複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

조선후기 서울 포전(布廛)이 남긴 기록의 조각들 -"정승모 문서"의 소개와 분류-

정승모 ( Seung Mo Chung ),이영훈 ( Young Hoon Rhee ),조영준 ( Young Jun Cho ) 한국고문서학회 2016 古文書硏究 Vol.48 No.-

이 글에서는 故 정승모 박사가 발굴한 조선후기 서울 布廛의 문서를 소개하고, 그 식별 및 분류에 관해 試論하였다. 향후 여러 가지 측면에서 심화 연구가 이루어질 수 있도록, 書誌的 특징을 포함하여 검토하였다. 40여 장의 斷片으로 구성된 ‘정승모 문서’는 조선후기 서울의 포전 조직에서 작성한 것으로서, 18세기 후반에서 19세기 후반 사이에 생산된 문서가 뒤섞여 있음을 밝혔다. 포전의 삼베 구매 및 분배와 관련된 문서 중에는 공동 구매에 참여하여 지분(깃)을 행사한 포전 구성원이 나열된 사례가 있는데, 그 기록의 순서는 牛耕式을 따르고 있었다. 인명의 기재 양식에 대한 파악은 조직의 인적 구성을 비롯한 다각도의 후속 연구를 위해 반드시 선행되어야 하는 문제인데, 이글에서의 실증 분석을 통해 해결된 것이다. 삼베의 상납 및 운반과 관련된 문서의 이해는 그리 쉽지 않으나, 대략 다음과 같은 다섯 가지의 경로를 상정해 볼 수 있었다: (1) 포전에 속한 개별 상인에 대한 공급, (2) 고위 관료에 대한 衣資布 상납,(3) 민간을 대상으로 판매한 포전 건물[房]에의 공급, (4) 중앙 관청에의 貢布 상납, (5) 貢人에 대한 공포 공급. 삼베를 공급한 다음의 대금 정산은 별도의 기록을 통해 이루어지고 있었음이 확인되었다. 이 글에서, 비록 충분한 정보가 없는 상황임에도 여러 가지 추론을 통해 ‘정승모 문서’의 분류안을 제시한 결과, 다음과 같은 두 가지 효과를 기대해 볼 수 있다. 첫째, ‘정승모 문서’ 및 각종의 시전 관련문서에 대한 심층적 이해 및 실증 분석이 가능할 것이다. 둘째, 앞으로 이와 유사한 문서가 발굴될 경우에 ‘정승모 문서’의 분류안을 일반적 지침으로 활용할 수 있을 것이다. Ten years ago, a set of documents and scraps of the hemp merchant guild (p``ojn) in Seoul was introduced by the late Dr. Chung, Seung-Mo, a historical folklorist. This study attempts to identify each document and scrap by classifying all the materials. Various aspects, including bibliographic items, were discussed. The documents and scraps are assumed to have been written between the late 18th and late 19th centuries. Empirical analysis in this study reveals that the entries of the p``ojon members who joined each joint venture were written in ``boustrophedon.`` Using this knowledge, it is possible to perform further research, including personnel setup. Documents and scraps related to the procurement and supply of hemp cloths enabled us to suggest the five paths of distribution, namely, (1) supply for the individual members of the p``ojon guilds, (2) procurement for bureaucrats`` clothing, (3) supply for retail shops, (4) procurement for government offices, and (5) supply for tribute merchants. Despite the limited information, a categorization candidate was proposed through inductive reasoning. This proposal can serve as a guideline for the classification of new documents or scraps in the future.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

안면신경 마비 환자에 있어서의 측두근 및 근막피판을 이용한 안면근 기능 회복 증례보고

정창주,권혁도,엄인웅,우승철,민승기,정호용 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1

Generally, the totally paralyzed face can never be made normal by any of the current methods of reconstruction. Careful selection of patients based on sound judgment of what can and cannot be achieved by the proposed surgical technique is paramount to a successful operation and a satisfied patient. The results are related to time of delayed between injury and repair : the shorter the delay the better are the results. The objectives in correcting facial paralysis are to achieve normal appearance at rest ; symmetry with voluntary motion ; control of the ocular, oral, and nasal sphincter; symmetry with involuntary emotion and controlled balance when expressing when expressing emotion ; and no significant functional deficit secondary to the reconstructive surgery. It must be employed a number of concepts, for treatment of the paralyzed face by surgeon, depending on the cause, time interval, and wound characteristics, as well as the availability of and necessity for neuromuscular substitution. Nerve grafts, crossovers, muscle transfers, free muscle and nerve-muscle grafts, micronuerovascular muscle transfers, and regional muscle transpostion are the principal methods being developed. We applied the tmporal musle transposition for reanimation of unilatrally paralyzed faces for long times on two patients. The results of muscle transposition can be enhanced by the patient's learning to activate the transposed muscle by voluntary effort, and are best in patients who are motivated to learn the necessary motor-sensory coordination techniques.

우리나라 여성의 임신 중 커피 음용 실태와 산모혈 및 제대혈 중 지질치 변화에 미치는 영향

오승민(Seung Min Oh),정규혁(Kyu Hyuck Chung) 대한약학회 1998 약학회지 Vol.42 No.4

To investigate the effect of coffee consumption during pregnancy on serum lipids in maternal and infants` umbilical cord blood, 76 cases of newborn infants and women delivered of a child who had delivered at hospital located in Chung-Ju city from Feb. 1, 1996 to Aug. 31, 1996 were studied. The gestational ages of cases were 37 to 42 weeks and the average maternal ages were 28.3 +/- 4.63 years old without any other medical or obstetric problems. Infants` Apgar scores and birth weights were decreased by above 3 cups per day of coffee consumption during pregnancy. No relationships between coffee consumption during pregnancy and maternal serum lipid levels were observed. However, serum total cholesterol and LDL-cholesterol levels in infants` umbilical cord were significantly increased with increasing coffee consumption during pregnancy. In contrary to coffee consumption, alcohol drinking habits affected maternal serum lipid levels but not serum lipid levels in infants` umbilical cord blood. Coffee consumption during pregnancy increased caffeine concentration in infants` umbilical cord blood. These results suggest that caffeine from maternal consumption of coffee can easily pass to the fetus and significantly affect serum lipids levels in infants` umbilical cord blood rather than those in maternal blood.

근대무용의 기점과 최승희의 작품세계

정승희 ( Seung Hee Chung ) 대한무용학회 1995 대한무용학회논문집 Vol.17 No.-

패러글라이딩 사고에 대한 분석

김승환,김인병,정순미,정성필,장석준 대한외상학회 1999 大韓外傷學會誌 Vol.12 No.1

$quot;Background: Paragliding injuries are increasing recently due to the growing popularity of this sport. This topic has been discussed in numerous journals in the European countries with large mountains, such as Austria, Germany and Switzerland, Those studies gave information regarding the flight phase during which an injury ocurred, the type and site of injury, and suspected reasons for the accidents. This study was done to compare our data to those of other nations and give preventive advices to reduce injuries occurring during paragliding. Method: Nineteen paragliders documented as having injuries during paragliding at Chung-Ju, Korea from 1990 to 1997 were included in the study. Their accident reports including medical records, were analyzed retrospectively. Result: Eighteen of the injured were male with one female and their mean age was 25.6 years old. Five injuries were suffered during take-off, of which technical error was the cause in most cases. Also, 5 injuries occurred during flight due to a sudden change of thermal and wind condi- tions. The majority of injuries were suffered during the landing period, affecting 9 paragliders. They were mostly due to forced landings, unexpected obstacles, and sudden change of wind conditions. Thirty-three percent suffered spine trauma and 29% were involved in injuries of the lower extremities. Upper limb injuries occurred in 19%, and 19% also suffered cerebral concussion or contusion. Conclusion: We have found that spine and ankle injuries were commonly occur during paragliding, especially the landing phase. Proper knowledge of the procedures, adequate training and appropriate foot wear could help in reducing injuries while paragliding.$quot;

자가 골수 기질세포이식을 이용한 대퇴골두의 무혈성 괴사 및 장관골 골낭종의 치료

이승구,권순용,정진화,정도현,이주형,최숭욱 대한정형외과학회 골.연부조직이식학회 2003 대한골.연부 조직이식학회지 Vol.3 No.2

통풍성 관절염의 임상적 고찰

윤채중,정승문,김영학,김동규,허광식,김태원,배학연,정종훈,이승일,김평남 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2

통풍은 Purine 대사의 이상으로 발생하는 질환으로, 고뇨산혈증인 사람의 전부가 통풍으로 발현되지 않고 증상의 출현 양상이 다양하여 진단과 치료에 주의가 필요하며, 조기에 적절한 조치를 한다면 충분히 조절이 가능한 질환이다. 본대학 내과학교실에서는 통풍으로 치료한 32명의 환자에서 임상양상, 병력과 검사소견을 분석하여 다음과 같음 결과를 얻었다. 1. 32명 모두 남자이며, 최초 발병 시기는 24세에서 72세로 평균 43.8±11.9세이었으며, 30대에서 40대까지가 19명(59.4%)으로 대부분을 차지하였다. 내원 당시 나이는 27세에서 75세까지로 평균 52.3±10.4세였으며, 내원시 까지 평균 유병기간은 8.5±6.8년으로 나타났다. 2. 동반 질환으로는 고지혈증 12례, 신장질환 10례, 고혈압 12례, 비만 8례, 당뇨 2례 등이었다. 3. 이환된 관절은 단관절 침범이 19례(59.4%), 다관절 침범이 13례 이었으며, 최초 이한된 관절은 족무지 중족골지골 관절로 19례(59.4%)로 가장 많았고, 통풍 결절은 20례(62.5%)에서 관찰되었으며, 유병기간이 10년 이상된 12례중 11례 (91.7%)에서 결절이 관찰되었다. 4. 평균 혈중 요산치는 9.17±1.75 ㎎/dl이었으며, 8.0 ㎎/dl에서 9.9 ㎎/dl 사이가 19명으로 전체의 59.4%를 차지하였다. Objective: The gout is a heterogeneous group of diseases resulting from tissue deposition of monosodium urate or uric acid crystals from extracellular fluids supersaturated with respect to this end product of human purine metabolism. The clinical manifestations are such as hyperuricemia, gouty arthritis, gouty nephropathy, uric acid nephrolithiasis. We analyze of clinical manifestations and associated factors in gout. Method: We have reviewed the medical records, radiologic findings and clinical results of thirty-two patients admitted at our department from April 1996 to July 1997. Result: 1) All patients were male. The mean age at initial attack was 43.8 years old, ranging from 24 to 72 years old. 2) The mean level of serum uric acid was 9.17mg/dl on admission. 3) The first metatarsopharyngeal joint was involved in 19 cases (59.4%). Tophus was observed in 20 cases (62.5%). 4) Hyperuricemia was associated with hypertension, obesity, nephrolithiasis and hyperlipidemia.

Cystic Medullary Thyroid Carcinoma: A Case of Undergoing Endoscopic Thyroid Lobectomy

Dong Hae Chung,Jae Yeon Seok,Yoo Seung Chung1,Eun Mee Oh1,Jung Won Ryu1,Young Don Lee1 대한갑상선-내분비외과학회 2015 The Koreran journal of Endocrine Surgery Vol.15 No.1

On ultrasonography, medullary thyroid carcinoma (MTC) shows hypoechogenicity, an irregular margin, a predominantly solid composition, and microcalcifications, similar to those observed in papillary thyroid carcinoma (PTC). MTC presenting as a cystic lesion is rare, and endoscopic thyroidectomy can be performed for benign thyroid masses and early stage PTC, however it is inappropriate for MTC regardless of cystic change. The authors report a case of cystic MTC found after endoscopic thyroid lobectomy and provide a review of the literature on this topic.