스코폴라민의 흰쥐 피부투과에 대한 투과촉진제들의 영향

정재영,감성훈,김건남,지상철,박은석 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

The transdermal therapeutic system (TTS) of scopolamine has various advantages over its oral dosage forms. The ideal scopolamine TTS requires high skin permeation rate in short time after it is applied on the skin. In order to increase the initial skin permeation rate of scopolamine from TTS, various permeation enhancers were employed. Enhancers employed were fatty acids(oleic and linolenic acids), cyclic monoterpenes(menthol, camphor, cineole and limonene) and others(isopropyl myristate, sodium lauryl sulfate and glyceryl monostearate). The concentration of enhancers in the base were fixed to 5% (w/w). While fatty acids had little enhancing effect on the skin permeation of scopolamine, cyclic monoterpenes, isopropyl myristate and sodium lauryl sulfate resulted in 1.5∼2.36-fold higher skin permeation rate of the drug compared to the control. However, lag time was not affected by enhancers studied.

무균성 뇌막염에 있어 뇌척수액 추적검사에 대한 재평가

정은경,김경석,김갑승,문경래,박상기 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

The author evaluated the clinical manifestation of forty cases of aseptic meningitis who were admitted in the pediatric department of the Chosun University Hospital from March 1990 to September 1990, and also observed the clinical course of two groups of aseptic meningitis divided by admitting time and reevaluated the needness of follow-up lumbar puncture for CSF examination. The author performed follow-up lumbar puncture for CSF examination to the first group, on the 7th hospital day by conventional way, otherwise only observed the clinical course without follow-up lumbar puncture for CSF examination to the 2nd group. There was no difference between both groups, and clinical improvement was seen in both groups. In conclusion, the author considers that if clinical and laboratory finding were compatible with aseptic meningitis, there may be no need for follow-up lumbar puncture for CSF exmenation.

장내의 탄수화물과 지방 흡수 억제를 통한 체지방 및 비만 개선 효과에 관한 연구

정은희,윤승원,이홍석,윤유식,유경미,황인경 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.1

In a previous study, a dietary supplement was developed in our lab using natural herbal extracts against digest enzyme activity in GI tract for weight control. This natural herbal extracts could regulate absorption of glucose and lipid by the inhibition of digest enzyme activity. In this study, we screened the natural herbs that inhibit glucoamylase activity and developed an water extract of cinnamon. The cinnamon extract delayed and decreased the increment of carbohydrate degradation through the inhibition of glucoamylase activity in vitro. Fifty volunteers were subjected to the intake of the herbal extracts by taking twice a day for 60 days. As a result, the treated subjects lost 3kg of body weight and 3.5kg of body fat mass after the treatment. Furthermore, the body mass index and waist size were significantly decreased during the experimental period. Above results suggested that the administration of the dietary additives composed of cinnamon and natural herbal extract improves the obesity by the decrement of body weight and body fat mass.

이트라코나졸의 경구용 액제 처방화

정기섭,홍지웅,최기송,지상철,박은석 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

The oral bioavailability of itraconazole is variable and low in fasting state. This is mainly due to the low solubility of this drug. Bioavailability can be improved by changing the formulation and it is general that the liquid preparations show greater bioavailability than the solid dosage forms such as tablets and capsules do. Benzyl alcohol-water binary mixture showed the excellent solubilizing capacity for itraconazole but the release of the drug from the preparation needs to be enhanced. In this study, various nonionic surfactants and hydrophilic polymers, poloxamers, were screened to investigate their effects on the release of itraconazole from the liquid preparations. Poloxamer 407 showed the most enhancing effect on the drug release and the release rate was proportional to the amount of poloxamer 407 added. A liquid preparation of itraconazole, consisting of benzyl alcohol/water/poloxamer 407 ternary solvent system, released more than 80% of the total drug amount at 5 min and showed the possibility of a new formulation development.

신체형장애와 정신신체장애 간의 임상증상 및 자아기능에 관한 비교 : SCL-90-R와 Bellak의 자아기능척도를 이용한 Using SCL-90-R and Bellak's Ego Function Scale

은흥석,안정숙,김학렬 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.6

The purpose of this study was to investigate the difference in clinical symptoms and ego function between somatoform disorder and psychosomatic disorder by using Symptom Check List-90-Revision(SCL-90-R) and Bellak's Ego function Scale(EFS). The sample consisted of 30 somatoform disorder patients, 30 psychosomatic disorder patients, and 30 normal controls. The results were as follows: 1) In SCL-90-R 7 sacle, mean T-scores on each subscale were within normal range in all groups, but scores of somatoform group were significantly higher than other groups. Somatoform and psychosomatic group had similar profiles and clinical symptoms however somatoform group showed severe symptom and tended to amplify symptoms. Anxiety and interpersonal sensitivity subscale did not show significant differences, but somatization, depression, obsessive-compulsive, hostility, phobic anxiety and paranoid ideation subscale showed significant differences between somatoform and psychosomatic groups(P<.05) 2) In EFS, mean scores of somatoform group were significantly lower than psychosomatic group in all EFS-subscales except object relations(P<.01). Mean scores of Psychosomatic group did not show significant differences from those of normal control group and profiles of psychosomatic group were similar to those of normal control group.

의과대학생의 불안 및 자아강도가 스트레스 대처방식에 미치는 영향

박재석,류설영,장은진,김정범 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.1

OGGI 유전자의 다형성이 방광암에 미치는 영향

김은정,정필두,정춘구,서정원,윤석중,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적 : 손상된 유전자의 회복은 암의 발생 및 예방에 중요한 역할을 한다. 잘못된 염기의 제거 및 회복에 중요한 역할을 하는 OGGI 유전자의 다형성이 방광암에 어떠한 작용을 하는지를 환자-대조군 연구를 통해서 조사하였다. 대상 및 방법: 방광암 환자 168명과 건강인 672명을 대조군으로 하여 genomic DNA를 이용하여 SSCP (single-stranded conformational polymorphism), direct DNA sequencing 및 restriction fragment length polymorphism (RFLP) 방법을 통해 환자 및 대조군사이의 OGGI 유전자의 다형성을 조사하였다. 결과: 건강 한국인에서 OGGI 유전자의 유전형을 조사한 결과 econ 6의 Pro324Pro 부위(lb type)와 exon 7의 Ser326Cys 부위 (la type)에 유전자의 다형성이 있음을 발견하였다. Codon 324는 silent polymorphic site였으나 codon 326은 C→G로 nucleotide가 바뀌어 amino acid가 serine→cysteine으로 바뀌는 polymorphic site였다. 대조군에서 codon 326은 Ser326Ser 형이 127례 (18.9%), Ser326Cys 형이 363례 (54.0%) 및 Cys326Cys 형이 182례 (27.1%)이었으며, 168명의 방광암 환자군에서는 Ser326Ser 형이 44례 (26.2%), Ser326Cys 형이 87례 (51.8%)이고 0ys3260ys 형이 37례 (22.0%) 이었다(p=0.034) 즉 Cys326Cys 형 및 Ser326cys 형에 비하여 Ser326Ser 형에서 방광암이 생길 확율이 1.52배 (95% CI=0.439-0.969) 높았다 특히 40세 미만의 남자의 경우 Ser326Ser 형에서 방광암 발생확률이 다른 유전형에 비하여 6.1배 높았다. 결론: OGGI 유전자의 유전형은 서구인과 판이하게 달랐으며 방광암에서는 이 유전자의 변이가 빈번할 뿐아니라 codon 326의 Ser326Ser 형에서는 다른 유전자형에 비하여 방광암이 발생할 확률이 1.5배 이상 높았다. 특히 한국인 40세 미만의 남자에서는 방광암 발생확률이 6배이상 높았다. 본 연구결과 OGGI codon 326의 유전적 다형성은 방광암의 종양화 과정과 관계가 있을 것으로 여겨지며 특히 40세 미만의 한국 남자의 경우는 더욱 밀접한 관계가 있을 것으로 사료된다. Purpose: A repair of damaged DNA has been shown to be involved in the susceptibility to cancer development and prevention. Therefore, it is worth investigating genetic polymorphisms of the OGGl gene associated with the gene repair mechanism. In this study, we examined a possible association of genetic ploymorphisms in OGGl with the risk of bladder tumor. Materials and Methods: Hospital based, case-control investigation was carried out in 168 primary bladder tumor patients and 672 control subjects. We performed the SSCP, PCR-based restriction fragment length polymorphism (RFLP) and direct DNA sequencing to characterize the genetic polymorphism of OGGI in both cases and oontrols. Results: We found two polymorphic sites in OGGl. A Ser/Cys polymorphism at codon 326 (la type) in exon 7 was associated with an exchange of amino acid. Another polymorphic site at codon 324 (1b type) in econ 6 was silent. The association between codon 326 Polymorphism and the risk of the bladder tumor was examined by a age-sex adjusted analysis. We found that the distribution of OGGl Ser326Cys genotypes of controls(Ser/Ser, 18.9% ; Ser/Cys, 54.0% ; Cys/Cys, 27.1%) was significantly different from that of bladder tumor patients (36.2%, 51.8% and 22.0%, respectively) (p = 0.034, adjusted OR = 0.652, 95% Cl = 0.44 - 0.97). Especially, bladder tumor risk in Korean male under 40 years old was approximately 6 times higher than over 40 years old males. Conclusion : Our data suggested that Ser326cys polymorphism at codon 326 of OGGl male below 40 years old in Korea significantly increased the risk of tumorigenesis in the urinary bladder (p = 0.015, adjusted OR = 0.165, 95% CI = 0.04 - 0.75) Our results suggest that the OGGl Ser326Cys Polymorphism might play a role in the tumorigenesis of the bladder.

학동기 비만아동의 피부두께의 통계적 관찰

김경석,나기찬,정은경,문경래,박상기,박영봉 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

The measurements of triceps skinfold thickness, body weight and height were done in children aged 7 to 12 years(3,142 boys and 2588 girls) in Kwangju in 1992. The author also observed degree of obesity, prevalence of obesity and average value of triceps skinfold thickness. The results were summarized as follows: 1) The mean value of triceps skinfold thickness acceding to age in male was 7 years 10.5mm, 8 years 10.5mm, 9 years 10.2mm, 10 years 12.3mm, 11 years 13.8mm, 12 years 12.3mm. In the female it was 7 years 11.9mm, 8 years 11.9mm, 9 years 11.6mm, 10 years 12.6mm, 11 years 14.1mm, 12 years 13.6mm. 2) The mean value of triceps skinfold thickness acceding to age in obese male was 7 years 16.3mm, 8 years 17.3mm, 9 years 16.0mm, 10 years 19.5mm, 11 years 23.7mm, 12 years 20.1mm. In the obese female it was 7 years 17.3mm, 8 years 17.9mm, 9 years 18.4mm, 10 years 19.5mm, 11 years 21.2mm, 12 years 20.3mm.

로드셀을 이용한 직물의 신축성 측정에 관한 연구

최정수,김은석,주기세,왕지남 한국경영과학회 2002 한국경영과학회 학술대회논문집 Vol.- No.1(1)

So far, the common elasticity data of textile fabrics has not been present because the method depends on the knowledge of measurement operators. In this paper, the new measurement equipment using road cell is presented to measure the coefficient of textile fabrics in real time. The measurement method is based on the volt: among textile fabrics. The textiles with strong elasticity are high voltage produced from others are low. The presented method can be applied to visualize the textile, sew the cloth, contrc textile fabrics. Also, these measurement datum are used to B2B electronic trading system.

세균성 뇌막염과 병발된 다엽성이면서 다발성인 화농성 뇌농양 1예

최용석,김정미,한영수,차경만,한정호,조은경,김두응 최신의학사 2004 最新醫學 Vol.47 No.1