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RISS 인기검색어
- 검색키워드
- 저자 : 김경아(Kyoung Ah Kim) (검색결과 113 건)
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단순진폐증에 대한 흉부 고해상 전산화 단층촬영의 진단적 의의
김경아,김지홍,장황신,안형숙,임영,윤임중,Kim, Kyoung-Ah,Kim, Hi-Hong,Chang, Hwang-Sin,Ahn, Hyeong-Sook,Lim, Young,Yun, Im-Goung 대한예방의학회 1996 예방의학회지 Vol.29 No.3
Early recognition of coalescence in pneumoconiotic lesions is important because such coalescence is associated with the respiratory symptoms and deterioration of lung function. This complicated form of pneumoconiosis also has worse prognosis than does simple pneumoconiosis. High resolution computerized tomography(HRCT) provides significant additional information on the stage of the pneumoconiosis because it easily detects coalescence of nodules and emphysema that may not be apparent on the simple radiograph. The purpose of this study is to clarify the role of HRCT in detection of large opacity and the relationship of change between the coalescence of nodules or emphysema and lung function in dust exposed workers. 1. There was good correlation between the HRCT grade of pneumoconiosis and ILO category of profusion. 5(9.09%) in 55 study population had confluent nodule extending eve, two o, more cuts on HRCT. HRCT could identify the pneumoconiotic nodules which was not found by simple radiogrphy in 6 workers with category 0/0. 2. No significant difference was observed coalescence of nodules and emphysema by dust type. 3. There was no significant difference in pulmonary function according to ILO and HRCT classification. 4. HRCT could detect the significant reduction in $FEV_1,\;FEV_1/FVC$, PEFR, $FEF_{25},\;FEF_{50},\;and\;FEF_{75}$ and remarkable increase in RV and TLC in study persons with emphysema compared with non-emphysema group. 5. Emphysema was found more often in nodules-coalescence group than small opacity group by HRCT. We found that HRCT could easily detect areas of coalescence and complicated emphysema compared to plain chest X-ray. Also our data suggest that it is primarily the degree of emphysema rather than the degree of pneumoconiosis that determines the level of pulmonary function.
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PM2.5로 자극한 폐상피세포의 $NF{\kappa}B$ 활성화에 NO의 역할
김경아,남혜윤,문제혁,정진숙,임영,Kim, Kyoung-Ah,Nam, Hae-Yun,Mun, Je-Hyeok,Jeong, Jin-Sook,Lim, Young,Kai, Hirofumi 대한결핵및호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.52 No.6
Background : The present study was performed to further improve our understanding of molecular mechanisms involved in the activation of NFkB, a major transcriptional factor involved in the inflammatory response in the lung, by particulate matter in lung epithelial cells with an aerodynamic diameter of less than $2.5{\mu}m$(PM2.5). Materials and Methods : Immediate production of reactive oxygen species (ROS) and nitrogen species (RNS), with the PM2.5 induced expression of inducible nitric oxide synthase (iNOS), $I{\kappa}B$ degradation and $NF{\kappa}B$-dependent transcriptional activity, in 549 cells, were monitored. Addition, we also examined the effect of the iNOS inhibitor, L-N6-(1-iminoethyl) lysine hydrochloride (L-NIL), on the PM2.5-induced $NF{\kappa}B$ activation in A549 cells. Results : The rapid degradation of $I{\kappa}B$ and the increase of transcriptional activity of the $NF{\kappa}B$-dependent promotor were observed in A549 cells exposed to PM2.5. The immediate production of ROS in response to PM2.5 in A549 cells was not clearly detected, although immediate responses were observed in RAW264.7 cells. A 549 cells, cultured in the presence of PM2.5, produced an increase in NO, which was noticeably significant after 15 min of exposure with the expression of iNOS mRNA. The addition of L-NIL, an iNOS inhibitor, significantly inhibited the PM2.5-induced $I{\kappa}B$ degradation and the increase of the $NF{\kappa}B$-dependent transcriptional activity. Conclusion : These results suggest that PM2.5 stimulates the immediate production of RNS, leading to the activation of $NF{\kappa}B$ in the pulmonary epithelium.
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폐암에서 혈중 Cyfra 21-1, SCC 항원 및 CEA의 진단적 유용성
김경아 ( Kyoung Ah Kim ),이미화 ( Me Hwa Lee ),고윤석 ( Youn Suck Koh ),김선희 ( Seon Hee Kim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),김우성 ( Woo Sung Kim ),김동순 ( Dong Soon Kim ),김원동 ( Won Dong Kim ),문대혁 ( Dae H 대한결핵 및 호흡기학회 1995 Tuberculosis and Respiratory Diseases Vol.42 No.6
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원발성 항인지질 항체 중후군을 동반한 Budd - Chiari 중후군의 임상상 및 혈관조영상 특성
김경아(Kyoung Ah Kim),정영화(Young Hwa Chung),서동완(Dong Wan Seo),김선희(Seon Hee Kim),추윤호(Yun Ho Chu),고정민(Jeong Min Kho),유빈(Bin Yoo),박철민(Cheol Min Park),성규보(Kyu Bo Sung),이영상(Yung Sang Lee),서동진(Dong Jin Suh) 대한내과학회 1996 대한내과학회지 Vol.51 No.4
Objectives: Many patients with Budd-Chiari syndrome have no evident etiological factor especially in Asian countries. And various obstructive patterns of inferior vena cava and hepatic veins have been reported suggesting several different causes may be involved. Recently primary antiphospholipid antibody syndrome has been described as a characteristic clinical entity with multiple thromboembolic episodes and typical laboratory features such as serum antiphospholipid antibody, not being associated with any collagen vascular disease. To evaluate the etiological role of primary antiphospholipid antibody syndrome in Budd-Chiari syndrome and clarify the clinical features of Budd-Chiari syndrome patients with primary antiphospholipid antibody syndrome, we analyzed clinical and angiographic. data of 27 consecutive patients with Budd-Chiari syndrome (Age: 47±12 years, M: F=13:14). Methods: We analyzed clinical manifestations and angiographic characteristics of 4 Budd-Chiari syndrome patients with primary antiphospholipid antibody syndrome, comparing to those of 23 without it. Results: Underlying etiological factors were identified only in 6(22%); 4(15%) were associated with primary antiphospholipid antibody syndrome. Most of patients with Budd-Chiari syndrome showed superficial abdominal collaterals, ascites, symmetrical lower leg edema and hepatosplenomegaly with laboratory features of liver cirrhosis, regardless the association of primary antiphospholipid antibody syndrome. However, only out of 4 with primary antiphospholipid antibody syndrome, 2 had asymmetrical lower leg edema with ulcer; 2 complained of unexplained long-standing dry cough, 1 of intermittent fever. In both with lower leg ulcer, thrombotic obstructions of deep veins were identified. Another one with primary antiphospholipid antibody syndrome was proved to have pulmonary hypertension without definite vascular obstruction. All of 4 patients(100%) with primary antiphospholipid antibody syndrome in contrast to only 8 out of 23(35%) without it showed broad obstruction of inferior vena cava and all three hepatic veins(Sugiura type II; p<0.05). Conclusion: These data suggested that primary antiphospholipid antibody syndrome is one of common etiological factors in patients with Budd-Chiari syndrome, and that especially in Hudd-Chiari syndrome patients who present asymmetrical lower leg edema with ulcer, long-standing dry cough, unexplained fever, pulmonary hypertension of unknown cause or broad obstruction of inferior vena cava, the possibility of association with primary antiphospholipid antibody syndrome should be considered.
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팔, 손가락, 정맥에서 채취한 혈액의 혈당검사결과 비교 분석
김경아(Kim, Kyung-Ah),이인광(Lee, In-Kwang),신은영(Shin, Eun-Young),김양미(Kim, Yang-Mi),김경옥(Kim, Kyoung-Oak),차은종(Cha, Eun-Jong),박경순(Park, Kyung-Soon) 한국산학기술학회 2012 한국산학기술학회논문지 Vol.13 No.4
팔부위에서 혈당을 측정하는 것은 모세혈관에서 혈액을 채취하는 동안 느끼는 통증을 줄일 수 있다. 본 연 구에서는 팔부위 혈당검사의 임상적 유효성을 평가하기 위해 팔부위 혈당검사결과를 손가락 및 정맥에서의 혈당검사 결과와 각각 비교하였다. 당뇨환자 61명이 포함된 555명의 피검자를 대상으로 금식 상태에서 휴대형 혈당계로 손가락 과 팔 안쪽 부위에서 혈당검사를 수행하였으며, 1시간 이내에 피검자 514명의 정맥혈액으로 혈당검사를 수행하였다. 측정값들에 대해 선형회귀분석, 급내 상관분석(intraclass correlation), Passing-Bablok 회귀분석 기법으로 다양하게 비교 분석해 보았다. 팔부위 혈당값은 환자군에서 손가락 및 정맥 혈당값과의 상관계수(r)가 0.97(P<0.0001)로 높은 선형관 계를 나타내었으며, 정상군에서도 r값이 약간 작았지만 유사하였다. 채혈 부위에 따른 혈당값의 평균 차이는 두 집단 에서 모두 ±10mg/dL 이내이었다. 급내 상관계수는 r값에 비교하여 약간 작았지만 두 집단이 유사한 수치를 나타내었 다. Passing-Bablok 분석에서 기울기의 95% 신뢰구간과 절편은 각각 <±20%, <±20mg/dL로서 임상 허용범위 이내의 값을 나타내었다. 본 연구에서 사용한 세 가지 통계분석 결과 팔부위 혈당값이 손가락과 정맥에서 측정한 혈당값과 충분히 일치함이 입증되었다. 팔부위 혈당검사가 표준방법인 손가락 혈당검사와 높은 일치성을 나타내었으므로 금식 상태에서의 임상적용 가능성을 확인할 수 있었다. Capillary blood sampling on the forearm reduces pain caused by skin puncture. The present study compared the blood glucose test results performed at different sampling sites of the forearm, finger, and vein to evaluate clinical validity of this alternative site blood sampling technique. Subjects numbered 555 including 61 diabetic patients participated to measure the glucose concentration on the finger (GF) and the forearm (GA) with a portable glucometer under overnight fasting state. Then, the venous glucose concentration (GV) was measured in 514 subjects in less than 1 hour. The test results were analyzed by simple linear regression, intraclass correlation, and Passing-Bablok regression techniques. GA was highly correlated with GF or GV showing the correlation coefficients (r) of approximately 0.97 (P<0.0001) in the normal group. The patient group also resulted similarly high correlation with only slightly lower r value. The mean differences in glucose concentration were less than ±10mg/dL regardless of the sampling sites. Intraclass correlation coefficients were slightly smaller than r but very much similar in value in both groups. The 95% confidence intervals of the slope as well as the intercept in the Passing-Bablok regression analysis were <±20% and <±20mg/dL, respectively, which were within the clinically acceptable ranges. These three statistical techniques introduced in the present study well demonstrated the consistency of GA with GF and GV. Therefore, the forearm blood glucose test could be considered as clinically valid under fasting condition. Key Words : Blood glucose test, Alternative blood sampling, Comparative analysis
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