함초관련 연구 및 상품화 현황

윤병재 한국식품영양과학회 2007 한국식품영양과학회 산업심포지움발표집 Vol.2007 No.6

Balloon Dilatation for Corrosive Esophageal Strictures in Children: Radiologic and Clinical Outcomes

윤병재,김우선,천정은,김화영,신수미,김인원,연경모 대한영상의학회 2010 Korean Journal of Radiology Vol.11 No.2

Objective: We retrospectively evaluated the effectiveness of the esophageal balloon dilatation (EBD) in children with a corrosive esophageal stricture. Materials and Methods: The study subjects included 14 patients (M:F = 8:6, age range: 17-85 months) who underwent an EBD due to a corrosive esophageal stricture. The causative agents for the condition were glacial acetic acid (n = 9) and lye (n = 5). Results: A total of 52 EBD sessions were performed in 14 patients (range 1-8 sessions). During the mean 15-month follow-up period (range 1-79 months), 12 patients (86%) underwent additional EBD due to recurrent esophageal stricture. Dysphagia improved after each EBD session and oral feeding was possible between EBD sessions. Long-term success (defined as dysphagia relief for at least 12 months after the last EBD) was achieved in two patients (14%). Temporary success of EBD (defined as dysphagia relief for at least one month after the EBD session) was achieved in 17 out of 52 sessions (33%). A submucosal tear of the esophagus was observed in two (4%) sessions of EBD. Conclusion: Only a limited number of children with corrosive esophageal strictures were considered cured by EBD. However, the outcome of repeated EBD was sufficient to allow the children to eat per os prior to surgical management. Objective: We retrospectively evaluated the effectiveness of the esophageal balloon dilatation (EBD) in children with a corrosive esophageal stricture. Materials and Methods: The study subjects included 14 patients (M:F = 8:6, age range: 17-85 months) who underwent an EBD due to a corrosive esophageal stricture. The causative agents for the condition were glacial acetic acid (n = 9) and lye (n = 5). Results: A total of 52 EBD sessions were performed in 14 patients (range 1-8 sessions). During the mean 15-month follow-up period (range 1-79 months), 12 patients (86%) underwent additional EBD due to recurrent esophageal stricture. Dysphagia improved after each EBD session and oral feeding was possible between EBD sessions. Long-term success (defined as dysphagia relief for at least 12 months after the last EBD) was achieved in two patients (14%). Temporary success of EBD (defined as dysphagia relief for at least one month after the EBD session) was achieved in 17 out of 52 sessions (33%). A submucosal tear of the esophagus was observed in two (4%) sessions of EBD. Conclusion: Only a limited number of children with corrosive esophageal strictures were considered cured by EBD. However, the outcome of repeated EBD was sufficient to allow the children to eat per os prior to surgical management.

시상 자기공명영상에서의 후경막외지방: 협부 척추골전전위증과 퇴행성 척추골전전위증을 구별하는데 있어서 유용한가?

윤병재,최정아,김정은,최자영,홍성환,강흥식 대한영상의학회 2004 대한영상의학회지 Vol.51 No.5

종암목장 사양관리의 실제

윤병재 한국종축개량협회 2001 젖소개량 Vol.6 No.12

부산지역 일부 산업장 근로자들의 유병률에 관한 연구

김광혁,윤병재 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1997 Journal of biomedical laboratory sciences Vol.3 No.2

1993년 1월 1일부터 1995년 12월 31일까지 부산시내 324개 사업장 16,453명의 근로자를 대상으로 성별, 연령별, 업종별 유병률을 조사하여 다음과 같은 결과를 얻었다. 조사대상자의 성별 비는 1.9:1.0이고 평균 연령은 남자가 43±17세, 여자는 38±15세로 나타났다. 전체 대상자 16,453명중 1,932명 (11.7%)이 질병을 앓고있는 사람이며 남자가 1,521명 (14.0%), 여자가 411명 (7.3%)으로 나타났다. 성별에 따른 유병률은 폐결핵, 간장질환, 소음성 난청은 남자가 여자보다 유의하게 높았고 빈혈증, 유기용제 중독은 여자가 남자보다 유의하게 높았다 (p<0.001). 연령별 유병률은 29세 미만과 30∼39세, 40∼49세에서 간장질환이 높았고 50세 이상에서 순환계 질환이 높았다 (p<0.001). 업종별 유병률은 전기 건설업, 신발 고무제조업에서 순환계 질환이 가장 높았고 1차금속, 운수 정비업, 섬유 피혁, 화학 석유제조업, 기타 제조업에서 간장질환이 가장 높게 나타났다. 음료 및 식료품 제조업과 기계제조업에 종사하는 사람은 소음성 난청이 가장 높았다. 근무 기간별 유병률은 연중독을 제외한 모든 질환에서 근무기간이 길수록 높았다 (p<0.001). This study was performed to investigat the prevalence rates disease in industrial workers (16,453) in Pusan city from Jan. 1, 1993 to Dec. 31, 1995. The results were as follows: The male to female ratio was 1.9:1.0 and average age was 43±17 in male, 38±15 in female of subjects. The percentage value of patients was 14.0% in male, 7.4% in female of total patients 1,932 (11.0%). The prevalence rates of pulmonary tuberculosis, hepatic disease, and occupational hearing loss were significantly increased in male than females (p<0.001). But anaemia and organic solvent poisonings significantly increased in females than males (p<0.001). The prevalence rates of hepatic disease increased significantly in below 29, 30-39 and 40-49 age groups, that of cardiovascular disease increased significantly in the age group over 50 years (p<0.001). According to industrial types, the prevalence rate of cadiovascular disease increased in electricity and constration and shoes and rubber in disease, there of hepatic disease increased in primary metal, transportation and maintenance and other industrial, those of occupational hearing loss in drink and food and machinery. The prevalence rate of disease increased significantly long working duration in all diseases except lead poisoning.

부산지역 일부 산업장근로자들의 유병률에 관한 연구

윤병재(Byung-Jae Yoon),김광혁(Kwang-Hyuk kim) 대한의생명과학회 1997 Biomedical Science Letters Vol.3 No.2

1993년 1월 1일부터 1995년 12월 31일까지 부산시내 324개 사업장 16,453명의 근로자를 대상으로 성별, 연령별, 업종별 유병률을 조사하여 다음과 같은 결과를 얻었다. 조사대상자의 성별 비는 1.9:1.0이고 평균 연령은 남자가43±7세, 여자는 38±5세로 나타났다. 전체 대상자 16,453명 중 1,932명 (11.7%)이 질병을 앓고있는 사람이며 남자가 1,521명 (14.0%), 여자가 411명 (7.3%)으로 나타났다. 성별에 따른 유병률은 폐결핵, 간장질환, 소음성 난청은 남자가 여자보다 유의하게 높았고 빈혈증, 유기용제 중독은 여자가 남자보다 유의하게 높았다 (p<0.00l). 연령별 유병률은 29세 미만과 30-39세, 40-49세에서 간장질환이 높았고 50세 이상에서 순환계 질환이 높았다 (p<0.001). 업종별 유병률은 전기 건설업, 신발 고무제조업에서 순환계 질환이 가장 높았고 1차금속, 운수 정비업, 섬유 피혁, 화학 석유제조업, 기타 제조업에서 간장질환이 가장 높게 나타났다. 음료 빛 식료품 제조업과 기계제조업에 종사하는 사람은 소음성 난청이 가장 높았다. 근무 기간별 유병률은 연중독을 제외한 모든 질환에서 근무기간이 길수록 높았다 (p<0.001). This study was performed to investigat the prevalence rates disease in industrial workers (16,453) in Pusan city from Jan. 1, 1993 to Dec. 31, 1995. The results were as follows: The male to female ratio was 1.9: 1.0 and average age was 43 ± 17 in male, 38 ± 15 in female of subjects. The percentage value of patients was 14.0% in male, 7.4% in female of total patients 1,932 (11.0%). The prevalence rates' of pulmonary tuberculosis, hepatic disease, and occupational hearing loss were significantly increased in male than females (p<0.00l). But anaemia and organic solvent poisonings significantly increased in females than males (p<0.001). The prevalence rates of hepatic disease increased significantly in below 29, 30-39 and 40-49 age groups, that of cardiovascular disease increased significantly in the age group over 50 years (p<0.001). According to industrial types, the prevalence rate of cadiovascular disease increased in electricity and constration and shoes and rubber in disease, there of hepatic disease increased in primary metal, transportation and maintenance and other industrial, those of occupational hearing loss in drink and food and machinery. The prevalence rate of disease increased significantly long working duration in all diseases except lead poisoning.

대금전초로부터 분리한 phenylpropanoid화합물이 glutathione S-transferase 활성에 미치는 영향

윤병재,최종원,천현욱,정운용,김회영,김동훈 慶星大學校 環境問題硏究所 1997 環境硏報 Vol.7 No.1

Lysimachiae christnae HANCE has long been used to induce diuresis, remove calculi and treat jaundice in oriental countries. Isoferulic acid(3-hydroxy-4-methoxycinnamic acid) is the major biological active component of Lysimachiae christinae in our experiment. Effect of isoferulic acid on the activities of free radical scavenging enzymes and glutathione-related enzymes as well as detoxiflcation mechanism of isoferulic acid against ethacrynic acid-induced hepatotoxicity was investigated in rat. Hepatic glutathione level in the isoferulic acid-treated group not effected as compared to that of the control group. Although the injection of ethacrynic acid results in the significantly decrease in the level of hepatic glutathione, glutathione S-transferase and glutathione reductase, this decreasing effect was markedly lowered in the isoferulic acid-pretreated group. But, v-glutamylcystein synthease activity was not affected. Furthemore, isoferulic acid prevented against ethacrynic acid-inducible hepatotoxicity in rat as evidenced by the decreased formation of lipid peroxide. Enzyme activity, however, in the isoferulic acid-treated rat, were affected Vmax and not affected Km value in vitro. Treatment with isoferulic acid did significantly increase glutathione-related enzymes activities such as glutatione S-transferase, and the characteristics of increase in the enzyme activity might include the induction of enzyme protein. Therefore, it can be concluded that mechanism for the observed preventive effect of isoferulic acid, active component of Lysimachiae christinae, against the ethacrynic acid-induced, hepatotoxicity was due to the induction of glutathione S-transferase which related with metabolism of these materials.

실험실적 당뇨성 흰쥐에서 acetaminophen의 대사에 관한 연구

임은주,윤병재,윤병재,조희숙,김대재,최종원 경성대학교 환경문제연구소 2000 環境硏報 Vol.10 No.1

Acetaminophen is one of the most important drugs used for the treatment of mild to moderate pain when an anti-inflammatory effect is not necessary. Phenacetin, a prodrug that is metabolized to acetaminophen, is more toxic than its active metabolite and has no rational indications. In this study, we were observed activities of free radical generating enzymes, free radical scavenging enzymes and glutathione-related enzymes as well as detoxification mechanism of against acetaminophen-induced hepatotoxicity in STZ-induced hyperglycemic rat. Activities of cytochrome p450, cytochrome b5, aminopyrine demethylase and aniline hydroxylase were changed by the treatment acetaminophen in hyperglycemic rats. It was also observed that activities of conjugating enzymes as sulfotransferase and UDP-glucuronyltransferase was slightly changes against acetaminophen-induced in hyperglycemic rats. Acetaminophen results in the significantly decrease in the level of hepatic glutathione concentration and √-glutamylcysteon, synthetase activities in hyperglycemic rats. And, glutathine S-transferase, superoxide dismutase and glutathione peroxidase activities were significantly increased against acetaminophen-inducedas in hyperglycemic rats. Glutathione reductase and catalase were not affected for experimental state. Furthemore, acetaminophen highered serum alanine, aspartate aminotransferase, sorbitol dehydrogenase, √-glutamylpeptidase, alkaline phosphatase and lactate dehydrogenase activities in hyperglycemic rats. Key Words: Hepatotoxicity, D/M, Acetaminophen, Glutathione, Glutathlone S-transferase, √-glutamylcystein synthetase

A-61 : 음식물류폐기물의 바이오가스화를 위한 2상 혐기성소화 공정의 상용화 Plant 운전 연구

어명철,윤병재,이용현 한국폐기물자원순환학회(구 한국폐기물학회) 2013 한국폐기물자원순환학회 추계학술발표논문집 Vol.2013 No.-

음식물류폐기물을 처리하는 방법 중 혐기성소화 공정은 부산물로서 메탄이 주성분인 바이오가스를 얻을 수 있기 때문에 국내·외에서 적용하는 사례가 크게 증가하고 있는 추세이다. 따라서 본 연구에서는 남양주시에서 발생하는 음식물쓰레기를 대상으로 고온(55±2℃) 2상 혐기성 소화조를 운전하였다. 산 발효조와 메탄 발효조내부는 상부 스컴 수집용 Blade가 설치되어 있으며, 상ㆍ하부의 완전 교반 및 순환으로 미생물 접촉시간 증대에 따른 고효율 유기물 제거를 확보할 수 있는 원형 내부 격벽 설치 구조로 되어있다. 또한 내부 격벽 내 저동력 다단형 교반기(VVVF 적용)가 설치되었다. 발생하는 바이오가스 중 제습을 위한 Water trap과 황성분을 제거하기 위해 건식탈황장치를 설치하였다. 정제된 바이오가스는 보일러의 연료로 사용되어 혐기성 소화조 가온에 이용하였으며, 잉여 steam은 소각시설에서 발생하는 steam과 혼합되어 판매하였다. 실증 Plant 운전결과 소화조로 유입되는 음식물의 평균 VS 농도는 76,033mg/L였으며, 평균 VS 제거율은 78.1%로 나타났다. 바이오가스 평균 발생량은 1,079Nm3/day이며, 메탄생성율은 0.7m3/kgVSremoved임을 확인 하였다.

항만 도선사 상해사고와 준사고의 관계

박상원,윤병재,김소라,박영수 한국항해항만학회 2023 한국항해항만학회지 Vol.47 No.3

도선사는 해상에서 도선사용 사다리나 승하선사다리를 통해 선박에 승선하고 있어 예측할 수 없는 해상환경의 위험에 늘 노출되어 있다. 도선사는 항만으로 입항하거나 출항하는 선박의 안전을 확보하는 중요한 역할을 수행하고 있으므로 도선사 부상은 선박 전체 안전에 큰 영향을 미친다. 본 연구의 목적은 도선사 관련 준사고를 분석하고 사고를 예측하는 것이다. 이를 위해 도선사 상해사고 사례를 분석하고 설문조사를 통해 잠재상황을 식별하고자 했다. 그리고 도선사 상해사고 경향을 예측하였다. 설문조사의 분석은 IPA 분석법을 활용했으며, 상해사고 경향 예측을 하기 위해 이항분포 및 푸아송분포를 활용하였다. 연구결과 도선사 상해사고 1건당 316.8건의 준사고가 발생했으며, 사고 관리 시스템의 현행 유지 시 3개월 내 도선사 상해사고가 발생할 확률은 64.4%로 나타났다. 연구결과를 바탕으로 도선사 상해사고 예방을 위한 관리 시스템의 필요성과 도선사 승선용 사다리에 대한 유지보수 및 설치 강화를 제언했다.