제2세대 Halon 대체 물질 FK-5-1-12에 관한 연구

고아라,박정화,박세훈,홍아름,손봉세 한국화재소방학회 2016 한국화재소방학회 학술대회 논문집 Vol.2016 No.춘계

GO-03 : Response of single-agent versus combination chemotherapy in patients of high-risk, non-metastatic gestational trophoblastic neoplasia

고아라,이신화,박정열,김대연,김종혁,김용만,김영탁,남주현 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

Women with stage 1 gestational trophoblastic disease (GTN) were usually treated with single-agent chemotherapy following 2004 ACOG guideline. Some of them were scored as high-risk group by FIGO system and we experienced frequent recurrence in them. And there are no clear guideline for high-risk stage 1 GTN. Here we want to compare outcomes between single-agent versus combination chemotherapy in non-metastatic, high-risk GTN. We retrospectively reviewed all non-metastatic, high-risk GTN patients treated with chemotherapy between 1998 and 2010 in single institute. 5 patients are treated with combination chemotherapy (EMA-CO) and 5 patients are treated with single-agent chemotherapy (Dactinomycin). Adjuvant surgery was performed in selective patients. Response to chemotherapy and other clinical outcomes were analyzed retrospectively. Age, parity, pretreatment b-hcg, initial tumor size measured by sonography, interval months from index pregnancy between two groups were not statistically different. The failure rate of single-agent chemotherapy using dactinomycin in high-risk, non-metastatic GTN was 60% (3/5), compared to 0% (0/5) of combination chemotherapy. (p=0.038). Patients resistant to single-agent therapy were treated with EMA-CO regimen, and all of them are cured so far (mean follow-up month: 40.6). Risk of hysterectomy is 60% (3/5) in single-agent group and 20% (1/5) in combination group (p=0.058). Severity of neutropenia and anemia during 1st line chemotherapy were similar in both groups. Even in stage 1 GTN, high risk groups might be initially treated with combination chemotherapy to avoid unnecessary additional chemotherapy and operation. Prognostic scoring system is considered more important than anatomic staging system to establish treatment plan in. Retrospective study with more numbers are needed to confirm the superiority of combination chemotherapy in stage 1, high risk GTN patients.

굿즈상품(GOODS)소비가치에 따른 PAD감정반응이 브랜드 카리스마 및 브랜드 충성도에 미치는 영향: MZ세대를 중심으로

고아라,이규민 한국서비스경영학회 2021 한국서비스경영학회 학술대회 Vol.2021 No.5

Association between Urinary Bisphenol A and Waist Circumference in Korean Adults

고아라,홍진환,황명실,박재홍,강희승,이희석 한국독성학회 2014 Toxicological Research Vol.30 No.1

Bisphenol A (BPA) is widely used in the production of polycarbonate plastics, epoxy resins, and food and beverage containers. In the present study, we aimed to investigate the relationship between urinary concentrations of BPA and waist circumference in Korean adults. A total of 1,030 Korean adults (mean age, 44.3 ± 14.6 years) were enrolled in the study on the integrated exposure to hazardous materials for safety control, conducted by the Ministry of Food and Drug Safety from 2010 to 2012. Abdominal obesity was defined as having a waist circumference of at least 90 cm and 85 cm for men and women, respectively. The participants were divided into 4 groups according to the urinary BPA concentration quartile. Waist circumference was significantly higher among subjects with a urinary BPA concentration in the highest quartile relative to those in the lowest quartile (p = 0.0071). Linear regression analysis revealed a significantpositive association between urinary BPA concentrations and body mass index, body fat, after adjusting for potential confounders. Moreover, subjects with urinary BPA concentrations in the fourth quartile were more likely to be obese compared to those with urinary BPA concentrations in the first quartile (odds ratio, 1.938; 95% CI: 1.314~2.857; p for trend = 0.0106). These findings provide evidence for a positive associationbetween urinary BPA concentration and waist circumference in Korean adults.

원전사고 후 광역의 방사성 오염부지 내 거주민에 대한시간에 따른 피폭방사선량 평가

고아라,김민준,조남찬,설증군,김광표 한국방사선산업학회 2015 방사선산업학회지 Vol.9 No.4

It has been about 5 years since the Fukushima nuclear power plant accident, whichcontaminated large area with radioactive materials. It is necessary to assess radiation dose toestablish evacuation areas and to set decontamination goal for the large contaminated area. Inthis study, we assessed temporal trend of radiation dose to the public living in the large areacontaminated with radioactive materials after the Fukushima nuclear power plant accident. The dose assessment was performed based on Chernobyl model and RESRAD model for twoevacuation lift areas, Kawauchi and Naraha. It was reported that deposition densities in theareas were 4.3~96 kBq m-2 for 134Cs, 1.4~300 kBq m-2 for 137Cs, respectively. Radiation dose tothe residents depended on radioactive cesium concentrations in the soil, ranging 0.11~2.4 mSvy-1 at Kawauchi area and 0.69~1.1 mSv y-1 at Naraha area in July 2014. The difference was lessthan 5% in radiation doses estimated by two different models. Radiation dose decreased withcalendar time and the decreasing slope varied depending on dose assessment models. Based onthe Chernobyl dosimetry model, radiation doses decreased with calendar time to about 65% levelof the radiation dose in 2014 after 1 year, 11% level after 10 years, and 5.6% level after 30 years. RESRAD dosimetry model more slowly decreased radiation dose with time to about 85% levelafter 1 year, 40% level after 10 years, and 15% level after 30 years. The decrease of radiation dosecan be mainly attributed into radioactive decays and environmental transport of the radioactivecesium. Only environmental transports of radioactive cesium without consideration of radioactivedecays decreased radiation dose additionally 43% after 1 year, 72% after 3 years, 80% after 10years, and 83% after 30 years. Radiation doses estimated with cesium concentration in the soilbased on Chernobyl dosimetry model were compared with directly measured radiation doses. The estimated doses well agreed with the measurement data. This study results can be applied to radiation dose assessments at the contaminated area for radiation safety assurance or emergencypreparedness.

유전자변형(GMO) 식품에 대한 성인 인식 실태

고아라,나지명,조재순 한국가정과교육학회 2015 한국가정과교육학회 학술대회 Vol.2015 No.-

국외 점자 교육 연구 동향분석(2013~2022)

고아라,홍재영 대구대학교 한국특수교육문제연구소 2023 특수교육저널 : 이론과 실천 Vol.24 No.1

[Purpose] The purpose of this study was to identify the current status of braille education in Korea and to investigate ways to improve the quality of domestic braille education by analyzing International research trends in braille education. [Method] A total of 46 braille education studies published from 2013 to 2022 were analyzed using the following criteria: publication and year, country/ first author country affiliation, research participants, research methods, and contents analysis. [Results] Results are summarized as follows. First, the most published is JVIB(Journal of Visual Impairment and Blindness)(14, 37.0%), and BJVI(British Journal of Visual Impairment) is the second(9, 19.6%), with a total of 23(50.0%) published in two journals. Second, the country with the most studies is the United States(17, 37.0%). Third, in terms of research participants, the visually impaired were the most(22, 51.2%), followed by the visually impaired and sighted(14, 32.6%). Fourth, as for the research methods, experimental studies accounted for more than half of the total(25, 54.3%). Lastly, the contents are classified into four categories: ‘Physical Characteristics of Braille', ‘Ways to Improve the Quality of Braille Education', ‘Teaching and learning Materials', and ‘Instructional Considerations'. [Conclusion] Based on these results, the implications for improving the quality of braille education in Korea were discussed. [목적] 이 연구는 점자 교육에 관한 국외의 연구 동향을 분석하여 국내 점자 교육의 현주소를 파악하고 국내 점자 교육의 질 향상 방안을 모색하는 것을 목적으로 한다. [방법] 이를 위해 2013년부터 2022년까지의 국외 점자 교육 관련 연구 46편을 분석하였다. 분석을 위해 선행연구를 기반으로 분석 준거를 설정하였으며, ‘학술지, 발행 연도, 국가, 연구 참여자, 연구 방법을 분석하고 총체적 내용 분석을 실시하였다. [결과] 분석 결과 분석 대상 논문 중 14편(37.0%)이 JVIB에, 9편(19.6%)이 BJVI에 게재되어 46편의 논문 중 23편(50.0%)이 2개의 학술지에 게재되어 있었다. 가장 많은 연구가 이루어진 국가는 미국으로 17편(37.0%)의 연구가 이루어졌으며, 연구 참여자는 시각장애인을 대상으로 한 연구가 22편(51.2%)으로 가장 많았으며, 시각장애인과 정안인을 대상으로 한 연구가 14편(32.6%)으로 뒤를 이었다. 연구 방법은 실험연구가 25편(54.3%)으로 절반 이상을 차지했다. 총체적 내용분석 결과 ‘점자의 물리적 특성’, ‘점자 교육의 질 제고 방안’, ‘교수·학습자료’, ‘교수·학습 시 고려사항’이라는 4가지 범주로 내용을 분류할 수 있었다. [결론] 이러한 결과를 바탕으로 국내 점자 교육의 질 향상 방안을 위한 시사점을 논의하였다.

Hypotonic hyponatremia by primary polydipsia caused brain death in a 10-year-old boy

고아라,김수정,정모경,김기은,채현욱,김덕희,김호성,권아름 대한소아내분비학회 2015 Annals of Pediatirc Endocrinology & Metabolism Vol.20 No.3

Hypotonic hyponatremia by primary polydipsia can cause severe neurologic complications due to cerebral edema. A 10-year-and-4-month-old boy with a psychiatric history of intellectual disability and behavioral disorders who presented with chief complaints of seizure and mental change showed severe hypotonic hyponatremia with low urine osmolality (serum sodium, 101 mmol/L; serum osmolality, 215 mOsm/kg; urine osmolality, 108 mOsm/kg). The patient had been polydipsic for a few months prior, and this had been worse in the previous few days. A diagnosis of hypotonic hyponatremia caused by primary polydipsia was made. The patient was in a coma, and developed respiratory arrest and became brain death shortly after admission, despite the treatment. The initial brain magnetic resonance imaging showed severe brain swelling with tonsillar and uncal herniation, and the patient was declared as brain death. It has been reported that antidiuretic hormone suppression is inadequate in patients with chronic polydipsia, and that this inadequate suppression of antidiuretic hormone is aggravated in patients with acute psychosis. Therefore, hyponatremia by primary polydipsia, although it is rare, can cause serious and life-threatening neurologic complications.

MZ세대를 중심으로 굿즈 상품 소비가치에 따른 PAD감정반 응이 브랜드카리스마 및 브랜드 충성도에 미치는 영향

고아라,이규민 한국서비스경영학회 2022 서비스경영학회지 Vol.23 No.2

In this study, the PAD emotional response was confirmed through the consumption value of merchandise. And whether this emotional response affects brand charisma and brand was examined. A total of 371 samples, generation MZ, were used for the final analysis. Firstly, out of five consumption values of merchandise, four(social, emotional, practical, and innovative values) had significant effects on the PAD emotional response. However, self-value showed a significant effect on ventilation and non significant effects on dominance and pleasure. Secondly, all three PAD emotional reactions(control, pleasure, and ventilation) showed significant effects on brand charisma. Finally, brand charisma also had a significant effect on brand loyalty. Finally, it is expected to provide various theoretical and practical implications in the foodservice market, especially for the marketing strategies on generation MZ. 본 연구에서는 상품의 소비 가치를 통해 PAD 감정 반응을 확인하였다. 그리고 이러한 감정적 반응이 브랜드 카리스마와 브랜드에 영향을 미치는지 여부를 조사했다. 최종 분석에는 총 371개의 샘플, 즉 MZ세대가 사용되었습니다. 첫째, 상품의 5가지 소비 가치 중 4가지(사회적, 정서적, 실용적, 혁신적 가치)가 PAD 정서적 반응에 큰 영향을 미쳤다. 그러나 자기 가치는 환기에 유의한 영향을 미쳤고 지배력과 즐거에 유의하지 않은 영향을 보였다. 둘째, 세 가지 PAD 감정 반응(지배력, 환기,즐거움) 모두 브랜드 카리스마에 상당한 영향을 미쳤다. 마지막으로 브랜드 카리스마는 브랜드 충성도에도 상당한 영향을 미쳤다. 외식산업시장에 다양한 이론적, 실무적시사점을 제공한다.

스핀-궤도 결합과 훈트 결합의 경쟁: t52g 전자구조를 중심으로

고아라 한국물리학회 2021 새물리 Vol.71 No.8

The effective angular momentum jeff efficiently describes the t2g orbitals in the presence of spin-orbit coupling. On the other hand, the d-orbital is spatially localized, and the local electrons have strong mutual two-body interactions, which play an important role in the metal-insulator transitions in transition-metal compounds. For a rotationally invariant d-orbital, the local interactions between electrons are expressed in terms of the local Coulomb interaction U and Hund’s coupling JH. The Coulomb interaction prevents electrons from gathering at the same position, and Hund’s coupling distributes the electron to maximize the spin and the orbital angular momenta. The Hund’s coupling often competes against spin-orbit coupling. We explain both the competition between spin-orbit coupling and local interactions in the t52 g orbital via an atomic limit description and the way in which the effects can be revealed in the electronic structure by dynamical mean-field calculation for a simplified lattice Hamiltonian. t2g 궤도는 강한 스핀-궤도 결합 아래 유효 각운동량 jeff 으로 기술된다. 한편 d-궤도는 공간적으로국소화되어 같은 위치의 전자들은 강한 이체 상호작용을 느끼며, 이 상호작용은 전이금속 화합물의금속-절연체 상전이에 중요한 역할을 한다. d-전자궤도가 회전 대칭성을 가질 때, 전자 사이의 국소적상호작용은 쿨롱 상호작용 U 와 훈트 결합 JH 으로 표시할 수 있다. 쿨롱 상호작용은 여러 전자가 한위치에 모이는 것을 방지하며 훈트 결합은 스핀 각운동량과 각운동량을 최대화하는 방향으로 전자 분포를조절하는데, 이중 훈트 결합은 종종 스핀-궤도 결합과 경쟁하게 된다. 이 논문에서는 t2g 궤도에 전자가5개 차있는 t52 g 상황에서 스핀-궤도 결합과 국소적 상호작용의 경쟁관계를 원자극한을 통해 설명하고그러한 경쟁관계가 격자의 전자 들뜸 스펙트럼에 끼치는 영향을 단순화된 모형 해밀토니안에 대한 동적평균장 이론(dynamical mean-field) 계산으로 살펴본다.