호중구 감소성 발열을 보인 고형암 환자의 임상양상 및 그람양성균 균혈증의 위험인자

구남수,김준형,최유경,정세진,오형중,윤기태,김연아,신소연,김명수,김영근,박윤선,최준용,송영구,이경원,김준명 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

목적 : 항암요법을 시행받고 호중구 감소성 발열이 발생한 고형암환자에서 임상양상을 분석하고 그람양성균균혈증의 위험인자를 알아보고자 하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 연세대학교 의과대학 세브란스 병원 종양내과에서 고형암으로 진단받고 항암요법을 시행받은 18세 이상의 암환자에서 호중구 감소성 발열이 있었던 288예를 대상으로 하였다. 결과 : 항암요법을 시행받은 고형암 환자 중 288예에서 호중구 감소성 발열이 발생하였다. 이중 원인을 찾을 수 있었던 경우는 130예로 전체 45.1% 이었으며 미생물학적 확인감염(microbiologically documented infection, MDI)은 53예(18.4%) 이었다. 균혈증이 동반된 호중구 감소성 발열의 원인균 분포를 보면 총 53예에서 그람양성균이 27예 분리되어 50.9%를 차지하였고 그람음성균이 25예(47.2%), 진균 1예(1.9%) 순이었다. 그람양성균 중에서 methicillin 내성 포도상구균의 비율은 35% 이었다. 호중구 감소성 발열 환자에서 그람양성균 균혈증의 독립적인 위험인자를 분석한 결과 중심정맥 카테터와 연관된 감염이 있는 경우, 구내 점막염이 발생한 경우, 그리고 피부 및 연조직 감염이 발생한 경우에서 그람양성균 균혈증의 위험이 높았다. 결론 : 호중구 감소성 발열이 발생한 고형암 환자에서그람양성균 균혈증이 가장 높은 빈도를 보였으며 특히 중심정맥 카테터와 연관된 감염이 있는 경우, 구내 점막염이 발생한 경우, 그리고 피부 및 연조직 감염이 발생한 경우에서 그람양성균 균혈증의 위험이 높음을 알 수 있었다. 따라서 호중구 감소성 발열이 발생한 고형암 환자에서 발열 당시에 위와 같은 위험인자가 있을 경우 glycopeptide의 조기 사용을 고려해야 할 것으로 사료되며 앞으로 더 많은 환자를 대상으로 하는 전향적 연구가 진행되어야 할 것으로 생각된다. Backgrounds : Recently, there has been a rise of prevalence of gram positive infection among cancer patients with febrile neutropenia. The proportion of antibiotic-resistant gram positive infection has been growing lately, especially in Korea, where the rate of MRSA infection was over 70%. It brings to careful consideration of early glycopeptide treatment in febrile neutropenic patients if gram positive infection is suspected. Also until now, most studies concerning febrile neutropenic patients were mainly related to hematologic malignancy rather than solid tumor. Materials and Methods : We evaluated clinical manifestations and risk factors for gram positive bacteremia in a cohort of 288 solid tumor patients who were more than 18 years old and had neutropenic fever after chemotherapy from January 2002 to December 2004 at the Department of Oncology, Yonsei Cancer Center, Seoul. Results : We identified the cause of fever in 130 (45.1%) cases, of which 53 (18.4%) cases were blood stream infection. Gram positive organism was isolated in 27 cases which comprises 50.9% of blood stream infections, followed by gram negative organism (47.2%) and fungus (1.9%). A logistic regression analysis revealed that gram positive bacteremia was associated independently with central venous catheter (CVC) infection, oropharyngeal mucositis, skin and soft tissue infection in febrile neutropenic patients with solid tumor. Conclusions : Gram positive bacteremia was common among febrile neutropenic patients in solid tumor and was associated with CVC infection, oropharyngeal mucositis, skin and soft tissue infection. The early use of glycopeptide must be taken into account in such conditions.

Frameshift Mutations in Repeat Sequences of ANK3, HACD4, TCP10L, TP53BP1, MFN1, LCMT2, RNMT, TRMT6, METTL8 and METTL16 Genes in Colon Cancers

Yeon, Su Yeon,Jo, Yun Sol,Choi, Eun Ji,Kim, Min Sung,Yoo, Nam Jin,Lee, Sug Hyung Springer-Verlag 2018 Pathology and Oncology Research Vol.24 No.3

손의 기능훈련이 실버세대의 정서변화에 미치는 효과

유수연(Yoo, Su Yeon),황성걸(Hwang, Sung Gul) 한국전시산업융합연구원 2015 한국과학예술융합학회 Vol.19 No.-

본 논문은 선행연구인 ‘조기인지장애의 뇌 활성화를 위한 기능성 장난감의 적응성 조사’에 근거한 후속연구로서, 실버세대에게 인지능력을 높이고 정서적 안정을 위한 손의 기능 훈련이 어떠한 영향을 주며 효과가 있는지를 알아보기 위한 사례중심 연구로 실시되었다. 선행연구에서 기능성 장난감을 통해 손의 움직임이 인지장애예방에 도움이 되고 있음을 알 수 있었으며, 본 연구를 통해 손의 기능 훈련과제를 제시하여 실버세대의 일상생활능력에 정서적으로 어떠한 효과가 있는지 알아보기 위해 정서측정도구(ARE) 검사를 실시하여 정서척도를 분석하는데 목표를 두었다. 본 연구는 선행연구를 비롯한 논문과 단행본을 포함한 도서?출판물을 통한 문헌조사와 과제를 이용한 실험으로 이루어졌다. 실험 연구대상은 기본적 의사소통과 손사용이 가능하나 지적기능과 기억력감소로 인하여 일상 생활능력에 부족함을 겪고 있는 75세 이상 85세 이하의 여성노인 5명을 S노인요양원 사회복지사의 추천을 받아 진행하였다. 훈련과제는 손가락뜨개질, 케른블록 활동 두 가지를 매주 1회씩 10회기로 나누어 실시하였다. 그 결과 손 기능 훈련과제 중에서 손가락뜨개질이 실버세대의 일상생활능력에 긍정정서에 효과가 있는 것으로 밝혀졌다. 앞으로도 실버세대의 정서안정이나 일상생활동작을 위한 유용한 훈련법을 고안하고 실천하는 연구가 지속적으로 이루어져야 할 것이다. This study was conducted focused on the case to research the effects of hand’s functional training on cognitive ability and emotional stability in silver generation as a follow-up study based on the preceding study, The Research on Adaptability of Functional Toys for Brain Activation in the Early Cognitive Impairments. Preceding studies showed that hand movements with functional toys helped prevent Cognitive Impairments. The purpose of this study was to analyze emotion scale by conducting inspection with Apparent Emotion Rating Instrument(ARE) to research emotional effects on daily life abilities, presenting hand’s functional training tasks to silver generation. This research was conducted in following methods : literature surveys of preceding studies, publications ( including theses and book ), and experiments with tasks. The subjects for this study were five elderly women from 75 to 85, who had basic communication ability and hand function but suffered from lack of daily life abilities because of decreased intellectual skill and memory, recommended by a social worker in the S. Nursing Home. The training tasks were hand knitting and Kern Block play carried out once a week for ten sessions. The findings from the study were that hand knitting of two tasks had a positive emotional effect on daily life abilities of silver generation. It is necessary to consistently study and practice training methods for emotional stability and daily life movements in silver generation.

Evidence-based clinical recommendations for hypofractionated radiotherapy: exploring efficacy and safety - Part 2. Lung (non-small cell lung cancer)

Kwak Yoo-Kang,Kim Kyung Su,Yoo Gyu Sang,Byun Hwa Kyung,Kim Yeon Joo,Kim Yeon-Sil,Sung Soo-Yoon,Song Jin Ho,Kim Byoung Hyuck 대한방사선종양학회 2024 대한방사선종양학회지 Vol.42 No.2

Several recent studies have investigated the use of hypofractionated radiotherapy (HFRT) for various cancers. However, HFRT for non-small cell lung cancer (NSCLC) with or without concurrent chemotherapy is not yet widely used because of concerns about serious side effects and the lack of evidence for improved treatment results. Investigations of HFRT with concurrent chemotherapy in NSCLC have usually been performed in single-arm studies and with a small number of patients, so there are not yet sufficient data. Therefore, the Korean Society for Radiation Oncology Practice Guidelines Committee planned this review article to summarize the evidence on HFRT so far and provide it to radiation oncology clinicians. In summary, HFRT has demonstrated promising results, and the reviewed data support its feasibility and comparable efficacy for the treatment of locally advanced NSCLC. The incidence and severity of esophageal toxicity have been identified as major concerns, particularly when treating large fraction sizes. Strategies, such as esophagus-sparing techniques, image guidance, and dose constraints, may help mitigate this problem and improve treatment tolerability. Continued research and clinical trials are essential to refine treatment strategies, identify optimal patient selection criteria, and enhance therapeutic outcomes.

손 기능훈련이 노인의 인지력향상과 정서변화에 미치는 효과연구

유수연(Yoo, Su Yeon),황성걸(Hwang, Sung Gul) 한국전시산업융합연구원 2015 한국과학예술융합학회 Vol.21 No.-

본 연구의 배경 및 목적은 다음과 같다. 현대사회는 의료기술의 발전과 생활수준의 향상으로 인간의 수명이 연장되었으며, 그에 따라 세계적으로 노령인구의 급증현상이 나타나고 있다. 따라서 노인의 돌봄, 건강관리, 상담 등 국민적 수요가 큰 유망사회 서비스 및 부처간 융 · 복합 서비스 연구와 발굴 및 확대 · 제도화가 이루어지고 있다. 우리나라도 노인문제 중 ‘노인건강과 노인 조기인지장애 예방을 위한 프로그램개발’에 대하여 무엇보다 중요하게 인식하고 논의되어야 할 사회적 문제로 등장하였다. 하지만 아직 노인건강과 노인의 인지장애에 대한 복합적인 대응책이 제대로 마련되지 못한 실정이다. 노년의 건강한 삶과 역동적인 생활을 위한 두뇌 활성화에 대해 많은 관심이 집중되고 있는 현실 속에서 뇌 활성화를 통해 노인의 인지력 유지와 향상이 가능하다는 긍정적인 보고가 제기되고 있다. 따라서 본 연구는 생활 속에서 즐기면서 훈련 가능한 Tool Kit프로그램을 제시하고, 인지장애예방을 위한 실증적 검증을 통하여 노령화 사회의 노인성 질환에 대한 당면과제를 해결할 수 있는 적극적 방법을 모색하고자 다음과 같이 연구를 진행하였으며 그 결과는 다음과 같다. 첫째, 연구대상인 노인의 인체특성에 대해서 이론적인 이해를 도모했다. 둘째, 뇌 활성화 향상을 위한 손 기능훈련의 효과를 검증하기 위해 손의 구조와 기능에 대하여 조사하고 선행연구를 통하여 검증하였다. 셋째, Tool Kit프로그램의 적용이 노인의 인지력향상과 정서변화에 미치는 효과를 검증하기 위해 Newell과 Rosenbloom(1981년)의 ‘손의 능숙도 훈련’과 산더 등이 1997년에 개발한 정서변화 측정도구 AER을 사용하여 결과를 도출하였다. 넷째, 본 연구 결과에 대해 기술하고 Tool Kit프로그램의 향 후 지속 가능한 방안에 대해서 제언하였다. The purpose and background of this study are as follows. Advances in medical technology and improvement in standards of living of modern society enable life extension and a consequential bulge in an aged population. So promising society service in great demand like caring, health management and counsel for the elderly and interdepartmental convergence service are researched, developed, enlarged and institutionalized. Korea has recognized the importance of the aged issue focused on the development of programs related to health and early cognitive impairment for the aged. However we don’t have comprehensive measures for health and cognitive disorder of the elderly. Recently the brain activation for healthy and dynamic life of the aged has been at the center of attention. Moreover positive reports has been suggested saying possibility of keeping and improving cognitive ability of the aged through brain activation. The purpose of this study are to suggest Tool Kit program that can train the elderly enjoying in everyday life and to find an active way to solve geriatric disorder in an aging society. For the purpose, this study was conducted as follows. First, body characteristics of the aged were promoted theoretically. Second, the structure and function of hands were studied and preceding studies were researched to verify the effects of hand function training. Third, this study deduced results by using “the Competence Training of Hands” (Newell &Rosenbloom, 1981) and “Apparent Emotion Rating Instrument: ARE” (Sander et al, 1997) to verify the effects of Tool Kit Program on the cognitive enhancement and emotional change of the elderly. Finally, this study described the results of this research and suggested sustainable measures of Tool Kit Program.

Thematic Poster : TP-46 ; Promoter Methylation of MIR137 and Its Clinical Significance in Surgically Resected Lung Cancer

( Nah Yeon Kang ),( Su Yeon Choi ),( Young Kyoon Kim ),( Ie Ryung Yoo ),( Dae Hee Han ),( Dong Soo Lee ),( Yeon Sil Kim ),( Sook Hee Hong ),( Jin Hyoung Kang ),( Kyo Young Lee ),( Jae Gil Park ),( Soo 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: Recent studies suggest that miR-137 functions as tumor suppressor in various tumors including colorectal cancer, glioblastoma multiforme, oral cancer, and squamous cell carcinoma of the head and neck. The silencing of miR-137 could be related with its abnormal promoter hypermethylation. The purpose of this study was to investigate the significance of MIR137 promoter methylation in lung cancer. Methods: Lung cancer cell lines were treated with DNA methyltransferase inhibitor (5’-Aza) and/or HDAC inhibitor (Trichostatin A) whether miR-137 could be reactivated. From paired tumor and adjacent non-tumor lung tissues (n=50), real-time RT-PCR for miR-137 expression and cyclin dependent kinase 6 (CDK6), quantitative methylation specific PCR for methylation analysis, and bisulfite modified DNA sequencing for validation were used for the study. Results: miR-137 was reactivated by treatment with 5’-Aza and/or Trichostatin A in lung cancer cell lines. miR-137 was significantly downregulated and CDK6 was significantly upregulated in lung tumor tissues compared with adjacent non-tumor tissues. Quantitative methylation specific PCR showed increased MIR137 promoter methylation in lung tumor tissues compared with adjacent non-tumor tissues, which was further validated with bisulfite sequencing. Conclusions: These results suggest that miR-137 has a role of tumor suppressor and its expression is regulated by promoter methylation. The decreased expression of miR-137 combined with increased expression of CDK6 could be associated with lung cancer carcinogenesis.

창의적 조형창조를 위한 종이블록 디자인제안

유수연(Su Yeon Yoo),김병수(Byung Soo Kim) 한국디자인문화학회 2012 한국디자인문화학회지 Vol.18 No.4

본 연구의 목적은 창의적 조형창조를 위한 블록놀이의 현황조사에 따른 블록디자인의 제안이다. 기존의 입체적인 형태감각의 개발을 위한 목재나 플라스틱과 같은 재질로 만들어진 일반적인 블록은 판형으로 이루어짐으로써, 일정한 형태의 구조물을 만들기 위해서는 많은 양의 블록이 필요할 뿐만 아니라 완성된 구조물의 부피가 커질 수밖에 없는 문제가 있다. 하지만 본 연구에서 제시하는 종이블록의 디자인은 90X45(mm) 의 사각형 종이재질의 판형으로 이루어지고 그 가장 자리에 중앙을 향한 다수의 결합 공을 형성함으로써 작은 비용과 설비로 간단하게 제작할 수 있으며 다양한 형상의 입체 조형물을 작은 부피로 쉽게 조립할 수 있도록 하였다. 이를 이용해서 어린이의 창의적 조형 활동에 대한 연구를 형태별로 살펴 본 결과, 정형적인 삼각형, 사각형, 오각형 등의 다양한 다면체형태의 입체 구조물을 만들 수 있었으며, 우연히 행해지는 조형 창의 놀이에서의 비정형적인 형태들, 그리고 창작자와 환경 간의 유기적인 상호관계를 나타낼 수 있는 공간적 측면의 구조물 창조 등의 다양한 활동이 관찰되었다. 본 연구의 주된 내용과 결과로서 종이라는 재질과 간단한 구조를 지닌 블록디자인을 통해 창의적 조형창조의 새로운 시도가 가능한 점을 알 수 있었고, 앞으로 보다 다양한 구조물 창조와 더불어 창의력 향상의 효과검증을 위한 후속연구의 기초로 삼고자 한다. The purpose of this study suggests a block design based on research into the block play activities. Typical blocks for the development of a sense of three-dimensional shape are made of wood or plastic, and they have volume inside themselves but are not a thin layer style. Thus there are problems that those blocks are bound to increase the volume of the finished structure, as well as it requires a large number of blocks to make certain types of structures. However, the paper block design presented in this research can be easily produced with less cost and fewer equipments, and the design allows users to assemble the blocks, ending up creating various styles of three-dimensional models with a small volume because the block design is a rectangular plate type(90X45mm) made from paper and there are a lot of holes for joining on its edge toward the center. With those blocks, children`s creative modeling activity types were investigated, and they showed that various types of polyhedron models such as typical triangle, square, and pentagonal ones could be built with the blocks. Moreover various activities such as making atypical shapes in the modeling plays happening by accident and building structures of spatial aspects representing the organic interrelationship between the originator and the environment were found. Thus, through the block design made from paper and with the simple structure, it was found that a creative new approach to the creation of form and structure is possible. It is hoped that this study becomes the foundation of further research for verification of creativity improvement along with the creation of more various structures.

주요기반시설 서비스의 안정적 운영을 위한 보안 프레임워크 설계에 관한 연구

이수연(Su yeon Lee),유지연(Ji yeon Yoo),임종인(Jong in Lim) 한국IT서비스학회 2016 한국IT서비스학회지 Vol.15 No.4

Critical infrastructure has been operating in a closed environment with a completely separate information system and in the private area. However, with the current ICT environment changes due to convergence and open platforms it has increased the threats and risks to critical infrastructure. The importance of cyber security is increasing in the infrastructure control system, such as the outbreak of Ukraine blackout in 2015 by a malicious code called black energy . This thesis aims to recognize the importance and necessity of protecting the critical infrastructure service, designing a security framework reflecting environmental and characteristic changes, and analyzing the management system suitable for a security framework. We also propose a theoretical basis for constructing a new security framework by comparing and analyzing seven international security management system standards, such as NIST 800-82 and IEC 62443-2-1, which are used in the control system. As a result, the environment surrounding critical infrastructure changes with the characteristics of connectivity, openness, and finality was studied, and as a response to this, many scholars and institutions present critical infrastructure security frameworks as cycle enhancement type structures, risk management structures, and management domain expansion structures. In response, the security framework encompassing these structures, CISF (Critical Infrastructure Security Framework), was designed. Additionally, through the security related international standard and criterion analysis, as a newly designed security standard suitable for CISF, IEC 62443-2-1 is reviewed and suggestions are made.

EV용 고효율 급속 충전기를 위한 비엔나 정류기 제어

유연수(Yeon-Su Yoo),김지환(Ji-hwan Kim),정성문(Sung-mun Jeong),박영훈(Young-hun Park ),신민호(Min-ho Shin),원충연(Chung-Yuen Won) 한국조명·전기설비학회 2018 한국조명·전기설비학회 학술대회논문집 Vol.2018 No.5

PCA-SVM 기반의 SMPS 고장예지에 관한 연구

유연수(Yeon-Su Yoo),김동현(Dong-Hyeon Kim),김설(Seol Kim),허장욱(Jang-Wook Hur) 한국기계가공학회 2020 한국기계가공학회지 Vol.19 No.9

With the 4th industrial revolution, condition monitoring using machine learning techniques has become popular among researchers. An overload due to complex operations causes several irregularities in MOSFETs. This study investigated the acquired voltage to analyze the overcurrent effects on MOSFETs using a failure mode effect analysis (FMEA). The results indicated that the voltage pattern changes greatly when the current is beyond the threshold value. Several features were extracted from the collected voltage signals that indicate the health state of a switched-mode power supply (SMPS). Then, the data were reduced to a smaller sample space by using a principal component analysis (PCA). A robust machine learning algorithm, the support vector machine (SVM), was used to classify different health states of an SMPS, and the classification results are presented for different parameters. An SVM approach assisted by a PCA algorithm provides a strong fault diagnosis framework for an SMPS.