전사억제인자 Small Hetrodimer Partner-Interacting Leucine Zipper(SMILE)의 당대사와 지질대사 조절

박우람,최병윤,사다시밤 난티니,김돈규 전남대학교 농업과학기술연구소 2022 농업생명과학연구동향 Vol.60 No.-

Small heterodimer partner-interacting leucine zipper (SMILE) is a member of the cAMP response element-binding protein / activator transcription factor (CREB/ATF) family of basic leucine zipper (bZIP) transcription factors. Structurally, it exists in small and long isoforms resulting from alternative usage of the initiation codon. Though structurally similar to bZIP proteins, SMILE cannot bind to DNA but can homodimerize like them. SMILE acts as a corepressor for nuclear receptors related transcriptional activity and other transc- ription factors. SMILE plays a crucial role in metabolic signaling pathways by inhibiting DNA binding, competing with coactivators, and directly repressing transcription. This review focuses on the role of SMILE in hepatic glucose and lipid metabolism. Regulation of SMILE improves pathological conditions such as hepatitis, diabetes and fatty liver disease. Therefore, understanding the role of SMILE in metabolism and signaling pathways paves the way to consider SMILE as a potential target in treating liver metabolic diseases.

Lingual K-loop archwire를 이용한 발치공간 폐쇄시 초기응력 분포에 대한 3차원 광탄성학적 연구

변보람,김성식,손우성 대한치과교정학회 2002 대한치과교정학회지 Vol.32 No.5

제1소구치 발치를 동반한 설측교정치료시 lingual K-loop archwire로 전치부 후방견인을 시행한 경우 전치부 및 구치부에서 치조골에 발생하는 초기응력을 알아보기 위하여, K-loop의 의 vertical lg 길이는 15mm로 하고 편측당 350gm의 힘으로 활성화시킨 후 상악궁 광탄성 모형의 응력동결을 시행하고 각 치아별로 절단하여 3차원 광탄성법으로 분석한 바 다음과 같은 결론을 얻었다. 1. 중절치의 근심면은 치관측일수록 더 큰 인장응력을 보였으며 원심면은 치관측일수록 더 큰 압축응력을 보였다. 순면에서는 치관측일수록 더 큰 인장응력을 보였으며 설면에서는 치근측일수록 더 큰 압축응력을 보였다. 치근첨에서는 압축응력이 나타났다. 2. 측절치의 근심면에서는 치관측만 인장응력이 관찰되었고 원심면에서는 고른 압축응력을 보였다. 순면에서는 치관측일수록 더 큰 인장응력이 관찰되었고 설면에서는 치관측에서는 인장응력을, 치근측에서는 압축응력을 보였다. 치근첨에서는 압축응력이 관찰되었다. 3. 견치의 근심면은 치관측에서는 인장응력을, 치근측에서는 압축응력을 보였고 원심면은 인장응력을 보였다. 순면과 설면은 치관측일수록 큰 인장응력을 보였다. 순면보다 설면에서 더 큰 인장응력을 보였다. 치근첨에서는 압축응력이 관찰되었다. 4. 제2소구치는 근심면은 인장응력을 보이며 원심면은 치관측에서는 압축응력을, 치근측에서는 인장응력을 보였다. 협면은 치관측에서 압축응력을 보였으며, 설면은 치관측일수록 더 큰인장응력이 관찰되었다. 치근첨에서는 인장응력을 보였다. 5. 제 1대구치는 근원심면 모두에서 치관측일수록 더 큰 인장응력을 보였다. 협면에서는 응력이 나타나지는 않았고 설면은 치관측일수록 더 큰 인장응력이 관찰되었다. 협측치근들의 치근첨에서는 압축응력을, 구개측치근의 치근첨에서는 무응력을 보였다. 6. 제2대구치는 모든 치근의 치근첨에서 압축응력이 관찰되었다. 근심면은 치관측일수록 더 큰 압축응력을, 원심면은 치관측일수록 더 큰 인장응력을 보였다. 협면은 치관측일수록 더 큰 인장응력을 설면은 치관측일수록 더 큰 압축응력을 나타내었다. 따라서 전치부 후방견인시 transverse bowing effect는 뚜렷이 나타났으나, vertical bowing effect는 나타나지 않고 오히려 전치부가 함입되려는 응력이 발생하였다. This study was designed to investigate the stress distribution of alveolar bone in case of en masse retraction with lingual K-loop archwire using the 3-dimensional photoelastic stress analysis followed by stress freezing process. Lingual K-loop archwire which had loop in 15mm height was used and activated by retraction force of 350gm per each side. The results were as follows : 1. Central incisor : As the closer side to crown, the larger tensile stress was distributed at both mesial and labial surfaces and the larger compressive stress was distributed at distal surface. As the closer side to root apex, the larger compressive stress was distributed at lingual surface. The compressive stress was distributed at root apex. 2. Lateral incisor : The tensile stress was distributed at the coronal side of mesial surface. The compressive stress was distributed at distal surface. As the closer side to crown, the larger tensile stress was distributed at labial surface. The tensile stress was distributed at coronal side and the compressive stress was distributed at apical side of lingual surface. The compressive stress was distributed at root apex. 3. Canine : The tensile stress was distributed at coronal side and the compressive stress was distributed at apical side of musial surface. the tensile stress was distributed at distal surface. As the closer side to drown, the larger tensile stress was distributed at both musial and distal surfaces. The compressive stress was distributed at root apex. 4. Second premolar : The tensile stress was distributed at mesial surface. The compressive stress was distributed at coronal side and the tensile stress was distributed at apical side of distal surface. the compressive stress was distributed at coronal side of buccal surface. As the closer side to crown, the larger tensile stress was distributed at lingual surface. The compressive stress was distributed at root apex. 5. First molar : As the closer side to crown, the larger tensile stress was distributed at both mesial and distal surfaces. No stress was distributed at buccal surface. As the closer side to crown, the larger tensile stress was distributed at both lingual surfaces. The compressive stress was distributed at buccal root apexes. 6. Second molar : The compressive stress was distributed at all root apexes. As the closer side to crown, the larger compressive stress was distributed at both mesial and lingual surfaces, and the larger tensile stress at both distal and buccal surfaces. Transverse bowing effect was observed in en-masse retraction with lingual K-loop archwire, however vertical bowing effect was not. Rather, reverse vertical bowing effect was developed.

능력스펙트럼법에 의한 복층 래티스돔의 성능점 산정에 관한 연구

정명채,조우람,김홍건 전주대학교 공학기술종합연구소 2002 전주대학교 공학기술종합연구소 학술논문집 Vol.8 No.1

Performance based seismic design is a very efficient method in checking the seismic capacity of buildings. In this study, the method evaluating performance point of a double layered lattice dome based on capacity spectrum method (CSM) is proposed Because behaviors of a double layered lattice dome are affected by higher modes of vibration, they need to be included in evaluating seismic resistant capacity. In this paper, they are considered in the lateral bad distribution on for the pushover analysis process. The proposed method is successfully applied to estimate the performance point of a double layered lattice dome.

Sonographic observation of the paradoxical masseteric bulging and clinical implication of functional compartment

Kyu-Ho Yi(Kyu-Ho Yi),Hyungkyu Bae(Hyungkyu Bae),Soo-Bin Kim(Soo-Bin Kim),Woo-Ram Kim(Woo-Ram Kim),Won Lee(Won Lee),Ji-Soo Kim(Ji-Soo Kim),Hee-Jin Kim(Hee-Jin Kim) 대한해부학회 2024 Anatomy & Cell Biology Vol.57 No.1

Masseter are commonly botulinum neurotoxin targeted muscle for facial contouring in aesthetic field. However, paradoxical masseteric bulging is common adverse effect that has not been discussed with ultrasonographic observations. Retrospective study has been conducted from October, 2021 to January, 2023, out of 324 patients have done blinded botulinum neurotoxin injection in the masseter at the middle and lower portion of the masseter with each side of 25 units (letibotulinum neurotoxin type A), 3 patients demonstrated paradoxical masseteric bulging has been reported and the image observed by ultrasonography by physician. Based on the observations made, we can infer that the function of the moving muscle involves twisting of the muscle fibers during contraction, along with the twisting of the deep inferior tendon, which causes the muscle to be divided into anterior and posterior compartments rather than into superficial and deep compartments of masseter. In ultrasonographic observe the skin surface of a patient with paradoxical masseteric bulging, it is observable that either the anterior or posterior part contracts significantly. The functional units of anterior and posterior compartment are observable as muscular contraction of inward movement of the muscle from either the anterior or posterior functional unit.

The Scaffold Protein Prohibitin Is Required for Antigen-Stimulated Signaling in Mast Cells

Kim, Do Kyun,Kim, Hyuk Soon,Kim, A-Ram,Jang, Geun Hyo,Kim, Hyun Woo,Park, Young Hwan,Kim, Bokyung,Park, Yeong Min,Beaven, Michael A.,Kim, Young Mi,Choi, Wahn Soo AAAS 2013 Science signaling Vol.6 No.292

<P><B>How to Prohibit Mast Cell Activation</B></P><P>Mast cells are the major effector cells of the allergic response. Binding of antigen to immunoglobulin E (IgE) molecules bound to the cell-surface, high-affinity IgE receptor FcεRI results in receptor clustering, mast cell activation, and degranulation, resulting in the release of factors that mediate the allergic response. Phosphorylation and activation of the Src family kinases Lyn and Syk are critical for mast cell activation. Kim <I>et al</I>. found that the scaffold protein prohibitin (PHB), which mediates functions such as mitochondrial biogenesis and transcriptional regulation (see commentary by Yurugi and Rajalingam), was abundant in intracellular granules in mouse mast cells. Stimulation of mast cells with antigen resulted in the translocation of PHB to plasma membrane lipid rafts, which was required for the association of FcεRI with Syk, the activation of Syk, and degranulation. Knockdown of PHB in mice inhibited mast cell activation and anaphylaxis, suggesting that targeting PHB therapeutically may reduce allergic responses.</P>

Interleukin-10–producing CD5⁺ B cells inhibit mast cells during immunoglobulin E–mediated allergic responses

Kim, Hyuk Soon,Kim, A-Ram,Kim, Do Kyun,Kim, Hyun Woo,Park, Young Hwan,Jang, Geun Hyo,Kim, Bokyung,Park, Yeong Min,You, Jueng Soo,Kim, Hyung Sik,Beaven, Michael A.,Kim, Young Mi,Choi, Wahn Soo AAAS 2015 Science signaling Vol.8 No.368

<P>Subsets of B cells inhibit various immune responses through their production of the cytokine interleukin-10 (IL-10). We found that IL-10-producing CD5(+) B cells suppressed the immunoglobulin E (IgE)- and antigen-mediated activation of mast cells in vitro as well as allergic responses in mice in an IL-10-dependent manner. Furthermore, the suppressive effect of these B cells on mast cells in vitro and in vivo depended on direct cell-to-cell contact through the costimulatory receptor CD40 on CD5(+) B cells and the CD40 ligand on mast cells. This contact enhanced the production of IL-10 by the CD5(+) B cells. Through activation of the Janus-activated kinase-signal transducer and activator of transcription 3 pathway, IL-10 decreased the abundance of the kinases Fyn and Fgr and inhibited the activation of the downstream kinase Syk in mast cells. Together, these findings suggest that an important function of IL-10-producing CD5(+) B cells is inhibiting mast cells and IgE-mediated allergic responses.</P>

Comparative study of oncologic outcomes for laparoscopic vs. open surgery in transverse colon cancer

Woo Ram Kim,Se Jin Baek,Chang Woo Kim,Hyun A Jang,Min Soo Cho,Sung Uk Bae,Hyuk Hur,Byung Soh Min,Seung Hyuk Baik,Kang Young Lee,Nam Kyu Kim,Seung Kuk Sohn 대한외과학회 2014 Annals of Surgical Treatment and Research(ASRT) Vol.86 No.1

Purpose: Laparoscopic resection for transverse colon cancer is a technically challenging procedure that has been excluded from various large randomized controlled trials of which the long-term outcomes still need to be verified. The purpose of this study was to evaluate long-term oncologic outcomes for transverse colon cancer patients undergoing laparoscopic colectomy (LAC) or open colectomy (OC). Methods: This retrospective review included patients with transverse colon cancer who received a colectomy between January 2006 and December 2010. Short-term and five-year oncologic outcomes were compared between these groups. Results: A total of 131 patients were analyzed in the final study (LAC, 84 patients; OC, 47 patients). There were no significant differences in age, gender, body mass index, tumor location, operative procedure, or blood loss between groups, but the mean operative time in LAC was significantly longer (LAC, 246.8 minutes vs. OC, 213.8 minutes; P = 0.03). Hospital stay was much shorter for LAC than OC (9.1 days vs. 14.5 days, P < 0.01). Postoperative complication rates were not statistically different between the two groups. In terms of long-term oncologic data, the 5-year disease-free survival and overall survival were not statistically different between both groups, and subgroup analysis according to cancer stage also revealed no differences. Conclusion: LAC for transverse colon cancer is feasible and safe with comparable short- and long-term outcomes.

Corrosion Behavior of Magnesium Alloy Prepared by Mechanical Alloying

Ka Ram Kim,Jin Woo Ahn,Gyeung-Ho Kim,Teak Soo Kim,Woo Jin Kim,Hye Sung Kim 한국표면공학회 2013 한국표면공학회 학술발표회 초록집 Vol.2013 No.11

꽈배기 모자반 물 추출물의 항산화능과 물리적 특성에 대한 감마선 조사의 영향

김아람(Ah-Ram Kim),송유진(Eu-Jin Song),김미정(Mi-Jung Kim),이소영(So-Young Lee),김꽃봉우리(Koth-Bong-Woo-Ri Kim),김진희(Jin-Hee Kim),김서진(Seo-Jin Kim),홍용기(Yong-Ki Hong),박진규(Jin-Gyu Park),김재훈(Jae-Hun Kim),이주운(Ju-Woon Lee) 한국식품영양과학회 2008 한국식품영양과학회지 Vol.37 No.3

본 연구에서는 꽈배기모자반 물 추출물에 식품산업에서 사용이 확대되고 있는 감마선 조사기술을 이용하여 항산화능의 변화를 알아보고, 꽈배기모자반 물 추출물의 높은 점성과 짙은 색상으로 인한 문제점을 개선하고자 하였다. 꽈배기모자반 물 추출물의 감마선 조사에 따른 항산화능의 변화를 알아보기 위해 총 페놀화합물 함량을 측정하고 DPPH radical 소거능을 측정하였다. 그 결과, 3~20 kGy의 감마선을 조사한 꽈배기모자반 물 추출물은 조사선량이 증가할수록 총 페놀화합물 함량이 증가하였고, DPPH radical 소거능도 증가하여 감마선 조사에 의해 항산화능이 증진되었다. 그리고 꽈배기모자반 물 추출물에 감마선 조사 시 물리적 특성 변화를 알아보기 위해 색상과 점도를 측정한 결과, 감마선 조사선량이 증가할수록 색이 옅어지고 점성이 감소하는 것으로 나타났다. 이를 통해 꽈배기모자반 물 추출물에 감마선을 조사한 후 식품에 적용 시 가공특성을 개선시킬 수 있을 것으로 사료된다. 따라서 감마선 조사는 꽈배기모자반 물 추출물의 물리적 특성을 개선시키고 항산화능 또한 증진시키므로 식품산업에 적용 시 기존의 천연 항산화제의 단점을 개선시킬 수 있는 기술로서 사용이 확대될 수 있을 것으로 사료된다. In this study, the antioxidant properties and physical characteristics of irradiated Sargassum siliquastrum water extract were evaluated. Samples were irradiated with Co<SUP>60</SUP> γ-ray at doses ranging from 3 to 20 kGy. They were then analyzed to investigate antioxidant properties, including total phenolic compound content and DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity. In addition, physical properties such as viscosity and color were evaluated. The results demonstrated that total phenolic compound content and DPPH radical scavenging activity were significantly improved (p<0.05) by irradiation. In terms of physical properties, viscosity and color were reduced in the irradiated extracts as compared to non-irradiated samples. In conclusion, gamma irradiation improved the antioxidant properties of Sargassum siliquastrum water extract, improving its original weak point as a natural antioxidant when applied in the food industry.

근력 운동과 균형 운동이 발목 불안정성이 있는 성인의 발목 불안정성 지표, 근력 및 균형 능력에 미치는 효과 비교

김태우 ( Tae-woo Kim ),홍유진 ( Yu-jin Hong ),김민서 ( Min-seo Kim ),강재원 ( Jae-won Kang ),김가람 ( Ga-ram Kim ),김영우 ( Young-woo Kim ),최우식 ( Woo-sik Choi ),차용준 ( Yong-jun Cha ) 대전대학교 기초과학연구소 2023 혜화보건의료학회지 Vol.2 No.1

Objectives: The purpose of this study was to suggest a more effective exercise method for chronic ankle instability by comparing an effect of strengthening exercise and the balance exercise. Methods: After recruiting 24 people in their 20s with chronic ankle instability(CAI) and dividing them into two groups. The control group performed strengthening exercises(calf raise, heel walks and theraband exercise) three times a week for four weeks for 30 minutes. In the experimental group, they conducted a combination of ankle strengthening exercises and balance exercises(dumbbell cross exercise, BOSU Exercise) three times a week for four week s for 40 minutes. We measured ankle instability index, muscle strength, and balancing abilities before and after the training. Results: In both the experimental group and the control group, there was a significant difference in the Cumberland ankle instability tool(CAIT), static balance before and after the intervention(p< .05). But there was no significant difference between the two groups(p >.05). In the dynamic balance, the experimental group had significant differences (p< .05). However, the control group had no significant difference(p >.05). There was no statistically significant difference in the outcomes both the experimental group and control group(p>.05). Conclusions: We propose that ankle strengthening exercises and balance exercises can be an effective clinical exercise method to improve the ankle instability and balance ability of people with ankle chronic ankle instability.