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p16과 RARB2 유전자의 비정상적인 메틸화 검사를 이용한 악성 흉수의 진단
나서희 ( Seo Hee Rha ),이수미 ( Su Mi Lee ),구태형 ( Tae Hyoung Koo ),신봉철 ( Bong Chul Shin ),허정훈 ( Jung Hun Huh ),엄수정 ( Soo Jung Um ),양두경 ( Doo Kyung Yang ),이수걸 ( Soo Keol Lee ),손춘희 ( Choon Hee Son ),노미숙 ( Mee 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.4
돈 혈청 투여에 의한 백서 간 중격상 섬유화에 있어서 비 적출 효과에 대한 연구
나서희(Seo Hee Rha),설미영(Mee Young Sol),이선경(Sun Kyung Lee) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
N/A Background/Aims: To elucidate splenic function in hepatic fibrosis, the authors evaluated the effects of splenectomy in experimental hepatic fibrosis. Methods: In splenectomized and non-splenectomized Sprague-Dawley rats, hepatic fibrosis was produced by intraperitoneal injection of normal swine serum. The liver tissue was examined hisiopathologically, immunohistochemically, and ultrastructurally and analyzed quantitatively. Results: The histopathological examination revealed mild septal fibrosis in three of ten at 6th week, mild to severe in five of ten at the 8th week, and severe fibrosis in six of ten at the 10th and 12th week in non-spelenectomized groups but no septal fibrosis through the observed time in splenectomized and control groups. The average number of fat-storing cells was significantly increased in both experimental groups, and increment of the number was more marked in nonsplenectomized ones. Electron microscopy revealed no morphologic differences in the ultrastructure of fat-storing cells between two groups, but there was a tendency of increment in the number of transitional cells in the nonsplenectomized group. Conclusions: It was considered that the hepatic fibrosis induced by administration of foreign sera would be due to activation of fat- storing cells, and that spleen would enhance the hepatic fibrosis by activation of FSC through certain splenic factors. (Korean J Gastroenterol 1996;28: 74 - 84)
이상용,김대철,나서희,홍숙희,강태훈,이영호,남경진,정진숙,Lee, Sang-Yong,Kim, Dae-Cheol,Rha, Seo-Hee,Hong, Sook-Hee,Kang, Tae-Hun,Lee, Young-Ho,Nam, Kyoung-Jin,Jeong, Jin-Sook 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.1
Malignant rhabdold tumor is a distinct renal tumor in the pediatric age group. It was originally described as a rhabdomyosarcomatold variant of Wilms' tumor. However, subsequent studies fatted to confirm myogenous differentiation, so it is now considered to be a distinct and unique type of highly malignant tumor, histogenetically unrelated. Although extrarenal forms of this tumor are rare, several examples have been described in other sites, especially the liver, prostate, paravertebral area, urinary bladder and soft tissue. We experienced a case of malignant rhabdiod tumor located in the intraabdominal cavity in a 10 month-old boy. Smear of peritoneal fluid showed round, polygonal and irregular shaped cells with large nuclei, ample cytoplasm containing light pink to purple cytoplasmic inclusions, and one or a few prominent nucleoli. Immunocytochemistry revealed positivity to cytokeratin, epithelial membrane antigen and vimentin, and negativity to desmin and neuron-specific enolase. These distinct cytologic appearance and immunophenotypes were most consistent with a diagnosis of extrarenal malignant rhabdoid tumor. The cytoplasmic inclusions were correlated with eosinophilic inclusions seen in histologic section and electron microscopy confirmed this interpretation, showing filamentous aggregations in the cytoplasms of the tumor cells.
증례 : 단백뇨가 있는 기관지 확장증 환자에 발생한 이차성 신장 유전분증 1예
남현경 ( Hyun Kyung Nam ),나서희 ( Seo Hee Rha ),이수걸 ( Soo Gul Lee ),이성원 ( Seong Won Lee ),안원석 ( Won Suk An ),김성은 ( Seong Eun Kim ),김기현 ( Ki Hyun Kim ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
6년 전에 기관지 확장증을 진단받은 29세 남자 환자에서 단백뇨가 발생하여 이차성 유전분증에 대한 검사 결과 신장, 갑상선, 직장에 이차성 유전분증이 확인되었다. 따라서 본 저자는 기관지 확장증과 같은 만성 염증성 질환 환자에서 단백뇨 발생시의 이차성 유전분증에 대한 평가의 필요성을 제기하는 바이다. Secondary amyloidosis is a disorder characterized by the deposition of amyloid A (AA) in multiple organs and tissues in the body. We report a case of bronchiectasis-related secondary renal amyloidosis with proteinuria. A 29-year-old male was admitted to our hospital for evaluation of foamy urine. He has been bothered from a large amount of mucopurulent sputum since 11 years. He had medical history of bronchiectasis and maxillary sinusitis. He had adenomatous goiter and showed hypothyroidism. Immunoelectrophoresis of serum and urine were nonspecific. Serum amyloid A level was high (243.0 ug/mL, reference value ; 0-8 ug/mL) and C-reactive protein was increased (3.8 mg/dL, reference value ; 0-0.5 mg/dL). Renal, thyroid and rectal biopsy revealed infiltration of homogenous material and showed apple-green birefringence in Congo-red stain. Apple-green birefringence in Congo-red stain of kidney, thyroid and rectum after potassium permanganate pretreatment was disappeared for the most part. We treated him with colchicine (1.2 mg per day). After a year, his proteinuria was persisted, but renal function was normal. (Korean J Med 69:S900-S905, 2005)
김병권,김성률,홍영습,나서희,김정만,정갑열,김준연,Kim, Byoung-Gwon,Kim, Sung-Ryul,Hong, Young-Seoub,Rha, Seo-Hee,Kim, Jung-Man,Jung, Kap-Yull,Kim, Joon-Youn 대한예방의학회 1996 Journal of Preventive Medicine and Public Health Vol.29 No.1
We experienced a case of nephropathy in chronic lead poisoning. The patient was 43-year-old male who has been working in secondary lead smelting plant for 14 years. On admission, blood pressure was 160/90 mmHg and the others were non-specific. In past history, he received chelating agent administration for lead poisoning irregularly and medicated for gout, and the blood lead concentration was $180.0{\mu}g/dl$ on 2 months before admission. Smoking habit has been 1 pack per day for 15 years and drinking habit has been 1 bottle of Soju per day but less flow. In liver function test, AST/ALT were 27/28 IU/l and $\gamma-GT$ was 456 IU/l. In blood test, Hb : 11.5 g/dl, Hct : 34.0% and basophilic stipplings were found in peripheral blood smear. Chest PA was normal and abdominal ultrasonographic finding was non-specific except fatty liver. In the test of lead exposure indices, $PbB:83.0{\mu}g/dl,\;PbU:28.3{\mu}g/l$, and blood ZPP was $300.0{\mu}g/dl$. And in renal function test, BUN : 31.4 mg/dl, blood creatinine : 2.7mg/dl, blood uric acid. 9.1 mg/dl, urinary albumin : 100.0 mg/g creatinine, urinary $\alpha_1-microglobulin$ : 120.5 mg/g creatinine, urinary $\beta_2-microglobulin$ : $183.8{\mu}g/g$ creatinine, and 24 hours urinary creatinine clearance was 31.9 ml/min. The ultrasonoguided renal biopsy showed the global sclerosis of glomerulus, moderate atrophy and loss of tubule, and interstitial fibrosis in light microscopy. There were diffuse losses of brush border of proximal tubule in electronmicroscopy.
Tramadol HCl/acetaminophen 복합제에 의한 급성신부전을 동반한 신증후군
손영기 ( Young Ki Son ),남영희 ( Young Hee Nam ),이수미 ( Su Mi Lee ),김혜인 ( Hye In Kim ),안원석 ( Won Suk An ),김성은 ( Seong Eun Kim ),김기현 ( Ki Hyun Kim ),나서희 ( Seo Hee Rha ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.5
Analgesics are used commonly because of their beneficial effects on various disease processes and pain control, and so the population of patients who are at risk for adverse effects of these drugs is rapidly expanding. A number of renal problems have been associated with the use of these drugs, including electrolyte imbalance, acute renal failure, nephrotic syndrome, and interstitial nephritis. We experienced a 65-year-old female patient who developed general edema and oliguria for 4 days and diagnosed as focal segmental glomerulosclerosis with interstitial nephritis. She had taken tramadol HCl/acetaminophen (Ultracet(R)) for 15 days before admission. Renal biopsy revealed that focal tubular atropy, focal interstitial fibrosis and evidence of diffuse inflammatory cell infiltrations. Tramadol HCl/ acetaminophen (Ultracet(R)) was discontinued on admission because of the likelihood the renal disease was drug-related and the patient improved after discontinuation of this drug without remained renal damage. This case suggests that Ultracet(R) must be an agent that causes nephrotic syndrome with acute renal failure. Therefore clinicians should use it with caution in high risk patients.
남성호르몬 투여 받은 성 주체성 장애 환자에서 적출된 자궁 및 부속기의 조직학적 특징에 관한 고찰
변재천,곽봉규,신지현,차문석,한명석,나서희,김석권,Byun, Jae Chun,Kwak, Bong Gyu,Shin, Ji Hyun,Cha, Moon Seok,Han, Myoung Seok,Rha, Seo Hee,Kim, Seok Kwun 대한생식의학회 2005 Clinical and Experimental Reproductive Medicine Vol.32 No.4
Objective: To investigate the histologic features of the uterus and adnexae extirpated from gender identity disorder (GID) patients that received depot androgen injection. Methods: We reviewed the histologic findings of the uterus and adnexae removed from sixteen GID patients, who had taken depot androgen injection for 5~168 months. Results: Fourteen patients (87.5%) showed the atrophied epithelium of exocervix and all of 16 patients (100%) showed the atrophy of endometrium. Seven patients (43.7%) showed multiple cystic follicles in the ovarian cortex and 6 patients (37.5%), 3 patients (18.7%) showed corpus albicans and corpus luteum, respectively. Conclusions: Exogenous androgen induced atrophy of cervix and endometrium. This effect was more prominent in the endometrium. In addition, PCO-like histologic features were observed in the ovary.
급성신부전과 현미경적 신석회화증을 동반한 부갑상선암 1예
최윤정 ( Yun Jung Choi ),안원석 ( Won Suk An ),강도영 ( Do Young Kang ),나서희 ( Seo Hee Rha ),김성은 ( Seong Eun Kim ),김덕규 ( Duk Kyu Kim ),김기현 ( Ki Hyun Kim ) 대한내과학회 2008 대한내과학회지 Vol.75 No.1
저자들은 급성신부전 및 고칼슘혈증을 보이는 환자에서 신조직검사상 현미경적 신석회화증을 확인하고 여러 영상학적 진단기술의 조합 및 수술 후 조직학적 확인을 통해 부갑상선암을 진단하여 동측 갑상선 엽절제술 시행 후 19개월간 경과관찰한 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Parathyroid carcinoma is a very rare disease in patients with primary hyperparathyroidism. Renal impairment and bone disease in the case of parathyroid carcinoma is common due to hypercalcemia. Renal diseases, including nephrocalcinosis, nephrolithiasis, and renal failure are frequent compared with those of benign parathyroid tumors. Nephrocalcinosis is a disorder of increased calcium content and deposition within renal parenchyma. Most cases reporting parathyroid carcinoma have shown medullary calcinosis on radiologic images, but there has been no definitive report of microscopic nephrocalcinosis which does not have a positive radiologic finding. In the case reported herein, a 50-year-old woman had experienced general weakness and a decline in vision. She had hypercalcemia and acute renal failure and the renal biopsy revealed nephrocalcinosis. The PTH level was elevated (940.47 pg/mL) and the parathyroid tumor was localized based on several radiologic findings. Capsular invasion was noted at the time right parathyroidectomy, indicative of parathyroid carcinoma, thus we carried out ipsilateral thyroidectomy. Hypercalcemia was improved after surgery, but renal function was not improved completely due to microscopic nephrocalcinosis. (Korean J Med 75:122-127, 2008)