고령자 급성 췌장염의 임상적 고찰

백용한,서정훈,송건훈,이진헌,송시영,정재복,강진경,박인서,이수진 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

네모나프라이드의 유효성 및 추체외로 부작용 : Haloperidol 및 Risperidone과의 자연관찰적 개방형 비교연구 A Naturalistic Open Comparative Study with Haloperidol and Risperidone

서영수,김용관,신동환,공보금,이정구,박정환,윤성환,정치영,이상경,김영훈 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

Objectives : This open prospective study was performed in order to evaluate the efficacy and extrapyramidal adverse effects of nemonapride in the schizophrenic patients, and was compared wit one of typical antipshchotics. haloperidol and one of atypical antipsychotics, risperidone. Methods : Thirty male and female schizophrenic patients(DSM-Ⅳ) were treated for 12 weeks with haloperidol(n=10), risperidone(n=10) and nemonapride(n=10). The overall efficacy was assessed at baseline, 1st week, 2nd week, 4th week, 8th week, and 12th week by the Positive and Negative Syndrome Scale for Schizophrenia(PANSS). Also the overall safety was assessed in the same time period by the Extrapyramidal Symptom Rating Scale(ESRS). Results : There were no significant differences in PANSS scores(total, positive, negative, and general psycho­pathology subscale) among haloperidol, risperidone, and nemonapride groups, Treatment responders, defined as at least 20% reduction of baseline total PANSS score, were achieved by 8 patients(80%) in haloperidol group, 10 patients(100%) in risperidone group, and 8 patients(80%) in nemonapride group. And there were no significant differences in ESRS total scores among haloperidol, risperidone, and nemonapride group. Inter-group comparison among haloperidol, risperidone and nemonapride group, as assessed by the ESRS, revealed no significant differences in the shifts to the maximum score, 9.4(±9.4), 6.2(±8.4), and 11.3(±8.1) respectively, and also revealed no significant differences in the mean time reaching the maximum score, 4.5(±4.5) week, 7.8(±4.8) week, and 4.6(±4.4) week, respectivily. Conclusion : There wee no significant differences in the efficacy and extrapyramidal adverse effects among haloperidal, rispecridone and nemonapride groups. These results suggest that nemonapride was as efficacious and safe in he treatment of schizophrenia, as well known and widely used antipsychotics, haloperidol and risperidone.

Hepatocellular Carcinoma in the Elderly: Clinical Characteristics, Outcomes and Treatment Efficacy, Safety in Older than 75 Years

( Ji Ho Seo ),( Sunmin Kim ),( Eunae Cho ),( Chung Hwan Jun ),( Sun Young Park ),( Sung Bum Cho ),( Chang Hwan Park ),( Hyun Soo Kim ),( Sung Kyu Choi ),( Jong Sun Rew ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The number of elderly patients diagnosed with hepatocellular carcinoma (HCC) has been increasing because the increase in the longevity of the general population. But there is no proper management based on age stratification in elderly patients. We compared clinical characteristics, outcomes and treatment efficacy, safety between oldest-old (aged more than 85 years), middle-old (aged between 80 and 85 years) and young-old (aged between 75 and 80 years) patients with HCC. Methods: We conducted a retrospective cohort study, from January 2010 to December 2016, at Chonnam National University Hospital. A total of 550 elderly patients whose data included demographics, co-morbidity, etiology of liver disease, presence of cirrhosis, staging of HCC, treatment modality and treatment related adverse event were evaluated retrospectively. Also overall survival was assessed in enrolled patient. Results: Fifty one patients (oldest-old; median 87 years old), 153 patients (middle-old; median 82 years old) and 346 patients (young-old; median 77 years old) were diagnosed with HCC. Both oldest- and middle-old patients, compared to young-old patients had significantly lower rate of alcohol-related disease (13.7% vs 20.9% vs 34.1%, P = 0.001). There were no significant difference in underlying sex, body mass index, presence of co-morbidity, hepatitis C-related disease and stage of HCC. The Child-Pugh class (CPT class A 88.9% vs 84.1% vs 83.6%, CPT class B 11.1% vs 15.9% vs 15.0% and CPT class C 0.0% vs 0.0% vs 1.3%, respectively, P = 0.912) and Model for End Stage Liver Disease score (mean MELD score 7.22±3.34 vs 5.88±3.01 vs 5.77±3.14, P = 0.166) were no significant difference between the patients with active treatment. The modified UICC staging (stage I 5.6% vs 17.1% vs 18.6%, stage II 55.6% vs 46.3% vs 47.3%, Stage III 22.2% vs 24.4% vs 24.8%, Stage IV-A 11.1% vs 6.1% vs 4.9% and Stage IV-B 5.6% vs 6.1% vs 4.4%, respectively, P = 0.826) and Barcelona Clinic Liver Cancer staging (stage 0 5.6% vs 9.8% vs 9.3%, stage A 16.7% vs 17.1% vs 22.1%, stage B 27.8% vs 29.3% vs 24.8%, stage C 50.0% vs 43.9% vs 41.2% and stage D 0.0% vs 0.0% vs 2.7%, respectively, P = 0.878) were no significant difference between the patients with active treatment. Furthermore, there were no difference between the age groups in treatment modality (Surgical resection 0.0% vs 3.3% vs 5.2%, P = 0.166; Radiofrequency ablation 2.0% vs 8.5% vs 11.0%, P=0.113; Transcatheter arterial chemoembolization 21.6% vs 34.6% vs 41.6%, P=0.014; Best supportive care 62.7% vs 40.5% vs 29.2%, P < 0.001), adverse event related treatment (P = 0.731) and disease-free survival days (329 .3±309.1 days vs 271.7 ± 414.2 days vs 357.2 ± 511.6 days, P = 0.336). Multivariate analysis showed that age, performance status, CTP class, MELD score, modified UICC staging, presence of portal vein thrombosis and ruptured HCC are risk factors for mortality. Conclusions: Clinician should make an active treatment in elderly patients with HCC not a age but performance status, liver function and disease status of cancer.

cis-platin에 의한 급성구토예방의 Dexamethasone의 4가지 정주량의 비교

김원,강지은,서영선,이동민,서정균,신병철,정기영,박유환,정춘해 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

B5-hydroxytryptamine _3수용체(5-HT_3) 길항제와 dexamethasone의 동시투여가 cis-platin에 의한 급성 구토를 막는데 가장 효과적이다. 그러나 현재까지 가장 적절한 정주dexamethasone의 용량이 알려져 있지 않았다. 이에 dexamethasone의 4가지 다른 용량을 투여하여 그 효과를 비교하였다. 환자는 임의 추출되어 cis-platin 투여 45분전에 15분 동안 정주로 각각 dexamethasone 5, 10, 15, 20 mg을 투여 받았다. cis-platin 투여 30분전에는 ondansetron 8 mg이 부가하여 정주 되었다. 1999년 3월부터 2000년 2월까지 54명의 환자가 연구에 등록되어졌고 53명의 환자가 연구 대상으로 실험에 4군 (dexamethasone 5 mg 13명, 10 mg 14명, 15 mg 13명, 20 mg 13명)으로 나뉘어 평가 되어졌다. 급성구토와 구역질의 완전한 예방은 dexamethasone 5 mg을 투여 받은 환자에서 각각 69.2%, 60.9%, dexamethasone 10 mg을 투여 환자에서 69.1%, 61%, dexamethasone 15 mg 투여 환자에서 78.5%, 66.9%, dexamethasone 20 mg을 투여 환자에서 83.2%, 71.0%로 나타났다. 구토로부터 완전한 예방은 dexamethasone 20 mg을 투여 환자에서 5, 10 mg을 투여 환자와 비교하여 높았고, dexamethasone 15 mg을 투여 군에 비교하여서는 약간 우수한 효과만 있었다. 구역질으로부터의 완전한 예방도 월등한 것은 아닐지라도 20 mg을 받은 환자에서 높았다. 항 구토 치료는 특별한 불편 없이 조절되었고, 부작용의 발생에서 4가지그룹간에는 커다란 차이가 발견되지 않았다. Dexamethasone의 20 mg 정주양이 cis-platin으로 인한 급성구토를 예방하는데 가장 효과적인 예방량으로 사료되어진다. Background and objective: A 5-hydroxytryptamine _3(5-HT_3) receptor antagonist plus dexamethasone is the most efficacious antiemetic prophylactic treatment for the prevention of cis-platin induced acute emesis, but the optimal intraveous (Ⅳ) dose of dexamethasone is unknown. This prompted us to perform a randomized, double-blind, dose-finding study that compared four different doses of dexamethasone. Materials and Methods: Patients were randomized to receive dexamethasone, either 5, 10, 15, 20 mg, administered by 15-minute Ⅳ infusion 45 minutes before cis-platin. Ondansetron 8 mg was added to dexamethasone and was administered Ⅳ 30 minutes before cis-platin. From March 1999 to February 2000, 54 patients were enrolled onto the study and 53 were assessable according to the intention-to-treat principle (13 patients received 5 mg; 14 patients, 10 mg; 13 patients, 15 mg and 13 patients, 20 mg of dexamethasone). Results: Complete protection from acute vomiting and nausea was achieved by 69.2% and 60.9% of patients, respectively, who received 5 mg of dexamethasone, by 69.1% and 61.0% of those who received 10 mg, by 78.5% and 66.9% of those who received 15 mg, and by 83.2% and 71.0% of those who received 20 mg of dexamethasone. Complete protection from vomiting was significantly superior in patients who received 20 mg compared with those who received 5 and 10 mg of dexamethasone (P<05) and was superior, but not significantly, compared with those who received 15mg. Complete protection from nausea was superior, but not significantly, in patients who received 20 mg of dekamethasone. Multifactorial analysis confirmed these results. Antiemetic treatment was well tolerated, and no significant difference was found among the four groups in the incidence of adverse events. Conclusion: A 20mg single Ⅳ dose of dexamethasone should be considered the most efficacious prophylactic dose for the prevention of ois-platin induced acute amesis in treatment of cancer.

Biomass 유래 퓨란계 단량체를 이용한 폴리에스터의 중합 및 특성 연구

정용석(Yong Seong Chung),이영철(Young Chul Lee),서강진(Kang Jin Seo),김명준(Myeong Jun Kim),정지혜(Ji Hea Jeong),노시태(Si Tae Noh) 한국고분자학회 2011 폴리머 Vol.35 No.6

바이오매스에서 유래된 2,5-dihydroxymethylfuran(DHMF)을 KMnO4 산화반응으로 furan-2,5- dicarboxylic acid(FDCA)를 합성하였다. 합성한 FDCA와 다이올류를 에스테르화 반응과 축중합 반응을 진행시 켜 폴리에스터를 중합하였다. 폴리에스터는 NMR을 통해 조성을 분석하였고 DSC와 TGA를 통해 열적특성을 분 석하였다. 합성된 폴리에스터의 고유점도는 0.78∼1.2 dL/g으로 상용화된 poly(ethylene terephthalate)(PET) 와 비슷하였다. 다이올의 길이가 증가할수록 Young`s modulus와 strength는 낮아지고 elongation-to-break는 높아지는 경향을 확인하였다. 합성한 poly(ethylene furandicarboxylate)(PEF)의 Young`s modulus는 3551 MPa, strength는 103 MPa로 상용화된 PET와 비슷하였다. Furan-2,5-dicarboxylic acid (FDCA) was synthesized by KMnO4 oxidation of 2,5-dihydroxymethylfuran( DHMF) derived from biomass. Polyesters were synthesized by esterification and polycondensation of FDCA with various diols(ethane-1,2-diol, propane-1,3-diol, butane-1,4-diol, hexane- 1,6-diol, decane-1,10-diol). The composition of polyesters was characterized by using 1H NMR. Thermal properties of the polyesters were characterized by DSC and TGA. Intrinsic viscosities(IV) of the polyesters were measured to be 0.78∼1.2 dL/g comparable with IV of commercial poly(ethylene terephthalate)(PET). As the chain lengths of diols increased, Young`s modulus and strength decreased and elongation-to-break generally increased. Young`s modulus and strength of the polyesters were measured to be 3551 MPa and 103 MPa, respectively, comparable with commercial PET.

水中擴聲器의 試作

정용진,서두옥 제주대학교 1992 논문집 Vol.35 No.-

A underwater speaker was made by driver unit of usual speaker using acryl boards, polyester resin and the castor oil, and it was used to analyze frequency characteristics for lower frequency audiable pure sound in a water tank. A pure sound of which the frequency was from 300Hz to 500Hz was good frequency characteristics in a water tak experiment. But a pure sound which it were from 100Hz to 250Hz and from 600Hz to 1,000Hz were bad frequency characteristics. This underwater speaker make good use of sound fishing method which a shoal of fish are gathered, when it is broadcasted a audiable sound in underwater. This method is applied hair tail hand line fishing, squid hand line fishing, chub mackerel and japanese horse mackerel purse seine fishing, anchovy scoop net fishing in the coast of Cheju Island.

소아과 입원 환자에 대한 통계적 고찰

정용현,서우식,유재홍,변상현 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

For the purpose of assessing the disease patterns by the body organ system in patients of the pediatric age, we performed a statistical analysis of diseases of patients admitted to the department of pediatrics at Chungnam National University Hospital from January 1990 to December 1994. The results obtained were as follows : 1. Total numbers of in-patients were 8,007, of which 4,923 were male and 3,084 were female. The ratio male to female was 1.60 : 1. 2. Prevalence of the diseases classified by body organ system was in the following order : neonatal diseases (34.6%), respiratory diseases (17.4%), infectious diseases (11.5%), congenital anomalies (5.5%), digestive diseases (5.1%), genitourinary diseases (4.9%), neoplasm (4.7%), blood diseases (3.3%), nervous system diseases (2.8%), metabolic and endocrine diseases (2.4%), circulatory system diseases (2.3%), skin and subcutaneous diseases (1.3%), musculoskeletal and connective tissue diseases (1.2%), mental and behavior disorders (0.4%). 3. Major diseases in each body organ system were as follows : 1) infectious diseases : unspecified acute gastroenteritis (35.9%), viral meningitis (10.4%), Rotaviral enteritis (6.8%), sepsis (6.7%), measles (5.8%). 2) neoplasm ; ALL (34.1%), AML (15.8%), Wilms tumor (12.8%), NHL (8.2%), neuroblastoma (5.6%) 3) blood diseases : allergic purpura (24.2%), aplastic anemia (17.1%), ITP (16.4%), iron deficiency anemia (15.8%). 4) metabolic and endocrine diseases : short stature (22.0%), hypocalcemia (13.8%), metabolic acidosis (9.6%), IDDM (6.4%). 5) mental and behavior diseases : neurosis (47.7%), mental retardation (18.2%). 6) Nervous and sensory system diseases : epilepsy (43.2%), cerebral palsy (12.1%), otitis media (9.3%), encephalopathy (6.2%). 7) circulatory system diseases: congestive heart failure (29.2%), dilated cardiomyopathy (8.0%), rheumatic fever (8.0%), mitral insufficiency (6.8%), hypertension (6.4%). 8) respiratory diseases : pneumonia (40.1%), URI (9.6%), acute tonsillitis (9.4%), asthma (8.5%), acute bronchiolitis (8.3%), croup (7.1%), acute bronchitis (4.1%). 9) digestive system diseases : unspecified hepatitis (22.8%), acute gastritis (13.8%). CAH (12.6%), intussusception (7.8%), constipation (7.1%). 10) skin and subcutaneous diseases : cellulitis (23.1%), lymphadenitis (19.7%), urticaria (15.6%), atopic dermatitis (8.8%), furuncle (8.2%). 11) musculoskeletal and connective tissue diseases : Kawasaki disease (76.8%), JRA (8.5%), SLE (7.0%). 12) genitourinary system diseases : UTI (29.0%), minimal change nephrotic syndrome (27.3%), APSGN (7.6%), APN (4.9%). 13) congenital or chromosomal abnormalities : VSD (38.7%), ASD (10.5%), TOF (8.4%), PDA (5.2%), CHPS (4.5%), Down syndrome (4.1%). 14) neonatal diseases : jaundice (32.0%), prematurity (12.7%), RDS (5.7%), sepsis (4.5%), birth asphyxia (3.0%), SGA (3.0%). 15) Others : febrile convulsion (45.6%), failure to thrive (9.2%), FUO (8.9%), drug intoxication (8.2%). 4. Common diseases for admission in pediatrics were in the following order : jaundice, pneumonia, unspecified acute gastroenteritis, VSD, RDS, URI, acute tonsillitis, acute lymphadenitis, ALL, sepsis, asthma, acute bronchiolitis, UTI.

CORBA 기반 SNMP 게이트웨이

정영준,송화선,서희정,김주영 강원대학교 정보통신연구소 1999 정보통신논문지 Vol.3 No.-

As telecommunicaton networks becomes more complex and intelligence, it is essential to develop an integrated network management system between heterogeneous telecommunication networks. To fulfil such demands, one solution is CORBA, which provides a distributed platform, in this paper, we present the design and implementation of a gateway between CORBA and SNMP, called as an Internet management protocol. The proposed scheme allows a CORBA managerto access the SNMP MIB without special transformation of SNMP managed objects and only but using SNMP API which the gateway provides. Also since managed objects are represented in CORBA IDL, a new SMI can be updated only by recompiling the interface. Consequently this gateway approach gives a great of advantages in a point that any changes of managed object implementation on managed agents MIBs are not required.

전합형 인버터에 의한 유도전동기의 속응제어

정은성,조문택,임영배,서영수 明知大學校 産業技術硏究所 1995 産業技術硏究所論文集 Vol.14 No.-

In this paper, the quick response control of induction motor was researched by presenting indirect vector control algorithm to improve the dynamic performance of induction motor, resulting in quick response characteristics such as DC motor. Speed detecting method was used by M/T method and made the simple speed calculation by the presentation of the a1gorithm using the the HSI.0 pin and HSI TIME of 80196KC. It was used each ,PI controller for current controller and speed controller of-control algorithm, 80196KC to CPU for fast velocity processing computation in designing control system, and the way of PWM for removing the current harmonics of voltage source inverter We would like to confirm through experiment the relatively fast response velocity and the superior quick response control characteristics with variable command-speed, applying proposed system to 1[HP] 3ø induction motor.

Bezier Spline을 이용한 용접 로봇의 새로운 Weaving Motion 궤적 생성 알고리즘

정원지,김대영,서영교,홍형표,홍대선 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.3

In this paper, we propose a new weaving trajectory algorithm for the are welding of a articulated manipulator. The algorithm uses the theory of Bezier spline. We make a comparison between the conventional algorithms using Catmull-Rom curve and the new algorithms using Bezier spline. The proposed algorithm has been evaluated based on the MATLAB environment in order to illustrate its good performance. Through simulations, the proposed algorithm can result in high-speed and flexible weaving trajectory planning so that it s trajectory cannot penetrate into a base metal compared to the conventional algorithm using Catmull-Rom curve.