한국인 임신부에 있어서 영양소의 역가측정

최기영,김웅철,박기현,배도환 중앙대학교 의과대학 의과학연구소 1982 中央醫大誌 Vol.7 No.2

Animal and human studies indicated that inadequate diet for a prolonged period during pregnancy could injure mother, child, or both. In order to prevent this problem, maternal nutyitional status during pregnancy is very important and the evaluation of nutrition during pregnancy have been preceded by many authors in another countries. In Korea, nutrient intake studies of the pregnant women and nutrition surveys in adult by biochemical method have been performed, but there are no data nutrition surveys of Korean pregnant women have been made by biochemical method. In this regard, an exact biochemical titer of the nutrients and the degree of nutrient deficits in Korean pregnant women are needed. In this study, the mean titer of some nutrients and the degree of nutrient deficits by biochemical method in Korean pregnant women were assessed. The objected materials were consisted of 30 cases which had visited the departmant of Obstetrics & Gynecology, Chung Ang University Hospital for antenatal care(32wk-40wk) from March, 1981 to June, 1981. The cases with twin pregnancy, and the cases complicated with materal chronic wasting disease, diabetes, hydroamniosis, hypertensive disorder in pregnancy were excluded in this study. The results were as follows: 1. Mean titer of 6 hours urine execretion of thiamine, riboflavin and N'-methylniacinamide in Korean pregnant women was 44㎍, 466㎍, and 2.33㎎. 2. Mean titer of serum vitamin A, carotene, vitamin C, total protein, calcium, phosphorus, iron and total lipid was 48.1㎍, 154.7㎍, 0.8㎎, 7.0g, 9.8㎎ 3.5㎎, 93㎍, and 578㎎. 3. Percentage of nutrient deficits in Korean pregnant women based on the mean titer of Korean adults was as follow; thiamine-20%, N'-methylniacinamide-7%, total protein-5%, calcuim13%, iron-19%. 4. No cases were deficient in riboflavin, carotene, phosphorus, total lipid and the mean titer of riboflavin and carotene in Korean pregnant women were high compared with thw mean titer of Korean adults.

京畿道의 植物相 : 태화산, 화야산, 대부도, 칠현산, 철마산, 검단산

崔道烈,張珍成,金正猷,全正壹,金輝,閔雄基,姜佑昌 서울대학교 수목원 2001 서울大學校 樹木園 硏究報告 Vol.- No.21

This study was conducted in order to explore general flora of the Gyounggi-do Province and to clarify the distribution of some specificated taxa of the Korea. Daebu-do Island, Mt. Taewha, Mt. Hwaya, Mt. Gumdan, Mt. Chilhyun and Mt. Chulma among eighth grade-area of the Degree of Green Naturality (DGN) within the boundary of the Gyounggi-do Province were visited to investigate local flora. The number of identified vascular plant species were as follow; Mt. Hwaya: 120 species (99 genera of 67 families), Mt. Teawha: 132 species (103 genera of 56 families), Daebu-do Island: 124 species (103 genera of 50 families), Mt. Chulma: 129 species (99 genera of 67 families), Mt. Gumdan: 121 species (96 genera of 52 families), Mt. Chilyun: 90 species (74 genera of 42 families). The endemic Clematis brachyura Maxim. was found to distribute Daeby-do. It seemed that plantation was occupying large area in forest of the Gyounggi-do Province. Forty two specificated taxa were identified and 3 taxa, 10 taxa, 5 taxa, and 24 taxa were sorted into forth grade, third grade, second grade, and first grade respectively. Mt. Taewha showed the highest record (16 taxa) in the number of specificated taxa, Mt. Hwaya was the next with 13 taxa. Mt, Chulma (12 taxa), Mt. Gumdan (11 taxa), Daebu-do Island (7 taxi), and Mt, Chylma (4 taxi) followed. Mt. Taewa and Mt. Whaya were found to be relatively higher in the score calculated front the specificated taxa distribution, while Daebu-do Island and Mt. Chilyun were lower, that difference was probably due in part to consequences of severe disturbance of human activities. With respect to the consequences of severe disturbance of human activities. With respect to the geographical proximity to the Gangwon Province, Mt. Hwaya showed higher similarity of the species composition to that of the Mt. Jumbong.

大岩山의 植物相

閔雄基,張珍成,全正壹,金輝,崔道烈,鄭承洙 서울대학교 수목원 2000 서울大學校 樹木園 硏究報告 Vol.- No.20

This study was carried out to investigate the flora of Mts. Dae-am, Dae-woo, Baek-suk, and Sa-myung located on the east side of DMZ in province Yang-gu-gun, from July 1999 to August 2000. Although two hundred and fifty eight vascular plant taxa (70 families 167 genera) were recorded, this was only a part of representatives in this community because of the restrictin of collections within the military zone. The overall forest stand age of this area was 40 to 50 years, but occasionally ca 70 years old trees were found. We reported 11 taxa of the rare and endangered species proposed by the Ministry of Environment in this area. The Yong-neup, the only high altitude (alt. 1,200m) moore in south Korea, are located in the peak of Mt. Dae-am-san. Some species of this moore (Carex chordorrhiza Ehrh., Carex limosa L., and Gentiana jamesii Hemsl.) - were only found in south Korea. This moor would suffer vegetation change by natural moorland succession and human disturbances. The long-term monitoring of variation of annual vegetation, species distribution, numbers and distribution pattern of individuals of rare species are recommended for the wetland conservation.

Trichloroethyene 처리한 흰쥐의 이물질 대사효소의 활성도에 관한 연구

김기웅,강성규,최병순,이종성,김종성,문영한 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.2

Trichloroethylene(TRI) is one of the most widely used organic solvent in many industries. It is used a degreasing agent, extract and dillution solvents. TRI is metabolized by liver microsomal cytochrome P450 to reactive intermediates, which are considered responsible for its hepatotoxicity. Cytochrome P450 is a key enzyme in the first step of TRI metabolism resulting in chloral hydrate(CH) formation, which is a rate-limiting step in TRI metalbolism. This study was performed to find change of hepatic cytochrome P$%) levels and of electron transport system for P-450 dependent reaction. Injections of TRI were done to the male Sprague Dawley rats(mean body wights, 170±10g) in corn the dosage of 150,300,600 ㎎/㎏ for 2 days. The results of experiments are following: 1. The contents of microsomal protein, cytochrome P450 and b5 are tended to be decreased with increasing amount of TRI, but not signifcantlly(p>0.05). 2. The activity of NADPH-cytochrome P450 reductase is slowly decreased by increasing amount of TRI, but not significantlly(p>0.05). On the other hand, the activity of NADH-b5 reductase is increased with increasing amount of TRI(p<0.05). 3. The activity of 7-ethoxyresolufin O-deethylase did not show any critical changes(P>0.05). This result suggests that the inductive pattern of TRI may not be related to P 450IA1 and P450IIB.

DC 배열을 이용한 JPEG 와 MPEG 압축 동화상 영상의 일시적인 세분화 연구

이웅기,최봉한 조선대학교 기초과학연구소 1996 自然科學硏究 Vol.19 No.1

연상 압축은 원 영상에서 허용되는 데이타의 질과 명료도와 간결성을 보존하면서 데이타를 최대한 압축하려는 것이다. 그러므로 영상 압축은 영상이 전송될 때 통신 채녈의 대역폭을 줄이거나 최소한의 영상 데이타에 포함된 중복성을 제거함으로서 영상 데이타를 다양한 비율로 압축할 수 있으며, 최소한의 저장 공간을 이용하여 방대한 영상 데이타를 전송및 저장하는 데 이용된다. 최근 영상 정보의 압축을 위한 여러가지 알고리즘이 제안되고 있으나, 이러한 연구들은 대부분 압축율 개선에 중점을 두기 때문에 원 영상으로 복원할 때 많은 문제점을 야기 시킨다. 따라서 본 논문에서는 JPEG의 표준인 이산 여현변환을 이용하는 영상 압축에서 영상 복원시 나타나는 문제점중 JPEG, MPEG 동화상 영상에서의 압축을 푸는 과정 없이 영상 데이타를 DC 배열(Sequence)상에서 작동한다. JPEG와 MPEG 압축 동화상 화면에서 갑작스럽고 점진적으로 변화하는 화면을 찾아내는 알고리즘을 개발한다. DC 이미지들은 중요하고, 전체적인 정보를 다 포함하고 있다. 이런 이미지들로 작업하는 것은 계산상 절약할 수 있다. 시뮬레이션 실험 결과 제안된 알고리즘이 기존에 사용한 알고리즘 보다 갑작스럽고 점진적으로 변화하는 화면을 찾아내는데 빠르고 효율적이라는 것을 보여주었다.

이트라코나졸의 경구용 액제 처방화

정기섭,홍지웅,최기송,지상철,박은석 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

The oral bioavailability of itraconazole is variable and low in fasting state. This is mainly due to the low solubility of this drug. Bioavailability can be improved by changing the formulation and it is general that the liquid preparations show greater bioavailability than the solid dosage forms such as tablets and capsules do. Benzyl alcohol-water binary mixture showed the excellent solubilizing capacity for itraconazole but the release of the drug from the preparation needs to be enhanced. In this study, various nonionic surfactants and hydrophilic polymers, poloxamers, were screened to investigate their effects on the release of itraconazole from the liquid preparations. Poloxamer 407 showed the most enhancing effect on the drug release and the release rate was proportional to the amount of poloxamer 407 added. A liquid preparation of itraconazole, consisting of benzyl alcohol/water/poloxamer 407 ternary solvent system, released more than 80% of the total drug amount at 5 min and showed the possibility of a new formulation development.

雲達山의 植物相

閔雄基,張珍成,全正壹,金輝,崔道烈,金承昆 서울대학교 수목원 2001 서울大學校 樹木園 硏究報告 Vol.- No.21

This study was carried out to investigate the flora of Mt. Undal (alt. 1,097.2m) located on the northwestern side of province Gyeongsangbuk-do, near Myngyeong-si city, from April 2000 to Sept. 2000. Total number of vascular plants discovered in Mt. Undal were 70 families, 154 genera, and 243 taxa(including species, subspecies, varieties and forma). Major vegetation was Acer pictum var. mono - Quercus mongolica - Carpinus laxiflora community. The overall forest stand age of this area was 40 to 50 years, and occasionally ca 70 years old Abies holophylla trees were found. Although, there were no rare and endangered speices, we found two species of level IV by the Ministry of Environment - Anemone koraiensis Nakai, Anemone reflexa. Steph. et Willd.

합성피혁제조업체 근로자들에 있어서 N-methylformamide 배설속도에 관한 연구

김기웅,최병순,강성규,문영한 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1

This study was conducted to examine the excretion rate of dimethylformamide(DMF) from the workers exposed to DMF. The study was done at two synthetic leather factories located in Kyeonggi-do from the period of May 2 to 30, 1996. N-methyl-formamide (NMF) concentrations in urine were measured and compared by the three exposure level of DMF in air. The mean concentration of the Low (dry and winder part), Moderate (rinsing part) and High (mixing and coating part) exposure group were 3.99±3.54, 10.19±5.69 and 32.10±7.87㎎/㎥ during workshift of 8 hours, respectively. The mean concentration of urinary N-methylformamide (NMF) were 2.13±2.58, 11.16±4.98 and 26.24±7.35㎎/g creatinine, respectively. The concentration of NMF in urine could reach to maximum in 3 hours and was reduced nearly to zero in about 18 hours after exposure to DMF.

내용기반 영상 검색 시스템에 관한 연구

정재영,최호진,이웅기 조선대학교 통계연구소 1999 統計硏究所論文誌 Vol.1 No.1

In this paper, The retrieval methods consists of histogram intersection and color pairs. The preprocessor for image retrieval manage linearly the existing HSI(hue, saturation, intensity). Hue and Intensity histogram thresholding for each color attribute are performed to split the chromatic regions and the achromatic regions. Region growing is used to solve oversegmentation problem. Each image is divided into a smaller number of cells of 32 × 32 pixels. Color pairs are used to representthe query during retrieval. The average Recall/Precision of histogram intersection is 0.66/0.69. The average Recall/Precision of color paris is 0.47/0.60. The average Recall/Precision of proposed method is 0.76/0.79. The proposed method increases the retrieval effectiveness. The results demonstrate that the proposed method has led to substantial improvement in the performance of the system.

딜티아젬 함유 코아 펠렛으로부터 약물의 용출에 미치는 폴록사머 함량의 영향

이승우,감성훈,홍지웅,최기송,박은석,지상철 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

In order to evaluate the effect of poloxamer 407 content on the dissolution profiles of pellets, diltiazem HCl (DTL) core pellets were prepared with poloxamer 407 (50∼90% w/w, with lactose as filler) using an extruder and a spheronizer. Any possible interaction between the drug and excipients was evaluated using DSC, IR and TLC. Dissolution tests were performed using USP basket method. In addition, scanning electron micrograph was performed to examine the surface roughness and cross sections. The release of DTL from the core pellets was decreased with increasing poloxamer 407 content. Cracks appeared on the surface of the core pellets with increasing the poloxamer 407 content, which may play a role on the retardation of the release of DTL from core pellets. There was no any significant interaction between the drug and excipients employed to prepare the core pellets.