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      • KCI등재

        한국의 주택건설투자의 결정요인 분석

        오지윤 한국은행 2018 經濟分析 Vol.24 No.4

        This paper analyzes the determinants of Korean residential investment by dividing it into demand and supply using instrumental variable regressions. It turned out that housing prices reflecting demand pressure were the most important determinants of residential investment during the whole sample period (1988q1-2017q3). We add public supply of residential areas as an important policy variable. The effect of the public supply of housing sites on residential investment was large enough to reach about 80 percent of the impact of housing prices. The importance of demand and supply factors has varied significantly over the analysis period. Demand factor reflected in housing prices accounted for the major variations of residential investment in the preceding period (1988q1-2005q4), while supply factors such as construction costs, and public supply of residential areas were more significant in the later period (2006q1-2017q3). This result is additionally supported by the fact that correlation between residential investment and the relative price of residential investment turns into negative from positive in the latter phase. 본 연구는 한국 주택건설투자의 결정요인을 주택가격(수요)과 주택공급 이동요인의 영향으로 나누어 분석하고, 시기별로 이러한 요인들의 영향력이 변하였는지 살펴보았다. 도구변수 추정에 의한 분석 결과, 전체 분석기간(1988q1-2017q3) 중 주택가격이 주택공급의 가장 중요한 결정요인인 것으로 나타나 선행연구들의 결과를 지지하였다. 한국의 특수성을 반영하여 공공택지 공급의 영향을 추가하였는데, 공공택지 공급으로 인한 영향이 주택가격에 의한 영향의 약 80%에 이를 만큼 큰 것으로 나타났다. 이러한 요인들의 중요도는 분석기간에 따라 크게 달랐다. 전기(1988q1-2005q4)에는 주택수요 이동을 대변하는 주택가격의 영향이 유의하였으나, 후기(2006q1-2017q3)에는 유의하지 않았다. 후기에는 공공택지 공급면적의 설명력이 전기와 마찬가지로 유지되는 가운데 건축비용 요인이 중요한 역할을 하였다. 전기에는 상대적으로 수요 측 요인(demand driven)이 주택공급의 변동을 잘 설명하였으나, 후기에는 공급 측 요인(supply driven)의 영향력이 더 강해진 것으로 풀이된다. 주택건설투자 증가율과 주택건설투자의 상대가격 증가율 간의 관계가 전기에는 양(+)으로 나타나다가 후기 들어서 음(-)으로 전환된 점은 이러한 회귀분석 결과를 뒷받침한다.

      • KCI등재

        한방의료기기의 미국 시장 진출을 위한 심사제도 소개

        오지윤,최유나,조수정,정찬영,조현석,이승덕,김갑성,김은정 대한침구의학회 2015 대한침구의학회지 Vol.32 No.4

        Objectives: The Oriental medical device industry is expected to continue to experience signif- icant growth. It should increase its global market share rather than focusing on the domestic market. Countries around the world self-regulate their domestic market, so this study aims to aid in the development of a particular overseas market by introducing the U.S.(the largest market) medical device registration and approval process. Methods: For an understanding of the US medical device licensing process, we researched the relevant regulatory organization (FDA), the history, definition and classification of medical de- vices, the approval and 510(k) submission process related to substantial equivalence, IEC 60601-1 Edition 3, usability tests, and so on. Results: Medical devices in the United States are assigned to one of three regulatory classes: Class I, Class II and Class III, based on the level of control necessary to assure the safety and effectiveness of the device. If a company's device is classified as Class II and if it is not exempt, a 510k will be required for marketing. 1) A 510(k) is a premarket submission made to the FDA to demonstrate that the new device to be marketed is“substantially equivalent”to a legally marketed device (predicate device) 2) The IEC 60601-1 Edition 3 preparation process, which contains information related to us- ability, is expensive and time-consuming but a critical requirement. Conclusions: Although the U.S. market has high barriers to entry, access to this, large overseas market will encourage development of the Oriental medical device industry and commercial value enhancement is expected.

      • KCI등재

        Polarity형성 T 세포와 Non-polarity T 세포에서 Microvilli 형성의 Small GTPase RhoA의 관련성

        오지윤,서희주,이재설,김해영,문경미,최우봉,김병우,이종환 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.4

        The microvilli of circulating lymphocytes play an important role as specialized touching mediators including L-selectin and VLA-4 for transmigration of emigration from circulation to tissue during normal immunosurveillance and in response to inflammation. The microvilli change of circulatory T cells are controlled by the stimulation of chemokines or the interaction of other cells. In addition to this, T cell polarity is also important for cell biological function, effectively. Small GTPase RhoA controls cytoskeleton reorganization and ERM protein is a cross-linker between F-actin cytoskeleton and membrane proteins such as CD44, ICAM1-3. Above molecules is thought to be implicated to the control of cell polarity including microvilli formation. The present study was tried to understand some relation ship between polarity and microvilli. First of all, polarized T cells show that cell surface is smooth surface feature without microvilli, whereas non-polarized T cells display microvilli on the cell surface observed with SEM. Microvilli of non-polarized Jurkat T cell was disrupted in experiment to investigate the involvement of RhoA-ROCK signaling by using ROCK specific inhibitor, Y27632. Cells treated with bombesin, which is Rac1 activator, display surface feature without microvilli. When T cells touch BLDS that was derived from mouse lymph node microvilli was disappeared. In polarized EL4 T cells bearing over-expressing plasmid of PDZ domain constructed to increase active form of RhoA, polarity was disappeared, whereas microvilli was produced. Collectively, these data suggest that small GTPase RhoA and Rac1 is involved in microvilli formation. (Cancer Prev Res 15, 277-284, 2010)

      • KCI등재

        Transformation of Mouse Liver Cells by Methylcholanthrene Leads to Phenotypic Changes Associated with Epithelial-mesenchymal Transition

        오지윤,곽재환,권도영,김아영,오달석,제남경,이재원,정영석 한국독성학회 2014 Toxicological Research Vol.30 No.4

        Environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) havebeen implicated in cancer development and progression. However, the effects ofPAHs on carcinogenesis are still poorly understood. Here, we characterized amouse cancer cell line BNL 1ME A. 7R.1 (1MEA) derived by transformation of non-tumorigenic liver cell line BNL CL.2 (BNL) using 3-methylcholanthrene (3MC), acarcinogenic PAH. RT-PCR and immunoblot analysis were used to determine theexpression level of mRNA and proteins, respectively. To determine functionality, cellmotility was assessed in vitro using a transwell migration assay. Both mRNA andprotein levels of E-cadherin were significantly decreased in 1MEA cells incomparison with BNL cells. While the expression levels of mesenchymal markers and related transcription factors were enhanced in 1MEA cells, which could lead toincrease in cell motility. Indeed, we found that 7-day exposure of BNL cells to 3-MCreduced the level of the adhesion molecule and epithelial marker Ecadherinand increased reciprocally the level of the mesenchymal marker vimentin in a dose-dependent manner. Taken together, these results indicate that the process ofepithelial-mesenchymal transition (EMT) may be activated during premalignanttransformation induced by 3-MC. A mechanism study to elucidate the relationbetween 3-MC exposure and EMT is underway in our laboratory.

      • KCI등재

        한국경제 수요 측면에서의 상품 다양성 증가

        오지윤 한국응용경제학회 2020 응용경제 Vol.22 No.3

        This study empirically estimates variety growth in Korea according to Bills and Klenow (2001). Using the Household Income and Expenditure Survey, the annual growth rate of tradable goods between 1990 and 2012 is 4.7 percent and 4.2 percent for non-tradable goods. When the period is divided into the first period (1991~2000) and the second half (2001~2012), the tradable goods grow 1.4% annually and 7.5% in the second half, accelerating the growth rate in the second half. On the other hand, non-tradable goods grow an average of 5.0 percent annually in the first half and 3.2 percent annually in the second half. 상품의 다양성 확대는 내생적 경제성장 이론에서 혁신의 지표로 간주되고, 경제성장과 밀접한 관련이 있는 것으로 알려져 있으나, 거시적 실증 연구는 제한적이다. 본 연구는 Bils and Klenow(2001)의 방법론을 주로 이용하여 수요측면에서 접근 가능한 자료를 이용하여 한국의 상품 다양성을 실증적으로 추정하였다. 가계동향조사 자료를 이용하여 수요측면에서의 상품 다양성을 측정한 결과, 1990년부터 2012년까지의 기간 중 교역재는 연평균 4.7%, 비교역재는 연평균 4.2% 성장한 것으로 나타났다. 전체 기간을 1991년부터 2000년, 그리고 2001년부터 2012년까지 나누어 보면, 교역재는 전반기 연평균 1.4%, 후반기에는 7.5%로 성장하여 후반기에 큰 폭으로 증가한 것으로 나타난다. 서비스재 중심의 비교역재는 전반기 연평균 5.5%, 후반기 3.2% 성장하여 오히려 후반기에 다양성의 성장이 감소한 것으로 나타났다.

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