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요통환자에 있어서 방사통과 영상의학검사 소견상의 연관성 분석
김한겸,김석,반효정,윤현석,염선규,홍순성,Kim, Han-Kyum,Kim, Seok,Bahn, Hyo-Jung,Yoon, Hyun-seok,Yeom, Sun-kyu,Hong, Soon-Sung 척추신경추나의학회 2009 척추신경추나의학회지 Vol.4 No.1
Objectives : We studied in order to compare the differences between the symptoms of patients and findings of MRI and X-Ray of patients with herniated disc which has been diagnosed often recently. Methods : We randomly selected among the 301 patients with X-Ray and L-spine MRI films who have visited Jaseng Hospital with low-back pain and lumbar and low extremity pain from Jan.1st of 2009 to Jan.28. We used SPSS 13.0 for Windows I in analyzing statistical data of study results and the level of significance were below 0.05. Results and Conclusions : 1. If there were radiating pain, based on MRI findings, the amount of herniation was more severe(P>0.05). 2. If the finding of a X-ray showed narrowing, based on MRI findings, the amount of herniation was more severe(P>0.05). 3. There were no significant differences between the presence of radiating pain and the findings of X-Ray(P>0.05). 4. Among the 301 cases, cases which showed findings beside HIVD were 79. 7 cases of hemanggioma(2.3%), 24 cases of spinal neoplasm(cord cyst, tumor etc)(8%), 7 cases of spondylitis(2.3%), 16 cases of spinal canal stenosis(5,3%) 9 cases of ligamentum flavum thickening(3%) and 16 cases of facet syndrome(5.3%).
상부 흉추간에 발생한 연성 추간판 탈출증에 대한 치험 1례 : 증례보고 A Case Report
김한겸,김관태,염진영,송시헌,김윤 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.1
A case of T3-4 disc herniation is reported as follows. A 23 year-old patient was presented with paraparesis and anterior chest pain. With the anterolateral approach(transthoracic transpleural approach) decompression and removal of a disc fragment was refered: which resulted is an almost complete recovery of the patient MRI of the thoracic spine suggested a soft disc herniation. In addision literatures were reviewed in conjunction with this case report.
중증 미만성 뇌축색손상 환자의 MRI소견 및 임상적 고찰
김한겸,김성호,송시헌,김관태,김윤 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.1
The distribution and extent of traumatic lesions were evaluated with MRI in 31 patients with diffuse axonal injuries(DAI). Authors also analyzed patients with diffuse axonal injury, clinically. The patients with DAI showed statistically significant lower incidence of lucid interval, fracture of the skull and intracranial hematoma. Combined injuries, intracrnial hematomas and distribution of lisions were porved to be poor prognostic factors of DAI. Diffuse axonal injury is most commonly involved in the white matter of the frontal and temporal loves and the splenium of the corpus callosum. Patients with lisions in brainstem and cerebellum revealed worst prognoses. In our studies, the sensitivities of the imaging techniques for diffuse axonal injures were 7.3% with CT scan, 75.6% with T1WI, and with 97.6% in T2WI of MRI, respectively. The authors concluded that MRI has clear advantages over CT in evaluating diffuse axonal injuries.
N-Butyl-N-(4-Hydroxybutyl) nitrosamine에 의한 흰쥐의 방광암 발생에서의 종양원성 유전자의 역할에 관한 연구
김한겸,김인선,천준,백승룡 고려대학교 의과대학 1994 고려대 의대 잡지 Vol.31 No.2
Bladder cancer is expected to arise through a series of genetic changes which lead to tumor progression. These changes have been directly identified as alterations of various genes usually involved in cell growth and proliferation. Fifty-two female Wistar rats were treated with BBN for 12 weeks and evaluated for the tumor progression in urinary bladder. Among 60 rats, simple hyperplasia(SH) was seen in 3, atypical hyperplasia (AH) in 19 and carcinomas (CA) in 25. Overexpression of oncoprotein of c-erb B-2, c-fos and c-H-ras and heat shock protein was evaluated by immunohistochemical staining. The DNA content was also analyzed on Feulgen stained touch imprint of bladder mucosa using CAS 200 Image Analyzer. The obtained results were as follows : 1. DNA aneuploidy was seen in 2(9.5%) of 21 atypical hyperplasia, whereas it was found in 18 of 25(66.7%) cancer group. 2. c-H-ras oncoprotein was expressed in one of 6 normal mucosa, 2 of 3 simple hyperplasia, 15 of 19 atypical hyperpiasia, and 21 of 25 cancers. 3. The expression of c-erbB-2 oncoprotein was detected in one of 6 normal, all 3 simple hyperplasia, 18 of 19 atypical hyperplasia, and 21 of 25 cancers. 4. Expression of c-fos oncoprotein was found in all 3 simple hyperplasia, 18 of 19 atypical hyperplasia, and 24 of 25 cancers. 5. Heatshock protein 70 was not expressed in normal bladder, but expressed in 2 of 3 simple hyperplasia. 15 of 19 atypical hyperplasia, and 15 of 25 cancers. The above data suggest that the nuclear DNA content is changed during the progression of BBN-induced changes in rat urinary bladder, and c-H-ras, c-erbB-2, c-fos and heat shock protein may play role in chemical carcinogenesis of BBN in experimental animals.
척추전방전위증과 Tuffier's line 높이와의 상관관계
김한겸,홍순성,염선규,진은석,정해찬,Kim, Han-Kyum,Hong, Soon-Sung,Yom, Sun-Kyu,Jin, Eun-Seok,Jung, Hae-Chan 척추신경추나의학회 2008 척추신경추나의학회지 Vol.3 No.2
Objectives : One of the most important cause of spondylolisthesis is it's epidemiological structure and L5's stability takes a significant role. The purpose of this study is to assess the difference of the Tuffier's line among of Spondylolythesis patients. Methods : We analyzed the Anterior view of lumbar spine checked at erect position on 60 patients who had been diagnosed as spondylolythesis. We investigated the Tuffier's Line on X-ray film. Results and Conclusions : Age distribution was 15 to 66 and the average was 47.81. Men were 19 cases(31.6%) and women were 41 cases(68.4%). Compared to men, women were more exposed to spondylolisthesis and for the age distribution, 50's showed the biggest portion. Group of normal people showed proportion of 14.3% at L4, 44% at L4/5 and 41.7% at L5 each. And group of patients showed proportion of 48.4% at L4, 35% at L4/5 and 51.6% at L5 each. Comparing these results, significance probability was 0.004(<0.05) which was significant. As the results of comparing the relation between L4/5 and L5/S1 patients, Normal group showed average of 3.33 which were close to L4/5. When there are spondylolisthesis at L4/5, averege was 3.33, placed at lower part of the vertebra body. When there are spondylolisthesis at L5/S1, averege was 3.566, placed between lower part of the veterbra body of L4 and L4/5. The p value of Normal group and L4/5 spondylolisthesis patient group was 0.022(p<0.05) which was significant. But the p value of Normal group and L5/S1 spondylolisthesis patient group was 0.0239 which was not significant. Also p value of L4/5 spcndylolisthesis patient group and L5/S1 spondylolisthesis patient group was 0.721 which was also not significant.
김한겸,류영준,신봉경,김백희,김애리 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.2
Traditionally, pathologists have used human biological material primarily for diagnostic purposes. More recently, advances in biomedical technology and changes in the research environment have placed new demands on pathologists and their handling of human materials. Moreover, these technological advances have required pathologists to be not only experts in diagnosis, but also managers of biobanks storing human biological material. Consequently, pathologists might now be confronted with unanticipated legal and ethical questions. We investigated seven examples of South Korean legislation concerning human biological material, including "The Bioethics and Safety Act" (2005), and we considered possible conflicts of interest between donors and researchers. We also reviewed international bioethical guidelines and legal precedents from several countries with special regard to pathologic glass slides, paraffin blocks, remaining specimens and other guidelines. We conclude that a better understanding of the legal and ethical questions concerning human biological material leads pathologists to safer and more conscientious management of these samples.