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간호대학생이 지각하는 임상실습지도자의 교수효율성과 임상실습만족도의 관계
황현아,김희진,김예지,이규희,이영롱,박성희,손수빈 이화여자대학교 간호과학대학 2012 이화간호학회지 Vol.- No.46
Purpose: The purpose of this study was to investigate the relationship between teaching effectiveness and clinical practice satisfaction among nursing students. Method: The subjects of this study were 107 junior and senior nursing students in E university. Data were collected using self-reported questionnaire including general and practicum related characteristics, teaching effectiveness of clinical instructors and clinical practice satisfaction from September 12 to September 21, 2011. Collected data were analyzed by SPSS 19 program using t-test, ANOVA with Scheffe test, and Pearson`s correlation coefficients. Result: The mean score of teaching effectiveness was 3.35(±.51), and mean of clinical practice satisfaction was 3.19±.47. There were significant differences of teaching effectiveness of clinical instrutor by satisfaction of overall clinical practicum(F=8.332, p<.001), satisfaction of practice hour(F=3.230, p=.044), and satisfaction of major(F=9.883, p<.001). There were significant differences of clinical practice satisfaction by grade(t=2.274, p=.025), motive of choosing nursing science as a major(F=3.329, p=.007), satisfaction of overall clinical practicum(F=17.437, p<.001), satisfaction of practice hours(F=9.925, p<.001), and satisfaction of nursing major(F=12.748, p<.001). Relationship between teaching effectiveness of clinical instructor and clinical practice satisfaction showed positive correlation(r=.704, p<.001). Conclusion: In this study, teaching effectiveness of clinical instructor was related with clinical practice satisfaction. Therefore, we should consider improving teaching effectiveness of clinical instructor to improve clinical practice satisfaction.
Ye Ji Son,Eun Jung Thak,Dong-Jik Lee,Hyun Ah Kang 한국당과학회 2022 한국당과학회 학술대회 Vol.2022 No.07
The human fungal pathogen Cryptococcus neoformans assembles O-linked mannosyl glycans on its proteins in two types; Ktr3p-meidated major-O-glycans without xylose and Cap6-mediated minor-O-glycans without xylose, respectively1. The C. neoformans ktr3Δcap6Δ double mutant strain was constructed to block completely O-mannosylation extension in the Golgi. The ktr3Δcap6Δ strain accumulated the O-glycans carrying only a single mannose and displayed defective growth under several stress conditions, accompanied with completely attenuated virulence in a mouse model of cryptococcosis. By RNA-Seq-based transcriptome analysis, we investigated the effect of defective O-mannosylation on the stress-responsive signaling pathways associated with virulence. The comparative transcriptome analysis of the wild-type (WT) and ktr3Δcap6Δ cells under normal growth and tunicamycin (TM) treatment conditions, respectively, revealed the decreased induction of Mpk1p-and calcineurin-Crz1-mediated cell wall integrity (CWI) signaling pathways. Furthermore, we examined the possible change of physiochemical properties of cell surface in the ktr3Δcap6Δ cells, by profile analysis of N-linked glycans assembled on cell wall proteins, flow cytometry analysis of cell wall components, and filipin-staining analysis of erogosterol. Although no apparent difference in the total amount and overall length of N-glycans was observed, the N-glycan profile of ktr3Δ cap6Δ showed a marginal change with the decreased neutral glycan peaks and increased acidic glycan peaks compared to that of the WT strain. We also observed the slightly increased amount of chitin in ktr3Δ cap6Δ, which might reflect the compensation mechanism of defective CWI. Notably, the ktr3Δ cap6Δ cells showed defective trafficking of ergosterol, an immunoactive fungal molecule, from the ER to the plasma membrane. In conclusion, our results demonstrate the importance of extended O-glycan structure for cell wall integrity signaling and physiochemical properties of cell surface, which critically affect the survival in the host cell environments and the interaction with host cells of C. neoformans during infection process.
Pyruvate Kinase M2 : A Novel Biomarker for the Early Detection of Acute Kidney Injury
Ji Hyun Cheon,Sun Young Kim,Ji Yeon Son,Ye Rim Kang,Ji Hye An,Ji Hoon Kwon,Ho Sub Song,Aree Moon,Byung Mu Lee,Hyung Sik Kim 한국독성학회 2016 Toxicological Research Vol.32 No.1
The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidity and mortality. Conventional biomarkers, such as serum creatinine (SCr) and blood urea nitrogen (BUN), are frequently used to diagnose AKI. However, these biomarkers increase only after significant structural damage has occurred. Recent efforts have focused on identification and validation of new noninvasive biomarkers for the early detection of AKI, prior to extensive structural damage. Furthermore, AKI biomarkers can provide valuable insight into the molecular mechanisms of this complex and heterogeneous disease. Our previous study suggested that pyruvate kinase M2 (PKM2), which is excreted in the urine, is a sensitive biomarker for nephrotoxicity. To appropriately and optimally utilize PKM2 as a biomarker for AKI requires its complete characterization. This review highlights the major studies that have addressed the diagnostic and prognostic predictive power of biomarkers for AKI and assesses the potential usage of PKM2 as an early biomarker for AKI. We summarize the current state of knowledge regarding the role of biomarkers and the molecular and cellular mechanisms of AKI. This review will elucidate the biological basis of specific biomarkers that will contribute to improving the early detection and diagnosis of AKI.
천식 환자에서 전반적 자기 평가와 한국 성인 천식 환자의 삶의 질 평가 설문과의 비교 분석
정지예 ( Ji Ye Jung ),손지영 ( Ji Young Son ),홍수정 ( Soo Jung Hong ),이용원 ( Yong Won Lee ),신유섭 ( Yu Seob Sin ),박중원 ( Jung Won Park ),홍천수 ( Chein Soo Hong ) 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.2
Background: The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA) is a valid and reproducible tool for evaluating and monitoring Korean adult asthmatics. However, the questionnaire is still burden to some patients, so we developed a simplified global self-assessment scoring. Objective: The goal of this study is to compare the patient``s global self-assessment scoring method with the QLQAKA and evaluate how it reflects quality of life (QOL) of asthmatics. Method: One hundred ninety-nine adult asthmatics were enrolled and asked to answer the QLQAKA composed of 17 items in 4 domains (activity, symptom, emotion and exposure to environmental stimuli) and one more global self-assessment question with a 5-point scale was added. According to the Global Initiative for Asthma (GINA) 2006 guidelines, patients were divided into 3 groups: controlled, partly controlled and uncontrolled groups. Then, we analyzed the relationships between the QLQAKA scores, global self-assessment scores and various clinical parameters. Result: The mean QLQAKA score and global self-assessment score were statistically significantly different between the 3 groups. Pulmonary function tests were also statistically significantly different between the 5 QLQAKA score subgroups as well as 5 self-assessment score subgroups. Moreover, global self-assessment scores were well correlated with QLQAKA scores. Conclusion: In a busy outpatient clinic, we may estimate the QOL of asthma patients using a simplified patient``s global self-assessment scoring method. (Korean J Asthma Allergy Clin Immunol 2008;28:134-142)
배전계통의 태양광 수용용량 증대를 위한 지원금 기반 프로슈머 자가소비 최적화 기법
손예지(Ye-Ji Son),임세헌(Se-Heon Lim),윤성국(Sung-Guk Yoon) 대한전기학회 2021 전기학회논문지 Vol.70 No.4
In the power industry, renewable energy has been adopting into the power system to reduce global warming. However, renewable energy expansion such as solar photovoltaic (PV) raises a voltage stability issue for distribution systems. This work proposes a prosumers’ self-consumption optimization scheme through subsidy to increase the hosting capacity of solar PV in distribution systems. Therefore, it reduces cost and increases the utilization of solar PV. We investigate a case study using the IEEE 15 bus test model. The case study confirms that the overvoltage problem is solved by changing the prosumers’ power consumption pattern due to the subsidy. Therefore, the hosting capacity increases without system reinforcement and curtailment.