ST segment elevation myocardial infarction by coronary embolism in prosthetic valve thrombosis

유수지,강민규 대한내과학회 2018 대한내과학회 추계학술대회 Vol.2018 No.1

18~19세기 族譜를 통해 본 大丘徐氏 동족집단의 구성

유수지 조선시대사학회 2023 朝鮮時代史學報 Vol.- No.105

Daegu Seo Clan was active in the center throughout the Joseon Dynasty. However, their genealogy was published in the early 18th century. Daegu Seo first published "Daegu Seo Clan Sebo" in 1702, and then published a total of five copies until 1852, the mid-19th century. This paper analyzed the Daegu Seo clan group described in the preface and introductory remarks of the Daegu Seo clan from 1702 to 1852, and examined the composition of the clan group from the 18th to the 19th century. However, the Daegu Seo clan at this time was limited to the Daegu Seo clan, based in Seoul. This is to prevent confusion with Dalseong Seo, who is recognized as the same clan. Daegu Seo clan tried to distinguish itself from the Dalseong Seo clan through a genealogy in 1702. For this reason, Dalseong Seo was excluded from the main report of the genealogy and recorded as a separate report for the historical fact. Later, in 1775, they were moved back to Bonbo from Eulmibo, but the degree of description of Dalseong Seo Clan was the same as Imobo. Although the Dalseong Seo clan group was recognized as a kinship, the Daegu Seo clan tried to organize the mainstream kinship group embodied in the genealogy only with Gyeongpa with Seo-han as its founder. However, not all Daegu Seo Clan was published in the Daegu Seo Clan Sebo. In the genealogy, the Daegu Seo clan continued to mention the prosperity of the family of Seo-seong and his sons. Seo-seong and his descendants were those who had a marriage relationship with the royal family, produced government officials continuously, and had a higher social and political status than other Daegu Seo Clan at the time. In other words, the Daegu Seo Clan tried to show the social and political status of the Daegu Seo Clan by using them as the mainstream of the Daegu Seo Clan Sebo. This was particularly noticeable in Eulmibo, the most complete genealogy. In Eulmibo, unlike before, the distinction between grandchildren and sons-in-law was clarified to emphasize the four households under Seoseong. It was not until the late 18th century that the construction of a genealogy centered on paternal blood ties was attempted. However, it did not completely exclude grandchildren and sons-in-law. This is because they still acted as beings that could represent relationships with other clan groups. On the other hand, the genealogy report centered on four households under Seo Seong led to the exclusion of descendants of the same Daegu Seo Clan in the mid-19th century. They were the descendants of Bokgyeong, who were excluded because the genealogy was not clear and wrote a separate paper. However, in fact, it is believed that this is because they were descendants of the Seo Geo-jeong family, unlike the four households under Seo-seong, the Seo Geo-gwang family. As such, Daegu Seo tried to maintain a genealogy centered on certain households until the 19th century, and a more expanded form centered on paternal blood ties did not take place until the 20th century. 대구서씨는 조선 전 시기를 통틀어 중앙에서 활발하게 활동한 巨姓이었다. 그러나 그들의 족보는 18세기 초반에서야 비로소 작성되었다. 대구서씨는 1702년 첫 『大丘徐氏世譜』를 간행한 이후 19세기 중반인 1852년까지 총 5권의 세보를 간행하였다. 본고는 1702년부터 1852년까지 『대구서씨세보』의 서ㆍ발문과 범례에 서술된 대구서씨 동족집단을 분석하여 18세기부터 19세기까지 이들이 나타내고자 했던 동족집단의 구성을 살펴보았다. 단, 이때의 대구서씨는 徐閈을 시조로 하는 京派인 대구서씨로 한정하였다. 같은 성관으로 인식되고 있는 鄕派인 달성서씨와의 혼동을 막기 위해서이다. 대구서씨는 1702년 족보인 『임오보』부터 향파인 달성서씨와 구분하고자 하였다. 때문에 그 역사적 사실을 이유로 향파인 달성서씨를 족보의 본보에서 배제하여 별보로 기재하였다. 이후 1775년 『을미보』에서 이들을 다시 본보로 옮겼지만, 향파인 달성서씨 인물들의 기재 정도는 『임오보』와 같았다. 달성서씨 향파를 동족으로는 인식하였지만, 대구서씨는 족보에서 구현되는 주류의 동족집단은 서한을 시조로 둔 경파만으로 구성하고자 했던 것이다. 그런데 모든 경파인 대구서씨가 『대구서씨세보』에 실린 것은 아니었다. 대구서씨는 족보에서 서성과 그 이하 아들 가계의 번성에 대해 지속적으로 언급하였다. 서성과 그 이하의 후손들은 왕실과 혼인관계를 맺고 꾸준하게 관직자들을 배출하며 다른 대구서씨 가계 보다 당대 사회적ㆍ정치적으로 위상이 높은 이들이었다. 즉 대구서씨는 이들을 『대구서씨세보』의 주류로 하여 사회적ㆍ정치적 위상을 나타내고자 한 것이다. 이는 특히 족보 중 가장 완성도가 높은 『을미보』에서 두드러졌다. 『을미보』에서는 서성 이하 네 가계를 강조하기 위해 기재상 이전과는 달리 외손 및 사위와의 구분을 명확히 하였다. 18세기 후반에 이르러서야 부계혈연 중심의 족보 구성을 시도한 것이다. 그러나 외손 및 사위를 완전히 배제하지 않았다. 이들은 타성들과의 관계를 나타낼 수 있는 존재로 여전히 인식되었기 때문이다. 한편 서성 이하 네 가계 중심의 족보 수보는 19세기 중반 같은 대구서씨 후손들을 배제하는 결과를 불러왔다. 바로 福慶 이하 자손들로, 이들은 계보가 명확하지 않다는 이유로 배제되어 따로 파보를 작성하기도 했다. 그러나 실질적으로 이들은 서거광 계열인 서성 이하 네 가계들과는 다르게 서거정 계열의 후손이었기 때문인 것으로 파악된다. 이처럼 대구서씨는 19세기에 이르러서도 특정 가계를 중심으로 한 수보 형식을 유지하고자 했으며, 좀 더 확장된 형태의 부계혈연 중심의 동족집단화는 20세기가 되어서야 이루어졌다.

Backbone Dynamics and Model-Free Analysis of the RecQ C-Terminal Domain of Bloom Syndrome Protein

유수지,이성진,박진주 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.11

Bloom syndrome protein (BLM) is one of RecQ helicases, which are conserved DNA unwinding enzymes in DNA metabolisms. The RecQ C-terminal domain (RQC) of BLM is a winged-helix motif, which recognizes various DNA structures. BLM RQC mediates electrostatic interactions with duplex DNA by using polar residues in the ?-wing and α2?α3 loop. In order to understand the dynamic properties of RQC for recognizing its substrate DNA, we measured 15N spin relaxation parameters of the protein and performed model-free analysis. Our results showed that the ?-wing region, which is used for the strand separation, has flexible backbone structure. The α2?α3 loop, the binding surface of the DNA major groove, was found to be relatively rigid. Our results contribute to a better understanding of molecular basis of BLM RQC?DNA interaction.

Backbone Dynamics and Model-Free Analysis of N-terminal Domain of Human Replication Protein A 70

유수지,박진주 한국자기공명학회 2018 Journal of the Korean Magnetic Resonance Society Vol.22 No.1

Replication protein A (RPA) is an essential single-stranded DNA binding protein in DNA processing. It is known that N terminal domain of RPA70 (RPA70N) recruits various protein partners including damage-response proteins such as p53, ATRIP, Rad9, and MRE11. Although the common binding residues of RPA70N were revealed, dynamic properties of the protein are not studied yet. In this study, we measured 15N relaxation parameters (T1, T2 and heteronuclear NOE) of human RPA70N and analyzed them using model-free analysis. Our data showed that the two loops near the binding site experience fast time scale motion while the binding site does not. It suggests that the protein binding surface of RPA70N is mostly rigid for minimizing entropy cost of binding and the loops can experience conformational changes. Replication protein A (RPA) is an essential single-stranded DNA binding protein in DNA processing. It is known that N terminal domain of RPA70 (RPA70N) recruits various protein partners including damage-response proteins such as p53, ATRIP, Rad9, and MRE11. Although the common binding residues of RPA70N were revealed, dynamic properties of the protein are not studied yet. In this study, we measured 15N relaxation parameters (T1, T2 and heteronuclear NOE) of human RPA70N and analyzed them using model-free analysis. Our data showed that the two loops near the binding site experience fast time scale motion while the binding site do not. It suggests that the protein binding surface of RPA70N is mostly rigid for minimizing entropy cost of binding and the loops can experience conformational changes.

코워킹 공간의 비공식적 커뮤니케이션 공간 특성 만족도 분석 - 서울시 무료로 이용 가능한 코워킹 공간 5곳을 중심으로 -

유수지,한혜련 한국문화공간건축학회 2016 한국문화공간건축학회논문집 Vol.- No.56

In this study, space characteristics for informal communication is analyzed and a checklist is created and then the evaluation proceeds. It aims to propose a direction of national coworking space in the future by investigating satisfaction of users through a survey. The scope of the study, 5 locations that are available to use for free or with a membership were chosen as the case study destination among coworking spaces which opened the last year in Seoul. The method of the study, the space configuration and classification of coworking space are investigated through literature review and previous studies. The terms and contents are derived by the space configuration which is applied to the domestic coworking space. Through a theoretical review of informal communication in the office space, concept, type and space characteristics are reviewed. Space characteristics of activating informal communication of coworking space are analyzed. The checklist extracted based on the field survey of 5 case study destination and previous research is applied to the case study destination. After creating a questionnaire through the checklist, based on it, the survey on ‘visiting type of coworking space’, ‘informal communication in coworking space’ and ‘space characteristics for informal communication of case study destination’ is conducted for target users of case study destination. Space characteristics for informal communication which is required for each case study destination is proposed by analyzing the survey result. Coworking space has the characteristic that the boundary of each area is not obvious, but it can be divided into public work space, private work space, business support space and rest space. Among those, space characteristics for informal communication between members were analyzed focusing on public work space, business support space and rest space which are ‘shared space’ where collaboration of many people can be expected. The analysis results are as follows. First, ‘informal communication’ in coworking space influences creative idea of members. Second, 6 space characteristics are actively tried and applied to coworking space for informal communication in coworking space. Third, space characteristics for informal communication can be classified to 6 items, variability, openness, amusement, contingency, mobility and centrality. In the public work space, satisfaction with variability and contingency was high. In case of business support space, satisfaction with contingency was high, but satisfaction with variability couldn’t reach 3 points(average) so that it needs to be improved. In case of rest space, satisfaction with amusement and centrality was high. Finally, space characteristics for informal communication need to be more addressed and applied in open office, meeting room, cafeteria space and community area.

Clinical efficacy of high-flow oxygen therapy through nasal cannula in acute heart failure

유수지,강민규,김계환,박현웅,고진신,황석재,황진용,박정랑 대한내과학회 2018 대한내과학회 추계학술대회 Vol.2018 No.1

A case of amiodarone-induced segmental spinal myoclonus

유수지,강민규 대한내과학회 2018 대한내과학회 추계학술대회 Vol.2018 No.1

Predictive Performance of Glycated Hemoglobin for Incident Diabetes Compared with Glucose Tolerance Test According to Central Obesity

유수지,정태식,김호수,김경영,김수경,정정화,함종렬,백종하 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.4

Background: To examine whether glycated hemoglobin (HbA1c) test would be a suitable screening tool for detecting high-risk subjects for diabetes compared to oral glucose tolerance test (OGTT) according to accompanied central obesity. Methods: In this prospective population-based cohort study, both OGTT and HbA1c tests were performed and continued every 2 years up to 12 years among individuals with non-diabetic state at baseline (aged 40 to 69 years, n=7,512). Incident diabetes was established by a doctor, HbA1c ≥6.5%, and/or fasting plasma glucose (FPG) ≥126 mg/dL, and/or 2-hour postprandial glucose (2hPG) level based on OGTT ≥200 mg/dL. Discriminative capacities of high HbA1c (≥5.7%) versus high 2hPG (≥140 mg/dL) for predicting incident diabetes were compared using Cox-proportional hazard regression and C-index. Results: During the median 11.5 years of follow-up period, 1,341 (17.6%) developed diabetes corresponding to an incidence of 22.1 per 1,000 person-years. Isolated high 2hPG was associated with higher risk for incident diabetes (hazard ratio [HR], 4.29; 95% confidence interval [CI], 3.56 to 5.17) than isolated high HbA1c (HR, 2.79; 95% CI, 2.40 to 3.26; P<0.05). In addition, high 2hPG provided better discriminatory capacity than high HbA1c (C-index 0.79 vs. 0.75, P<0.05). Meanwhile, in subjects with central obesity, the HR (3.95 [95% CI, 3.01 to 5.18] vs. 2.82 [95% CI, 2.30 to 3.46]) and discriminatory capacity of incident diabetes (C-index 0.75 vs. 0.75) between two subgroups became comparable. Conclusion: Even though the overall inferior predictive capacity of HbA1c test than OGTT, HbA1c test might plays a complementary role in identifying high risk for diabetes especially in subjects with central obesity with increased sensitivity

단일 2차 기관에서 소아 마이코플라스마 폐렴 환자의 치료를 위한 스테로이드 사용 현황과 효과

유수지 ( Susie Yoo ),최성은 ( Seong Eun Choi ),전지영 ( Jiyoung Chun ),안요한 ( Yo Han Ahn ),조기영 ( Ky Young Cho ),이용주 ( Yong Ju Lee ),성태정 ( Tae Jung Sung ),이건희 ( Kon Hee Lee ) 대한천식알레르기학회(구 대한알레르기학회) 2018 Allergy Asthma & Respiratory Disease Vol.6 No.2

Purpose: Steroids can be used as an adjuvant therapy in the management of mycoplasma pneumonia, but no definite guidelines for the use of steroids have been established. The purpose of this study was to analyze the current usage and effects of steroids in the management of childhood mycoplasma pneumonia in a secondary hospital in Korea. Methods: We retrospectively reviewed the medical records of 152 patients who were admitted due to mycoplasma pneumonia. The patients were divided into 3 groups as follows: those who did not use steroids (81 patients, 53%), those who used steroids after their fever subsided (42 patients, 28%) and those who used steroids during fever (29 patients, 19%). Results: In decreasing order of values, the duration of fever during hospitalization (60.0±40.2 hours vs. 37.3±28.5 hours vs. 29.7±29.5 hours, P=0.006) and duration of hospitalization (5.9±1.7 days vs. 5.0±1.4 days vs. 4.0±1.5 days, P<0.001) were reported in the group which received steroids during fever, the group which received steroids after the fever subsided and the group which did not receive steroids. In the group which received steroids during fever, patients with early steroid use (within 24 hours) had a shorter fever duration in the hospital (12.0 hours vs. 73.5 hours, P<0.001) and a hospitalization duration (5.0 days vs. 6.5 days, P=0.007) than those with late steroid use (after 24 hours). Conclusion: Steroids were used in 47% of patients with mycoplasma pneumonia. The patients who received early steroids had a shorter fever duration and a shorter hospital stay than those who received late steroids. (Allergy Asthma Respir Dis 2018;6:122-127)

비공식적 커뮤니케이션을 위한 코워킹 공간 특성

유수지(Yu, Suzie),한혜련(Han, Hae-Ryon) 한국실내디자인학회 2016 한국실내디자인학회 학술대회논문집 Vol.2016 No.05

This study aims at and finds its meaning in classifying and analyzing spatial characteristics which activates unofficial communication in elements that coworking space is composed of, and presenting the coworking space which enables active cooperation and sharing. Through a theoretical investigation of coworking space and unofficial communication, correlation is defined, and then the characteristics of space for the activation of unofficial communication in coworking space are analyzed. Based on the contents of analysis, a visit was paid to an exemplary site in Korea in person, and observation was made, and checklists were made, and an analysis framework was designed. With regard to the scope of study, among coworking spaces set up within recent 1 year in Seoul, 4 spaces, which can be used free of charge or after obtaining membership, were selected. And users were surveyed. According to the results of study, it was construed that unofficial communication was necessary for free and creative thinking in the coworking space. Spatial characteristics for unofficial communication are summarized into 6 things, i.e., openness, contingency, centrality, mobility, flexibility and playfulness, and are applied to the coworking space in complex form. Coworking space is divided into public working space, private working space, support space and rest space. And in detail, spatial characteristics should be more intensively applied in open office, meeting room, eating and drinking area and community section. It is possible to say that a specific study will be necessary for additionally analyzing whether spatial characteristics for unofficial communication have a positive effect on coworking space users, and providing an effective space to users in a follow-up study.