근 피판술을 이용한 기관흉막루의 치료

류한영,설정현,김정철,한승세,우상현,최시호 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2

Bronchopleural fistula and chronic empyema are the difficult problems in the thoracic surgery field. We experienced 3 cases of chronic empyema and complicated bronchopleural fistulas treated with muscle flap and concomitant thoracoplasty. The causative primary diseases were pulmonary tuberculosis and bronchiectasis. All the three cases have failed to control the chronic empyema and bronchopleural fistula with conventional method such as closed or open drainage and Eloesser flap after lobectomy. The unresponsive infection on bronchopleural fistula and pleural space was well controlled after muscle flap with thoracoplasty. Complete decortication, closure of bronchopleural fistula as much as possible and coverage of closed fistula with good vascularized tissue are the essential factors for the success of operation on chronic empyema and bronchopleural fistula. The results of operations were satisfactory and the respiratory function was well preserved or improved in one patient. But, the contour of chest wall was deformed in patient with extensive concomitant thoracoplasty.

자동영상추적장치를 이용한 카드뮴 처리 Oryzias latipes의 행위독성연구

류지성,이철우,최필선,최성수,류홍일,이길철,정규혁,박광식 한국환경독성학회 1999 환경독성보건학회지 Vol.14 No.4

Changes in certain fish behaviors are known to be very sensitive indicators of sublethal exposure to environmental contaminants. Therefore, behavioral toxicity tests, if properly designed, can be very useful to assess the influence of hazardous chemicals on fish. However, quantitative analysis of xenobiotic -mediated changes in locomotor behavior in fishes are rare, due mainly to the methodological difficulties. In general, fish movement has been known to be hypertrophic or hypotrophic according to the chemicals. As a study of fish behavioral toxicities, we quatified the swimming movement of Orydas latipes using computer-automated video tracking system. Oryzias latipes was exposed to cadmium of 128 mg/L for 1 hour in a limited aquaria, then the total swimming distance, the average swimming velocity, the histogram of turning angles, and the turning frequency were analyzed. Fish treated with cadmium showed decreased swimming activities, decreased velocity, and decreased turning frequency, which means hypotrophic activity. From these results, the computer-automated video tracking system of this study seems to be a good tool for the evaluation of the potential ecotoxicological studies.

頭鍼이 中風患者의 단기간 NIHSS와 MBI에 미치는 영향

류재춘,박인범,김상우,김철홍,서정철,윤현민,장경전,송춘호,안창범 동의대학교 한의학연구소 2002 동의한의연구 Vol.6 No.-

Objective ; The aim of this study was to investigate the effect of Scalp acupuncture on recovery of motor disorders in stroke patients. Methods ; Twenty two patients with poststroke-hemiplegia were randomized into two groups. Ten patients(test group) treated by 2 methods-Scalp acupuncture and body acupuncture. The other twelve patients(control group) treated only by body acupuncture. The activity of daily living was measured with a National Institutes of Health stroke scale(NIHSS) and Modified Barthel Index(MBI). The therapy was performed one a day for 2 weeks. Results ; In terms of score of NIHSS, the test group showed statistically meaningful decrease after 2 week treatment, but the control group showed statistically meaningful decrease after 1 week(p<0.05). And in terms of score of MBI, the test group did not show statistically meaningful increase but the control group showed statistically meaningful increase after 1 week(p<O.05). There was no statistically meaningful difference after 1 and 2 week treatment between the groups. Conclusions ; These results support that test group has almost same effectness compared with control group in improvement of the activity of daily living of poststroke-hemiplegic patients.

유리섬유를 적층한 에폭시 수지의 충격특성에 관한 연구

류공식,최상구,이화우 群山大學校基礎科學硏究所 1993 基礎科學硏究 Vol.8 No.-

에폭시 수지의 경화제와 경화조건을 변화시켜가며 유리섬유/에폭시 적층판의 충격특성을 연구하였다. 상온경화에서는 분자사슬이 긴 폴리아미드(G-1034)를 경화제로 사용했을 때 가장 큰 충격강도를 나타내었다. 가열경화에서는 파괴개시에너지가 상온경화에 비하여 높게 나타났으며, 후경화에서는 파괴 전파에너지가 높게 나타났다. 저온시험에서는 모재로부터 섬유의 이탈이 많이 일어난 것이 높은 충격 강도를 나타내었다. The influence of hardener and curing condition were studied on the impact properties of epoxy resin laminated with glass- fiber experimentally. Generally, the initiation energy of the epoxy composites was increased with heat - cure, and the propagation energy was also increased with post-cure. The total impact strength of composites cured with hardener of polyamide type was than that of aliphatic or aromatic amine type. The impact strength was increased with enhancement of propagation energy when it was tested at low temperature.

디지탈적으로 프로그램이 가능한 CNN칩 설계

류성환,전흥우 金烏工科大學校 1998 論文集 Vol.19 No.-

In this paper, the digitally programmable 6×6 cellular neural network chip is designed and the circuit operation is confirmed by the HSpice simulation of edge detection and hole filling. The designed cellular neural network allows for increased flexibility compared to the analog tuning mode due to the fact that synapse weights can be both programmed and stored digitally. The network considered in this design is a current mode cellular neural networks. Since the number of different weights is very small for this cellular neural networks. the programmability issues can be easily incorporated by just adding several global control lines. And the current mode circuit also provides the simplicity over voltage mode circuit.

ZnO 박막 센서의 DMA 가스 검지 특성

김성우,최우창,류지열,박성현,최혁환,이명교,권태하 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

The DMA(Dimethylamine) gas sensors were fabricated with the ZnO-based thin films grown by a RF magnetron sputtering method. We investigated the sensitivity and response time according to temperature variation and DMA gas concentration. The ZnO-based thin film sensors sputtered in oxygen atmosphere showed higher sensitivity than those sputtered in argon atmosphere. The ZnO-based thin film sensors doped with Al_(2)O_(3), In_(2)O_(3) and V_(2)O_(5) and sputtered in oxygen atmosphere showed the maximum sensitivity of 218(working temperature, 250 ℃, DMA gas, 160 ppm) and speedy response time. The ZnO-based thin film sensors doped with Al_(2)O_(3), In_(2)O_(3), TiO_(2) and V_(2)O_(5), sputtered in oxygen atmosphere and aged at 330 ℃ showed the maximum sensitivity of 156(working temperature, 250 ℃, DMA gas, 160 ppm).

Non-typhi Salmonella 균혈증의 임상양상과 항균제 내성빈도

이상오,이미숙,양성연,조용균,김은옥,김양수,우준희,류지소,배직현 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

목적 : Non-typhi Salmonella는 대부분 발열과 설사를 동반한 급성 위장관염을 일으키며 수일에서 수주후 자연 치유된 다. 그러나 때로는 항균제 치료를 요하는 균혈증을 일으키기도 한다. 이에 저자들은 non-typhi Salmonella 균혈증이 혈액 배양에서 증명된 환자들에서 연령 및 기저질환의 유무에 따른 임상양상의 차이와 내성균 발생빈도에 대해 고찰하고자 한다. 방법 : 1989년 6월 1일부터 1996년 5월 31일까지 서울중앙병원에 입원했던 non-typhi Salmonella 균혈증 환자 66예를 대상으로 후향적으로 조사하였다. 임상미생물 기록을 조사하여 연도별 각 혈청군의 분포와 항균제 내성빈도를 분석하였다. 이들 중 56예의 의무기록을 검토하여 소아와 성인, 기저질환의 유무에 따른 임상양상의 차이와 치명율을 비교하였다. 결과 : 대상 환자 56예중 남자가 30예, 여자가 26예이었고, 소아가 16예(평균 20±1.9세, 범위 21일-7세), 성인이 40예(평균 45.7±19.1세, 범위 18세-19세)이었다. 소아에서는 4예(25.0%)에서만 기저질환이 있었고 사망환자는 한 예도 없었으나 성인에서는 27예(67.5%)에서 다양한 기저질환이 있었고(p<0.01) 4예의 환자가 패혈성 쇽으로 사망하였다. 이는 성인군에서는 10%, 성인 기저질환군에서는 14.8%(p=0.06)의 치명율을 나타내는 것이었다. 균혈증의 원발부위에 따라 분류하여 보면 위장관염 기원이 총 56예 중 31예(55.4%)로 가장 많았고 소아군에서는 기저질환이 없는 12예 중 11예(91.7%), 성인군에서는 13예 중 10예(76.9%)였으며 이들 중 사망은 한 예도 없었다. 원발성 균혈증으로 나타났던 성인 19예(47.5%) 중 18예(94.7%)에서 기저질환이 있어서(p<0.01) 기저질환이 있는 성인 환자에서 주로 원발성 균혈증이 발생함을 알 수 있었다. 국소형 감염에서 기원한 균혈증은 2예(3.6%)로 각각 담도염과 담낭염에서 발현하였다. 각 혈청군별 분포는 총 66예 중 A군 11예(16.7%), B군 25예(37.9%), C₁군 3예(4.5%), C₂군 2예(3.0%), D군 24예(36.4%), E군 1예(1.5%)이었다. 1993년 이전에는 B군이 전체의 51.6%로 다수를 차지하였으나 1994년 이후로는 D군이 57.1%로 주종을 이루었다. 한 개 이상의 항균제에 내성을 보인 내성균 발생빈도는 66예 중 18예로 27.3%를 보였다. 혈청군별로는 B군이 D군에 비해 더 높은 내성율을 보였다(44.0% ; 8.3%, p<0.01). 항균제별 내성율은 ampicillin, piperacillin이 각각 15.1%, ampicillin/sulbactam, trimethoprim/sulfamethoxazole이 각각 6.0%, tetracycline, aztreonam이 각각 3.0%, ticarcillin, gentamicin이 각각 1.5%를 보였다. 그러나 3세대 cephalosporin계와 quinolone계에는 내성을 보인 예가 없었다. 결론 : Non-typhi Salmonella 균혈증은 지저질환이 없는 소아나 성인에서는 급성 위장관염의 합병증으로 일시적인 균혈증을 보일 수 있으나 양호한 예후를 보인다. 그러나 면역기능 저하를 동반하는 기저질환을 가지고 있는 환자에서는 주로 원발성 균혈증으로 나타나며 중증의 임상 경과와 사망을 초래 할 수 있다. 항균제 내성율은 전체적으로 27.%였고 3세대 cephalosporin계와 quinolone계에는 내성을 보인 예가 없었다. Objectives :Non-typhi Salmonella causes acute gastroenteritis accompanied with fever and diarrhea, but it's usually cured spontaneously several days or weeks later. Sometimes, however, it can result in bacteremia which requires antibiotic treatment. In this paper, we're going to discuss differences in clinical manifestation depending on the age and existence of the underlying diseases and incidence of the resistant strains in the patients who suffer from bacteremia with non-typhi Salmonella proved in the blood culture. Methods : We retrospectively studied 66 cases of bacteremia with nontyphi Salmonella treated at Asan Medical Center from June 1, 1989 to May 31, 1996. The clinical microbiology records were examined and the yearly distribution of each scrogroup and the rate of resistance of antibiotics were analysed. We reviewed the medical records of 56 cases and compared the differences in clinical manifestation and fatality rate among children and adults, and the existence of the underlying diseases. Results : Of 56 ones for this study, there were 30 males, 26 females, and 16 children (mean age:2.0±1.9, range:21days-7years old) and 40 adults(mean age:45.7±9.1, range:18-91years old) were involved. Only 4 cases(25.0%) of children had underlying diseases with no dead cases, however, in adults, 27 cases(67.5%) had various underlying diseases(p<0.01), and 4 cases died of softie shock. In result, the fatality rate was 10% in adults group and 14.8%(p=0.06) in adults with underlying diseases. The origin of bacteremia of 31 cases(55.4 %) was gastroenteritis. Eleven cases(92.7%) of 12 children and ten(76.9%) of 13 adults without underlying diseases were from gastroenteritis and there were no dead cases. Of the cases of aults, the primary bacteremia were 19 cases(49.5%) and 18 cases(94.7%) of them had various underlying diseases(p<0.01). So we found that the bacteremia with non-typhi Salmonella occurred mainly as the primary bacteremia in adult cases with underlying diseases. Only two cases of bacteremia were originated from localized infection and each of them manifested at cholangitis and cholecystitis. Related to the serogroup distribution of total 66 cases, there were 11 cases(16.7%) in A group, 25 cases(37.9%) in B, 3 cases(4.5%) in C₁, 2 cases(3.0%) in C₂, 24 cases(36.4%) in D, and one case(1.5%) in E group. Until 1993, B group was a majority(51.6%), but D group became a majority(57.1%) since 1994. The rate of resistance of one or more antibiotics was 27.3%(18 cases of 66 cases). B group showed higher rate of resistance than D group(44.0% vs. 8.3%, p<0.01). Related to the respective rates of resistance of antibiotics, ampicillin and piperacillin showed 15.1%, ampicillin/sulbactam and trimethoprim/sulfamethoxazole were 6.0%, tetracyclin and aztreonam were 3.0%, and ticarcillin and gentamicin were 1.5%. The third generation cephalosporins and quinotones, however, had no cases showing resistance. Conclustion : Non-typhi Salmonella can show a transient bacteremia as the complication of acute gastroenteritis to the children as well as adults without underlying diseases. In general, it can be easily cured. To the patients with underlying diseases causing immunocompromised state, however, it can be manifested to the primary bacteremia and can cause fetal disease or death. General rate of resistance of antibiotics reaches at 27.3%, but the third generation cephalosporins and quinolones had no cases showing resistance.

표정인식을 위한 PCA와 템플릿 정합을 사용한 얼굴 요소 추출

우효정, 이슬기, 김동우, 류성필, 안재형 충북대학교 산업과학기술연구소 2013 산업과학기술연구 논문집 Vol.27 No.2

This paper proposed an extracting algorithm of human facial components for the recognition of facial expressions. First face image is acquired using the Haar-like feature mask from an input image. The face image is divided into two images. One is the upper image including eye and eyebrow. The other is the lower image including mouth and jaw. The extraction of facial components, such as eye and mouth, begins getting eye image and mouth image. Then eigenfaces are produced by the PCA training process with learning images. An eigeneye and an eigenmouth are produced from eigenfaces. Result eye image is obtained by template matching the upper image with the eigeneye, and the mouth image is obtained by template matching the lower image with the eigenmouth. The simulation results show that the proposed method has superior extraction ratio than previous method.

골수염의 진단에 있어서의 Tc-99m Hexamethylpropylene amine oxime 백혈구 스캔의 임상적 유용성

최상호,김양수,정준원,정진원,추은주,서동대,배인규,양승오,우준희,류지소 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

배경 : 골수염의 진단에 있어 Technetium-99m을 이용한 삼상 골스캔(Tc-99m MDP스캔)은 단순방사선 검사상 정상소견을 보이는 경우에 쓰이는 1차적 검사로 매우 높은 민감도를 보인다. 그러나 Tc-99m MDP 스캔은 골절이나, 정형외과적 삽입물, 신경병적 관절병변과 같이 뼈의 재형성이 증가되는 상황에서도 양성소견을 보여 특이도가 낮은 단점이 있다. 이러한 단점을 보완하고자 골수염의 진단에 있어 Tc-99m HMPAO 백혈구 스캔의 유용성을 알아보고자 하였다. 대상 및 방법 : 골수염이 의심되어 Tc-99m HMPAO 백혈구 스캔을 시행했던 15명의 의무기록을 후향적으로 분석하였다. 골수염의 확진은 임상관찰 소견과 배양검사 결과와 병리소견을 기준으로 하였다. 결과 : 골수염의 진단에 있어 Tc-99m HMPAO 백혈구 스캔의 민감도와 특이도는 각각 100%와 78%였고 Tc-99m HMPAO 스캔의 경우는 100%와 18%였다. 가장 흔한 원인균은 methicillin-resistant S. aureus였다. Tc-99m MDP 스캔에서 양성소견을 보였던 환자중 3명의 환자가 Tc-99m HMPAO 백혈구 스캔에서 음성 소견을 보였으며 이 환자들은 추적관찰상 골수염이 없는 것으로 확인되었다. 결론 : Tc-99m HMPAO 백혈구 스캔은 골수염의 존재를 진단하는데 있어 민감도와 특이도가 높으며, 특히 뼈의 재형성이 증가되어 Tc-99m MDP 스캔의 특이도가 낮게 나타나는 상황에서 유용하리라 사료된다. Background Three phase bone scintigraphy, performed with technetium-labeled diphosphonates (Tc-99m MDP scan), is the very sensitive radionuclide procedure of choice for diagnosing osteomyelitis. But, Tc-99m MDP scan is less specific when bone remodeling is increased. To overcome this limitation, we evaluated the diagnostic value of technetium-99m hexamethylpropyleneamine oxime (HMPAO) labeled leukocyte scan in osteomyelitis. Methods : We retrospectively reviewed 15 patients with suspected osteomyelitis who performed Tc-99m HMPAO labeled leukocyte scan. The diagnosis of osteomyelitis was based on clinical course and bacterial culture, and pathologic findings. Results The sensitivity and specificity of Tc-99m HMPAO leukocyte scan was 100% and 78%, and those of Tc-99m MDP scan was 100% and 18%, respectively. The most common organism was Methicilein-Resistant S. aureus. Among the patients that showed persistent accumulation on Tc-99m MDP scan, three patients showed no uptake on Tc-99m HMPAO leukocyte scan and these patients were confirmed that had no osteomyelitis. Conclusion : Tc-99m HMPAO leukocyte scan is a useful test for determining the presence or absence of osteomyelitis, especially under condition that bone remodelin is increased.

Fluoroquinolone 항생제에 교차반응을 보인 ofloxacin에 의한 아나필락시양 반응 1례

김철우,김덕영,류성태,김상용,장창수 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1

Fluoroquinolones are antimicrobial agents that have a broad range of activity against both gram-negative and gram-positive organisms. Anaphylactoid reactions have been sporadically reported with fluoroquinolones. There have been a few reports that describes cross-reactivity between fluoroquinolones. We experienced case of ofloxacin-induced anaphylactoid reaction, and confirmed cross-reactivity between ofloxacin and ciprofloxacin with the oral challenges test. Cross-reactivity between fluoroquinolones may be important, and avoidance of any fluoroquinolones should be mandatocy for patients with hypersensitivity reaction to one of these drugs. (J Asthma Allergy Clin Immunol 24 : 146-51, 2004)