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      • KCI등재

        호주의 유전자변형생물체(Genetically Modified Organisms) 안정성 심사절차 및 유전자변형식품의 표시제도

        김태산,김영미,손성한,김용환,박용환 한국국제농업개발학회 2002 韓國國際農業開發學會誌 Vol.14 No.1

        1. 호주는 GMO의 실험 및 상업화를 규제하는 신법 "유전자기술에 관한 법(Gene Technology Act 2000)을 제정 운영중임 2. GMO를 관리 감독하기 위하여 보건후생성산하에 유전자기술 감독국(Office of the Gene Technology Regulator)이 신설됨 3. GMO를 취급(dealings)형태에 따라서 면제(exemption), 위험이 매우적은 취급(notifiable low risk dealing), 면허(licensing), 등록(register)의 4가지로 분류하여 감독함 4. GM식품의 안전성 심사는 호ㆍ뉴식품청(Australia New Zealand Food Authority, ANZFA)에서 관장하며 호주식품 강령 기준 18(Standard A18 of the Australian Food Standards Code)이 근거 법임 5. ANZFA에서는 제초제 저항성 콩, 옥수수, 면화, 감자, 카놀라 등 6작물 12종의 GM작물에 대하여 식품안정성 확인을 완료함 6. 호주에서는 2001년 12월 7일부터 유전자변형식품의 의무 표시제를 시행하고 있으며 비의도적 혼입 허용치는 1%로 설정함 As Australia's new national gene technology regulatory system began on 21 June 2001, the Office of the Gene Technology Regulator (OGTR) was newly established to regulate GMO related research and GM products throughout the nation. "Gene Technology Act 2000" is the statutory basis the new regulatory system. The OGTR is within the Commonwealth Department of Health and Aged Care, responsible for overseeing the gene technology research and development including the GMO field trials across Australia. For the regulation of genetically modified food, the Australia New Zealand Food Authority(ANZFA) is responsible for developing and reviewing national food standards. All foods available for sale in Australia and New Zealand must comply with the relevant national food standards. ANZFA also responsible for carrying out safety assessments of GM foods on behalf of the Commonwealth, State and Territory Governments of Australia and the Government of New Zealand. The ANZFA's safety assessment process for GM foods is based on concepts and principles that have been developed through international organizations such as the World Health Organization(WHO) and the Food and Agriculture Organization(FAO) and the Organization for Economic Co-operation and Development(OECD). Mandatory labelling of GM foods containing either introduced DNA or protein in the final food came into effect on 7 December, 2001.

      • SCISCIESCOPUS

        Mercury concentrations in environmental media at a hazardous solid waste landfill site and mercury emissions from the site

        Han, Young-Ji,Kim, Pyung-Rae,Lee, Gang-San,Lee, Jae-In,Noh, Seam,Yu, Seok-Min,Park, Kwang-Su,Seok, Kwang-Seol,Kim, Hyuk,Kim, Young-Hee Springer-Verlag 2017 Environmental Earth Sciences Vol.76 No.10

        <P>Mercury (Hg) concentrations in air, effluent water, landfill gas, leachate, groundwater, and soil at a hazardous solid waste landfill site in Korea were measured along with air-soil surface Hg exchange fluxes at the site. The concentrations and fluxes were considerably higher than have been found elsewhere in Korea. Gaseous Hg concentrations in the air peaked during the day, coinciding with Hg being released from the landfill surface. This suggests that air-soil exchange increased the Hg concentrations in the atmosphere. The air-soil exchange flux increased abruptly when solar radiation reached the soil surface. The Hg flux peaked about 3 h before the solar radiation peaked, possibly because reducible Hg was abundant at the soil surface. The Hg emission flux activation energy (Ea) was low, indicating that the Hg species present and Hg-soil binding were probably not as important (because of the high Hg content of the soil) as in previous studies. The methylmercury to total Hg ratios in the discharged effluent, groundwater, and leachate was clearly higher than typically found in coastal water and freshwater, suggesting bacteria caused active methylation to occur under the reducing conditions in the anaerobic landfill. The results suggested that considerable amounts of Hg are probably transported from the landfill to nearby environmental media and that this will continue if waste with a high Hg content continues to be added to the landfill without being pretreated.</P>

      • Cloning and expression patterns of 14-3-3ζ from the beet armyworm, Spodoptera exigua

        Mi Young Noh,Yong Hun Jo,Cheol Hong Park,Young S. Hong,San Sun Kang,Yong Seok Lee,Iksoo Kim,Namjung Kim,Seongon Kim,Jong Dae Park,Yeon Soo Han 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.10

        14-3-3 proteins are known to play a pivotal role in a diverse array of cellular events such as cell survival, apoptosis, and signal transduction. Numerous 14-3-3 ζ have been cloned and characterized from a host of eukaryotic organisms including human, plants, yeast, fruit fly and silkworm. However, no study on Spodoptera exigua 14-3-3ζ in conjunction with virus infection has so far been reported in insects. It appears that expression of Se14-3-3ζ was decreased starting 24 h post-SeNPV infection as SeNPV titers seemed to increase as evidenced by intense bands of SeNPV IAP3. Interestingly, confocal microscopic analysis revealed that Se14-3-3ζ is expressed at the apical side of the NPV-uninfected gut cells, whereas it was detected mainly in the nucleus of the NPV-infected cells. Thus, despite the biological significance of Se14-3-3ζ in S. exigua in conjunction with molecular interactions between SeNPV and S. exigua is unclear now, our data suggest that Se14-3-3 ζ protein plays a role to protect S. exigua from the infection or inhibit replication of SeNPV.

      • KCI등재

        대북축산지원사업 우선순위 설정에 관한 연구

        김영섭 ( Young Sup Kim ),최종산 ( Jong San Choi ),이종인 ( Jong In Lee ),양가영 ( Ka Young Yang ),송영한 ( Young Han Song ) 한국국제농업개발학회 2015 韓國國際農業開發學會誌 Vol.27 No.5

        1. 1995년부터 2014년까지의 대북의 공공적 지원과 민간차원으로서의 대북지원사업을 조사 연구하고 이미 발표된 통일대비 축산지원정책 자료를 토대로 26개 설문문항을 작성,AHP방법을 이용 우선순위 분석결과를 다음과 같이 요약하였다. 2. 평가대항목 중에서 공공성이 0.5229로 절반이상의 수치를 보이고 2위로 기술성, 3위로 시장성의 순이며, 평가소항목에서는 기술실현성 0.6220이 또한 높은 수치를 보이며 2위엔시장성장성, 3위엔 국가전략과의 부합성 순이다. 3. 각 대항목과 소항목간의 종합가중치에선 공공성에서 국가전략과의 부합성, 사회적 영향성, 산업적파급성 순으로 나타났으며, 기술성 측면에서는 기술실현성, 기술파급성, 기술독창성 순이고 시장성 측면에서는 시장성장성, 투자수익성, 시장규모성 순으로 각각 나타났다. 4. 평가대안의 대북축산지원사업 우선순위 1위인 “지역특화사업단지 조성”부터 26위인 “통일 후 축산지원방향 협의체구성”까지의 지원사업 전체가 중요하다고 판단돼 정부의 미래대북지원정책 수립과정에서 기초자료로 사용되었으면 한다. 또한 26개 대북축산지원우선순위에 관해 전문가들에게 Delphi설문조사방법을 시행하여 각각의 지원사업에 적절한 예산안 분배배치가 이루어질 필요성이 있다고 판단된다. This research surveys North Korean aid from 1995 to 2014, and comprises survey items of26 investment fields based on Animal Husbandry Aid policy materials which have already been identified as a component of unification preparation. We used analytic hierarchy process (AHP) methods in order to establish priority order among these 26 investment items. A series of pairwise comparison judgment is performed to evaluate the relative intensity about the elements in the hierarchy process based on expertise survey. Three kinds of policy evaluation criteria, such as Technology, Marketability, Publicness and each has 3 different subcategories evaluation criteria and 26 types of Animal Husbandry policy measures are applied in the study. The analytical results showed that the highest priority among the policy measures was District specialization project development as 0.5889 and the Consultative Group of Animal Husbandry Aid Direction after Unification was 0.3772 as the lowest mark. However, this number showed not much difference as -0.0028 when it was compared with average level C 0.38 of absolute measurement. Therefore, the entire 26 investment projects are considered to be very important with regard to the North Korea Aid Policy.

      • KCI등재
      • GG-25 : Scheduled Injection of Ramosetron for the Prevention of Nausea and Vomiting after Single Port Access Total Laparoscopic Hysterectomy : A Prospective Randomized study

        ( San Hui Lee ),( Eui Hyeok Kim ),( Sang Won Han ),( Sang Wun Kim ),( Young Tae Kim ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

        목적: The purpose of this study was to evaluate the effect of scheduled ramosetron injection during hospitalized period in patients undergoing single port access total laparoscopic hysterectomy (SPA-TLH). 방법: In this prospective, randomized, double-blinded, placebo-controlled study, 131 patients who were undergoing SPA ?TLH in National Health Insurance Service Ilsan Hospital from March 2013 to May 2014 were enrolled. Patients were divided into two groups: the ramosetron group (0.3 mg i.v.; n=65), and the placebo group (normal saline i.v.; n= 66). Both groups received their respective injection on post-operative day 1 and day 2. The incidence of postoperative nausea and vomiting (PONV), the severity of PONV (numerical rating scale 0-10), and the use of rescue antiemetic requirements during the first 24 h after surgery were evaluated. 결과: Demographic and perioperative differences were not observed between the two groups. The incidence of postoperative nausea and vomiting in the ramosetron group and the placebo group were 40.1% and 42.7%, respectively (p=0.213). However, there was a significant difference between the groups in the scale of PONV during 24 hours and 48 hours after surgery (p=0.042, p=0.034, respectively). The use of rescue antiemetics was significantly lower in the roamsetron group (p=0.021). 결론: After general anesthesia in the same fashion, the scheduled injection of ramosetron reduced the intensity of PONV and the use of rescue antiemetics. Administration of ramosetron can be considered not only immediately after the SPA-TLH but also during the recovery period.

      • Polydopamine-mediated all-in-one device with superhydrophilicity and superhydrophobicity for one-step oil/water separation and pollutant purification

        Han, Nara,Lim, Yong Taek,Jang, Wooree,Koo, Hye Young,Choi, Won San Elsevier 2016 Polymer Vol.107 No.-

        <P><B>Abstract</B></P> <P>Polydopamine (Pdop) is coated on copper mesh (Cu mesh/Pdop). Upon heat treatment of the Cu mesh/Pdop, Pdop particles are newly formed at the surface of the Cu mesh/Pdop, which is used as a superhydrophilic mesh. After octadecylamine (ODA) is coated on the heat-treated Cu mesh/Pdop, hierarchical and strong ODA crystals are formed by special interactions between the ODA and the Pdop. The surface morphologies of the ODA crystals are tuned by varying the amount of Pdop particles. Similar results are obtained when the sponge is used as a template in lieu of the Cu mesh, and this sponge is used as a superhydrophobic sponge. A self-floating all-in-one device that simultaneously coexists in water as well as in oil is also prepared by combining the Pdop particle-mediated superhydrophilic mesh and superhydrophobic sponge composites. The self-floating all-in-one device simultaneously exhibits excellent removal performance for heavy metal ions in the water layer and excellent separation efficiency of oil in the oil layer due to its amphiprotic nature.</P> <P><B>Highlights</B></P> <P> <UL> <LI> All-in-one device with superhydrophilicity and superhydrophobicity is prepared. </LI> <LI> This self-floating device can simultaneously coexist in water as well as in oil. </LI> <LI> This device is used for simultaneous oil/water separation and pollutant purification. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • SCISCIESCOPUS

        Mineralized hyaluronic acid nanoparticles as a robust drug carrier

        Han, Song-Yi,Han, Hwa Seung,Lee, Sang Cheon,Kang, Young Mo,Kim, In-San,Park, Jae Hyung Royal Society of Chemistry 2011 Journal of materials chemistry Vol.21 No.22

        <P>Hyaluronic acid nanoparticles (HA-NPs), mineralized by calcium phosphate, were synthesized as a robust carrier of the anticancer drug, doxorubicin (DOX). The HA-NPs were readily mineralized in the presence of calcium nitrate and ammonium phosphate, which was confirmed by various instruments such as FT-IR, thermogravimetric analysis, transmission electron microscopy, and energy-dispersive X-ray photoelectron spectroscopy. Mineralization reduced the particle size of the HA-NPs in PBS (pH 7.4) from 263 nm to 142 nm, indicating the formation of compact nanoparticles. Mineralized HA-NPs were highly stable at pH 7.4, whereas their particle size rapidly increased in a mildly acidic solution, which was due to the dissolution of calcium phosphate. When DOX-loaded bare HA-NPs were exposed to buffer solutions of various pH, most of the DOX (>80%) was released within 48 h, and the release behavior was not dependent upon the pH of the solution. Notably, the mineralized HA-NPs released DOX in a sustained manner at pH 7.4, whereas a rapid release of DOX was observed in the acidic solution. The release rate of DOX from the mineralized HA-NPs was higher in the solution with a lower pH. These results indicate that mineralized HA-NPs have potential as robust nanoparticles that can release DOX at specific sites under mildly acidic conditions, such as in the extracellular matrix of tumor tissue and in intracellular compartments (<I>e.g.</I>, endosome and lysosome) of the cell.</P> <P>Graphic Abstract</P><P>The mineralized hyaluronic acid nanoparticles have potential as the robust carrier that can release hydrophobic drugs at specific sites under mildly acidic conditions. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1jm10466g'> </P>

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