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Non-invasive assessment of vascular alteration using ultrasound
양우인,하종원 대한고혈압학회 2015 Clinical Hypertension Vol.21 No.24
It is well known that arterial function relates to cardiovascular morbidity and mortality. The noninvasive technology for the assessment of arterial function has developed as the importance of prevention of early cardiovascular disease has been emphasized. Over 2-D and Doppler echocardiography, speckle-tracking echocardiography has emerged as a valuable ultrasound imaging technique that allows for an objective and quantitative evaluation of global and regional myocardial function. Recently, several studies have extended its applicability beyond cardiac chambers, such as artery. Measurement of carotid arterial strain with speckle tracking ultrasound has been shown to be feasible and reliable. This review describes the new ultrasound techniques to assess arterial function and their clinical implications.
Hemorrhagic Transformation of Ischemic Stroke: Severe Complications of Prosthetic Valve Endocarditis
김진선,양우인,심지영,하종원,정남식,장혁재 대한심장학회 2011 Korean Circulation Journal Vol.41 No.8
Ischemic stroke is a common complication of infective endocarditis (IE), occurring in 20-40% of left side IE cases. In these subsets, anticoagulation therapy may provoke hemorrhagic transformation (HT) of ischemic stroke, and complications of this magnitude deteriorate the clinical course for IE patients. However, in cases of IE complicated with a mechanical prosthetic valve, the physician can be concerned over the maintenance of anticoagulation due to the risk of thrombotic complication. According to our retrospective review, HT of ischemic stroke in prosthetic valve endocarditis occurred 13.8% (4/29) of the time in a variety of situations. Some of these even arose in patients with a subtherapeutic range of prothrombin time.
ON HOLDER'S INEQUALITY FOR THREE SEQUENCES
권언근,양우인 영남수학회 2013 East Asian mathematical journal Vol.29 No.5
Recent results of Wu and Tian on refined Holder's inequality for two sequences are extended to the case of three sequences.
문정근,이상학,양우인,고영국,한웅규,장양수 대한심장학회 2010 Korean Circulation Journal Vol.40 No.7
Triple antiplatelet therapy has been known to be superior to the conventional dual regimen for preventing stent thrombosis after coronary stenting, and the addition of oral anticoagulation to antiplatelet therapy is also considered an option. However,the risks and benefits of a triple antiplatelet regimen plus additional oral anticoagulation must be taken into account. Here,we report a case of fatal renal bleeding in a patient treated with triple antiplatelet plus oral anticoagulant therapy for the prevention of recurrent stent thrombosis.
예쁜꼬마선충 파킨슨병 모델에서 구룡목 메탄올 추출물의 신경보호 효과
차동석,이병주,양우인,지정구,전용덕,전 훈 한국생약학회 2024 생약학회지 Vol.55 No.1
Parkinson’s disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's, is marked by progressive loss of dopaminergic (DA) neurons in the substantia nigra. Although drugs like levodopa, selegiline, and amantadine offer symptomatic relief, they fail to address the underlying cause of PD. In this study, we explored the neuroprotective potential of Prunus padus methanolic extract (PPE) using the Caenorhabditis elegans model system. Our results demonstrate that PPE treatment significantly mitigated MPP+-induced morphological defects in DA neurons. Similarly, PPE-fed mutant worms overexpressing tyrosine hydroxylase showed reduced damage to DA neurons. In addition, the food-sensing ability of worms was ameliorated by PPE supplementation under MPP+ exposure conditions, suggesting its potential for the functional restoration of DA neurons. PPE also has the ability to down-regulate the formation of α-synuclein oligomers and fibrils in mutant worms expressing human α-synuclein. Moreover, under conditions of tunicamycin-induced endoplasmic reticulum stress, PPE treatment attenuated hsp-4 expression, indicating its role in preserving protein homeostasis. Overall, our findings suggest that P. padus has strong neuroprotective properties and may be a promising drug candidate for PD therapy.
박지원,안순영,윤선화,신윤쳘,양우인,이세연,차동석,전훈 한국생약학회 2019 생약학회지 Vol.50 No.4
Corylopsis gotoana has been widely used as a traditional medicine for the treatment of lots of disease including cold, edema and vomiting. However pharmacological and phytochemical studies on the C. gotoana are extremely limited. Here in this study, the author investigated the anti-nociceptive effects of the methanolic extract of Corylopsis gotoana (MCG) using various pain models. In the present study, MCG exhibited strong and dose-dependent anti-nociceptive activities on various experimental pain models including thermal nociception and chemical nociception, compared to positive control such as tramadol and indomethacin. In addition, the result from combination test using naloxone, analgesic activity of MCG was slightly reduced, indicating that MCG acts as a partial opioid receptor agonist. These results demonstrated that MCG has potent analgesic potential and thus it may be possibly used as a valuable anti-nociceptive agent.