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김선아(Kim Sun Ah) 한국영화학회 2011 영화연구 Vol.0 No.48

A foundation of North Korean cinema was established during the 1960s to 1970s and Film Art by Kim Jong-il is placed in its core. Re-mediating Kim Il-sung Suryung(the great leader)’s struggle and revolutionary operas written by Kim Il-sung into cinema as a modern technology, Kim Jong-il reformed North Korea as Cinema-state. In doing so, the heredity of the dictatorial power was naturalized and necessitated just as a transmission to new modern media. Cinema operated as signs of everyday life which North Korean people could interpret their reality through, and provided an opportunity that people took part in and shared Kim Il-sung Suyung’s myth. As accelerating the centralization and unification of economy, politics and culture under the name of Suryung, North Korean cinema has been distorted with a drastic development. Kim Jong-il deleted the existing film history with emphasizing the tradition of revolutionary cinema and wrote Film Art that became the origin of other art theories. Since then Kim created films of the Suryung figure and established the Juche Idea(self-reliance/subjecthood). The procedure of development of North Korea film history from a revolutionary cinema during 1960 to 1970 and Film Art to a cinema of a Suryung figure let us know a birth and fall of Kim’s Cinema-State and a perfect union of technology and state power. Film Art provided the foundation for the aestheticization of politics and melodramaticization of a history in the Cinema-state. Film Art was the only art theory written by Kim Jong-il in the 1970s where Kim reckoned cinema as the representative art of socialist realism for the age of independent and creative Juche. It emphasizes a human being’s consciousness-raising, the organization of feelings and contents. At the same time it inherited the problems of romanticism, organicism and passive human being. The illusion of Father-Nation-State on a huge cinematic screen in North Korea during the 1960s to 1970s were vanished. Cinema-State faced to the end because of intolerable distance between a reality and a cinema and the development of multimedia technology.

Voice Mismatch Meets Neurolinguistics

Gui-Sun Moon,Sun-Woong Kim,Jeong-Ah Shin,Hae-Kyung Wee,Jong Un Park,Myung-Kwan Park,Wonil Chung 현대문법학회 2018 현대문법연구 Vol.99 No.-

Gui-Sun Moon, Sun-Woong Kim, Jeong-Ah Shin, Hae-Kyung Wee, Jong Un Park, Myung-Kwan Park, and Wonil Chung. 2018. Voice Mismatch Meets Neurolinguistics. Studies in Modern Grammar 99, 85-115. This paper aims to investigate Korean advanced L2 English learners’ strategies for ellipsis resolution during sentence processing. Ellipsis resolution is known to involve several stages of information processing from the initial step of detecting an ellipsis-licensing element by the parser to the final stage of integrating the ellipsis site with the information retrieved from the antecedent of the ellipsis site. In examining these steps, we have manipulated three factors: (i) TP vs. VP-ellipsis; (ii) two types of discourse coherence relations (resemblance(-contrast) vs. cause-effect relations); (iii) voice match vs. mismatch. We found through the ERP recordings that voice mismatch in TP ellipsis elicited N400, followed by P600, irrespective of discourse coherence relations. In contrast, voice mismatch in VP-ellipsis registered N400 only in resemblance(-contrast) relation, but not in cause-effect relation. These findings lead us to conclude that Korean advanced L2 learners of English seem to undergo the full sequence of processing stages required for ellipsis resolution.

EGFR 돌연변이와 ROS1 전위를 동시에 가진 폐선암 환자의 Erlotinib 치료 1예

김민환,박예현,박혜정,지아영,송창호,진무년,김영주,김선욱,이중희,김인수,김혜련,김주항,조병철 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

The rearrangement of c-ros oncogene 1 (ROS1) has been recently identified as an important molecular target in non small cell lung cancer (NSCLC). ROS1 rearrangement and epidermal growth factor receptor (EGFR) mutation were mutually exclusive each other in previous studies, and the clinical implication of co-existence of the two genetic alterations has not been determined. We report a case of 46-year-old female never-smoker NSCLC patient whose tumor harbored ROS1 rearrangement and EGFR mutation concomitantly. She had undergone curative surgery for stage IIIA NSCLC, and the recurrence in left pleura and brain occurred at 2 years after the surgery. She received several lines of chemotherapy including docetaxel plus carboplatin, erlotinib, pemetrexed, and gemcitabine. Erlotinib therapy showed a favorable treatment response with progression-free survival of 9.5 months and partial response of tumor on radiologic evaluations. This case represents a successful erlotinib treatment in a NSCLC patient with concurrent ROS1 rearrangement and EGFR mutation.

랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

자료포락분석(DEA)를 이용한 보건의료의 효율성 측정

김남송,박홍섭,김은진,김설화,김정숙,김현아,김경숙,신지혜,최은정,양은진,유선미,유수진 圓光大學校 醫科學硏究所 2007 圓光醫科學 Vol.22 No.1

Original Article : Geographic difference of epidemiological features of HCV infection in Korea

( Kyung Ah Kim ),( Sook Hyang Jeong ),( Eun Sun Jang ),( Young Seok Kim3 ),( Youn Jae Lee ),( Eun Uk Jung ),( In Hee Kim ),( Sung Bum Cho ),( Mee Kyung Kee ),( Chun Kang ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4

Background/Aims: The prevalence of hepatitis C virus (HCV) infection in Korea exhibits significant geographic variation, with it being higher in Busan and Jeonam than in other areas. The reason for this intranational geographic difference was investigated in this study by conducting a comparative analysis of the risk factors related to HCV infection among three geographic areas: the capital (Seoul), Busan, and the province of Jeolla. Methods: In total, 990 patients with chronic HCV infection were prospectively enrolled at 5 university hospitals located in Seoul (n=374), Busan (n=264), and Jeolla (n=352). A standardized questionnaire survey on the risk factors for HCV infection was administered to these three groups of patients, and a comparative analysis of the findings was performed. Results: The analysis revealed significant regional differences in exposure to the risk factors of HCV infection. By comparison with patients in Seoul as a control group in the multivariate analysis, patients in Busan had significantly more experience of invasive medical procedures, acupuncture, cosmetic procedures, and multiple sex partners. In contrast, patients in Jeolla were significantly older, and they had a higher prevalence of hepatocellular carcinoma, a lower prevalence of multiple sex partners, and had experienced fewer invasive procedures. Conclusions: There was a significant geographic difference in the exposure to potential risk factors of HCV infection between patients from the three studied regions. This may explain the regional variation of the prevalence of HCV infection in Korea, and should be taken into account when planning strategies for the prevention and management of HCV infection. (Clin Mol Hepatol 2014;20:361-367)

우울증과 정신증 환자군의 성격특성의 차이 : 내향성의 세부 요소를 중심으로

김선아,우석엽 한국분석심리학회 2003 心性硏究 Vol.18 No.1

요로결석 환자의 체외충격파쇄석술 치료경과와 결석 특성과의 관련성

김성길,김기순,류소연,한미아,이선옥,노준 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

요로 결석에 대한 비 침습적 치료 방법인 체외충격파쇄석술에 의한 치료경과와 결석 특성과의 관련성을 파악키 위해 2002년 12월부터 2008년 3월까지 G시 H병원에서 요로 결석으로 진단되어 체외충격파쇄석술을 받은 33l례를 대상으로 의무기록 자료를 이용하여 분석한 결과는 다음과 같다. 1. 조사 대상자 331례중 남자는 68.6%, 여자는 31.4%이었으며 평균연령(표준편차)은 44.2 (13.9)세 이었고 84%가 G시내 거주자였다. 2. 조사 대상자에게 시행된 체외충격파쇄석술의 평균 시술횟수(표준편차)는 1.9(1.5)회 이었으며 평균 통증제거기간(표준편차)은 3.2(2.1)일 이었고 요로결석 진단 시로부터 치료가 완료되었다고 의사가 판정했을 때까지의 치료기간의 평균(표준편차)은 10.3(8.4)일 이었다. 3. 시술횟수에 통계적으로 유의하게(P<0.01) 관련된 요인은 결석크기, 결석의 방사선 투과성, 요관 폐색여부 이었으며 모형의 설명력은 13.5%이었다. 4. 통증제거기간에 통계적으로 유의하게(P<0.01) 관련된 요인은 결석의 방사선 투과성 이었으며 모형의 설명력은 7.4%이었다. 5. 치료기간에 통계적으로 유의하게(P<0.01) 관련된 요인은 결석크기와 결석의 방사선 투과성 이었으며 모형의 설명력은 13.5%이었다. 따라서 결석의 크기가 크거나 결석이 방사선에 비 투과성일 때, 요관이 폐색되어 있을 때 치료경과가 늦게 됨으로 이러한 사실을 참고 하여 추후 진료지침을 작성 시 보다 효과적이고 효율적인 치료법을 적용할 필요가 있다고 판단되며 보다 체계적인 평가와 연구가 필요할 것이다. Objectives & Methods: To find the treatment process by extracorporeal shock wave lithotripsy (ESWL) and its related stone characteristics in urinary tract stone patients, an analysis was done from medical records of 331 cases who were treated by ESWL from December 2002 to March 2008 at H hospital in G city. Results: Among 331 study subjects 68.6% were male and 31.4% were female. Their mean age (standard deviation, SD) was 44.2 (13.9) years old and 84.0% lived in G city. Average frequency of ESWL done toward study cases were 1.9±1.5 times. Mean duration of disappearance from pain was 3.2±2.1 days and total treatment period for a stone was 10.3±8.4 days. Statistically significant (p<0.01) stone and urinary tract characteristics related with frequency of ESWL were stone size, radio-opacity of the stone, and obstruction of urinary tract. The model composed of these 3 independent variables explained 13.5% of frequency of ESWL. Statistically significant (p<0.01) variable related with disappearance from pain was radio-opacity of the stone, and this model explained 7.4%. Statistically significant (p<0.01) variables related with treatment duration due to stone were stone size and radio-opacity of the stone. These two variables explained 13.5%. Conclusion: The bigger the size of stone are, the slower the treatment process will be. And when the stone is radio-opaque and urinary tract is obstructed, the treatment process will be slower than stone is radio-luscent and urinary tract is not obstructed. So to make effective and efficient treatment manual for ESWL, above fact must be considered and continuous systematic evaluation and research toward ESWL are necessary.

근적외 분광 분석법을 이용한 사향 대체 물질별 우황청심원액의 분류

김선민,우영아,김효진,조창희,조정희 동덕여자대학교 종합약학연구소 2005 동덕약학연구지 Vol.9 No.-

The object of this study is to develop a nondestructive and rapid analytical method to classify WooHwangChongShimWon solution according to the types of musk substitutes such as L-muscone, civet, camphor, etc. Its indications are apoplexy, hypertension, palpitation, convulsions and unconsciousness. Musk was one of major components for WooHwangChongShimWon in the traditional prescription which is secreted by the glands of the male Moschus moschiferus parvipes. Because the use of musk is prohibited for the animal protection by the Convention on International Trade in Endangered Species of wild Fauna and Flora(CITES), manufacturing companies are using various type of substitutes for musk for musk in the recent. The quality and price of the musk substitutes will be different. However, there have been difficulties to classify of different products from different companies base on the substitutes. In this study, Near infrared spectroscopy was used for the development of classification methods. Seven different samples depending the substitutes from five pharmaceutical companies were used as samples and Near infrared(NIR) transmittance spectra were collected over the region 1100 to 1750nm. Even though spectral features based on the substitutes were not different, NIR spectral data of samples were clearly classified using principal component analysis(PCA). The proper conditions for sample preparation and measurement of spectral data were investigated; sampling preparation such as clear supenatant samples after centrifugation and uniformly suspended samples were compared and the comparison of water and air as reference materials were performed when acquring spectral data. In the PCA, the optima PC numbers were also investigated for classification condition. Overall, NIR transmittance spectroscopy using PCA was shown to have significant potential as a rapid method for classification of WooHwangChongShimWon solution based on musk substitutes.

측두엽 경화증을 가진 측두엽 환자에서 시상의 손상

김영대,허경,이승구,박선아,박수철,장진우,이병인 대한간질학회 2002 대한간질학회지 Vol.6 No.2