지중내 공동 탐지를 위한 비파괴 검사 기법에 대한 실험적 연구

유정동(Jund Dong?Yoo),양학모(Hak Mo?Yang),장기창(Ki Chang?Jang),강승민(Seung Min?Kang),조소현(So Hyun?Cho),김현기(Hyun-Ki?Kim),Seung Soo?Kim,Da Bin?Jin 대한토목학회 2018 대한토목학회 학술대회 Vol.2018 No.10

경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

이면성 및 도플러 심초음파도를 이용하여 진단한 선천성 거대 좌회선지-좌심실 관동맥루

진승원,박준철,이영중,유병현,박현옥,김용주,윤호중,김재형,홍순조,최규보,권종범,원용순,박건 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

비만 청소년의 심폐기능과 혈중지질에 관한 연구

유승희,김성진 慶熙大學校 1997 論文集 Vol.26 No.-

The purpose of this study was to investigate how exercise affect the cardiorespiratory function and level of serum lipids in adolescent obesity. The test subjects were twenty obesity men(obesity group) and twenty general men(general group) enrolled at N.S junior high school in March, 1997. The age of subjects were distributed between thirteen and fifteen. The heart rate(HR), VO_2max, systolic blood pressure, and serum lipids were measured before and after the Ergometer exercise for 12 minutes. All data were processed by IBM package SPSS-PC^+ for statistical analysis. The results obtained in this study were summarized as follows; 1. The %fat were 13.9±1.86% in general group and 24.5±1.68% in obesity group. 2. The Heart Rate at resting were 75.4±7.02beats/min in general group and 85.8±5.53beats/min in obesity group. And the HR after twelve minutes ergometer exercise were 163.2±4.52beats/min in general group, 175.5±5.13beats/min in obesity group. 3. The Systolic Blood Pressure at resting were 117.0±7.32mmHg in general group and 121.0±6.41mmHg in obesity group. And the Systolic Blood Pressure after twelve minutes ergometer exercise were 160.3±6.58mmHg in general group, 169.0±8.67mmHg in obesity group. 4. The VO_2max were 45.38±6.22㎖/㎏/min in obesity group. 5. The serum Total-Cholesterol level at resting were 133.3±16.01㎎/㎗ in general group and 179.9±30.82㎎/㎗ in obesity group. And the serum Total-Cholesterol level after twelve minutes ergometer exercise were 136.5±15.04㎎/㎗ in general group and 184.5±33.14㎎/㎗ in obesity group. 6. The serum Triglyceride level at resting were 61.8±11.77㎎/㎗ in general group and 112,3±22.55㎎/㎗ in obesity group. And the serum Triglyceride level after twelve minutes ergometer exercise were 69.7±12.08㎎/㎗ in general group and 120.9±20.09㎎/㎗ in obesity group. 7. The serum HDL-C level at resting were 48.4±4.97㎎/㎗ in general group and 36.9± 4.69㎎/㎗ in obesity group. And the serum HDL-C level after twelve minutes ergometer exercise were 49.2±4.49㎎/㎗ in general group and 38.9±5.79㎎/㎗ in obesity group. 8. The serum FFA level at resting were 565.1±125.09㎎/㎗ in general group and 679.2 ±179.76㎎/㎗ in obesity group. And the serum FFA level after twelve minutes ergometer exercise were 720.1±131.59㎎/㎗ in general group and 882.9±191.57㎎/㎗ in obesity group.

모래다짐말뚝의 원심모델링

유남재,정길수,김상진,채승호 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

This paper is results of extensive centrifuge model experiments about design factors influencing the bearing capacity and the settlement behaviors of SCP (Sand Compaction Pile). Centrifuge model tests were carried out changing design factors for SCP method such as replacement area ratio (as= 20, 40, 70%), improvement ratio to footing width (W/B = 1, 2, 3), and amount of fines in sand pile (#200 = 5, 10, 15). Therefore, the effects of these design factors on the bearing capacity and the settlement behavior of SCP were investigated and changes of stress concentratio rato due to such an design factors were also investigated. Centrifuge model testing technique for preparing and installing centrifuge model of sand compaction pile, using freezing them, was also developed. As results of centrifuge model tests, more fines in sand compaction pile increases the bearing capacity of SCP. Optimum improvement ratio to footing width was found to be 2. Values of stress concentration ratio was in the ranges of 1.5 - 3.5. The depth of bulging in sand piles was found in the range of 2.0 - 2.5 times of pile diameter.

비소세포암에서 C-erbB-2와 COX-2 발현의 면역조직화학적 관련성

유승진 외 중앙대학교 의과대학 의과학연구소 2010 中央醫大誌 Vol.35 No.1/2

Background & Purpose: The study for inhibitors of gene products participating in multistep carcinogenetic event of human cancer is important target relevant to chemoprevention or adjuvant therapy of cancer. This study was performed to search basic data for chemoprevention or adjuvant therapy of human non-small cell lung cancer and to evaluate coexpression of each gene product, the relationship between the expression of each gene product and clinicopathologic factor or prognosis. Method: The following formalin-fixed paraffin embedded surgical specimen was immunohistochemically stained by avidin-biotin complex method for C-erbB-2 and COX-2; 55 cases of squamous cell carcinoma and 29 cases of adenocarcinoma of lung. Results: Positive C-erbB-2 and COX-2 expression is more often seen in adenocarcinoma compared with squamous cell carcinoma. Correlation between early and advanced cancer was insignificant. Coexpression of C-erbB-2 and COX-2 expression is more often seen in adenocarcinoma compared with squamous cell carcinoma. Conclusion: These results suggested that degree of C-erbB-2 and COX-2 expression depended upon histologic type of non-small cell lung cancer. However, further studies are required for the determination of significant relationship in coexpression of two gene products and clinicopathologic indices.

Sheehan 증후군 발생한 Torsades de Pointes

김승환,김남호,김용철,최준호,박은미,이상재,이은미,유남진,윤경호,오석규,정진원 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.1

재발하는 심실 빈맥으로 내원한 환자에서 Sheehan 증후군을 진단하였고, 적절한 호르몬 보충 치료 후 심전도 이상이 정상으로 회복된 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Torsades de Pointes is a form of polymorphic ventricular tachycardia that is associated with prolongation of QT intervals, characterized by QRS complexes of progressively changing ampulitude and cyclic length, giving the appearance of oscillations around the baseline. A 77 years-old woman was presented with hypotention and arrhythmia. Twenty four-hour ECG showed typical episodes of torsades de pointes with QT prolongation. This arrhythmia was controlled by isoproterenol and magnesium infusion, but it was not disappeared. She was diagnosed as Sheehan's syndrome by past history, anterior pituitary stimulation test and empty sella on CT scan. After hormone replacement treatment, Prolonged QT interval was normalized and polymorphic ventricular tachycardia has not recurred. We report a case of torsades de pointes associated with Sheehan's syndrome

석이로부터 분리한 페놀성 화합물의 phospholipase A_2 저해활성

김진우,송경식,유익동,장현욱,유승현,배강규,민태진 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

호알카리성 진균 Cephalosporium sp. RYM-202가 생산하는 alkaline xylanase (CX-III)의 작용에 의해 xylan 기질로부터 생성되는 주요 가수분해 산물은 xylobiose와 중합도가 4 이상인 xylooligosaccharides이었다. 이 효소는 xylobiose에 대한 분해능을 가지고 있지 않지만 xylotriose로부터는 xylobiose를, xylotetraose로부터는 xylobiose와 xylotriose를 주산물로 형성하였다. 이러한 결과들은 CX-III가 transglycosidase 활성을 소유하는 전형적인 endo-type xylanase임을 보여준다. N-bromosuccinimide에 의한 CX-III의 화학적 변화 실험 결과 효소 1분자 당 2개의 tryptophan 잔기가 활성에 관여하는 것으로 나타났다. 그러나 iodoacetamide 및 diethylpyrocarbonate에 의한 효소활성의 저해효과는 나타나지 않음으로써 이 효소의 활성부위에 cysteine과 histidine 잔기가 필수적이지 않음이 확인되었다. The hydrolysis products formed from birchwood xylan by the action of an alkaline xylanase (CX-III) from alkalophilic Cephalosporium sp. RYM-202 were xylobiose and xylooligosaccharides polymerized with more than 4 sugar molecules. This enzyme was not active on xylobiose but readily attacked xylotriose accumulating xylobiose as a major product. The predominant end-products from xylotetraose by CX-III were xylobiose and xylotriose. These results indicate that the enzyme is typically endo-type xylanase possessing transglycosidase activity. Chemaical modification of CX-III with N-bromosuccinimide revealed that two tryptophan residues per molecule of CX-III were essential for its catalytic activity on xylan. On the other hand, iodoacetamide and diethylpyrocarbonate did not influence the activity of the enzyme, suggesting that cysteine and histidine residues are not involved in the active site of this alkaline xylanase.

22q11.2 미세 결실 증후군 환아에서 내분비 기능 및 성장에 관한 연구

이종승,최진호,유한욱 대한소아내분비학회 2004 Annals of Pediatirc Endocrinology & Metabolism Vol.9 No.1

소아에서의 급성 파종성 뇌척수염의 임상적 고찰

조수진,박은애,유은선,김혜순,손세정,서정완,이승주,한후재 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

목적: 급성 파종성 뇌척수염은 감염이나 예방 접종 후 발생하는 중추 신경계의 급성 자가 면역 염증성 질환으로 탈수초를 일으킨다. 신경학적인 증상으로 발현되고 대부분 환전히 회복되지만 신경학적 후유증을 남기거나 사망 할 수도 있다. 이에 저자들은 본원에서 발생 한 14명을 분석하여 조기 진단과 치료에 도움을 주고자 하였다. 대상과 방법: 1998년 3월부터 2003년 8월까지 이대목동병원에서 급성 파종성 뇌척수염으로 진단 받은 14명의 의무기록을 후향적으로 조사하였다. 결과: 환자들의 평균 발생 연령은 5±7.8개월이였고, 특정계절이나 연도에 집중되어서 나타나지는 않았다. 선행질환은 주로 비특이적인 상기도 감염이 가장 많았고, 초기증상으로는 경련이 가장 많았다. 그 외에 의식저하나 운동장애도 있었다. 뇌척수액 검사에서 백혈구 증가증이 발견된 경우는 있었으나 단백이 증가된 경우는 없었다. 뇌 자기공명 촬영에서 T2 증강시 뇌백질과 기저핵에 고음영의 다발성 병소가 발견되었고 추적 촬영에서 대부분에서 소실되었다. 뇌파 검사가 시행되었던 경우 전반적인 서파가 가장 많았고 국소적인 극파가 나온 경우도 한 명 있었다. 환자들은 정맥 면역 글로블린과 메틸프레드니졸론으로 치료하였고 치료 시작 후 3~7일내 증상이 호전되었다. 모든 환자를 2달 이상 추적 관찰하였고 항경련제가 지속적으로 필요한 정도의 경련성 질환이 두 명, 신경아교증이 남아잇는 경우가 한 명, 외래에서 다발성 경화증이 의심되는 경우가 한 명 있었다. 결론: 급성 파종성 뇌척수염은 침범 부위에 따라서 다양한 임상 상으로 나타나며 면역 글로블린과 메틸프레드니졸론이 치료에 효과적이였다. 본 연구에서는 대상 환자수가 적어 신경학적 후유증의 위험요소는 밝힐 수는 없으나, 예후는 검사소견과 연관되어 있지는 않았고, 대부분에서 양호하여 완전히 회복되었으나, 신경학적 후유증이 남은 경우도 있었다. Objective:Acute disseminated encephalomyelitis(ADEM) is an acute demyelinating autoimmune inflammatory disease of the central nervous system which develops after infection of vaccination. It may be fatal, and produce a permanent residual static disability or fully recover. We retrospec-tively studied 14 cases to investigate the clinical findings and outcome of ADEM. Methods : 14cases of ADEM diagnosed at Ewha Womans University Mokdong Hospital from 1998 to 2003 were retrospectively reviewed. Results : The age of onset was 5years±7.8 months and no seasonal clustering was found. The time of onset of symptoms was between 3 to 30 days. The preceding events were nonspecific upper respiratory infections in 9 cases, aseptic meningitis in 4 cases, and gastroenteritis in one case..The initial symptoms were seizure, altered consciousness, hemiparesis, fever, headache, and vomiting. Brain MRI showed multifocal high signal intensity lesions on T2 weighted image mainly in the cerebral whith matter, basal ganglia and periventricular white matter. EEG was performed in some cases and showed generalized or focal slow waves and only one case showed focal spikes. Patients were treated with IV globulin and methylprednisolone and the symptoms improved within 3-7 days after treatment. All patients were followed up for more than 2 months and most of them fully recovered except two. Conclusion : ADEM presents in various clinical manifestations depending on its involvement of the brain lesions. Most cases recovered fully but in some cases, residual permanent neurologic sequelae remained.