ca^{2+}]_i$, was also reversed by the application of 1 mM octanol. 3. Octanol did not block the initial increase in $[Ca^{2+}]_i$ caused by CCh, which suggested that the reduction of $[Ca^{2+}]_i$, caused by gap junction blockade was not resulted from the inhibition of $Ca^{2+}$ release from intracellular $Ca^{2+}$ stores. 4. Addition of octanol during stimulation with $1{\mu}M$ thapsigargin, a potent microsomal ATPase inhibitor, reduced $[Ca^{2+}]_i$, to the basal level. This suggested that inhibition of gap junction permeability closed plasma membrane $Ca^{2+}$ channels. 5. 2,5-di-tert-butyl-1,4-benzohydroquinone (TBQ) generated $[Ca^{2+}]_i$ oscillations resulting from periodic influx of $Ca^{2+}$ via plasma membrane. The TBQ-induced $[Ca^{2+}]_i$ oscillations were stopped by the application of 1mM octanol which implicated that gap junctions modulate the permeability of plasma membrane $Ca^{2+}$ channels. 6. Glycyrrhetinic acid, another well known gap junction blocker, also inhibited CCh-induced salivary secretion from rat mandibular glands. These results suggested that gap junctions play an important role in the modulation of fluid secretion from the rat mandibular glands and this was probably due to the inhibition of $Ca^{2+}$ influx through the plasma membrane $Ca^{2+}$ channels.

원자력공인검사 사업단의 역할

이주석,박반욱,Lee, Ju-Seok,Park, Ban-uk 재료연구소 1993 機械와 材料 Vol.5 No.4

온라인게임핵, 그리고 그들의 생존 전략

이주석,이진경 한국정보과학회 2013 정보과학회지 Vol.31 No.7

고혈압성 뇌증을 동반한 섬유근성 이형성증 1례

이주석,배상남,남상욱,김수영,박희주 대한소아청소년과학회 2000 Clinical and Experimental Pediatrics (CEP) Vol.43 No.5

Fibromuscular dysplasia is the single leading etiology of renovascular hypertension in children. We report an eight-year-old girl who was admitted for generalized tonic seizure with fibromuscular dysplasia of right renal artery. On admission, she presented hypertension and altered mentality. She had suffered from intermittent severe headache for the past year. Renal angiography of right renal artery showed stenosis, beaded pattern and aneurysms. Brain MRI showed multifocal lesions in parietooccipital, periventricular and external capsular area. She was diagnosed as hypertensive encephalopathy due to fibromuscular dysplasia of renal the artery. Renal angioplasty with ballooning catheter was performed. Successful renal angioplasty dropped her blood pressure to normal level and no more headaches has occurred for more than a year after discharge. 섬유근성 이형성증은 소아에서 가장 흔한 신동맥 협착의 원인으로 이전에는 Captopril을 이용한 약물치료와 신절제술이 치료의 근간을 이루어 왔으나 최근 성인을 중심으로 풍선도자 혈관확장술이 사용되고 있다.