http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
손춘희 ( Choon Hee Son ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.3
호산구성 폐렴은 혈중 호산구가 1,000/mm3 이상이거나 폐포 내 호산구 분획이 25% 이상으로 나타나는 다양한 폐 질환을 총괄하여 부르는 용어이다. 혈중 호산구증가증은 특발성 급성 호산구 폐렴의 초기나 이미 부신피질호르몬 제제를 투여받은 환자에서는 나타나지 않을 수 있다. 호산구성 폐렴은 무증상의 폐 침윤에서 기계 환기가 필요한 급성 호흡 부전 증후군까지 증상의 중증도도 다양하다. 호산구성 폐렴의 원인으로 약제나 기생충이 있지만 많은 경우 원인을 찾을 수 없다. 폐 외 증상이 동반될 경우 Churg-Strauss 증후군이나 과다호산구증가 증후군의 가능성을 생가해야 되며 이런 경우 심장을 침범하였는지 여부에 따라 예후가 결정된다. 가능한 원인에 대한 노출을 피하는 것 외에는, 부신피질호르몬 제제 투여가 가장 중요하며 대부분 극적인 호전을 보인다. 하지만 약제의 감량 중이나 치료 종결 후 재발하는 경우가 자주 있다. HES의 골수 증식성 변이형 치료에 imatinib의 효과가 최근 입증 되었다.
p16과 RARB2 유전자의 비정상적인 메틸화 검사를 이용한 악성 흉수의 진단
나서희 ( Seo Hee Rha ),이수미 ( Su Mi Lee ),구태형 ( Tae Hyoung Koo ),신봉철 ( Bong Chul Shin ),허정훈 ( Jung Hun Huh ),엄수정 ( Soo Jung Um ),양두경 ( Doo Kyung Yang ),이수걸 ( Soo Keol Lee ),손춘희 ( Choon Hee Son ),노미숙 ( Mee 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.4
흰쥐에서 폐 방사선 조사 후 interleukin - 1α ( IL-1α ) 및 interleukin - 6 ( IL-6 ) 발현에 대한 연구
장광열(Kwang Yul Chang),손춘희(Choon Hee Son),양두경(Doo Kyung Yang),김기현(Ki Hyun Kim),이혁(Hyuk Lee),윤선민(Seon Min Youn),양광모(Kwang Mo Yang),허원주(Won Joo Hur),노미숙(Mee Sook Roh),정진숙(Jin Sook Jeong),한진영(Jin Yeong Han 대한내과학회 2002 대한내과학회지 Vol.62 No.4
연구배경: 방사선 조사는 흉부 종양의 치료에 중요한 역할을 하지만 방사선 폐렴 때문에 용량의 제한을 받는다. 이런 폐 손상의 기전을 이해함으로써 부작용을 줄이고 손상을 예방할 수 있는 방법을 찾기 위하여 폐 섬유화에 기인한다고 알려져 있는 interleukin-1 alpha (IL-6 α)와 interleukin-6 (IL-6)의 방사선 폐 손상에서의 역할을 알아보기 위하여 이 연구를 시작하였다. 실험 방법: 30마리의 흰쥐를 대상으로 우측 폐에 20 Gy를 단일 조사하고, 20주까지 2주 간격으로 흰쥐를 희생시킨 후 절제한 폐조직에 대하여 일반병리조직학적 검사 및 IL-1α와 IL-6에 대한 면역조직화학적 연구를 실시하여 결과를 분석하였다. 결과: 방사선 조사 1∼2주 후까지는 폐간질의 부종, 모세혈관의 울혈이 주된 소견이었다. 4주까지는 폐포내에 대식구 및 림프구 등의 단핵구와 단백양 물질이 증가하였고, 폐포간격에도 단핵구들의 침윤이 관찰되었으며 이러한 소견은 8주까지 진행되었다. 6주부터 20주까지 염증세포의 침윤과 더불어 점차 진행되는 폐섬유화를 관찰하였다. IL-1α 및 IL-6의 발현정도에 대한 염색은 전 기간을 통하여 증가하는 양상을 보였지만 3주 전후까지는 급격한 증가를 보였고 그 후부터는 감소하는 경향을 나타내었다. 염색반응은 주로 폐포간질, 폐포내 및 기관지주위의 대식구, 폐포세포, 혹은 혈관내피세포에서 관찰되었다. 12주에서 20주까지는 섬유모세포에서도 염색되었지만 섬유화가 진행된 병변에서는 그 염색정도가 약한 반면 주변 폐포부위의 염색정도는 강하게 나타났다. 방사선 조사로 유도한 흰쥐의 폐손상은 시간의 경과에 따라 방사선 폐렴에서 폐섬유화로 진행되었고 이러한 폐손상의 진행에 따른 IL-1α 및 IL-6의 발현에 대한 염색정도는 급격히 증가하여 3주경에서 최고치를 나타내다가 그 이후부터는 감소하였지만 조사 후 희생까지의 전기간에 걸쳐 증가되어 있었다. 결론: IL-1α 및 IL-6는 방사선 조사 후 섬유화성 진행을 보이기 전단계에서 발현되어 폐섬유화 유발인자로 작용하는 것으로 생각된다. Background: One of the limitation during the irradiation of malignant tumor is hazard to normal tissue although it is important and effective tool for treating malignant tumor. We studied the role of interleukin-1 alpha (IL-1α) and interleukin-6 (IL-6) in the radiation-induced lung injury especially on fibrosis. Methods: We irradiated right-side lungs of thirty Sprague-Dawley rats with single fraction of 20 Gy and then sacrificed the animals until 20th week at intervals of two weeks. Both irradiated and unirradiated lung tissues were stained hematoxilin and eosin, Masson trichrome, reticulin and immunohistochemical staining for IL-1α and IL-6. The degree of the staining for IL-1α and IL-6 were examined semiquantitatively. Results: Two weeks after irradiation interstitial edema and capillary congestion appeared, followed by increase of the monocytes infiltration and proteinaceous material during 4th and 8th week. After eight weeks of irradiation, collagen and reticulin fibers were detected along alveolar wall. 12th to 20th week, fibrosis in interstitium, decreased number of alveoli and thickening of bronchial wall were observed. The degree of immunohistochemical staining for IL-1α and IL-6 was increased rapidly during the first three week and then decreased slowly, but remain increased until 20th week. Conclusion: Our Study demonstrate the early and persistent elevation of cytokines IL-1α and IL-6 by immunohistochemical stain in rat lung following pulmonary irradiation. We think cytokines are produced immediately after irradiation, make collagen genes turn on and perisist until the expression of late effects become apparent pathologically and clinically. (Korean J Med 62:453-464, 2002)
정일환 ( Il Hwan Jeong ),남영희 ( Young Hee Nam ),김대철 ( Dae Cheol Kim ),이혜원 ( Hye Won Lee ),윤늘봄 ( Neul Bom Yoon ),엄수정 ( Soo Jung Um ),이수걸 ( Soo Keol Lee ),손춘희 ( Choon Hee Son ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.3
Background: Churg-Strauss syndrome is a rare systemic disorder characterized by bronchial asthma, hypereosinophilia and systemic vasculitis. The prevalence and severity of renal involvement in patients with Churg-Strauss syndrome is not well known. We report a rare case of a patient with Churg- Strauss syndrome accompanied by acute renal failure. Case History: A 52-year-old woman with skin rash and generalized edema was admitted to our hospital via the emergency room. She had a 7-year history of bronchial asthma and allergic rhinitis. Laboratory evaluation showed marked eosinophilia, elevated creatinine, and heavy proteinuria. She was positive for anti-neutrophil cytoplasmic antibody. Computed tomography of chest and paranasal sinuses revealed pulmonary infiltration and pansinusitis. Peripheral neuropathy was confirmed and small vasculitis was noted in a skin biopsy specimen. Results: She was diagnosed with Churg-Strauss syndrome and showed rapidly progressive renal insufficiency despite systemic corticosteroid administration. Oilguria was aggravated, and hemodialysis was thereafter started. Despite 2 weeks of continuous hemodialysis, her renal function was not improved. Conclusion: We report a rare case of Churg-Strauss syndrome associated with acute renal failure. A long-term follow- up is needed in Churg-Strauss syndrome patients.
한국인 폐암환자와 대조군의 CYP2D6 유전적 다형성에 관한 연구
전진호,이창희,엄상화,손병철,박준한,정귀옥,손창학,윤혜경,손춘희,김형인,정진숙,Chun, Jin-Ho,Lee, Chang-Hee,Urm, Sang-Hwa,Son, Byung-Chul,Park, Jun-Han,Jung, Kui-Oak,Sohn, Chang-Hak,Yoon, Hye-Kyoung,Son, Choon-Hee,Kim, Hyung-In,Jeong, J 대한예방의학회 1998 Journal of Preventive Medicine and Public Health Vol.31 No.1
The genetically determined CYP2D6 activity as considered to be associated with cancer susceptibility with inter-individual variation. Genetic polymorphism of CYP2D6(B) and CYP2D6(T) was determined by the two polymerase chain reaction(PCR) and BstN1 and EcoN1 restriction fragment length polymorphisms(RFLP) for 67 lung cancer cases and 95 healthy volunteer controls. The cases were composed of 26 squamous cell carcinoma, 14 small cell carcinoma, 10 adenocarcinoma, 3 large cell undifferentiated carcinoma, and 14 not histologically diagnosed. The results were gained from the 142 subjects (57 cases and 85 controls) who observed successfully in two PCR and BstNl/EcoN1 RELP. Only one and no mutant allele of the CYP2D6(B) and CYP2D6(T) gene was detected, that is, the frequency of mutant allele was very low; 0.7%(1/142) and 0%(0/142), respectively. Detected mutant allele of the CYP2D6(B) was beterozygous type(WM). The odds ratios for lung cancer susceptibility with CYP2D6(B) and CYP2D6(T) genotype were not calculated. These results are similar to the previous understanding that the mutant allele is very rare in Orientals compared to Caucasians, therefore, it considered that CYP2D6(B) and CYP2D6(T) genotypes have maybe no association with lung cancer susceptibility in Koreans. This is the basic data of CYP2D6(B) and CYP2D6(T) genotypes for Koreans. It would be hepful for further study to determine lung cancer susceptibility of Koreans with the data about CYP1A1, CYP2E1, GSTM1 from future study.
악성 종양 표지자가 상승된 만성 흉수를 동반한 종격동 기형종
엄수정 ( Soo Jung Um ),양두경 ( Doo Kyung Yang ),이수걸 ( Soo Keol Lee ),손춘희 ( Choon Hee Son ),노미숙 ( Mee Sook Roh ),김기남 ( Ki Nam Kim ),이기남 ( Ki Nam Lee ),최필조 ( Pil Jo Choi ),방정희 ( Jung Heui Bang ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.66 No.2
Most mediastinal teratomas are histologically well-differentiated tumors and benign. The majority of patients with a mediastinal teratoma are asymptomatic and their tumors are usually discovered incidentally on chest radiography. On rare occasions this tumor will rupture spontaneously into the adjacent organs. A 72-year-old female patient was admitted for dyspnea and she had a multiloculated pleural effusion in the left lung field. Although repeated pleural biopsy and pleural fluid cytology did not prove the presence of malignancy, we assumed that this was a malignant effusion because it revealed consistently high levels of carcinoembryonic antigen and carbohydrate antigen 19-9, and the chest CT scan did not show typical fat or bone density in the mass. Secondary infection and an uncontrolled septic condition due to pleural empyema finally compelled the patient to undergo a surgical operation. Mature teratoma was the final diagnosis and she has done well without recurrence for 2 months.
간흡충 감염가토의 간내 담관에 대한 병리조직학적 및 조직화학적 연구
송근암(Geun Am Song),김진도(Jin Do Kim),이동완(Dong Wan Lee),손춘희(Choon Hee Son),양웅석(Ung Suk Yang),허윤(Yoon Hue),문한규(Han Gue Moon),유방현(Bang Hyun Liu),이선경(Sun Kyung Lee) 대한내과학회 1989 대한내과학회지 Vol.37 No.3
N/A This study was undertaken to examine the histopathological changes of the bile duct in rabbits heavily infested with Clonorchis sinensis for 6-18 months, and then to investigate the histochemical properties and compositions of epithelial mucosubstances. In 9 rabbits, each rabbit was orally infested with about 500 metacercariae and was sacrificed when general conditions were poor. The specimens were stained with H-E, PAS, alcian blue (pH 2.5), alcian blue (pH 1.0), alcian blue (pH 2.5) -PAS, and FITC- conjugated lectins. The results obtained were as follow 1) The pathological changes in the infested rabbits were papillary and adenomatous hyperplasia, goblet cell and mucus-cell metaplasia, ductal wall fibrosis, and infiltration of eosinophils in the ductal wall, and then the metaplasia of ductal epithelium was more marked in the deep gland than in the surface. 2) The epithelial mucosubstances in the normal intrahepatic bile duct were produced in the border and supranuclear portion of the epithelium. The histochemical composition of these was a mixture of neutral and acid mucosubstances with a predominant acid group. 3) In infested rabbits, the epithelial mucosubstances were produced in the border and supranuclear portion of the covering epithelium, goblet cell, and hyperplasia and metaplasia cells of the deep gland. The mucosubstances were much more produced in the goblet cell, hyperplasia and metaplasia cell of deep gland, and the composition was mixture of neutral and acid substances with a predominance of the neutral group in goblet cell and adenomatous hyperplasia, and a predominance of the acid group in mucus-cell metaplasia of the deep gland. 4) In the normal intrahepatic bile duct, labeling of FITC-conjugated lectins of WGA and Con-A was weakly localized in the border of the epithelium and its grade was trace. 5) In infested rabbits, F1TC-WGA and FITC-Con-A labeling was seen in the border and supranuclear portion of the covering epithelium, goblet cell, and hyperplasia and metaplasia cells of the deep gland, but FITC-PNA and FITC-SBA labeling was graded from zero to trace. 6) Mucin secreting cell metaplasia stained by PAS and AB showed very significant labeling of E1TC-WGA and FITC-Con-A, which are lectins that are highly specific in their recognition of glycosylated residues.