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Concept Verification of Three-Layer DOI Detectors for Small Animal PET
Hong, Seong Jong,Kwon, Sun Il,Ito, Mikiko,Lee, Geon Song,Sim, Kwang-Souk,Park, Kwang Suk,Rhee, June Tak,Lee, Jae Sung IEEE 2008 IEEE transactions on nuclear science Vol.55 No.3
<P> Improved spatial resolution without sacrificing sensitivity is one of the most challenging developmental goals for small animal PET scanners. The 3-layer configuration that we propose here utilizes relative offsets of half a crystal pitch in x- and y-directions, and pulse shape discrimination to obtain depth of interaction (DOI). Three layers of crystals with a dimension 1.5<TEX>$\,\times\,$</TEX>1.5<TEX>$\,\times\,$</TEX>7.0mm <TEX>$^{3}$</TEX> were composed of a L <TEX>$_{0.2}$</TEX> GSO (Lu<TEX>$_{0.4}$</TEX> Gd<TEX>$_{1.6}$</TEX> SiO<TEX>$_{4}$</TEX>: Ce) crystal layer and a L<TEX>$_{0.9}$</TEX> GSO (Lu<TEX>$_{1.8}$</TEX> Gd <TEX>$_{0.2}$</TEX> SiO<TEX>$_{4}$</TEX> : Ce) crystal layer aligned with each other, and a L <TEX>$_{0.9}$</TEX> GSO crystal layer offset at half a crystal pitch in x- and y-directions. The L<TEX>$_{0.9}$</TEX> GSO crystal layer was attached to a Hamamatsu H9500 flat-panel PMT. The devised small animal PET scanner has a diameter of 84 mm with one detector ring, and can be upgraded to two detector rings. GEANT4 Monte-Carlo simulation was used to estimate sensitivities of <TEX>$\sim 12\hbox{\%}$</TEX> and <TEX>$\sim 20\hbox{\%}$</TEX>, respectively, at the center of one and two PMT ring system with an energy window of 350 <TEX>$\sim$</TEX> 750 keV. We present flood images with peak-to-valley ratios of about 5–6 obtained using <TEX>$^{22}$</TEX> Na and layer identification capability of <TEX>$\sim 99\hbox{\%}$</TEX> with pulse shape analysis, and verified the basic concepts of multi-layer small animal PET. </P>
정은아,김희정,심상범,김종우,김남재,Jung, Eun-Ah,Kim, Hee-Jung,Sim, Sang-Bum,Kim, Jong-Woo,Kim, Nam-Jae 한국생약학회 2000 생약학회지 Vol.31 No.2
The dried roots of Rehmannia glutinosa (RG) have been used in the traditional medicine for treatment of diabetes, fever and dysuria, etc. In order to investigate the quality evaluation of the dried roots of RG, we conducted the physico-chemical and biological evaluation method. The amount of catalpol from commercial samples is very diverse about $0.00{\sim}3.89%$ by using HPLC method, because it is easily decomposed by processing of RG. So, we should try to identify the correlation with the contents of catalpol and biological activities of RG. We chose 3 samples which were a wide difference of catalpol contents between each sample (Sample-I; 3.4%, Sample-II; 2.8%, Sample-III; 0.05%). Sample-I and Sample-II were found to be more effective than Sample-III on the DPPH free radical scavenging effect and inhibitory effect on $H_2O_2-catalyzed$ lipid peroxidation in rat liver in vitro. And, Sample-I and Sample-II exhibited more significant effects than Sample-III on accelerating actions of the small and large intestinal transport, and diuretic action in mice. So, it is suggested that the quantitative determination of catalpol should be required for the tandardization of the dried roots of RG.
수확후 채소류에 발생하는 진균독소의 탐색과 방제 (II) 이병된 양념 채소류(양파, 마늘, 고추)에서 주요 진균독소 검출
정일민,주호종,심성철,백수봉,유승헌,Chung, Ill-Min,Ju, Ho-Jong,Sim, Sung-Chur,Paik, Su-Bong,Yu, Seung-Hun 한국분석과학회 1998 분석과학 Vol.11 No.3
수확후 Alternaria, Penicillium 및 Fusarium에 이병된 고추, 양파, 마늘을 HPLC로 주요독소들을 검정한 결과 고추에서 Alternaria 독소의 AOH(alternariol)는 소량~$400{\mu}g/g$, ALT(alternuene)는 소량~$103{\mu}g/g$, TeA(tenuagonic acid)는 $249{\sim}342{\mu}g/g$ 및 AME(alternariol monomethyl ether)는 $206{\sim}294{\mu}g/g$이 검출되었고 양파, 마늘에서 Penicillium 독소의 citrinin이 $2.8{\sim}18.4{\mu}g/g$, penicillin-G는 $0{\sim}439.0{\mu}g/g$, penicillic acid는 $0{\sim}10.2{\mu}g/g$ 및 patulin은 $0{\sim}7.0{\mu}g/g$ 검출되었다. 그리고 양파, 마늘에서 Fusarium 독소로는 fusaric acid가 $0{\sim}553.6{\mu}g/g$ 검출되었을 뿐 deoxynivalenol과 nivalenol은 검출되지 않았다. The major mycotoxins were detected from peppers, onions and garlics infected postharvest pathogens, Alternaria, Penicillium and Fusarium. Analyses of the major mycotoxins were conducted using HPLC. Detected Alternaria mycotoxins per gram of infected postharvest peppers were alternariol (AOH) with amount ranged from small quantity to $440{\mu}g/g$, altenuene (ALT) with amount ranged from small quantity to $103{\mu}g/g$, tenuagonic acid (TeA) with amount ranged from 249 to $342{\mu}g/g$ and alternariol monomethyl ether (AME) with amount ranged from 206 to $294{\mu}g/g$. Penicillium toxins per gram of infected postharvest onions and garlics were citrinin with amount ranged from 2.8 to $18.4{\mu}g/g$, penicillun-G with amount ranged from no detection to $439.0{\mu}g/g$, penicillic acid with amount ranged from no detection to small quantity and patulin with amount ranged from no detection to small quantity. Fusarium toxins per gram of infected postharvest onions and garlics were fusaric acid with amount ranged from no detection to $553.6{\mu}g/g$. However, deoxyrivalenol and nivalenol were not detected from onins and garlics infected by Fusarium.
( Sung Chul Choi ),( Beom Jin Kim ),( Poong Lyul Rhee ),( Dong Kyung Chang ),( Hee Jung Son ),( Jae J. Kim ),( Jong Chul Rhee ),( Soon Im Kim ),( Young Sil Han ),( Ki Hyeon Sim ),( Seok Nam Park ) 대한소화기기능성질환·운동학회 2011 Gut and Liver Vol.5 No.1
Background/Aims: Although controversial, probiotics and dietary fiber are commonly used for patients with irritable bowel syndrome (IBS). We evaluated the effects of multistrain probiotics on the symptoms of IBS to determine whether the addition of dietary fi ber had an additive effect on constipation-predominant IBS. Methods: A total of 142 participants who met the Rome III criteria were recruited and randomized into a control group or a test group. Participants in the control group received multistrain probiotic fermented milk with Streptococcus thermophilus, Lactobacillus acidophilus and Bifi dobacterium infantis; the participants in the test group received the same probiotic fermented milk mixed with dietary fi ber such as sea tangle extracts, radish extracts and glasswort extracts. The patients were treated for four weeks. Results: Most of the symptoms of IBS, with the exception of fl atulence, stool consistency, and frequency of defecation, signifi cantly improved in both groups. In the analysis of IBS subtypes, especially constipation-predominant IBS, the frequency and duration of defecation and straining at stool were improved more in the test group than in the control group. Conclusions: Dietary fiber had additive benefits for the symptoms of constipation, especially in constipationpredominant IBS. (Gut Liver 2011;5:22-28)
A Case of IgG4-Related Disease Presenting as Massive Pleural Effusion and Thrombophlebitis
( Jong Hyun Choi ),( Jae Kyeom Sim ),( Jee Youn Oh ),( Eun Joo Lee ),( Gyu Young Hur ),( Seung Heon Lee ),( Sung Yong Lee ),( Je Hyeong Kim ),( Sang Yeub Lee ),( Chol Shin ),( Jae Jeong Shim ),( Kwang 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.76 No.4
Immunoglobulin (Ig) G4-related disease is a recently recognized systemic fibroinflammatory condition characterized by a lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells with elevated circulating levels of IgG4. The disease can either be localized to one or two organs, or present as diffuse multi-organ disease. Furthermore, lesions in different organs can present simultaneously or metachronously. In the pulmonary manefestations, lesions associated with IgG4-related disease have been described in the lung parenchyma, airways and pleura, as well as the mediastinum. We report a case of IgG4-related disease presenting as massive pleural effusion and thrombophlebitis.
Jong Hwa Kwon,Sang Il Kwak,Dong-Uk Sim,육종관 한국전자통신연구원 2010 ETRI Journal Vol.32 No.2
To supply a power distribution network with stable power in a high-speed mixed mode system, simultaneous switching noise caused at the multilayer PCB and package structures needs to be sufficiently suppressed. The uni-planar compact electromagnetic bandgap (UC-EBG) structure is well known as a promising solution to suppress the power noise and isolate noise-sensitive analog/RF circuits from a noisy digital circuit. However, a typical UC-EBG structure has several severe problems, such as a limitation in the stop band’s lower cutoff frequency and signal quality degradation. To make up for the defects of a conventional EBG structure, a partially located EBG structure with decoupling capacitors is proposed in this paper as a means of both suppressing the power noise propagation and minimizing the effects of the perforated reference plane on the signal quality. The proposed structure is validated and investigated through simulation and measurement in both frequency and time domains.
Sang Hun Lee,Myung Ho Jeong,Joon Ho Ahn,Dae Young Hyun,Kyung Hoon Cho,Min Chul Kim,Doo Sun Sim,Young Joon Hong,Ju Han Kim,Youngkeun Ahn,Jin Yong Hwang,Weon Kim,Jong Seon Park,Chang-Hwan Yoon,Seung Ho 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.4
Background/Aims: Recurrent acute myocardial infarction (AMI) is an adverse cardiac event in patients with a first AMI. The predictors of recurrent AMI after the first AMI in patients who underwent successful percutaneous coronary intervention (PCI) have not been elucidated. Methods: We analyzed the data collected from 9,869 patients (63.2 ± 12.4 years, men:women = 7,446:2,423) who were enrolled in the Korea Acute Myocardial Infarction Registry-National Institute of Health between November 2011 and October 2015, had suffered their first AMI and had received successful PCI during the index hospitalization. Multivariable logistic regression analysis was performed to identify the independent predictors of recurrent AMI following the first AMI. Results: The cumulative incidence of recurrent AMI after successful PCI was 3.6% (359/9,869). According to the multivariable logistic regression analysis, the significant predictive factors for recurrent AMI were diabetes mellitus, renal dysfunction, atypical chest pain, and multivessel disease. Conclusions: In this Korean prospective cohort study, the independent predictors of recurrent AMI after successful PCI for the first AMI were diabetes mellitus, renal dysfunction, atypical chest pain, and multivessel disease.