관상동맥 시술 도중 발생한 좌주간부 관상동맥 박리에 대한 스텐트 삽입 치료의 단장기 임상 결과 : acute and long-term results

이세환,이승환,홍명기,김영학,이철환,한기훈,송종민,강덕현,송재관,김재중,박성욱,박승정 대한내과학회 2004 대한내과학회지 Vol.66 No.6

목적 : 심도자 사용 시술과 관련된 좌주간부 관상동맥박리에 대한 적절한 치료는 아직 확실히 정립되지 않은 상태이다. 이에 본 연구는 좌주간부 관상동맥 박리에 대한 스텐트 삽입술의 단장기 임상결과를 후향적으로 분석하였다. 방법 : 좌주간부 관상동맥 박리에 대한 치료로 즉각적인 스텐트 삽입술을 시행하는 것이 안전하고 효과적인 방법임을 가설하였고, 이러한 즉각적인 스텐트 삽입을 시행한 10명의 환자를 대상으로 단장기적 임상경과를 의무기록 고찰과 전화 면담을 통해서 평가하였다. 결과 : 전체 환자 모두 처음부터 좌주간부 관상동맥에 유의한 협착을 가진 환자는 없었으며, 8명의 환자는 심도자의 조작으로 인한 박리가 발생한 경우였고(진단적 혈관 조영술 중에 3명, 유도 도자 조작 중에 5명), 나머지 2명은 다른 병변에 스텐트 삽입시술을 하는 중에 박리가 발생하였다. 이 10명의 환자에서 모두 즉각적인 스텐트 삽입술이 시행되었고, 4명의 환자에서 시술 도중 혈압 저하로 Intra-aortic Ballon Pump (IABP)를 장착하였다. 모든 환자에서 성공적으로 스텐트가 삽입되었고, 병원내 사망은 1명도 없었다. 6개월 추적 관상동맥 조영술은 8명의 환자에서 시행되었다. 혈관 조영상의 재협착(직경 협착 50% 이상)은 8명 모두에게서 관찰되지 않았으며, 퇴원 후 평균 31±25개월의 추적관찰 결과 주요 심장사건은 1건도 발생하지 않았다. 결론 : 비록 대상 환자가 적은 연구였지만 좌주간부 관상동맥 박리에 대한 스텐트 삽입술은 기술적으로 안전하고 빠르게 시행 할 수 있으며, 훌륭한 단장기적인 치료 효과를 보여준다. Background : The optimal treatment of patients with left main coronary artery (LMCA) dissection during catheter-based procedure remains uncertain. We retrospectively analyzed the acute and long-term results of bail-out stenting for LMCA dissection. Methods : In cases with significant LMCA dissection occurring during catheter-based procedure, prompt stent implantation may be safe and associated with favorable clinical outcome. We evaluated the acute and long-term results of bail-out stenting for LMCA dissection occurring during catheter-bases procedure in 1- patients. Results : Initially, there was significant stenosis of LMCA segment in these patients. Catheter-induced dissection occurred in 8 patients (during diagnostic angiography in 3 patients and guiding catheter manipulation in 5 patients). Two patients suffered dissection in the setting of stent deployment in other vessels. Therefore, bail-out stenting LMCA dissection was performed in a total of 10 patients. In 4 patients, hypotension developed and intra-aortic balloon pump was placed during procedure. Stents were successfully deployed in all patients. There was no in-hospital mortality. Six-month angiographic follow-up was performed in 8 patients. Angiographic restenosis(diameter stenosis 50%) was not observed in all patients at follow-up study. During a mean follow-up of 31±25 months after hospital discharge, there was no major adverse cardiac event (death, myocardial infarction, and target lesion revascularization). Conclusion : Bail-out LMCA stenting is technically feasible, and showed good acute and long-term results in a small series of patients.

긴 관동맥병변에서 긴 스텐트삽입에 대한 임상경과 및 재협착율

김영학,박성욱,정상식,박훈기,이상곤,이일수,이철환,김재중,홍명기,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

IMT-2000 위성통신 시스템에서 폐쇄루프 전송 다이버시티 기법의 성능 분석

오관명,김학성,김산해,이경규,이원철,신요안 崇實大學校 2000 論文集 Vol.30 No.1

In this paper, we apply a close loop transmit diversity scheme to IMT-2000 satellite systems, and investigate the performance of the scheme in both ideal and more realistic situations. We verify that the performance of the closed loop transmit diversity scheme is quite sensitive to errors in feedback information. However, we also show that the number of quantization bits for feedback information does not significantly affect the system performance when considering the feedback of phase information only. In addition, 2-bit quantized system achieves the better performance than 4-bit quantized system in terms of slot error rate.

역압력구배하에서 윗벽면 및 평판슬릿흡입이 난류경계층의 구조에 미치는 영향

박계향,이학성,윤명식,유상신 한국항공대학교 1994 論文集 Vol.32 No.-

역압력 구배하에서 벽면흡입과 모델 평판의 슬릿흡입이 난류 경계층구조에 미치는 영향에 대하여 실험적으로 연구하였다. 압력탭이 설치된 평판을 실험부에 설치한 후 평판위에 역압력구배가 작용되도록 하고 경계층 내의 속도 분포와 난류강도를 열선유속계로 측정하였다. 역압력구배가 커지면 경계층의 천이점은 평판의 상류쪽으로 이동하며 평판의 벽면에서 슬릿흡입을 하면 경계층내의 난류강도가 감소하고, 흡입량을 증가하면 난류 강도는 더욱 감소한다. An experimental study on the boundary layer structure on the flat plate with upper wall and slit suction under adverse pressure gradients is presented. Velocity profiles and turbulent intensities in the boundary layer are measured by hot-wire anemometer system. The transition point of a bondary layer moves upstream direction as the adverse pressure gradient increases. Slit suction causes a reduction of turbulent intensity of boundary layer. Reduction of trubulent intensity increases as the suction coefficient increases.

Process development of oxalic acid production in submerged culture of Aspergillus niger F22 and its biocontrol efficacy against the root-knot nematode Meloidogyne incognita

Lee, Sang Il,Lee, Keon Jin,Chun, Ho Hyun,Ha, Sanghyun,Gwak, Hyun Jung,Kim, Ho Myeong,Lee, Jong-Hee,Choi, Hak-Jong,Kim, Hyeong Hwan,Shin, Teak Soo,Park, Hae Woong,Kim, Jin-Cheol Springer-Verlag 2018 BIOPROCESS AND BIOSYSTEMS ENGINEERING Vol.41 No.3

<P>Oxalic acid has potent nematicidal activity against the root-knot nematode Meloidogyne incognita. In this study, fermentation parameters for oxalic acid production in submerged culture of Aspergillus niger F22 at 23, 25, and 30 A degrees C were optimized in 5-L jar fermenters. The viscosity of the culture broth increased with increasing temperature. There was a negative correlation between oxalic acid production and the apparent viscosity; high volumetric productivity of oxalic acid was obtained at low apparent viscosity (less than 1000 cP), with a productivity of more than 100 mg/L h. When the apparent viscosity was over 2500 cP, the volumetric productivity decreased below 50 mg/L h. In addition, the volumetric mass transfer coefficient, K (L) a, positively correlated with volumetric productivity. When the K (L) a value increased from 0.0 to 0.017 /s, the volumetric productivity proportionally increased up to 176 mg/L h. When the temperature decreased, K (L) a increased due to the decrease in viscosity, leading to increased volumetric productivity. The highest productivity of 7453.3 mg/L was obtained at the lowest temperature, i.e., 23 A degrees C. The nematicidal activity of culture filtrate was proportional to the content of oxalic acid. Based on a constant impeller tip speed, oxalic acid production was successfully scaled up to a 500-L pilot vessel, producing a final concentration comparable to that in the 5-L jar.</P>

Chloride-enhanced oxidation of organic contaminants by Cu(II)-catalyzed Fenton-like reaction at neutral pH

Lee, Hongshin,Seong, Juhee,Lee, Ki-Myeong,Kim, Hak-Hyeon,Choi, Jaemin,Kim, Jae-Hong,Lee, Changha Elsevier 2018 Journal of hazardous materials Vol.344 No.-

<P><B>Abstract</B></P> <P>The Cu(II)-catalyzed Fenton-like reaction was found to be significantly accelerated in the presence of chloride ion (i.e., the Cu(II)/H<SUB>2</SUB>O<SUB>2</SUB>/Cl<SUP>−</SUP> system), enhancing the oxidative degradation of organic contaminants at neutral pH. The degradation of carbamazepine (a select target contaminant) by the Cu(II)/H<SUB>2</SUB>O<SUB>2</SUB> system using 1μM Cu(II) and 10mM H<SUB>2</SUB>O<SUB>2</SUB> was accelerated by 28-fold in the presence of 10,000mg/L Cl<SUP>−</SUP> at pH 7. The observed rate of carbamazepine degradation generally increased with increasing doses of Cu(II), H<SUB>2</SUB>O<SUB>2</SUB>, and Cl<SUP>−</SUP>, and exhibited an optimal value at around pH 7.5. Various other organic contaminants such as propranolol, phenol, acetaminophen, 4-chlorophenol, benzoic acid, and caffeine were also effectively degraded by the Cu(II)/H<SUB>2</SUB>O<SUB>2</SUB>/Cl<SUP>−</SUP> system. Experiments using oxidant probe compounds and electron paramagnetic spectroscopy suggested that cupryl (Cu(III)) species are the major reactive oxidants responsible for the degradation of these organic contaminants. The enhanced kinetics was further confirmed in natural seawater.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Cu(II)-catalyzed Fenton-like reaction was accelerated in the presence of Cl<SUP>−</SUP>. </LI> <LI> The Cu(II)/H<SUB>2</SUB>O<SUB>2</SUB>/Cl<SUP>−</SUP> system was optimized at neutral pH. </LI> <LI> Cu(III)-chloro complexes were suggested as major reactive oxidants. </LI> <LI> The Cu(II)/H<SUB>2</SUB>O<SUB>2</SUB>/Cl<SUP>−</SUP> system can be a useful approach to treat saline wastewater. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Factors predictive of cardiac events and restenosis after sirolimus-eluting stent implantation in small coronary arteries

Lee, Cheol Whan,Suh, Jon,Lee, Se-Whan,Park, Duk-Woo,Lee, Seung-Hwan,Kim, Young-Hak,Hong, Myeong-Ki,Kim, Jae-Joong,Park, Seong-Wook,Park,, Seung-Jung WILEY-LISS 2007 CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS Vol.69 No.6

<B>Objectives:</B><P>Predictors of cardiac events and restenosis after sirolimus-eluting stent (SES) implantation in small coronary arteries were evaluated.</P><B>Background:</B><P>Although SES implantation has markedly reduced the risk of restenosis, small vessel disease remains a major cause of SES failure.</P><B>Methods:</B><P>We prospectively investigated the factors predictive of cardiac events and restenosis in 1,092 consecutive patients who received SES implantation for 1,269 lesions in small coronary arteries (≤2.8 mm). Follow-up angiography at 6 months was performed in 751 patients with 889 lesions (follow-up rate 70.3%).</P><B>Results:</B><P>Restenosis (diameter stenosis ≥ 50%) was angiographically documented in 65 patients with 77 lesions (8.7%): 55 focal (71.4%), 8 diffuse (10.4%), 2 diffuse proliferative (2.6%), and 12 total (15.6%). Lesion length, stent length, reference artery size, and in-stent restenotic lesions were univariate predictors of restenosis. By multivariate analysis, lesion length (OR 1.04; 95% CI 1.02–1.05; P < 0.001) and in-stent restenotic lesions (OR 3.38; 95% CI 1.80–6.35; P < 0.001) were significant independent predictors of restenosis. During follow-up (23.2 ± 7.9 months), there were 17 deaths (5 cardiac and 12 noncardiac), 5 nonfatal Q-wave myocardial infarctions, and 42 target lesion revascularizations. The cumulative probability of survival without major adverse cardiac events (MACE) was (96.6 ± 0.6)% at 1 year and (95.1 ± 0.7)% at 2 years. In multivariate analysis, lesion length (HR 1.04; 95% CI 1.01–1.07; P = 0.004) and in-stent restenotic lesions (HR 3.29; 95% CI 1.58–6.86; P = 0.001) were independently related to MACE.</P><B>Conclusions:</B><P>SES implantation in small coronary arteries is safe and effective, with lesion length having a major impact on restenosis and MACE. © 2006 Wiley-Liss, Inc.</P>

Protein Patterns on a Corpus Luteum during Pregnancy in Korean Native Cows

Hak-Jae Chung,Dong-Min You,Hyo-Ju Kim,Hye-Young Choi,Myeong-Suk Lee,Jin-Bum Kim,Suck-Dong Lee,Jung-Yong Park,Myeung-Sik Lee 한국동물번식학회 2010 Reproductive & developmental biology Vol.34 No.3

Age-related Apoptotic Gene and Its Protein Expression during Spermatogenesis in the Bovine Testis

Hak-Jae Chung,Myeong-Sik Lee,Jung-Yong Park,Suck-Dong Lee,Dong-Min You,Seung-Hwan Lee,Yeoung-Tae Hey 한국동물생명공학회(구 한국동물번식학회) 2010 발생공학 국제심포지엄 및 학술대회 Vol.2010 No.1

The Effects of Simultaneous Pulmonary Rehabilitation during Thoracic Radiotherapy in the Treatment of Malignant Diseases

( Myeong Geun Choi ),( Hyang Yi Lee ),( Si Yeol Song ),( Su Ssan Kim ),( Seung Hak Lee ),( Won Kim ),( Chang-min Choi ),( Sei Won Lee ) 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.2

Background: Radiotherapy is a common treatment option for lung or esophageal cancer, particularly when surgery is not feasible for patients with poor lung function. However, radiotherapy can affect pulmonary function and thereby induce pneumonitis or pneumonia, which can be fatal in patients with respiratory impairment. The purpose of this study is to evaluate if reductions in pulmonary function after radiotherapy can be minimized through simultaneous pulmonary rehabilitation (PR). Methods: In this matched case control study, we retrospectively analyzed patients who had undergone radiotherapy for thoracic malignant disease between January 2018 and June 2019. We analyzed results from pulmonary function tests and 6-minute walking tests (6MWT) conducted within the six months before and after radiotherapy treatment. Results: In total, results from 144 patients were analyzed, with 11 of the patients receiving PR and radiotherapy simultaneously. Of the 133 patients in the control group, 33 were matched with 11 patients in the PR group. Changes in forced expiratory volume in one second (FEV₁) and FEV₁/forced vital capacity were significantly different between the PR group and the matched control group (240 mL vs. -10 mL, p=0.017 and 5.5% vs. 1.0%, p=0.038, respectively). The median distance of 6MWT in the PR group also increased significantly, from 407.5 m to 493.0 m after radiotherapy (p=0.017). Conclusion: Simultaneous PR improved pulmonary function, particularly in measures of FEV₁, and exercise capacity for patients with lung or esophageal cancer even after radiotherapy treatment. These findings may provide an important base of knowledge for further large population studies with long-term follow-up analysis in the identification of the PR’s effects during thoracic radiotherapy.