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Clinical Immune Tolerance in Liver Transplantation: Present and Future
최규성 한양대학교 의과대학 2014 Hanyang Medical Reviews Vol.34 No.4
Liver transplantation is the most effective treatment for end-stage liver diseases (ESLD) with satisfactory clinical results and so is considered as the treatment of choice for ESLD and early hepatocellular carcinoma with cirrhotic liver. Unfortunately, adverse effects of life-long immunosuppression prevent the development of alternative strategies to achieve better long-term outcome. Achieving clinical operational tolerance is one of the ultimate goals in the clinical transplantation field. Around 15% of liver transplantation recipients develop spontaneous operational tolerance after immunosuppression withdrawal, and the percentage may be even higher in pediatric living donor liver transplantation recipients. One of the possible explainable mechanisms is a T cell fatigue from large amount of antigen loaded. Despite continuing progress, clinical operational tolerance is still rare in liver transplantation. Reprogramming the recipient immune system by creating chimerism and utilizing regulatory cell therapies are among the newer promising means to achieve clinical liver transplantation tolerance in the future. In animal studies, administration of donor specific regulatory T cells allows a prolonged survival without immunosuppressive agents. In this review, proposed mechanisms for clinical tolerance will be offered and current experimental trial will be introduced.
최규성,김지대,김효철,민상일,민승기,제환준,정진욱 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.4
To evaluate the technical feasibility and clinical outcome of percutaneous aspiration embolectomy for embolic occlusion of the superior mesenteric artery (SMA). Between January 2010 and December 2013, 9 patients with embolic occlusion of the SMA were treated by percutaneous aspiration embolectomy in 2 academic teaching hospitals. The aspiration embolectomy procedure was performed with the 6-Fr and 7-Fr guiding catheter. Thrombolysis was performed with urokinase using a multiple-sidehole infusion catheter. The clinical outcome was investigated retrospectively. Superior mesenteric artery occlusion was initially diagnosed by computed tomography (CT) in all patients, and all patients had no obvious evidence of bowel infarction on CT scan. Percutaneous aspiration embolectomy was primarily performed in 6 patients, and thrombolysis was initially performed in 3 patients. In 3 patients who received primary thrombolysis, percutaneous aspiration was undertaken because the emboli were resistant to urokinase. Complete angiographic success was achieved in 6 patients and partial angiographic success was accomplished in 3 patients. One patient underwent bowel resection. One patient died of whole bowel necrosis and sepsis, and 8 patients survived without complications. Percutaneous aspiration embolectomy is a useful tool in recanalization of embolic occlusion of the SMA in select patients.
Matlab/Simulink를 이용한 FTS 수신기 디코더부의 FPGA 설계
최규성,고정환,심형석,노웅래,황수설,노성민 한국항공우주학회 2012 한국항공우주학회 학술발표회 논문집 Vol.2012 No.11
아날로그 신호를 사용하는 IRIG 톤 방식은 우주발사체용 비행종단시스템에서 오랜 기간동안 사용되고 있으나 보안성 문제와 외부 잡음 신호에 취약한 특성을 가지고 있어 안정적인 운영을 위해서 디지털 명령 전송 방식으로의 변경이 검토되고 있다. 이의 일환으로, FTS 수신기 decoder부의 디지털 신호 처리를 FPGA(Field Programmable Gate Array)로 구현하였다. 본 논문에서는 Matlab/Simulink와 System Generator를 이용하여 FPGA 알고리즘 설계 및 검증을 수행하였다. IRIG standard tone method based on an analogue signal has been used in the flight termination system of space launch vehicle for decades. However, due to the vulnerabilities to signal security and external noise signal of the current flight termination system, modification of digital command transmitting method is reviewed for the purpose of stable operation. As a part of this, digital signal processing of FTS receiver decoder is implemented in a Field Programmable Gate Array(FPGA). In this paper, design and verification of FPGA algorithm are performed utilizing Matlab/Simulink and System Generator.
최규성,고정환,심형석,노웅래,박정주,조광래 한국항공우주학회 2013 한국항공우주학회 학술발표회 논문집 Vol.2013 No.4
나로호(KSLV-I)의 3차 비행시험이 2013년 1월 30일 나로우주센터에서 수행되었다. 레이다를 비롯한 추적시스템으로부터의 비행데이터 및 발사체 내부 데이터를 이용한 비행상황 감시는 정상적으로 이루어졌으며, 실시간으로 동작하는 비행안전 알고리듬 계산도 정상적으로 수행되었다. 본 논문은 비행안전시스템 및 비행안전영역 설정을 설명하고 비행중 실시간으로 처리된 데이터 및 수행된 알고리듬의 분석결과를 제시하였다. The third flight test of KSLV-I was performed on January 30th, 2013 at Naro space center. Utilizing flight data obtained by tracking system such as radar and onboard telemetry data, monitoring of flight status is normally performed and the algorithms for flight safety calculations including the one for instantaneous impact point computations are also executed normally. This paper describes flight safety hazard areas and flight safety information system and presents algorithm"s analysis results and data processed in real-time during KSLV-I 3rd flight test.
Hydrazide Schiff Base 리간드와 Cd(II) 이온과의 착물 형성에 관한 연구
최규성,김용규,김용남,Kyu-Seong Choi,Yong-Kyu Kim,Yong-Nam Kim 대한화학회 1991 대한화학회지 Vol.35 No.2
N,N'-oxalylbis(salicylaldehyde hydrazone), N,N'-malonylbis(salicylaldehyde hydrazone), 그리고 N,N'-succinylbis(salicylaldehyde hydrazone)과 Cd(II) 이온과의 착물형성에 따르는 안정도상수를 DMSO 용액에서 폴라로그래피법으로 측정하였다. 안정도상수의 크기는 OBSH < MBSH < SBSH의 순서로 증가하였으며, Cd(II) 이언은 이들 리간드와 매우 안정한 착물을 형성하였다. 안정도 상수를 여러 온도에서 측정하여 엔탈피 및 엔트로피 변화를 측정한 결과, 착물형성에 기여를 하고 있음을 알았다. The complexation of hydrazide schiff base ligands such as N,N'-oxalylbis(salicylaldehyde hydrazone), N,N'-malonylbis(salicylaldehyde hydrazone), and N,N'-succinylbis(salicylaldehyde hydrazone) with Cd(II) ion was studied by polarographic method in DMSO solution. The order of stability constants was OBSH < MBSH < SBSH, and these ligands formed stable complexes with Cd(II) ion. The stability constants of complexation were measured at various temperatures. As the results, ${\Delta}$H and ${\Delta}$S of the complexation were distributed on the complex stabilities.
N,N'-Oxalylbis(salicylaldehyde hydrazone)과 중금속이온과의 착물 형성에 관한 연구
최규성,이익희,김용남,Kyu-Seong Choi,Ick-Hee Lee,Yong-Nam Kim 대한화학회 1991 대한화학회지 Vol.35 No.2
The complexation of N,N'-oxalylbis(salicylaldehyde hydrazone) (OBSH) with Zn (II), Cd (II), and Pb(II) ions was studied by polarographic method in DMSO solution. The order of stability constants was Cd(II) < Zn(II) < pb(II), and all heavy metal ions formed stable complex with OBSH ligand. The stability constants of complexation were measured at various temperatures. As the results, enthalpy and entropy changes of the complexation were distributed on the complex stabilities. N,N'-oxalylbis(salicylaldehyde hydrazone) (OBSH)과 Zn (II), Cd (II) 및 Pb(II) 이온들과의 착물 형성에 따르는 안정도상수를 DMSO 용액에서 폴라로그래피법으로 측정하였다. 안정도상수의 크기는 Cd(II) < Zn(II) < pb(II) 이온의 순서로 증가하였으며, 모든 중금속이온들의 OBSH 리간드와 매우 안정한 착물을 형성하였다. 안정도상수를 여러 온도에서 측정하여 엔탈피 및 엔트로피 변화를 구한 결과, 착물의 안정도에 많은 기여를 하고 있음을 알았다.