Production of 2,3-Butanediol by NAD+/NADH Ratio Change

Sung-yeob LEE,Hyun-soo KIM,Jeong-Woo CHOI,Byung-Keun OH 한국생물공학회 2013 한국생물공학회 학술대회 Vol.2013 No.4

High Efficiency Exciplex Emitters Using Donor–Acceptor Type Acceptor Material

Oh, Chan Seok,Kang, Yu Jin,Jeon, Sang Kyu,Lee, Jun Yeob American Chemical Society 2015 The Journal of Physical Chemistry Part C Vol.119 No.39

<P>A design rule of the acceptor material of exciplexes was studied by synthesizing two acceptor materials with only acceptor moieties and with both a donor and an acceptor simultaneously. Molecular calculation and photophysical measurements of the exciplexes revealed that the donor acceptor type acceptor materials promoted the exciplex formation by charge transfer character and increased the photoluminescence quantum yield of the exciplexes. The combination of a donor material and the donor acceptor type acceptor material achieved a high quantum efficiency of 12.6% in the green exciplex devices.</P>

Original Article : Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea

( Sung Jun Chung ),( Tae Yeob Kim ),( Sun Min Kim ),( Min Roh ),( Mi Yeon Yu ),( Jung Hoon Lee ),( Chang Kyo Oh ),( Eun Young Lee ),( Seung Lee ),( Yong Cheol Jeon ),( Kyo Sang Yoo ),( Joo Hyun Sohn ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2

Background/Aims: The incidence of symptomatic hepatitis A reportedly increased among 20- to 40-year-old Korean during the late 2000s. Vaccination against hepatitis A was commenced in the late 1990s and was extended to children aged <10 years. In the present study we analyzed the changes in the seroprevalence of IgG anti-hepatitis A virus (HAV) over the past 13 years. Methods: Overall, 4903 subjects who visited our hospital between January 2001 and December 2013 were studied. The seroprevalence of IgG anti-HAV was analyzed according to age and sex. In addition, the seroprevalence of IgG anti-HAV was compared among 12 age groups and among the following time periods: early 2000s (2001-2003), midto- late 2000s (2006-2008), and early 2010s (2011-2013). The chi-square test for trend was used for statistical analysis. Results: The seroprevalence of IgG anti-HAV did not differ significantly between the sexes. Furthermore, compared to the seroprevalence of IgG anti-HAV in the early 2000s and mid-to-late 2000s, that in the early 2010s was markedly increased among individuals aged 1-14 years and decreased among those aged 25-44 years (P<0.01). We also found that the seroprevalence of IgG anti-HAV in individuals aged 25-44 years in the early 2010s was lower than that in the early 2000s and mid-to-late 2000s. Conclusions: The number of symptomatic HAV infection cases in Korea is decreasing, but the seroprevalence of IgG anti-HAV is low in the active population. (Clin Mol Hepatol 2014;20:162-167)

Cilostazol Improves HFD-Induced Hepatic Steatosis by Upregulating Hepatic STAMP2 Expression through AMPK

Oh, Yoo Jin,Kim, Hye Young,Lee, Mi Hwa,Suh, Sung Hwan,Choi, Yongmun,Nam, Tae-gyu,Kwon, Woo Young,Lee, Sang Yeob,Yoo, Young Hyun American Society for Pharmacology and Experimental 2018 Molecular pharmacology Vol.94 No.6

<P>Nonalcoholic fatty liver disease (NAFLD) is an increasingly studied condition that can progress to end-stage liver disease. Although NAFLD was first described in 1980, a complete understanding of the mechanism and causes of this disease is still lacking. Six-transmembrane protein of prostate 2 (STAMP2) plays a role in integrating inflammatory and nutritional signals with metabolism. Our previous study suggested that STAMP2 may be a suitable target for treating NAFLD. In the current study, we performed a focused drug-screening and found that cilostazol could be a potential STAMP2 enhancer. Thus, we examined whether cilostazol alleviates NAFLD through STAMP2. The in vivo and in vitro pharmacological efficacies of cilostazol on STAMP2 expression and lipid accumulation were analyzed in NAFLD mice induced by high-fat diet (HFD) and in HepG2 cell lines treated by oleic acid (OA), respectively. Cilostazol increased the expression of STAMP2 through transcriptional regulation in vivo and in vitro. Cilostazol also dampened the STAMP2 downregulation caused by the HFD and by OA in vivo and in vitro, respectively. Cilostazol activated AMP-activated protein kinase (AMPK) in vivo and in vitro, and AMPK functions upstream of STAMP2, and reversed downregulation of STAMP2 expression through AMPK in the NAFLD model. Cilostazol ameliorates hepatic steatosis by enhancing hepatic STAMP2 expression through AMPK. Enhancing STAMP2 expression with cilostazol represents a potential therapeutic avenue for treatment of NAFLD.</P><P>[Figure]</P>

Synthesis of Artemisinins with Substituted Sulfidyl or Sulfonyl Moiety and Their Anti-angiogenesis Activity

Oh, Sang-Tae,Shin, Woon-Seob,Ham, Jung-Yeob,Lee, Seok-Joon Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.8

Vocabulary Recognition Rate Enhancement using Clustering Model and Non-parametric Correlation Coefficient

Sang Yeob Oh 한국정보기술학회 2024 한국정보기술학회논문지 Vol.22 No.4

Vocabulary recognition technology is a technology that mechanically understands and processes language. Although the speech recognition rate has recently improved due to artificial intelligence-based speech processing, the original voice cannot be accurately recognized due to noise in the usage environment. In addition, in the artificial intelligence environment, there is a data shortage problem due to many model parameters, and the number of training data for each model is usually uneven. To solve this, improved clustering modeling and selective voice feature extraction are used. A correlation map of auditory elements was constructed using the Non-parametric Correlation Coefficient , and in an experiment of the proposed method, it was confirmed that the result average distortion of separation was reduced by 0.36dB, improving the recognition rate.

원시코드의 메타 정보 관리를 위한 버전 제어 시스템의 설계와 구현

오상엽(Oh Sang Yeob),장덕철(Chang Duk Chul) 한국정보처리학회 1998 정보처리학회논문지 Vol.5 No.3

Rapid computing environment, change of the application structure, and various user demand will increase the demand of the software development. Version control is helpful to improve productivity using delta, and useful to establish component from existing data of source code. This paper presents the design and implementation of the version control system, which is composed of retrieval system and delta management system. In retrieval system, various retrieve methods are proposed. This methods provides the process methodology with filename, content, size and date. Various retrieve methods are important for the effective delta management. Meta data can be easily composed for the delta management by these methods. Compared with other systems, this implemented version control system has some advantage. First, for delta management, version maintenance for delta management becomes easier by integrating the forward and backward methods. Seconds, delta management part of a project is to unite the forward and backward method. The efficiency of this system is to increased in management. Also, this system supports a technique of using the database and files for project repository and makes version management more effective.

감자 재배 화산회토양에서 질소시비 수준, 강우 및 온도 환경 변화에 따른 아산화질소 배출 특성

양상호(Sang-Ho Yang),강호준(Ho-Jun Kang),이신찬(Shin-Chan Lee),오한준(Han-Jun Oh),김건엽(Gun-Yeob Kim) 한국토양비료학회 2012 한국토양비료학회지 Vol.45 No.4

본 연구는 감자 재배 화산회 토양에서 질소시비 수준 및 강우, 온도 환경 변화에 따른 N₂O 배출량을 측정하고 배출에 영향을 미치는 요인 특성을 구명하기 위하여 제주특별자치도농업기술원 시험포장에서 2년간 (2010~2011년) 수행되었다. 감자 재배기간 동안 N₂O 배출량은 질소시비량이 많을수록 많았다. 재배시기별 N₂O 배출량은 강우량 많은 시기인 재배 초기와 중기에 많았으나, 강우가 적고 한발 시기인 재배 말기에는 매우 적거나 거의 없는 경향을 보였다. N₂O 배출 양상은 강우량 및 토양수분함량 변화와 대체로 유사한 경향을 보였다. N₂O 배출량과 상관관계 (r)를 분석한 결과, ‘10년도에는 토양수분과 토양온도는 각각 0.6251<SUP>**</SUP>, 0.6082<SUP>**</SUP>로 고도로 유의성이 인정되었으나, 토양 EC와는 0.1082로 유의성은 인정되지 않았다. ’11년도에는 토양온도와는 0.4879<SUP>**</SUP>로 유의성이 인정되었으나, 토양수분과 토양 EC와는 각각 0.0469, 0.0400으로 유의성은 인정되지 않았다. NH₄-N과는 0.7476<SUP>**</SUP>로 고도로 유의성이 인정되었으나, NO₃-N과 토양 질소 (NO₃-N + NH₄-N)와는 각각 0.0843과 0.1797로 유의성이 인정되지 않았다. 질소시비량에 따른 2년 동안의 N₂O 배출량을 배출계수로 환산한 값은 0.0040 N₂O-N ㎏ N?¹ ㎏?¹로 IPCC 가이드라인의 기본계수인 0.0100 N₂O-N ㎏ N?¹ ㎏?¹ 보다는 약 2.5배 낮은 것으로 분석되었다. This study was conducted to investigate the characteristic factors which have been influenced on nitrous oxide (N₂O) emissions related to the environment change of nitrogen application level, rainfall and temperature during the potato cultivation at black volcanic ash soil from 2010 to 2011. During the potato cultivation, the more amount of nitrogen fertilizer applied, N₂O emissions amounts were released much. N₂O emissions with the cultivation time were released much at the first and middle of cultivation with heavy rainfall, but it was released very low until the end of cultivation and drought season. N₂O emissions mainly were influenced by the rainfall and soil water content. The correlation (r) with N₂O emissions, soil wate, soil temperature in 2010 were very significant at 0.6251<SUP>**</SUP> and 0.6082<SUP>**</SUP> respectively, but soil EC was not significant to 0.10824. In 2011, soil temperature was very significant at 0.4879<SUP>**</SUP>, but soil water and soil EC were not significant at 0.0468 and 0.0400 respectively. Also, NH₄-N was very significant at 0.7476<SUP>**</SUP>, but NO₃-N and soil nitrogen (NO₃-N + NH₄-N) were not significant at 0.0843 and 0.1797, respectively. During the potato cultivation period, the average emissions factor of 2 years released by the nitrogen fertilizer application was presumed to be 0.0040 (N₂O-N ㎏ N?¹ ㎏?¹). This factor was lower about 2.5 times than the IPCC guideline default value (0.0100 N₂O-N ㎏ N?¹ ㎏?¹).

블루사파이어와 루비의 고온산소 화염처리에 의한 색향상

송오성(Oh Sung Song),김상엽(Sang Yeob Kim) 한국표면공학회 2005 한국표면공학회지 Vol.38 No.2

We enhanced the color of blue sapphires and rubies successfully by using a oxygen-propane torch flame annealing, which had not been employed so far. We confirmed that about 1 ㎜-thick de-coloring of the corundum samples were available with 60 minutes flame annealing through eye evaluation, color coordination characterization, and methylene iodide immersion observation. We also suggest that the color centers such as [Fe<SUP>Al</SUP>˙], [Cr<SUP>Al</SUP>˙] may transform into transparent [FeAl<SUP>x</SUP>], [Cr<SUP>Al</SUP>x] sites with [V<SUP>o</SUP><SUP>"</SUP>] generation at the elevated temperature in oxygen-rich atmosphere by diffusion mechanism. Our results implied that the longer diffusion time and the higher oxygen partial pressure might lead to the better de-coloring enhancement in corundum gem stones.

콩 재배 화산회토양에서 질소시비 수준 및 강우, 온도 환경 변화에 따른 아산화질소 배출 특성

양상호(Sang-Ho Yang),강호준(Ho-Jun Kang),이신찬(Shin-Chan Lee),오한준(Han-Jun Oh),김건엽(Gun-Yeob Kim) 한국토양비료학회 2012 한국토양비료학회지 Vol.45 No.3

본 연구는 콩 재배 화산회 토양에서 질소시비 수준 및 강우, 온도 환경 변화에 따른 N₂O 배출량을 측정하고 배출에 영향을 미치는 요인 특성을 구명하기 위하여 제주특별자치도 농업기술원 시험포장에서 2년간 (2010~2011년) 수행되었다. 콩 재배기간 동안 N₂O 배출량은 질소시비량이 많을수록 많았다. 재배시기별 N₂O 배출량은 강우량이 많은 재배 초기와 중기에 많았으나, 강우가 적고 한발 시기인 재배 말기에는 매우 적거나 거의 없는 경향을 보였다. N₂O 배출 양상은 강우량 및 토양수분함량 변화와 대체로 유사한 경향을 보였다. N₂O 배출량과 상관관계(r)를 분석한 결과, ’10년도에는 토양수분, 토양온도 및 토양 EC는 각각 0.6312<SUP>**</SUP>, 0.4591<SUP>**</SUP>, 0.3691<SUP>**</SUP>로 모두 고도로 유의성이 인정되었다. 그러나 ’11년도의 경우는 토양수분과는 0.4821<SUP>**</SUP>로 고도로 유의성이 인정되었으나, 토양온도와 토양 EC와는 각각 0.1646, 0.1543로 유의성이 인정되지 않았다. NO3-N과 토양 질소 (NO3-N+ NH4-N)와는 각각 0.6902<SUP>**</SUP>, 0.6277<SUP>*</SUP>로 유의성이 인정되었으나, NH4-N과는 0.1775로 유의성은 인정되지 않았다. 질소 시비량에 따른 2년 동안의 N₂O 배출량을 배출계수로 환산한 값은 0.0202 (N₂O-N kg N<SUP>-1</SUP> kg<SUP>-1</SUP>)로, 일본의 배출계수인 0.0073 N₂O-N kg N<SUP>-1</SUP> kg<SUP>-1</SUP>보다는 약 2.8배, 2006 IPCC 가이드라인의 기본계수인 0.0100 N₂O-N kg N<SUP>-1</SUP> kg<SUP>-1</SUP>보다는 약 2배 정도 높은 것으로 분석되었다. This study was conducted to investigate the characteristic factors which have been influenced on nitrous oxide (N₂O) emissions related to the environment change of nitrogen application level, rainfall and temperature during the soybean cultivation at black volcanic ash soil from 2010 to 2011. During the soybean cultivation, the more amount of nitrogen fertilizer applied, N₂O emissions amounts were released much. N₂O emissions with the cultivation time were released much at the first and middle of cultivation with heavy rainfall, but it was released very low until the end of cultivation and drought season. N₂O emissions mainly were influenced by the rainfall and soil water content. The correlation (r) with N₂O emissions, soil water, soil temperature and soil EC in 2010 were very significant at 0.4591<SUP>**</SUP>, 0.6312<SUP>**</SUP> and 0.3691<SUP>**</SUP> respectively. In 2011, soil water was very significant at 0.4821<SUP>**</SUP>, but soil temperature and soil EC were not significant at 0.1646 and 0.1543 respectively. Also, NO3-N and soil nitrogen (NO3-N + NH4-N) were very significant at 0.6902<SUP>**</SUP> and 0.6277<SUP>*</SUP> respectively, but NH4-N was not significant at 0.1775. During the soybean cultivation, the average emissions factor of 2 years released by the nitrogen fertilizer application was presumed to be 0.0202 (N₂O-N kg N<SUP>-1</SUP> kg<SUP>-1</SUP>). This factor was higher about 2.8 and 2 times than the Japan’ (0.0073 N₂O-N kg N<SUP>-1</SUP> kg<SUP>-1</SUP>) value and 2006 IPCC guideline default value (0.0100 N₂O-N kg N<SUP>-1</SUP> kg<SUP>-1</SUP>) respectively.