색소성 접촉피부염

안필수(Phil Soo Ahn),이주흥(Joo Heung Lee),이호균(Ho Gyun Lee),은희철(Hee Chul Eun) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5

Pigmented contact dermiatitis is a disease resulting from recirrent contact dermatitis due to hypersensitivity to cosmetic components, which produces secondery bizarre dark brown hyperpigmentation. Histological examinaition of this condition reveals liquefaction degeneration of the basal cells of the epidermis and melanopbages in the upper dermis. We report a case of pigmented contact dermatitis from musk tibeten, which was diagnosed by the histological examination, the patch and photopatch tests. Residul hisperpigmentation was seen on the region of the patch testing. (Kor J Dermatol 1994;32(5):899-902)

편평태선 35예의 임상적 관찰

안필수 ( Phil Soo Ahn ),조광현 ( Kwang Hyun Cho ),윤재일 ( Jai Il Youn ),문상은 ( Sang Eun Moon ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4

Background : Lichen planus is a papulosquarnous disease characterized by pruritic violaceous papules most commonly an the extremities of middle-aged adults. It may or may not be accompanied by oral and genital mucous membrane involvement. Its course is generally self-limited for a period of several months to years, but it may last indefinitely. Objectiye : This study was performed to find the clinical characteristics of lichen planus. Methods : Thirty-five cases of lichen planus comfirrned clinically and histopathologically were analyzed. Results. The incidenc of lichen planus was 0.073% of the total number of dermatologic patients. The age distribution was in the range of 14-63 years old being most prevalent in the 6th decade and there was ariequal sex ratio. The most common site of involvement was the mucous membrane, and the extremities were more common than the trunk. Pruitus or pain and discomfort developed in 28 pat,ients(80% ). In most cases, the treatment was topical corticosteroid and antihistamine. Sixteen cses improved within 1 month to 2 years. Five cases recurred in the improved cases. Conclusion : The clinical analysis of 35 patients with lichen planus was performed. The incidence of lichen planus was 0.073% of the total number of dermatologic patients. Males and females were equally affected Mucous membrane involvement was detected in 21 patients(60%). (Kor J Dermatol 1995;33(4): 655-660)

변형 Ingram법에 의한 건선의 치료 효과 및 호전기간

안필수,윤재일 ( Phil Soo Ahn,Jai Il Youn ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6

N/A Background : The Ingram regimen has been advocated for t.he treatment of psoriasis. It is an effective therapeutic moiality, but its complexity and frequent side reactions have restricted its use for therapy. There are several modified Ingrarn regimen, change of vehicle, shortening of application time, low-strerigth anthralin, combination with emollient. Previously, we have reportved the effectiveness of mocified Ingram regimen for psoriasis, however, the remission time and relapse rate of psoriasis h;is not been reported in Korea. Objective : This study was performed to evaluate the efficacy of the modified Ingram region for the treatment of psoiasis and the remission time and relapse rate of psoriasis following moclified Ingram therapy. Methods : Sixty patients with plaque-form psoriasis were treated with the modified Ingra,n therapeutic regimen. They were divided into two groups, a moderate group which included 39 patients, and 21 patients in a severe group. Results : The follwing results were obtained from this study. 1. Among 60 patients, 52 patients(86.6%) were successfully healed and 8 patients(13.3%) showed failure in their t eatment. 2. In 52 patients, 44 patients(73.3%) showed a clearing of psoriasis, 8 patients(13.3%) showed some improvement. 3. In 44 cleared patients mean numbers and duration of therapy reaching grade 4 were 13.0 and 21.0 days for the trunk and 15.1 and 24.7 days for the extremities, the difference was not significant statistically(p$gt;0.05). The difference between the total dose in trunk and extremitis was significant statistica,ly(p$lt;0.05). 4. In 44 cleared patients mean numbers, duration and total dose of therapy reaching grade 4 in the severe group were significantly higher than those in the moderate group (p$lt;0.05). 5. There were some rotable side effects such as staining(17.3%), erythema(15.4%) and pruitus(13.5%), but in no case therapy was terminated. 6. According to the everity in 33 of the cleared patients, we observed 10 patients(17.4%) with early relapse((6 months), 7(21.7%) with late relapse($gt;6 months) and 14(60.9%) with riorelapse($gt;12 months) in the moderate group and also observed 10 patients(70.0%) with early IP, lapse, 2(20.0%) with latrelapse and 1(10.0%) with no relapse in the severe group. 7. In 33 pat,ients who were followed up at least one year later, the mean time of remission was 31.4 months in the moderate group and 6.0 mont,hs in the severe group. There were signilicant differences in the two groups(p$lt;0.05). Conclusion : The results of this study suggest that the modified Ingram regimen is one of the effective therapeutic mocialities for cases of moderate psoriasis. (Kor J Dermatol 1995;33(6): 1014-1020)

성인 아토피피부염 환자의 성격특성에 관한 연구

방형돈 ( Hyeong Don Bang ),안필수 ( Phil Soo Ahn ),김규한 ( Kyu Han Kim ),박경찬 ( Kyoung Chan Park ),권준수 ( Jun Soo Kwon ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.3

Background: Atopic dermatitis will persist into adult life and chronic severe atopic dermatitis may cause significant interference in social interaction. Despite the controversy concerning the existence of specific personality exhibited by patients with atopic dermatitis, psychological and social factors have long been considered important factors that have influence on the course of the disease. Objective : The purpose of this study was to investigate the charateristics of the personalities of adult patients with atopic dermatitis and their relationship to psychological factors and clinical characteristics. Methods : Eysenck Personahty Questionnaire(EPQ) was carried out on 54 adult patients with atopic dermatitis. Using the EPQ scores, a cluster analysis was done to identify the subgroup of psychologically disabled patients. The psychological and social aspects of the identified patients were then investigated using a designed questionnaire. Results : 1. A cluster analysis identified two patient subgroups. Psychoticism(P), extroversion-introversion(E), and neuroticism(N) scores were significantly different between the subgroups. The neuroticism scores were above the upper limit of the normal range in the higher EPQ scored subgroups. However, the total clinical severity score which was evaluated in 25 patients showed no significant difference between these subgroups. 2. The higher psychoticism, extroversion-introversion, and neuroticism scored patients tended to express severe disability due to atopic dermatitis and a high level of stress which was evaluated by the designed questionnaire. Conclusion : Eysenck personality questionnaire can be helpful in identifying a subgroup of patients who may need psychiatric intervention. (Kor J Dermatol 1996;34(3): 359-365)

손등에 국한되어 발생한 한관종

윤상호 ( Sang Ho Youn ),안필수 ( Phil Soo Ahn ),조광현 ( Kwang Hyun Cho ),송계용 ( Kye Yong Song ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2

Although syringoma is a relatively common adnexal tumor, syringoma of the hand has not been reported previously in Korea. We report a case of acral syringoma that appeared as grouped yellow-brownish papules limited to the dorsum of the right hand in a 40 year-old woman. The histopathologic findings were typical of syringoma and were characterized by the presence of numerous solid strands of basophilic epithelial cells and small cystic ducts embedded in a fibrous connective tissue stroma in the dermis. The classical tadpole or comma-like tail structures were also observed. Our case of acral syringoma presented a distinctive clinical picture, and this condition should be considered in the differential diagnosis of papular lesions of the hands. (Kor J Dermatol 1996;34(2): 314-316)

재조합 감마 인터페론 치료로 호전을 보인 아토피피부염 2예

안필수,정진호,김규한 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.1

아토피피부염 환자에 대한 thymopentin 의 치료효과

이현승,김규한,박경찬,안필수,방형돈,서대현 대한알레르기학회 1998 천식 및 알레르기 Vol.18 No.4

Background: Thymopentin(TP-5) is an immunomodulatory agent which may be a promising new drug in the treatment of patients with severe atopic dermatitis. Objective: The aim of this study was to evaluate the efficacy of thymopentin for treatment of severe atopic dermatitis. Material and Method: Fifteen patients with severe atopic dermatitis received subcutaneous injections of 50mg thymopentin three times per week for 6 weeks. Clinical extent and severity parameters were assessed at baseline, at regular intervals during therapy and 4 weeks posttherapy. Use of antihistamine and topical steroid were permitted. Result: Significant reduction in severity scores and body surface area involvement was ob- served and no significant side effects were noted(p$lt;0.05). Conclusion : Thymopentin may be considered to be an effective adjunctive therapeutic agent in the treatment of severe atopic dermatitis. Further studies will be needed to determine the action mechanism of thymopentin.

Diagnosis of Xeroderma Pigmentosum by Measuring Unscheduled DNA Synthesis

김규한,정진호,박경찬,안필수 대한피부과학회 1996 Annals of Dermatology Vol.8 No.1

The unscheduled DNA synthesis assay has become the most important laboratory method for confirmative diagnosis of xeroderma pigmentosum (XP). Cases of XP diagnosed on clinical grounds alone have been reported in Korea. We experienced a boy who showed typical features of XP clinically and tried to confirm the diagnosis of XP experimentally. Fibroblasts were cultured from the patient and from a normal healthy volunteer. Unscheduled DNA synthesis (UDS) after UVB irradiation to the fibroblasts was measured autoradiographically. In addition, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with A1wNI in exon 4 of XP group A complementing (XPAC) gene was done after an extraction of genomic DNA from the patient and his parents. The level of UDS in our patient was 63% of that of the normal control. No cleavage site for the AlwNI was found in the PCR samples. The diagnosis was confirmed in vitro by measuring UDS autoradiographically. Our patient was believed to belong to the variant group based on clinical findings and on our experimental results.

A Case of Cutaneous Angiomyolipoma

조광현,Kye Yong Song,문상은,안필수,이용숙 대한피부과학회 1996 Annals of Dermatology Vol.8 No.1

We describe a case of cutaneous angiomyolipoma found in the ear lobe, that is not associated with tuberous sclerosis. The lesion developed on the youngest patient yet reported in the literature.

한국인 인슐린의존형 및 지진형 인슐린의존형 당뇨병에서 항 ICA512 항체와 항 GAD 항체의 측정

박해준,진동규,김광원,이문규,민용기,이명식,김병태,정재훈,김경아,오필수,안규정 대한당뇨병학회 1998 Diabetes and Metabolism Journal Vol.22 No.4