http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Minji,Furuzono, Tomoya,Yamakuni, Kanae,Li, Yongjia,Kim, Young-Il,Takahashi, Haruya,Ohue-Kitano, Ryuji,Jheng, Huei-Fen,Takahashi, Nobuyuki,Kano, Yuriko,Yu, Rina,Kishino, Shigenobu,Ogawa, Jun,Uchid The Federation of American Societies for Experimen 2017 The FASEB Journal Vol.31 No.11
<P>Gutmicrobiota can regulate the host energymetabolism; however, the underlying mechanisms that could involve gut microbiota-derived compounds remain to be understood. Therefore, in this study, we investigated the effects ofKetoA [10-oxo-12(Z)-octadecenoic acid]-a linoleic acidmetaboliteproduced by gut lactic acid bacteria-on whole-body energy metabolism and found that dietary intake of KetoA could enhance energy expenditure in mice, thereby protecting mice from diet-induced obesity. By using Ca2+ imaging and whole-cell patch-clamp methods, KetoA was noted to potently activate transient receptor potential vanilloid 1 (TRPV1) and enhance noradrenalin turnover in adipose tissues. In addition, KetoA up-regulated genes that are related to brown adipocyte functions, including uncoupling protein 1 (UCP1) inwhite adipose tissue (WAT), whichwas later diminished in the presence of a b-adrenoreceptor blocker. By using obese and diabetic model KK-Ay mice, we further show that KetoA intake ameliorated obesity-associatedmetabolic disorders. In the absence of any observedKetoA-induced antiobesity effect or UCP1 up-regulation in TRPV1-deficient mice, we prove that the antiobesity effect of KetoAwas caused by TRPV1 activation-mediated browning inWAT. KetoA produced in the gut could therefore be involved in the regulation of host energy metabolism.-Kim, M., Furuzono, T., Yamakuni, K., Li, Y., Kim, Y.-I., Takahashi, H., Ohue-Kitano, R., Jheng, H.-F., Takahashi, N., Kano, Y., Yu, R., Kishino, S., Ogawa, J., Uchida, K., Yamazaki, J., Tominaga, M., Kawada, T., Goto, T. 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1.</P>
Yuho Shimizu,Tomoya Takahashi,Kenichiro Sato,Susumu Ogawa,Daisuke Cho,Yoshifumi Takahashi,Daichi Yamashiro,Yan Li,Keigo Hinakura,Ai Iizuka,Tomoki Furuya,Hiroyuki Suzuki 질병관리본부 2023 Osong Public Health and Research Persptectives Vol.14 No.5
Objectives: As the population ages worldwide, including in Japan, there is a growing expectation for older adults to remain active participants in society. The act of sharing one’s experiences and knowledge with younger generations through social engagement not only enriches the lives of older individuals, but also holds significant value for our society. In this study, we examined both positive and negative perceptions of older adults and investigated the correlation between these perceptions and generativity among older citizens. Additionally, we evaluated the impact of life satisfaction on these factors. Methods: We conducted a survey of 100 older adults in Japan (mean age, 71.68 years) and utilized multiple regression analyses, using positive and negative perceptions of older adults, life satisfaction, and demographic factors as independent variables. The sub-categories of generativity—namely, generative action, concern, and accomplishment—were used as dependent variables. Results: Participants who held a more positive perception of older adults demonstrated a higher level of generative actions and concerns. Additionally, participants who reported higher levels of life satisfaction also exhibited more generative actions, concerns, and accomplishments. Conversely, those who held a more negative perception of older adults were found to have higher levels of generative actions. Conclusion: Enhancing positive perceptions of older adults among them can boost the sub-categories of generativity. This study, which was conducted from an exploratory perspective, has several limitations, including a potential sampling bias. A more comprehensive examination of the relationship between perceptions of older adults and generativity is anticipated in future research.
박인환,Jared Gong,Gregory L. Lyons,Tomoya Hirota,Michio Takahashi,김보라,이승연,김영신,이정수,Bennett L. Leventhal 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.11
Through this meta-analysis, we sought to examine the prevalence of, risks for, and factors associated with bullying involvement(victimization, perpetration, perpetration-victimization) among students with autism spectrum disorder (ASD). Additionally, weattempted to examine sources of variance in the prevalence and effect sizes of bullying in students with ASD across studies. Systematicdatabase and literature review identified 34 relevant studies (31 for Western countries, three for Eastern countries). Pooledprevalence estimates for victimization, perpetration, and perpetration-victimization in general were 67%, 29%, and 14%, respectively. The risk of victimization in students with ASD was significantly higher than that in typically developing students and studentswith other disabilities. Further, deficits in social interaction and communication, externalizing symptoms, internalizing symptoms,and integrated inclusive school settings were related to higher victimization, and externalizing symptoms were related to higherperpetration. Finally, moderation analyses revealed significant variations in the pooled prevalences thereof depending on culture,age, school settings, and methodological quality and in the pooled effect sizes according to publication year and methodologicalquality. Our results highlight needs for bullying intervention for students with ASD, especially those who are younger, are in aninclusive school setting, and have higher social difficulties and externalizing/internalizing symptoms; for intensive research of bullyingexperiences among students with ASD in Eastern countries; and for efforts to improve the methodological quality of suchresearch.
Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice.
Kang, Min-Sook,Hirai, Shizuka,Goto, Tsuyoshi,Kuroyanagi, Kayo,Kim, Young-Il,Ohyama, Kana,Uemura, Taku,Lee, Joo-Young,Sakamoto, Tomoya,Ezaki, Yoichiro,Yu, Rina,Takahashi, Nobuyuki,Kawada, Teruo Published for International Union of Biochemistry 2009 Biofactors Vol.35 No.5
<P>Terpenoids, which are contained in a large number of dietary and herbal plants, have many biological effects. In this study, the effects of dehydroabietic acid (DAA), a diterpene, on glucose and lipid metabolism were examined using obese diabetic KK-Ay mice. We showed here that DAA treatment decreased not only plasma glucose and insulin levels but also plasma triglyceride (TG) and hepatic TG levels. To examine the mechanism underlying the effects of DAA, the production of inflammatory cytokines was measured. It was shown that the DAA treatment suppressed the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNFalpha) (proinflammatory cytokines) and increased that of adiponectin (an anti-inflammatory cytokine). As a result of the changes in the production of inflammatory cytokines caused by the DAA treatment, the accumulation of macrophages in adipose tissues was reduced. These results indicate that treatment with DAA improves the levels of plasma glucose, plasma insulin, plasma TG, and hepatic TG through the decrease in the macrophage infiltration into adipose tissues, suggesting that DAA is a useful food-derived compound for treating obesity-related diseases.</P>