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- 저자 : 이상경(Sang-Kyeong Lee) (검색결과 45 건)
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부분 강박된 백서에서 클로자핀에 의해 유발된 간대성 근경련에 대한 단가아민계 작용 약물들의 영향
이상경,김현,김선희,박철균,윤성환,김영훈,Lee, Sang-Kyeong,Kim, Hyun,Kim, Sun-Hee,Park, Cheol-Gyoon,Yoon, Seong-Hwan,Kim, Young-Hoon 대한생물정신의학회 1999 생물정신의학 Vol.6 No.1
This study was performed to investigate the mechanism of the clozapine-induced seizures in partially restrained rats by concomitant treatment with drugs affecting monoaminergic systems. Partially restrained rats treated with acute single doses of 10mg/kg clozapine exhibited myoclonic jerks (MJs). Drugs affecting the monoaminergic systems, including 2mg/kg haloperidol, 5mg/kg propranolol, 2mg/kg ritanserin, 20mg/kg fluoxetine, and 20mg/kg imipramine, were concomitantly treated with clozapine to observe the effects of these drugs on the MJs. The drugs were given intraperitoneally either as acute single doses(haloperidol, propranolol, ritanserin, and fluoxetine) or as chronic doses for 21days(haloperidol, imipramine, ritanserin, and fluoxetine). The effects of the concomitant treatment of other drugs on the clozapine-induced MJs were evaluated by comparison of the total numbers of the MJs between the clozapine-treated and concomitantly treated groups. The results were as follows. 1) Concomitant treatment with acute single doses of haloperidol, propranolol, and fluoxetine reduced the total numbers of the clozapine-induced MJs, while concomitant treatment with ritanserin did not. 2) Concomitant treatment with chronic doses of imipramine and ritanserin increased the total numbers of the MJs, while concomitant treatment with fluoxetine reduced them. Concomitant chronic treatment with haloperidol did not affect the numbers of the MJs. These results suggest that dopamine and serotonin, not noradrenalin may be involved in the clozapine-induced MJs in partially restrained rats. Future research needs to study the function of each subtype of monoaminergic receptors on the mechanism of the clozapine-induced seizure.
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신경회로망을 이용한 4차원 방사선치료에서의 조사 표적 움직임 예측
이상경,김용남,박경란,정경근,이창걸,이익재,성진실,최원훈,정윤선,박성호,Lee, Sang-Kyung,Kim, Yong-Nam,Park, Kyung-Ran,Jeong, Kyeong-Keun,Lee, Chang-Geol,Lee, Ik-Jae,Seong, Jin-Sil,Choi, Won-Hoon,Chung, Yoon-Sun,Park, Sung-Ho 한국의학물리학회 2009 의학물리 Vol.20 No.3
Studies on target motion in 4-dimensional radiotherapy are being world-widely conducted to enhance treatment record and protection of normal organs. Prediction of tumor motion might be very useful and/or essential for especially free-breathing system during radiation delivery such as respiratory gating system and tumor tracking system. Neural network is powerful to express a time series with nonlinearity because its prediction algorithm is not governed by statistic formula but finds a rule of data expression. This study intended to assess applicability of neural network method to predict tumor motion in 4-dimensional radiotherapy. Scaled Conjugate Gradient algorithm was employed as a learning algorithm. Considering reparation data for 10 patients, prediction by the neural network algorithms was compared with the measurement by the real-time position management (RPM) system. The results showed that the neural network algorithm has the excellent accuracy of maximum absolute error smaller than 3 mm, except for the cases in which the maximum amplitude of respiration is over the range of respiration used in the learning process of neural network. It indicates the insufficient learning of the neural network for extrapolation. The problem could be solved by acquiring a full range of respiration before learning procedure. Further works are programmed to verify a feasibility of practical application for 4-dimensional treatment system, including prediction performance according to various system latency and irregular patterns of respiration.
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한국인 인슐린 비의존성 당뇨병환자에서 미토콘드리아 유전자 3243 위치의 점돌연변이
이상경(Sang Kyeong Lee),송종훈(Jong Hoon Song),우정택(Jung Taek Woo),김성운(Sung Woon Kim),양인명(In Moon Yang),김진우(Jin Woo Kim),김영설(Young Seol Kim),최영길(Young Kil Choi) 대한내과학회 1996 대한내과학회지 Vol.51 No.3
Objectives: It is well-known that inheritant factors contribute to the development of noninsulin-dependent diabetes(NIDDM). Several candidate genes, including genes for insulin, the insulin receptor, glucokinase and facilitative glucose transporters, have been examined for their involvement in the pathogenesis of NIDDM. Recently it is of interest to focus to relation of mutations in the mitochondrial gene and maternally inherited diabetes and deafness world wide. But in Korea, a few studies have been repirted about the mitochondrial gene mutation in patients with diabetes and so, as a first step of the study of mitchondrial DNA(mtDNA) mutation, we screened 500 NIDDM patients to know the prevalency of A to G transition at nucleotide pair 3243 of mitochondrial DNA tRNALeu(UUR) gene. Methods: Genomic DNA was extracted from the peripheral leukocytes of the patients who diagnosed as NIDDM during the period from march 1993 to december 1994. The mtDNA fragment surrounding the nucleotide pair 3243 site was amplified by polimerase chain reaction using sense primer 5'- AGGACAAGAGAAATAAGGCC(np 3130-3149) and antisense primer 5'-CACGTTGGGGTTCTTGCGTA (np 3404-3423). These fragments were digested with restriction endonuclease Apa I, and subjected to 1.5% agarose gel electrophoresis Results: No digested mtDNA band was found. In other words, Any A to G transition at np 3243 of the mitchondrial gene was not identified in 500 unrelated NIDDM patients screened. Conclusion: A subtype of diabetes mellitus associated with a mitochandrial tRNALeu(UUR) gene mutation seems to be very rare in Korea.
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Rim1α and Neurexin3 Regulate Synaptosomal Dopamine Release
Sang Kyeong Lee(이상경),Joo-Cheol Shim(심주철),Young-Hoon Kim(김영훈),Bo-Geum Kong(공보금),Dae-Hyun Seog(석대현) 한국생명과학회 2009 생명과학회지 Vol.19 No.9
신경전달물질의 분비는 시냅스전 신경말단의 active zone에 있는 다양한 단백질들에 의해 조절된다. 도파민은 정신분열병, 약물중독과 같은 여러 가지 행동, 정신질환의 병태생리와 연관된 필수적인 신경전달물질이다. 저자들은 본 연구에서 신경전달물질 분비와 관련된 주요 유전자가 결여된 knockout (KO) 생쥐의 시냅토좀(synaptosome) 도파민 분비를 측정하였다. 시냅토좀 도파민 흡수와 분비는 [³H]-도파민과 관류실험을 이용하여 시행, 측정하였다. 17 KO 생쥐 가운데 3 종류의 생쥐에서 그들의 littermate 대조군과 비교하였을 때 변화된 도파민 분비를 보였다. Rim1α KO에서 세포막 탈분극에 의한 [³H]-도파민은 유의하게 감소되었으며, 또한 Rim1α의 도파민 신경에서의 조건 KO에서는 생리적 완충용액에 의한 기본적인 도파민 분비 및 세포막 탈분극에 의한 도파민 분비 모두가 유의하게 감소되어 있었다. neurexin3의 도파민 신경에서의 조건 KO에서는 세포막 탈분극에 의한 도파민 분비의 증가를 보였다. 이 데이터들은 도파민 분비와 글루타메이트, GABA와 같은 전통적 신경전달물질 분비의 유사성과 차별성을 설명한다. 결론적으로, Rim1α와 neurexin3는 시냅스전 도파민 분비의 중요한 조절자이며 신경계 질환과 연관될 가능성이 있다. Neurotransmitter release is regulated by various proteins of the active zone in the presynaptic nerve terminals. Dopamine (DA) is an essential neurotransmitter associated with the pathophysiology of diverse behavioral and mental illness such as schizophrenia and drug addiction. We measured synaptosomal DA release of knockout (KO) mice which lacked major genes related to neurotransmitter release. Synaptosomal DA uptake and release were performed and measured using [³H]-DA and superfusion experiments. 3 of the 17 KO mice exhibited altered DA release compared to their littermate controls. In Rim1α KO, [³H]-DA release evoked by membrane depolarization significantly decreased. Both basal (physiological buffer-evoked) and membrane depolarization-evoked DA release significantly decreased in dopaminergic conditional KO of Rim1αβ. Dopaminergic conditional KO of neurexin3 demonstrated a significant increase of membrane depolarization-evoked DA release. These data explain the similarities and distinctions between DA and other classical neurotransmitters such as glutamate and GABA (γ-aminobutyric acid) release. In conclusion, Rim1α and neurexin3 may be important regulators of presynaptic DA release and related to disorders of the nervous system.
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