소아 야뇨증에 대한 임상적 고찰

김승수,곽병곤,김영대,김우경,김영균,이종국 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Objectives: The aim of this study was to describe the clinical characteristics of enuretic children and to evaluate the efficacy of treatments. Methods: Our study subjects enrolled were 52 children with nocturnal enuresis, who visited outpatient clinic of pediatrics in Seoul Paik Hospital and Ilsan Paik Hospital, during the period from October 1998 to August 2004. The data of gender, age, family history, symptom, clinical type of enuresis and drug therapy were collected and analyzed retrospectively. Results: The male : female ratio was 2.25 : 1. The mean age at diagnosis was 6.8 years with an age range from 4.3 years to 12.5 years. Fourty five cases(86.5%) were diagnosed as primary enuresis and 7 cases(13.5%) were diagnosed as secondary enuresis. A family history of enuresis was noted in 5 cases(9.6%) including 4 cases with parental enuresis history. The accompanying urinary symptoms were urgency(11.5%), frequency (7.7%), and dysuria(2.0%). Conclusion: We found frequent occurrences of enuresis in boys and primary type and an occasional association with a family history of enuresis. The two main treatment modalities were behavior control with an alarm system and drug therapy with imipramine, desmopressin, or oxybutynin. We recommend continuous drug medications to control nocturnal enuresis along with encouragement.

플라즈마 이온주입기에서의 시변환 쉬스 연구

김곤호,김건우,김영우,최영도,김종식,김상진,한승희,홍문표 漢陽大學校 工學技術硏究所 1998 工學技術論文集 Vol.7 No.1

Abstract- In a plasma source ion implantation, the target is successively biased by negative voltage pulses with an intrinsic finite rise time, resulting in the time-dependent sheath formation around the target. Measurement of time-dependent sheath during the pulse rise show the ion matrix sheath development which is in proportion to square root of time and pulse rise rate over plasma density but independent of the ion mass.

사회적 변화에 따라 정신질환자들의 피해망상 속에 나타난 박해자 유형변화

강승범,황인복,김한석,김승곤,김학렬,박상학,김상훈,황걸 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.3

Objective: The authors investigated the frequency of persecutors in persecutory delusions of the psychiatric patients who didn't undergo the arrest or traumatic injury, reside in Gwangju Jeonnam area, and were admitted to the hospital after the 5.18 prodemocracy movement in Gwangju in 1980 upward 10 years. Also this study investigated the frequency of the persecutors before and after the prodemocracy movement and in capital and Gwangju Jeonnam area. Subjects and Methods: Among the 896 patients who were admitted to department of psychiatry, Chosun University Hospital from Jan. 1. 1989 to Dec. 31. 1991, we choosed 144 patients with persecutory delusion who had lived in Gwangju Jeonnam area for 10 years after 5.18 prodemocracy movement as subjects. Persecutors were classified into 7 class: unspecified, family, neighbors, communist or spy, police or army or secret agent, impersonal, others. Results: 1) In our study, the frequency of persecutors was family, unspecified, neighbors, police or army or secret agent, impersonal, others, communist or spy in descending order. As compared to previous studies (1956-2003) including our study about frequency of persecutor at capital area and Gwangju Jeonnam area, and before and after 5.18 prodemocracy movement, 2) At capital area, in the early 1980s, police, family, neighbors, unspecified person was frequent in descending order. In the both of early 1970s, 1990s, neighbors, family, unspecified person, police was frequent in descending order. 3) At Gwangju Jeonnam area, in the early 1970s, family, unspecified person, neighbors, police was frequent in descending order. In the early 1990s, unspecified person and family, neighbors, police was frequent in descending order. 4) The police class was most frequent at capital area in the early 1980s. Conclusions: We suppose that class of persecutor in persecutory delusions of psychiatric patients are changing according to social change, and frequency of police class was decreasing in both of capital and Gwangju, Jeonnam area.

우리나라 아파트團地의 問題點 分析 및 造景設計基準에 關한 硏究

金貴坤,任勝彬,曺正松,安建鏞 서울大學校 農科大學 1980 서울대농학연구지 Vol.5 No.2

It has been 22 years since the first apartment was built in Korea. Recently more and more apartments have been being introduced to Korean people and has been changing traditional Korean life style. Residents of apartment complexes in Korea suffer from various problems such as sisregarding of traditional Korean exterior space, pathology, improper community facilities and green spaces, destruction of natural environment, and lack of diversity and chracter in buildings and outdoor spaces. Historically the techniques of residential site design have been developed through three evolutionary steps. The first step was the Garden City idea of Ebenezer Howard in England(1898). In his conceptual plan he located Grand Avenue in the center of residential site. However, the green space was divided by road from residential site. The second step was the Sunnyside Gardens in New York(1924). The city Housing corporation of New York City built apartments with new concept which contained large common green spaces within a block surrounded by apartment buildings. This was possible because the lot subdivision no longer existed. The third step was the Radburn Plan(1929) in New Jersey. This was the second project of the City Housing Corporation. This plan invented two important concepts in residential site design. The one is super block concept which does not permit vehicle road within a large block. The other one is culs-de-sac road of which has a dead end on the one end. These two concepts contribute to making internal common green space without car traffic. With this concept the housing was ideally interwoven with green spaces. The Radburn Plan was the beginning of cluster development in residential site and innovation for moter age. At present, after 50 years from Radburn Plan, the basis concept of it is still valid and useful in residential site design. However, we need to make another evolutionary step for the better quality of living. The situations in Korea are different from those in western countries. Apartment is one of the western-origin housing types. Koreans have to modify western-oriented apartment buildings and site plans for cultural adaptation. Furthermore, we have to create new concepts for the better quality of living. Followings are the propositions for site design of apartment complex in Korea. 1. Cultural Aspect-One of the traditional characters of Korean exterior space os intermediate space between interior and exterior space. In order to provide intermediate space, sequence planning and gradual change of space atmosphere in outdoor space design is needed. 2. Social Aspect-We have to consider life cycle of residents, provide various community activities, increase natural elements, and decrease pathologh in apartment complex. 3. Functional Aspect-Pedestrian was should be separated from vehicle way in any case. Pedestrian way system can be benefited from combining with green space system. Green spaces should have systematic link instead of dispersed disposition without connection. The land use pattern should also have systematic and functional relationship. 4. Ecological Aspect-Dynamic equlibrium in eco-system should be preserved or modified with minimum change during and after development. The elements in inventory should be checked are land slide, erosion, surface and ground water, vegetation, wildlife, micro climate, etc. 5. Perceptional Aspect-Apartment complex should be considered as a group form as well as individual form of buildings. It is recommendable to divide outdoor spaces into human scale and to give diversity to each space and building instead of uniform treatment.

불소인식정도에 대한 조사보고

김미라,백병주,김재곤,이승익,양연미 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4

저자는 1998년 6월과 7월에 전북대학교병원 소아치과에 내원한 초진환자중 설문지에 응답할 수 있는 환자 50여명과 보호자 100명을 대상으로 불소에 대해 어느정도 인식하고 있는지 알아보고자 설문지를 이용하여 조사하여 다음과 같은 결론을 얻었다. 1. 불소의 치과에서의 사용여부에 대한 인식정도는 환자 26%, 보호자 51%, 전체적으로 42.7%를 보였다. 2. 불소의 우식예방효과에 대한 인식정도는 환자 86%, 보호자 85%, 전체적으로 85.7%의 높은 비율을 보였다. 3. 이에 반해 불소도포희망 여부에 대하여 환자 46%, 보호자 44%만이 긍정적으로 답하였다. 4. 불소를 이용하거나 도포한 경험은 환자 60%, 보호자 55%로 낮은 비율을 보였다. 5. 불소의 우식예방효과에 대한 인식여부와 실제이용 정도는 일치하지 않았다. 이에 치과 종사자 및 대중매체를 통해 보다 적극적인 불소사용의 교육이 이루어진다면 불소이용은 증가할 것이다. At the department of Pediatric Dentistry in Chonbuk National University Hospital, authors conducted a survey of 50 new patients and 100 new parents regarding fluoride in order to discover what they think about fluoride. The results obtained were as follows ; 1. It answered patients 26%, parents 51% and total 42.7% in knowledge about the use of fluoride in dental clinics. 2. The knowledge about caries prevention effect of fluoride is high ; patients 86%, parents 85% and total 85.3% 3. The patients and parents who wanted to use fluoride are 46%, 44% respectively 4. The patients and parents who experienced fluoride are 60%, 55% respectively 5. It is not correspond the knowledge about caries prevention effect of fluoride and the practical method of application These results suggest that the number of patients and parents who use fluoride will increase if we advise them adequately

담도폐쇄증 환아의 치과치료 : 증례보고

김재곤,양연미,백병주,이승익 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

Intra-& extra-hepatic duct system의 경화를 야기하는 Biliary atresia는 출생시 1:10,000의 발생빈도를 보이며, 5년 이하의 생존율을 나타내는 예후가 좋지 않은 질환이다. 담도폐쇄증의 원인은 아직 명확하지 않으나, 유전적인 요소나 발육성 원인으로 믿고 있다. 임상적 특징으로 두드러진 황달, 간비증대, 가려움증, 지방변, 황색종, 성장지연, 문맥압항진증, 출혈, 골연하증, 복수 그리고 호흡기계 감염 등을 나타낸다. 구강내 소견으로 녹색을 띄는 변색치아, 유치의 확장된 치수강과 치근관, 치아맹출지연, 법랑질 형성부전, 그리고 심한 치아 우식 등이다. 담도폐쇄증은 조기진단과 수술에 의해 사망률이 감소되고, 성장과 발달이 정상으로 돌아오며 생존율도 향상되었으나 여전히 그 원인과 치료에 대한 연구가 계속되어야 할 것이다. 이에 저자는 전북대학교 치과병원에 내원한 2명의 담도폐쇄증환아에 대해 임상, 방사선학적 특징 및 적합한 처치에 대하여 보고하고자 한다. Congenital biliary atresia with pregressive sclerosis of the intra-and extra-hepatic duct system occurs in 1:10,000 live births, and has a poor prognosis with an expected survival of less than 5 years. Etiology of biliary atresia is unclear, however, it is believed a genetic or developmental cause. The clinical characteristics include pronounced jaundice, hepatosplenomegaly, pruritus, steatorrhea, xanthomas, growth retardation, portal hypetension, bleedings, ascites and respiratory infections. Oral manifestations have seldom been reported in patients with biliary atresia, but there may be enamel hypoplasia, delayed tooth eruption, and green teeth. Early diagnosis and surgical intervention have decreased morbidity, returned growth and development to normal and improved the prognosis for survival. Authors report the clinical and radiologic characteristics, proper managements about two cases with biliary atresia.

여가활동 유형과 여가만족 및 생활만족의 관계

김승곤,양명환 濟州大學敎 體育科學硏究所 1995 체육과학연구 Vol.1 No.-

The purpose of this study was to determine the relationship of leisure activity types, leisure satisfaction and life satisfaction among college students. Specifically, two purposes were established for this study. The first purpose was to examine the effects of gender, age and types of leisure activity on leisure satisfaction and life satisfaction. The second purpose was to examine a casual relationship among types of leisure activity, leisure satisfaction, and life satisfaction. The subjects in this study were 115 male and 109 female college students. A purposive sampling method was used to select subjects who participated in three leisure activities including sport & exercise program(n=70,31.3%), hobby & creative activity(n=68, 30.4%),and amusement activity(n=86, 38.4%). Data were collected from all subjects during the fall of 1995. The Leisure Satisfaction Scale(Ragheb & Beard, 1980)was used to provide a measure of the extent to which individuals perceive that certain needs are met or satisfied through leisure activities. Life satisfaction was assessed by using a semantic differential technique. A 5 point Likert response scale was adopted for the instruments. One-way MANOVA, ANOVA and multiple regression analyses were used for research problems testing. MANOVAs indicated that gender, age, and leisure activity type had a significant effects on leisure satisfaction. Posttesting showed that male group perceived significantly higher in leisure satisfaction(psychological, educational, social, relaxational physio1ogical)than female group. The higher the age, the greater the leisure satisfaction(psychologica1, educational, social, relaxational physiological), and sport activity group perceived more leisure satisfaction (psychological, educational, social, relaxational, physiological, physical environment)than did the hobby & creative activity group and amusement group. ANOVA indicated that gender, age, leisure activity types had a significantly effects on life satisfaction. The male group perceived significantly higher in life satisfaction than female group. Scheffe multipe comparison indiacted that the higher the age, the greater the life satisfaction, and sport activity group perceived more life satisfaction than did the hobby & creative activity group and amusement group. Also multiple regression analysis and path analysis revealed that life satisfaction could be the best predicted from leisure satisfaction and could be affected through the sport activity indirectly. The findings provide significant casual relationships among leisure activity type, leisure satisfaction and life satisfaction in college students.

여러가지 수복물의 polishing조건에 따른 치수 온도변화

김재곤,이승영,박종하,백병주,양종숙 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.2

수복물의 연마의 중요성에 대하여 많은 연구들이 이루어져 왔으며, 이는 수복물의 금속성질의 개선, 변연적합성의 증가 그리고 치태축적의 감소 등을 이유로 시행된다. 그러나 불행하게도 수복물에 대한 연마시 열의 발생으로 인하여 치수부위에 손상을 초래하므로 열의 발생을 최소화하려는 노력이 뒤따라야 할 것이다. 이에 본 연구에서는 수복물의 연마시 회전속도의 차이, 냉각제의 적용 유무, 여러 종류의 수복물의 차이, 간헐적인 연마와 연속적인 연마의 차이 그리고 잔존 상아질의 두께의 정도에 따른 치수내부에서의 열의 변화를 알아보기 위하여 발거된 구치에 5급 와동을 형성한 후 복합레진(Z100, 3M co), resin-mod-ified GLC(Dyract, Fuji II LC), 그리고 아말감(Degussa)등으로 충전하였으며, 다양한 조건에서의 연마를 시행, 치수내부에서의 열의 변화를 측정하여 다음과 같은 결과를 얻었다. 1. Amalgam을 건조한 상태에서 연마시 다른 재료에 비해 큰 치수내 온도 상승을 보였다.(P<0.05). 그러나 Z100, Dyract, Fuji II LC간에는 간헐적 수복물 연마와 연속적인 수복물 연마 모두 어떤 경우든 유의차가 없었다.(P>0.05). 2. 같은 조건으로 연마를 시행했을 때, 간헐적인 연마보다 연속적인 연마를 한 경우가 치수내 온도가 더 크게 상승하였다.(p<0.01). 3. 아말감과 Dyract에 있어서는 잔존 상아질의 차이에 따른 치수내 온도변화에 유의한 차이를 보였으나(P<0.01), Fuji II LC에 있어서는 유의성이 없었다(P>0.01). 4. 냉각제의 유무에는 관계없이 어떤 경우든 시간에 따른 온도 상승을 보였다. 그러나, 냉각제를 사용한 경우가 냉각제를 사용하지 않은 경우에 비해 온도 상승값이 훨씬 작았다.(P<0.01) The importance of finishing and polishing the restoration has been described by several authors. The final step provides for improved metallurgical properties, better marginal adaptation, reduced plaque accumulation. Unfortunately, finishing of the restorations can produce damage from temperature rises at the pulpal wall. The aim of this study was to determine the changes in temperature can be occurred during the use of finishing and polishing instruments under a variety of conditions. ; with or without a water coolant, intermittent or continuous operation, high or low rotation speed, remaining dentin thickness, and various restorative materials. Class V preparations were cut on extracted molars and restored with composite resin(Z 100), resin-modified glass ionomer cements(Dyract, Fuji II LC), and amalgam. Finishing was done with aluminum oxide coated disc(Sof-lex polishing disc, 3M, USA). The following results were obtained. 1. The rise of temperature during polishing of amalgam restorations was the highest among the all experimental groups except polishing with water coolant(P<0.05). However, there were no statictical differences in temperature rises between Z 100, Dyract and Fuji II LC(P>0.05). 2. The intrapulpal temperature was greatly influenced by the applied time, and intermittent polishing was showed significantly lower temperature rises than continuous polishing(p<0.01). 3. The intrapulpal temperature was increased according to the application of polishing regardless of using water coolant. However, polishing with water coolant showed significantly lower temperature in the pulp than not used water coolant(P<0.01).

유전적 불안정성과 세포 사멸사

김승곤,황걸 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Genome integrity and cell proliferation and survival are regulated by an intricate network of pathways that include cell-cycle checkpoints, DNA repair and recombination, and programmed cell death. Permanent or transient genomic instability, which represents one of the fundamental characteristics of cancer, might be ascribed to deficiencies in numerous cellular processes including mitotic-checkpoint regulation, and DNA-damage signalling and repair, as well as telomere maintenance and centrosome function. This review will focus on the complex interplay between genomic instability and apoptosis regulation that participates in carcinogenesis. The relationship between genomic integrity and cell-death regulation can follow at least three different non-exclusive patterns, all of which might be important for the development of cancer. First, genomic instability can lead to the mutation, or altered expression levels, of cell-death regulators. Second, disabled apoptosis can favor genomic instability. Indeed, numerous cellular mechanisms enforce the rule 'better dead than wrong', which means that cells that have a damaged genome or are afflicted by many disorders will be aborted by apoptosis - thereby avoiding the propagation of potentially oncogenic mutations. DNA double-strand breaks (DSBs), telomere dysfunction, illicit polyploidy or abnormal mitoses can directly trigger apoptosis through a default pathway. However, if apoptosis is inhibited for some reason, this increases the risk of chromosomal instability (CIN) at several levels, and cells that are sufficiently fit to survive can be at a growth advantage, which can lead to cancer. Third, a single protein or process might be involved in the control of both apoptosis and genomic instability, which allows 'crosstalk' between the processes. Here, we will discuss these different possibilities, their molecular mechanisms and their possible impact on carcinogenesis.

신경계통의 유전자 손상과 복구 시스템에 대한 임상적 의의

김경환,김승곤,황걸 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.3

Defects in the response to DNA single-strand or double-strand breaks underpin many human diseases associated with disorders of the nervous system. Duhng nervous system development endogenous DNA damage often results in apoptosis, although cell replacement can occur from germinal zones within this rapidly proliferating tissue. However, if this damage surveillance is faulty, cells with genomic damage may inappropriately become incorporated into the nervous system, and the subsequent demise of these cells may result in neurodegeneration. I will discuss the various DNA repair pathways known to be active in the nervous system. The importance of DNA repair to the nervous system is most graphically illustrated by the neurological abnormalities observed in patients with hereditary diseases associated with defects in DNA repair, I will consider the mechanisms underlying the neurological abnormalities ob- served in patients with four of these diseases: xeroderma pigmentosum(XP), Cockayne's syndrome (CS), ataxia telangectasia (AT) and AT-like disorder (ATLD).