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( Phill Seung Jung ),( Yeon Sik Na ),( Shin Wha Lee ),( Jeong Yeol Park ),( Jong Hyeok Kim ),( Young Man Kim ),( Joo Hyun Nam ),( Young Tak Kim ),( Dae Yeon Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
To correlate pathologic findings on conization specimens and other clinical parameters with residual disease in radical hysterectomy specimens in patients with cervical cancer to determine which subgroup of patients may be eligible for less radical surgery Between 2003 and 2011, we perfomed 472 conizations before treating cervical cancer patients. The exclusion criteria were the patients who were given neoadjuvant chemotherapy and/or definitive CCRT and/or radical trachelectomy and the patients whose pathologic reports were missing or unclear. A total of 292 patients who underwent radical hysterectomy after conization were included in this retrospective study. Mean age of this patients were 51.7 years (28-85) and mean size of residual tumor was 1.3cm (0-7.3 cm). FIGO stage distribution were 17 patients in IA1, 21 in IA2, 233 in IB1, 10 in IB2 and 11 in others. At radical hysterectomy, 87 patients (30%) had no residual cancer, while 205 patients (70%) had residual cancer. Univariate analysis showed that positive resection margin and tumor size more than 2cm were significant factors for predicting residual disease. These factors also significant in a multivariate analyisis (positive resection margin OR 6.869, 95% CI 2.734-17.262, p<0.001; tumor size >2cm OR 3.090, 95% CI 1.744-5.474, p<0.001). Of the resection margin status, Positive endocervical and deep margin were significant but not significant in exocervical margin. The patients with negative resection margin and small tumor (< 1 cm) had no residual disease and no recurrences in the median FU of 32 months. Positive resection margin on conization and large tumor size (>2c m) were significant factors for predicting residual cancer after radical hysterectomy. Using these factors, we can develop the predicting models for detecting subgroup of patients who are eligible for less radical surgery.
GO-10 : Poor prognosis after conservative surgery in stage I mucinous epithelial ovarian cancer
( Phill Seung Jung ),( Shin Wha Lee ),( Jeong Yeol Park ),( Dai Shik Suh ),( Dae Yeon Kim ),( Jong Hyeok Kim ),( Yong Man Kim ),( Young Tak Kim ),( Joo Hyun Nam ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: To evaluate the oncologic safety and to identify prognostic factor for recurrence in premenopausal women with stage I mucinous epithelial ovarian cancer (mEOC) who underwent conservative surgery. 방법: We enrolled 97 patients who were 1) premenopausal at the time of surgery and 2) confirmed to be the FIGO stage I. The surgical procedure of conservative surgery was unilateral salpingo-oophorectomy with/without contralateral ovarian wedge resection. 결과: The median age was 33 (range: 13-50) years at the time of surgery. Sixty-three (64.9%) patients were stage Ia, and 34 (35.1%) were Ic. Fifty-three (54.6%) patients underwent conservative surgery, and adjuvant chemotherapy was administrated to 61 (62.9%) patients. During 73.7 (range: 7.1-243.5) months of the median follow-up duration, 13 (13.4%) patients recurred and 8 (8.2%) of them died of disease. Among patients who underwent conservative surgery, there were 10 recurrences and the majority of recurred site was intraperitoneal cavity (n=8) with median age of 25 (range: 14-46) and median PFS of 17.8 (range: 5.1-53.3) months. In multivariate analysis, a significantly poorer prognosis was noted in patients who underwent conservative surgery (HR: 6.26, 95% CI: 1.53-25.53, p=0.011) and in patients with high preoperative CA-125 (HR: 1.98, 95% CI: 1.26-3.11, p=0.003). In patients with high preoperative CA-125 (>35U/mL, n=48), conservative surgery caused significantly higher recurrence rate (HR: 5.73, 95% CI: 1.22-27.03, p=0.027). 5-year disease-free survival rate was significantly lower in patients who underwent conservative surgery than in patients who did not (77.7% vs. 94.2%, p=0.047). 결론: In conclusion, conservative surgery might cause the poor prognosis in premenopausal women with stage I mEOCs, particularly with high preoperative CA-125 level. The further multicenter study with larger cohort would be needed to verify the oncologic safety of conservative surgery in mEOCs.
( Phill Seung Jung ),( Shin Wha Lee ),( Dae Yeon Kim ),( Jong Hyeok Kim ),( Yong Man Kim ),( Young Tak Kim ),( Joo Hyun Nam ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: The aim of this study is to evaluate diagnostic accuracy of combined 18F-fluoro-2-deoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) imaging in suspected recurrence of epithelial ovarian cancer with non-disseminated lesions by correlating with pathologic report after secondary cytoreduction. 방법: We retrospectively reviewed patients with recurrent epithelial ovarian cancer after primary treatment at Asan Medical Center from January, 2004 to December, 2013. Among those, 130 patients underwent secondary cytoreduction after imaging studies such as combined 18F-FDG-PET/CT or CT. We evaluated the sensitivity and positive predictive value (PPV) of combined 18F-FDG-PET/CT imaging and compared with those of CT correlating with the pathologic result of the secondary cytoreduction. 결과: A total of 63 patients with a median age of 46 (range: 21-68) were enrolled in this study. 46 patients underwent combined 18F-FDG-PET/CT and 61 did CT imaging before their secondary cytoreduction. The distribution of the cell type is as followed; 44 papillary serous adenocarcinomas, 5 clear cell carcinomas, 6 serous carcinomas, 2 mucinous adenocarcinomas, 3 endometrioid adenocarcinomas, 3 other types. The median level of CA-125 before the secondary cytoreduction was 22.3 (range: 2.4-1380.0) U/mL, and the mean max standardized uptake value of 18F-FDG-PET in the study cohort was 6.2 (range: 1.6-26.7). After the secondary cytoreduction, 54 (85.7%) patients were confirmed to have recurred with a median maximal tumor diameter of 3.5 (range: 0.1-10.0) cm on the pathologic report. Combined 18F-FDG-PET/CT showed a sensitivity of 70.4% and a PPV of 82.6% with false positive rate of 17.4% in detecting recurrent epithelial ovarian cancer. 결론: Our study demonstrated a discrepancy from previous studies in respect of a diagnosis value of combined 18F-FDG-PET/CT imaging in recurrent epithelial ovarian cancers with non-disseminated lesions. A prospective study with larger cohort would be needed.
Case Report : A case report of prenatally diagnosed tetrasomy 18p
( Phill Seung Jung ),( Hye Sung Won ),( In Ji Cho ),( Min Kyung Hyun ),( Jae Yoon Shim ),( Pil Ryang Lee ),( Ahm Kim ) 대한산부인과학회 2013 Obstetrics & Gynecology Science Vol.56 No.3
Tetrasomy 18p, one of the most commonly observed isochromosomes, consists of two copies of the p arms on chromosome 18[i(18p)]. It is known as a de novo occurrence of non-disjunction or centromeric mis-division during meiosis II in the vast majority of cases. It has a prevalence of 1/140,000-180,000 live births and affects both genders equally. A 28-year-old woman was referred at 33+2 weeks gestation to rule out fetal congenital heart disease. Her prenatal ultrasonography showed intrauterine growth retardation, cardiomegaly, and imperforate anus. Doppler ultrasonographic finding showed fetal anemia. Tetrasomy 18p was confirmed by conventional karyotyping and fluorescence in situ hybridization. Because of its very low prevalence rate, only several cases of tetrasomy 18p has been reported worldwide and it has not yet been reported in Korea before. Therefore, we report a case of prenatally diagnosed tetrasomy 18p.
주성분 분석과 가보 제트를 이용한 얼굴 인증 시스템 구현
이승영(Seung-Young Lee),박준우(Jun-Woo Park),이정훈(Jung-Hun Yi),이필규(Phill-Kyu Rhee) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.1B
컴퓨터의 보편화와 멀티미디어의 발전으로 많은 인공지능의 분야들이 실생활에 응용되고 있다. 이 중에서 얼굴 인식은 최근에 연구가 활발한 분야 중의 하나이며 인터넷 또는 멀티미디어를 통한 보안 시스템 등에서 많은 응용이 기대되고 있다. 이러한 이유로 향후 얼굴인식이 차지하는 비중은 더욱 커질 것으로 예상된다. 본 논문에서는 조명에 대한 환경 변화에 덜 민감한 시스템을 구현하기 위하여 주성분 분석(PCA; Principal Component Analysis)과 가보 제트(Gabor jet)에 환경 파라미터를 추가하여 병렬적으로 수행하는 얼굴 인증시스템을 구현 하였다. 실험을 통하여 기존의 주성분 분석이나 가보 제트 만을 이용한 얼굴인식 알고리즘 보다 환경 변화에 덜 민감하고 오 인증률이 저하된 결과를 나타낸 것을 알 수 있다.
영산강 하류 유역에 분초하는 유기물층에 관한 연구 : 양장리 일대를 중심으로 example of Yangjangri
박승필,위현정 한국지형학회 1996 한국지형학회지 Vol.3 No.2
본 연구에서는 영산강 하류 유역의 양장리 일대에 분포하는 충적지에서 관찰된 다량의 유기물을 포함하고 있는 충적층을 대상으로, 퇴적층 구조와 퇴적상을 밝히고 粒度分析 및 花粉分析을 실시하였다. 이를 통하여 양장리 일대 층적층의 특성과 퇴적환경을 究明하였으며, 흑색 유기물층이 소택지 환경에서 생성되었음을 밝혔다. 양장리 일대는 지난 빙기 동안 한냉한 환경 하에서 건특상태의 산골짜기에 sollfluction 퇴적물이 덮이고, 후빙기 이래 기온상승에 따라 해수면이 상승하면서 침수된 후, 소택지가 형성되면서 청회색 또는 암회색의 glei층이 생성되었다. 해수면의 미변동을 겪으면서 본 연구지역은 B.P. 1,645±75년 경에는 육지화한 상태였으며 해수가 침입되지 않는 위치였으나 다시 해수면의 상승으로 저습지성의 소택지화한 후 흑색유기물층이 형성되었다. The study area Is a 「Yangjangri」, which is located near of estuary in Yeongsan River. The purpose of this study is to find the depositional environment of organic matter layers in alluvial deposits at Yangjangrl area and to clarify the geomorphic development of these deposits in relation to post-glacial sea level changes. The analytic methods, such as the classification of micro topography and the analysis of depositional facies of boring data, grain size and pollen are employed for this study. The main findings are as follows; The organic matter layers(7.5Y 2/1) found in a Yangjangri were caused by bog sediments which were formed In the process that river valleys were downed under the periglacial climatic environment of the last glacial age and then buried by the transgression of post glacial age. Namely, the study area was influenced by the sea-level fall during 1645±75y. BP. and then covered with the bog sediments formed through the sea-level rise.
이영재,김용만,Phill-Seung Jung,,이종진,김정곤,김영탁,남주현 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.3
Objective: The aim of this study was to evaluate the diagnostic value of integrated 18F-fluoro-2-deoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) for suspected recurrence of epithelial ovarian cancer (EOC) with non-disseminated lesions. Methods: We retrospectively reviewed the medical records of recurrent EOC patients who underwent secondary cytoreduction from January 2000 to December 2013. A total of 134 patients underwent secondary cytoreduction after imaging with either 18F-FDG-PET/CT or contrast-enhanced computed tomography (CECT). Results: In a patient-based analysis of 134 patients, 124 (92.5%) were confirmed to be positive for malignancy. Among 72 patients with suspected non-disseminated recurrence on 18F-FDG-PET/CT, 65 (89.0%) were confirmed to have recurrence, giving 98.5% sensitivity, 87.7% accuracy, and 88.9% positive predictive value (PPV). In the 65 patients with recurrence, residual tumor remained in 14 patients, giving an accuracy of patient selection for secondary cytoreduction of 69.4% (50/72) and it is higher than that of CECT (64.0%). In 169 lesions removed from patients who underwent preoperative 18F-FDG-PET/CT, 135 (79.9%) were confirmed to be positive for malignancy and 124 were accurately detected by 18F-FDG-PET/CT, giving 91.9% sensitivity, 81.1% accuracy, and 85.5% PPV. Foreign body granuloma was found in 33.3% of 21 lesions with false-positive 18F-FDG-PET/CT findings (7/21). The mean preoperative cancer antigen 125 (CA-125) level in false-positive patients was 28.8 U/mL. Conclusion: Compared with CECT, 18F-FDG-PET/CT shows higher sensitivity in lesion-based analysis and better accuracy of patient selection for secondary cytoreduction. However, there is still a need for integration of the results of 18F-FDG-PET/CT, CECT, and CA-125 levels to aid treatment planning.
마이크로 픽셀구조와 Gd₂O₂S: Tb를 이용한 디지털 래디오그래피용 섬광체 패널의 제작
배공명(Kong Myeong Bae),정임덕(Im Deok Jung),이상민(Sang Min Lee),정필구(Phill Gu Jung),배승일(Seung Il Bae),김호경(Ho Kyung Kim),고종수(Jong Soo Ko) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5
The fabrication method of scintillator panel for digital radiography is proposed and demonstrated. The micro pixel structures were fabricated by DRIE(Deep Reactive Ion Etching) process and the scintillator was filled in the micro pixel structures using doctor blade. The micro pixel structures prevent the scattered visible light from spreading to neighboring pixels. The experimental results of X-ray image verified that the scintillator panel with smaller pixel size has better spatial resolution.