강황(薑黃)과 울김(鬱金)의 역대문헌(歷代文獻)에 대(對)한 비교(比較) 연구(硏究)

김용률,이현정,정현종,금경수,Kim, Yong-Ryul,Lee, Hyun-Jeong,Jeong, Hyun-Jong,Keum, Kyung-Soo 대한한의정보학회 2011 大韓韓醫情報學會誌 Vol.17 No.1

This study covers the historical aspects of the turmeric and curcuma only in detail on the medicinal uses, supported by references to the medical texts. And the result is as follows: 1. Turmeric and curcuma are rhizomatous herbaceous perennial plants of the ginger family, but both produced on the same herb. The rhizome is considered turmeric while the tuber is considered curcuma. 2. Turmeric is the round, oval, or ovate, and scutiform rhizome. 3. Curcuma is yellowish externally, internally more or less orange-yellow passing into reddish-brown. The tuber has a round and cuspidate appearance. The smell is aromatic, somewhat analogous to ginger. 4. Turmeric is somewhat analogous to curcuma in shape, but turmeric is pungent and bitter in taste, warm and intoxious in property, and yellow in color, acting on the spleen and liver channels and governing the gi of the blood while curcuma is pungent and bitter in taste, cold and intoxious in property, red in color, acting on the heart and pericardium channels and governing the blood. 5. Turmeric is referred to zedoary, sliced turmeric, old jaundice, precious aromatic, and ovate rhizoma, and curcuma is referred to radix curcuma, curcuma aromatica, and cicada-belly curcuma

울금 처리에 따른 펌 중복 시술 모발의 손상도 및 형태 변화에 미치는 영향

양진모 ( Jin Mo Yang ),노정애 ( Jung Ae Roh ),리순화 ( Shun Hua Li ) 한국미용학회 2011 한국미용학회지 Vol.17 No.3

This study was to investigate effects of Curcuma longa L. (C. longa) on the damaged hair caused by repetitive permanents. For this, we have examined physical and morphological changes of damaged hair when pre-treated with C. longa and Poly Peptide Treatment (PPT) and post-treated with C. longa and SPA-T3 (Hair Recovery SPA Treatment 3). Also, the absorbance, tensile strength, and elongation rates were compared with each samples. After performing the tensile strength test, morphological changes of each were also observed by electron microscopy. As the frequency of permanent was increased, the absorbance value was increased from 0.078 to 0.170 and 0.280, and the tensile strength value was reduced from 158.17 to 132.65 and 12.31, indicating that levels of hair damage in each sample were gradually increased. The absorbance of hair sample treated with C. longa before repetitive permanents was reduced more than the one treated with repetitive permanents without C. longa. Also the former`s hair tensile strength value was increased more than the latter`s one, so the results showed that the C. longa treatment before repetitive permanents had certain effects protecting hair. For the case of 3-time permanents and then received C. longa and SPA-T3 treatment, the absorbance of the former panel only received 3-time permanents was decreased into 0.355, and the latter panel received C. longa treatment into 0.208. For the tensile strength values, the former panel with only 3-time permanents was increased into 121.32, and the latter panel with C. longa was increased into 128.90. These results showed that treatment with C. longa has certain effects protecting the hair. As the result observing the hair`s side and fractured side, the former panel hair was seriously damaged, its coherence was weaken, and separation was occurred between epidermis and cortex of hair. Contrary to these observations, the latter panel was observed that the float phenomenon became less in the epidermis of hair and the damage of cell membrane complexes between hair cortex was low. It is therefore considered that a product using the C. longa added to keratin and other nutrients will be used as a hair treatment goods caring damaged hair resulting from repetitive permanents as well as managing the hair`s epidermis-related troubles.

강황 추출물의 항산화 및 면역 활성 증진 효과

정지은,이은별,김시현,최지혜,김지수,김주희,정운율,최활,이유석,이성현 동아시아식생활학회 2022 동아시아식생활학회지 Vol.32 No.3

This study sought to investigate the antioxidant and immune-stimulatory effects of different Curcuma longa (C. longa) extracts based on their color (random, light, medium, dark orange), the soil of cultivation (clay, granite), drying temperature (50∼80℃), and extraction methods (water, ethanol). The antioxidant factors of C. longa were determined by the total phenolic content and DPPH and ABTS radical scavenging activities. The nitric oxide (NO) production of the macrophage cell line (RAW264.7) and the proliferation of splenocytes were investigated to assess the immune-enhancing effects of C. longa. The antioxidant activity was higher in the dark color and the ethanol extracts. All the types of extracts were nontoxic and enhanced the production of NO in RAW264.7 at less than 250 μg/mL of C. longa. When mouse splenocytes were exposed to various concentrations of hot water or ethanol extracts of C. longa with media, concanavalin A (Con A), lipopolysaccharide (LPS), and cyclophosphamide (CPA), their proliferation increased. Specifically, the 70% ethanol extract of C. longa showed the highest levels of splenocyte proliferation among all samples. These results suggest that the antioxidant and immune-stimulating activities of C. longa were most affected by the extracting solvent rather than color, soil in which it was cultured, and drying temperature. Appropriate extraction methods for C. longa should be researched further to develop good healthy foods with high antioxidant and immune-enhancing activities.

≪대한약전≫ 제9개정에서 Curcuma속(屬)의 한약명과 약성에 관한 연구

김인락 ( In Rak Kim ) 대한본초학회 2009 大韓本草學會誌 Vol.24 No.3

Objectives: The purpose of this study is to determine the herbal name and four Qi(四性) of genus curcuma in the Korea Pharmacopoeia ninth Edition. Methods: Compare with the name and four qi of genus curcuma from the Korea Pharmacopoeia ninth Edition and the other nation`s Pharmacopoeia and main herbal medicine books. Results: 1. The Rhizoma of Curcuma longa is called Kanghwang in KP 9, but is called Ulgeum in the main herbal medicine book. 2. The Rhizoma of genus curcuma except Curcuma longa is called Achul in KP 9, but is called Kanghwang in the main herbal medicine book. 3. The root of genus curcuma is called Ulgeum in KP 9, but is called Achul in the main herbal medicine book. 4. The four qi of the Rhizoma and Radix of genus curcuma is recorded worm and cold in the Ch. p 2005, but is recorded cold and worm in the main herbal medicine book. Conclusions: Kanghwang, Achul, Ulgeum in the KP 9 is equivalent Ulgeum, Kanghwang, Achul in the main herbal medicine book. The four qi of Rhizoma is cold, Radix is warm.

Quality Assessment of Curcuma longa L. by Gas Chromatography-Mass Spectrometry Fingerprint, Principle Components Analysis and Hierarchical Clustering Analysis

Ming Li,Xin Zhou,Yang Zhao,Xiao-Na Hu,Dao-Ping Wang 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.10

Gas Chromatography-Mass Spectrometry (GC-MS) fingerprint analysis, Principle Components Analysis (PCA),and Hierarchical Cluster Analysis (HCA) were introduced for quality assessment of Curcuma longa L. (C. longa).The GC-MS fingerprint method was developed and validated by analyzing 33 batches of samples of C. longa from different geographic locations. 18 chromatographic peaks were selected as characteristic peaks and their relative peak areas (RPA) were calculated for quantitative expression. Two principal components (PCs) were extracted by PCA. C. longa collected from Guizhou and Fujian were separated from other samples by PC1, capturing 71.83% of variance. While, PC2 contributed for their further separation, capturing 11.13% of variance. HCA confirmed the result of PCA analysis. Therefore, GC-MS fingerprint study with chemometric techniques provides a very flexible and reliable method for quality assessment of C. longa.

Quality Assessment of Curcuma longa L. by Gas Chromatography-Mass Spectrometry Fingerprint, Principle Components Analysis and Hierarchical Clustering Analysis

Li, Ming,Zhou, Xin,Zhao, Yang,Wang, Dao-Ping,Hu, Xiao-Na Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.10

Gas Chromatography-Mass Spectrometry (GC-MS) fingerprint analysis, Principle Components Analysis (PCA), and Hierarchical Cluster Analysis (HCA) were introduced for quality assessment of Curcuma longa L. (C. longa). The GC-MS fingerprint method was developed and validated by analyzing 33 batches of samples of C. longa from different geographic locations. 18 chromatographic peaks were selected as characteristic peaks and their relative peak areas (RPA) were calculated for quantitative expression. Two principal components (PCs) were extracted by PCA. C. longa collected from Guizhou and Fujian were separated from other samples by PC1, capturing 71.83% of variance. While, PC2 contributed for their further separation, capturing 11.13% of variance. HCA confirmed the result of PCA analysis. Therefore, GC-MS fingerprint study with chemometric techniques provides a very flexible and reliable method for quality assessment of C. longa.

Production of <small>L</small>- and <small>D</small>-lactic acid from waste <i>Curcuma longa</i> biomass through simultaneous saccharification and cofermentation

Nguyen, Cuong Mai,Kim, Jin-Seog,Nguyen, Thanh Ngoc,Kim, Seul Ki,Choi, Gyung Ja,Choi, Yong Ho,Jang, Kyoung Soo,Kim, Jin-Cheol Elsevier 2013 Bioresource technology Vol.146 No.-

<P><B>Abstract</B></P> <P>Simultaneous saccharification and cofermentation (SSCF) of <I>Curcuma longa</I> waste biomass obtained after turmeric extraction to <SMALL>L</SMALL>- and <SMALL>D</SMALL>-lactic acid by <I>Lactobacillus coryniformis</I> and <I>Lactobacillus paracasei</I>, respectively, was investigated. This is a rich, starchy, agro-industrial waste with potential for use in industrial applications. After optimizing the fermentation of the biomass by adjusting nitrogen sources, enzyme compositions, nitrogen concentrations, and raw material concentrations, the SSCF process was conducted in a 7-l jar fermentor at 140g dried material/L. The maximum lactic acid concentration, average productivity, reducing sugar conversion and lactic acid yield were 97.13g/L, 2.7g/L/h, 95.99% and 69.38g/100g dried material for <SMALL>L</SMALL>-lactic acid production, respectively and 91.61g/L, 2.08g/L/h, 90.53% and 65.43g/100g dried material for <SMALL>D</SMALL>-lactic acid production, respectively. The simple and efficient process described in this study could be utilized by <I>C. longa</I> residue-based lactic acid industries without requiring the alteration of plant equipment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A method for <SMALL>L</SMALL>- and <SMALL>D</SMALL>-lactic acid production from waste <I>Curcuma longa</I> biomass. </LI> <LI> The method produces <SMALL>L</SMALL>-lactic acid at 97.13g/L with productivity of 2.7g/L/h. </LI> <LI> The method produces <SMALL>D</SMALL>-lactic acid at 91.61 97.13g/L with productivity of 2.08g/L/h. </LI> <LI> This economical lactic acid production process using a renewable biomass has potential for industrial applications. </LI> </UL> </P>

The genome-wide expression profile of <i>Curcuma longa</i>-treated cisplatin-stimulated HEK293 cells

Sohn, Sung-Hwa,Ko, Eunjung,Chung, Hwan-Suck,Lee, Eun-Young,Kim, Sung-Hoon,Shin, Minkyu,Hong, Moochang,Bae, Hyunsu Blackwell Publishing Ltd 2010 British journal of clinical pharmacology Vol.70 No.4

<P><B>WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT</B></P><P>• High doses of cisplatin more effectively suppress cancer, but high dose therapy is limited by nephrotoxic side effects, Nephrotoxicity is of critical concern during the early stages of drug development when selecting new drug candidates. <I>Curcuma longa</I> (CL) has been widely used for its anti-inflammatory, antioxidant and antitumour activities and has been taken orally to treat dyspepsia, flatulence and liver and urinary tract disease.</P><P><B>WHAT THIS STUDY ADDS</B></P><P>• New information indicated that the mechanism responsible for the effects of CL on HEK 293 cells was closely associated with regulation of the NF&kgr;B pathway.</P><P>• This study confirmed the association of CL with the NF&kgr;B pathway.</P><P>• CL may be an effective therapeutic approach to the alleviation of the progression of renal disease through cell anti-apoptosis and proliferation that occurs via inhibition of the inflammatory cytokines and the NF&kgr;B signaling pathway.</P><P>AIM</P><P>The rhizome of turmeric, <I>Curcuma longa</I> (CL), is a herbal medicine used in many traditional prescriptions. It has previously been shown that CL treatment showed greater than 47% recovery from cisplatin-induced cell damage in human kidney HEK 293 cells. This study was conducted to evaluate the recovery mechanisms of CL that occur during cisplatin induced nephrotoxicity by examining the genome wide mRNA expression profiles of HEK 293 -cells.</P><P>METHOD</P><P>Recovery mechanisms of CL that occur during cisplatin-induced nephrotoxicity were determined by microarray, real-time PCR, immunofluorescent confocal microscopy and Western blot analysis.</P><P>RESULTS</P><P>The results of microarray analysis and real-time PCR revealed that NF&kgr;B pathway-related genes and apoptosis-related genes were down-regulated in CL-treated HEK 293 cells. In addition, immunofluorescent confocal microscopy and Western blot analysis revealed that NF&kgr;B p65 nuclear translocation was inhibited in CL-treated HEK 293 cells. Therefore, the mechanism responsible for the effects of CL on HEK 293 cells is closely associated with regulation of the NF&kgr;B pathway.</P><P>CONCLUSION</P><P>CL possesses novel therapeutic agents that can be used for the prevention or treatment of cisplatin-induced renal disorders.</P>

Fermented Curcuma longa L. Prevents Alcoholic Fatty Liver Disease in Mice by Regulating CYP2E1, SREBP-1c, and PPAR-α

이모은,남승희,윤호근,김신태,유양희,최경철,이유현,이정민,박정진,전우진 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.4

We examined the efficacy of fermented Curcuma longa L. (FT) on the development of alcoholic fatty liver in mice and investigated the underlying mechanism. The protective potential of FT against ethanol-induced fatty liver was determined using C57BL/6 male mice allocated into four groups (8 mice/group). Control groups received either distilled water or 5 g/kg body weight (b.w.) per day ethanol for 8 days. Treatment groups were administered either 300 mg/kg b.w. per day of milk thistle or FT before receiving ethanol. FT contained a higher amount of caffeic acid and tetrahydrocurcumin than C. longa. FT pretreatment significantly suppressed the elevated hepatic lipid droplets associated with ethanol ingestion. In comparison with ethanol-treated control, FT pretreated mice showed inhibited cytochrome P4502E1 (CYP2E1), sterol regulatory element-binding protein-1 (SREBP-1c), and acetyl-CoA carboxylase production but elevated AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha (PPAR-α), and carnitine palmitoyltransferase 1 (CPT-1) levels. Taken together, FT is a promising hepatoprotectant for preventing of alcoholic fatty liver through modulating fatty acid synthesis and oxidation.

Partially purified <i>Curcuma longa</i> inhibits alpha-melanocyte-stimulating hormone-stimulated melanogenesis through extracellular signal-regulated kinase or Akt activation-mediated signalling in B16F10 cells

Jang, Ji Yeon,Lee, Jun Hyuk,Jeong, Seong Yun,Chung, Kyung Tae,Choi, Yung Hyun,Choi, Byung Tae Blackwell Publishing Ltd 2009 Experimental dermatology Vol.18 No.8

<P>Abstract: </P><P>Bioassay-guided fractionation of <I>Curcuma longa</I> by solvent partitioning and purification with octadecylsilane open column chromatography yielded a partial purification. The active 80% methanol chromatographic fraction from the ethyl acetate layer [partial purification from <I>C. longa</I> (PPC)] was used to investigate the alpha-melanocyte-stimulating hormone (&agr;-MSH)-stimulated melanogenesis signal pathway in B16F10 cells. In cells stimulated &agr;-MSH, PPC inhibited cellular melanin contents, tyrosinase activity and expression of melanogenesis-related proteins including microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related proteins (TRP). Melanogenesis-regulating signalling such as mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3-kinase (PI3K)/Akt was activated by PPC in &agr;-MSH-stimulated B16F10 cells. The suppressive activity of PPC on &agr;-MSH-induced melanogenesis was abrogated by selective inhibition of MEK/ERK (PD98059) and PI3K (LY294002). MEK/ERK or Akt activation by PPC may contribute to reduced melanin synthesis via MITF and its downstream signal pathway including tyrosinase and TRPs in &agr;-MSH-induced melanogenesis.</P>