서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

유방의 비종양성 및 종양성 병변에서 actin과 broad-spectrum keratin 양성세포에 대한 면역조직화학적 검사

이규범,김인선,백승룡 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.2

An immunohistochemical study was done in nonneoplastic and neoplastic breast diseases to detect the distribution and pattern of action-positive myoepithelial cells, and keratin-positive epithelial cells by using strept ABC method if formalin-fixed and paraffin-embedded tissues. The results obtained are as follows: 1. In 7 cases of fibrocystic diseases including sclerosing adenosis, a continuous layer of actin-positive myoepithelial cells and less prominent keratin-positive inner epithelial cells were noted. Actin reactivity was weaker in the smaller ducts. 2. The staining pattern with antibodies to actin and keratin in 11 cases of fibroadenoma was similar to that found in the fibrocystic disease, except more actin-positive myoepithelial cells in the intracanalicular type of fibroadenoma than those in the pencanalicular type. 3. In 13 cases of invasive ductal carcinomas, all showed actin-positive and keratin-positive tumor cells, and among them 4 cases revealed the heterogenity of tumor cells with both actin and keratin positivity. In 4 cases of invasive lobular carcinomas, actin-positive cells were found in all, whereas keratin -positive tumor cells were in only one.

T1 강조 영상에서 선조체 고신호강도를 보이는 당뇨 환자에서의 편측무도증

정승철,이병철,김상윤,배재천,황성희,도화범,박종호 대한신경과학회 1997 대한신경과학회지 Vol.15 No.1

편평세포폐암에서 p53 돌연변이의 발현과 TNM 병기와의 상관관계

이상숙,한승범,전영준 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Primary lung cancer is now recognized as a major cause of cancer death in Korea as well as the whole world. Non-small-cell lung cancers(NSCLC) comprise about 75% of lung cancer and squamous cell carcinoma is the most common type in Korea. Mutations of p53 gene are common in variety of human cancers, including lung cancer. The p53 gene appears to inhibit the proliferation of cells from the G1 to the S phase of cell cycle and is able to suppress the transformations of cells by other oncogenes, to inhibit the growth of malignant cells in vitro and suppress the tumorigenic phenotype of transformed cells. Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumor viruses, can lead to cancer. These mutations seems to be the most common genetic changes in human cancers. p53 gene mutation is known to be a poor prognostic marker in breast cancer and has significant association with lymph node involvement. But in human lung cancer the association of p53 mutations and TNM stages are controversial. Immunohistochemical staining can detect only mutant p53 protein bacause of markedly prolonged half life of mutant p53 protein. We performed the immunohistoschemical staining on 48 surgically resected and 10 bronchoscopically biopsized specimens of primary squamous cell carcinoma of the lung with monoclonal antibody(DO 7) and analyzed the relationship between the expression of p53 protein and clinical TNM stages. p53 protein was detected in 60.3% of total 58 cases. p53 protein was positive in 52.9% of stage I(17cases), 83.3% of stage Ⅱ(6 cases), 72.2% of ⅢA(18 cases), 42.9% of ⅢB(7 cases) and 50% of stage Ⅳ(10 cases) which revealed no significant correlation between p53 protein detection and stages. There was no significant correlation between p53 protien detection and No and N₁-₃as well Mo and M₁. In conclusion, we couldn't find any significant correlation between p53 protein detection and TNM stages which suggests p53 mutation is frequent in squamous cell carcinoma of the lung but play different role in progression of clinical stages.

팥바구미 저항성 녹두의 작물학적 특성

이구환,정승근,박상일,송범헌,조용구,김홍식 忠北大學校 農業科學硏究所 2002 農業科學硏究 Vol.19 No.-

보호계전 종합환경을 위한 HMI 개발

이남호,이승재,조범섭 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

The protective relaying setting job which has been performed manually, takes a long time and is vulnerable to errors. The goal of this paper is to develop the user-friendly interface for integrated protection system environment and to control protection-related jobs and the database management system efficiently and conveniently.

20년전과 비교한 한국청년의 미소 변화에 관한 연구

범승균,정지혜,김태영,이경은,동진근 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3

Purpose: Teeth are generally exposed when people smiling. Moreover, the exposed teeth and soft tissue when smiling becomes an important guideline for esthetically prosthetic restoration. This research is to compare and find out differences of Korean young men's smile living in presence and twenty years ago. Materials and methods: Subjects, 100 young men (50 male and 50 female), were required about several aspects; normally developed physical condition, no psychological or genetic disorders, a fine face with no loss of teeth, no experience in orthodontic or prosthetic treatment, relatively normal occlusion, aged between 20 - 29. The photos of the subject at rest position and front face when fully smiled were taken three times. 100 photos (50 male and 50 female) were chosen at random from the 240 university students' smile photos taken by Yoon and his colleagues in 1991. By Hulsey's method of measuring smile, several factors; the change of upper lip curvature, the change of the relation between the upper lip and teeth, parallelism between Mx. incisor and lower lip, contact relation between Mx. incisor and lower lip and teeth displayed in a smile, were measured and analyzed. Meanwhile, ten dentists assessed aesthetic evaluation about men and women's smile for twice and recorded and compared smile score. The -test (P<.05) was used to compare the measured value. The difference of smile score was analyzed by t-test (P<.05). Results: The smile score calculated in 2011 (60.22) was higher than that of 1991 (52.80). Among five measurement categories, the noticeable difference was distinguished from two factors; the change of upper lip curvature and contact relation between Mx. incisor and lower lip. Conclusion: The Korean young men's smile has been considerably improved for twenty years. And it is found that the change of upper lip curvature plays an important role, that is, the smile formed with an ascended labial commissure has been increased significantly. 연구 목적: 일반적으로 치아는 미소 지을 때 가장 많이 노출되며, 미소 시에 나타나는 치아와 연조직과의 관계 등은 심미적인 보철 수복에 있어서 중요한 지침이 된다. 본 연구는 20년 전 한국 청년들의 미소와 현재 한국 청년들의 미소를 비교하여 그 차이를 알아보고자 하였다. 연구 재료 및 방법: 신체적인 발육 상태가 정상적이고 전신적 또는 유전적 질환이 없으며, 안모가 양호하고 치아의 결손이 없으며 교정 및 보철치료를 받은 경험이 없고, 교합상태가 비교적 정상적인 20 - 29세 사이의 청년 100명(남자 50명, 여자 50명)을 대상으로, Cephalometer에 사용되는 두부 고정 장치를 사용하여 피검자의 F-H plane이 지면에 평행하도록 한 후, 35 mm 카메라(400D. Cannon, Japan), 120 mm 렌즈 그리고 삼각대를 사용하여 피검자의 midsagittal plane에 카메라 렌즈의 중심을 맞추고 상악 중절치 절단과 렌즈와의 거리를 930 mm로 하여 안정위 및 full smile 시의 안모 정면 사진을 3회씩 촬영하였다. 1991년 윤 등이 촬영한 대학생 240명 중 무작위로 선택한 100명(남자 50명, 여 자 50명)의 미소사진과 함께 개인용 컴퓨터 및 V-ceph 6.0 프로그램을 이용하고 Hulsey의 미소 계측 방법을 참고로 하여, 상순의 형태, 상순과 치아와의 관계, 하순과 상악 전치 절단연과의 평행 관계, 하순과 상악 전치 절단연과의 접촉 관계, 미소시 나타나는 치아 등을 계측하고 분석하였다. 한편 치과의사 10인이 남,녀 각 2회씩 미소에 대한 미적 평가를 시행하여 미소평점을 기록하고 비교하였다. 결과: 지난 20년간 한국 청년의 미소가 크게 향상되었으며 이러한 변화는 주로 상순의 형태가 영향을 준 것을 알 수 있었다. 즉 입꼬리가 위로 올라가는 형태의 미소가 괄목할 만한 증가를 보인 반면 입 꼬리가 아래로 처지는 형태의 미소는 현저한 감소를 보였다. 결론: 지난 20년간 한국 청년의 미소가 크게 향상되었는데 이러한 변화는 주로 상순의 형태가 영향을 준 것으로 나타났다.

알긴산나트륨 및 첨가제를 함유한 서방성 매트릭스 정제

이범진,이태섭,신성이,허보욱,유승구 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.3

The matrix tablet containing sodium alginate and CaHPO₄ can release drugs in a controlled fashion from hydrogel with gelling and swelling due to their interaction as water penetrates the matrices of the tablet. The purpose of this study was to evaluate release characteristics of the matrix tablet varying the amount of sodium alginate, CaHPO₄ and other excipients such as chitosan, hydroxypropyl methylcellulose (HPMC) and Eudragit^ⓡ RS100 in the simulated gastric and intestinal fluid. The practically soluble ibuprofen was used as a model drug. The release profiles of matrix tablet in the gastric fluid as a function of sodium alginate/CaHPO₄ ratio was not pronounced because of low solubility of drug and stability of alginate matrices. However, release rate of drug from the matrix tablet in the intestinal fluid was largely changed when sodium alginate/CaHPO₄ ratio was increased, suggesting that the ratio of sodium alginate/CaHPO₄ was an important factor to control the gelling and swelling of the matrix tablet. The incorporation of other excipients into the matrix tablet also influenced the release rate of drug. The chitosan and HPMC decreased the release rate of drug. No release of drug was occurred when Eudragit^ⓡ RS100 was added into the tablet. The retarded release of matrix tablet when excipients were added resulted from the hindrance of swelling and gelling of the matrix tablet containing sodium alginate and CaHPO₄. The hardness and bulk density of the matrix tablet was not correlated with release rate of drug in the study. From these findings, the ratio of sodium alginate and CaHPO₄ in the matrix tablet in addition to incorporation of excipients could be very important to control the release rate of drug in dosage form design.

순·구개열 환자의 두부규격방사선사진상을 이용한 친자간의 유사성에 관한 연구

이언경,나승목,고광준,조수범 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.2

The purpose of this study was to determine whether any similarity existed in craniofacial morphology between parents and offspring in cleft lip with or without cleft palate. Thirty three measurements of the various regions of cranium and face were obtained from lateral cephalometric radiograms in 28 families comprising 28 fathers, 28 mothers and 28 cleft patients. The measurements of cleft patients were compared with those of their fathers, mothers and midparents. The obtained results were as follows: 1. There were similar measurements between the cleft patients and their father; ramal height(Ar-Go), mandibular angle(∠MP-RP). 2. There were similar measurements between the cleft patients and their mothers; cranial base angle(∠NSBa), relation of maxilla to the cranial base(∠SNA), relation of maxilla to the cranial base(soft tissue:∠BaN"Sn), angle of inferior border of mandible(∠SNL-MP) and convexity of nose apex(soft tissue:N"PrnPog"). 3. There were similar measurements between the cleft patients and their mdparents; ramal height (Ar-Go), cranical base angle(∠NSBa), relation of maxilla to the cranial base(soft tissue:∠BaN"Sn), Y axis angle(∠NSGn) and mandibular angle(∠MP-RP). 4. There was no similar measurements between the cleft patients and their fathers and mothers simultaneously.