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타액선 종양 중 다형성 선종, 선양 낭포성암, 및 점막 표피암의 세침흡인 세포학적 감별
남은숙,조원보,한정호,김인선,Nam, Eun-Sook,Jo, Won-Bo,Han, Jung-Ho,Kim, In-Sun 대한세포병리학회 1990 대한세포병리학회지 Vol.1 No.1
To evaluate the diagnostic findings of salivary gland tumors, we reexamined aspiration cytology smears of 7 cases of pleomorphic adenoma, 3 cases of adenoid cystic carcinoma, and 3 cases of mucoepidermoid carcinoma, performed during April 1986 to March 1990, which were comfirmed by surgical excision and histologic diagnosis. The results obtained are summarized as follows : 1. All cases of pleomorphic adenoma showed branching cellular clusters of epithelial and myoepithelial cells. Acellular elements including myxomatous and chondroid components were observed. There were no cellular pleomorphism and nucleoli. Keratinizing squamous epithelial cells and keratin pearls were noted. 2. The smears of adenoid cystic carcinoma showed cell bails or cell cords containing a central hyaline core. Nuclear atypism and the nucleoli were frequently observed. There were no keratinizing squamous epithelial cells. 3. The smears of mucoepidermoid carcinoma showed mainly sheets or clusters of intermediate cells and some mucin-producing cells. Some nuclear pleomorphism was observed. Mucinous material and many inflammatory cells were present in the background.
사회적 지지가 스트레스 및 적응에 미치는 효과에 관한 고찰
남은숙 中央醫學社 1991 中央醫學 Vol.56 No.3
Social support serves as a moderator of life stress by assisting coping, adaptation during life transition and crisis. It has a positive influence on health and well being generally. Social support encompasses three components of affect, affirmation, and aid conceptually. Recent research indicates that the direct and buffering effects of social support on health and well being are not necessarily mutually exclusive but may function simultaneously. Lack of social support increases mortality risks, and stress and social support influences physical and emotional symptomatology. Social support can protect people in crisis from a wide variety of pathological states: from low birth weight to death, from arthritis through tuberculosis to depression, alcoholism, and the social breakdown syndrome. Social support may reduce the amount of medication required, accelerate recovery, and facilitate compliance with prescribed medical regimens. The relations of social support and morbidity, recovery from illness, health practice are ,not consistently established and further research. is needed.
폐종괴에 대한 경피적 세침흡인세포검사와 자동총부착 침생검의 비교
남은숙,김덕환,신형식,Nam, Eun-Sook,Kim, Duck-Hwan,Shin, Hyung-Sik 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.1
To compare the diagnostic yields and complication rates of transthoracic fine needle aspiration cytology(FNAC) and gun biopsy in the diagnosis of pulmonary mass, a retrospective review was performed in 125 cases. Under the fluoroscopic guide, FNAC was performed by 20G Chiba needle in 91 cases, core biopsy was done by 18.5 G vaccum needle attached with automated biopsy gun in 74 cases and both procedures were done together in 37 cases. Overall sensitivity was 88.4% in FNAC and 87.5% in gun biopsy. For malignant pulmonary tumors, correct type correlation with final diagnosis was obtained in 33(76.7%) out of 43 cases by FNAC and 30(75.0%) out of 40 cases by gun biopsy. For benign pulmonary lesions, there were correct type correlation in 14(35.0%) out of 40 cases by FNAC and 14(53.8%) out of 26 cases by gun biopsy. The complication was pneumothorax and hemoptysis. Pneumothorax occured in 11.1% of FNAC, 10.9% of gun biopsy and 10.9% of both technique, among which chest tube drainages were necessary in one patient by gun biopsy and in three patients by both technique. Although no significant difference of diagnositc accuracy and complication rate was found between FNAC and gun biopsy, gun biopsy was more helpful in the diagnosis of pulmonary benign lesions than FNAC.
한국인 위암 발생의 원인 인자로서 Helicobacter pylori CagA 의 역할에 관한 연구
남은숙,김우중,김학양,유재영,박충기,김종혁,김용범,주상언 대한소화기학회 1998 대한소화기학회지 Vol.31 No.2
Background/Airns: Gastric cancer is one of the most prevalent malignant tumors and is a leading cause of cancer death in the world. Recent studies have been shown that Helicobacter pylori (H. pylori) can colonize the gastric mucosa for decades and are strongly associated with chronic atrophic gastritis, a lesion that is a precursor of gastric cancer. Although H. pylori infection is frequently observed in patients with gastric cancer, most H. pylori infected persons never develop gastric cancer. Some other factors may be related to differences between the infecting bacterial strains of H. pylori. We investigated the relationship between CagA status and the development of gastric cancer in Korea. Methods: Gastroduodenoscopy was done in patients with upper gastrointestinal complaints. During the examination, rapid urease test for the presence of H. pylori infection was done using gastric biopsy specimens taken from normal gastric antrum. Sera were collected from 20 chronic gastritis patients and 25 gastric cancer patients with H. pylori infection. Western blotting was carried out using a comrnercially prepared kit-Helicoblot 2.0. Results: Antibodies to CagA were significantly more prevalent in the group with chronic gastritis (14/20, 70%) than in those with gastric cancers (14/25, 56%)(p$lt;0.01). According to Lauren classification of gastric cancer, the number of patients with intestinal type was 13 and diffuse type was 12. Antibodies to CagA were more prevalent in the diffuse type than in the intestinal type (8/12, 67% and 6/13, 46% respectively, p$lt;0.01). Conclusions: Infection with CagA positive H. pylori strain is not associatecl with an increased risk for the development of gastric cancer in Korea.
A Case of Paraduodenal Pancreatitis and Immunohistochemical Analysis
남은숙,권미정,조성진,신형식,김주섭,김두진 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.2
Paraduodenal pancreatitis (PP) is a rare, distinct form of chronic pancreatitis, and it is related to alcohol abuse in middle-aged men. A 36-year-old man with a history of chronic recurrent pancreatitis for 4 years and alcohol abuse for 15 years presented with abdominal pain. Computed tomography revealed a multilocular cystic mass 3.2 ×3×3 cm in size and it was located within the muscular layer of the duodenal wall. The cysts were lined by a single layer of eosinophilic cuboidal epithelial cells that stained positively for mucin (MUC)1, MUC6, cytokeratin (CK)7 and CK19 and they stained negatively for MUC2, MUC5AC and CK5/6. Mild, chronic inflammatory reaction around the cystic wall, Brunner’ gland hyperplasia and several clusters of heterotopic pancreatic tissue were noted. We report here on a case of PP and we demonstrated that the pancreatitis was of pancreatic ductal cell origin according to the MUC and CK expression patterns we observed on the immunohistochemical analysis.
Maspin Suppresses Survival of Lung Cancer Cells through Modulation of Akt Pathway
남은숙,박채화 대한암학회 2010 Cancer Research and Treatment Vol.42 No.1
Purpose :Maspin is a tumor suppressor protein that has been reported to stimulate the cell death of cancer and inhibit the metastasis of cancer. The present study aimed to explore the survival pathway by which maspin modulates the resistance of human lung cancer cells to chemotherapeutic drugs, and the consequences of maspin gene therapy in an animal model. Materials and Methods :NCI-H157 and A549 cells were transfected with either a mock vector (pCMVTaq4C), maspin (pCMV-maspin), siControl or siMaspin. RT-PCR and Western blot analysis were performed to study the expressions of survival proteins in lung cancer. cDNA microarray analysis was carried out to compare the maspin-modulated gene expression between the xenograft tumors derived from the lung cancer cells that were stably transfected with pCMVTaq4C or pCMV-maspin. Maspin gene therapy was performed by intra-tumoral injections of pCMVTaq4C or pCMV-maspin into the pre-established subcutaneous tumors in nude mice. Results :Maspin significantly decreased the survival to doxorubicin and etoposide, whereas did not affect the survival to cisplatin in the NCI-H157 cells. Interestingly, transfection with a maspin plasmid resulted in a significant reduction of the phosphorylation of Akt in the NCI-H157 cells, whereas knockdown of maspin increased the phosphorylation of Akt in the A549 cells. Microarray analysis of the xenograft tumors revealed a specific gene expression profile, demonstrating that maspin is associated with the differential expressions of PTEN and IGF2R. Direct transfer of pCMV-maspin into the tumor significantly retarded the tumor growth in the animal experiments (p=0.0048). Conclusion :Lung cancer cells lacking maspin could be resistant to chemotherapeutic drugs such as doxorubicin or etoposide, at least in part by maintaining Akt phosphorylation.