정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

저항을 이용한 프로판-공기 혼합가스의 점화한계 개선에 관한 연구

이춘하,오종용,옥경재,지승욱,이광식,심광렬 한국화재소방학회 2004 한국화재소방학회논문지 Vol.18 No.1

본 논문은 IEC형 불꽃점화 시험장치를 이용하여 저압 유도회로의 최소 점화한계를 프로판-공기 5.25 Vol.%의 혼합 가스에 대하여 실험적으로 구하였으며, 또한 유도회로의 인덕턴스 L에 안전소자로서 저항을 병렬접속하였을 경우 프로판-공기 5.25 Vol.%의 혼합 가스에 대한 점화한계 개선효과를 관찰하였다. 그 결과, 최소 점화한계는 전류의 크기에 따라 좌우되었다 또한, 전원으로부터 공급되는 에너지는 인덕턴스에 우선 축적되고. 그 초과분의 에너지가 폭발성 가스의 점화원으로 작용하였다. 점화한계 개선효과는 인덕턴스가 300 mH일 때, 최고 330%의 개선효과가 나타났으며 인덕턴스가 클수록 점화한계 개선효과가 크게 나타났다. 또한 병렬로 접속한 저항의 크기가 적을수록 점화한계 개선 효과가 크다. 본 연구결과는 본질안전 방폭형 전기기기의 연구개발을 위한 기본자료로 활용할 수 있을 뿐만 아니라 이들 기기의 방폭성능에 대한 시험자료로도 활용이 가능할 것으로 사료된다. This paper describes the minimum ignition limits for propane-air 5.25 Vol.% mixture gases in low voltage inductive circiuts. The improved effects on the ignition limit are studied by parallel safety components(resistors) for propane-air 5.25 Vol.% mixture gas in low voltage inductive circuits. The experimental devices used in this test are the IEC type spark ignition test apparatus. The minimum ignition limits are controlled by the values of current in inductive circuit. Energy supplied from elect source is first accumulated at the inductance, it's extra energy is working as ignition source of the explosive gas. The improved effects on the ignition limit are respectively obtained as the maximum rising rate of 330% by composing parallel circuits between inductance and resistor as compared with disconnecting inductance with the safety components. The more values of inductance increase the higher improved effects of ignition limit rise. The less values of resistor the higher improved effects of ignition limit rise. It is considered that the result can be used for not only data for researches and development of intrinsically safe explosion-proof machines which are applied equipment and detectors used in dangerous areas but also for datum for its equipment tests.

연속 드레싱을 이용한 CNC Creep Feed 연삭기의 개발 및 연삭 평가에 관한 연구

이영욱,정재운,김종관,정윤교 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

The method of creep feed grinding is an effective technology process. It is used to improve the productivity & efficiency in form grinding. However there are some inherent difficulties throughout the grinding process. The progress of abrasive wear around the cutting edge is remarkable. The grinding force become intense and burn marks occur frequently. To grind a work piece of large length is clearly a tremendously difficult task. Also, domestically, creep feed grinding is a scarce development. We crucially depend on the imports of goods from abroad. Therefore, the purpose of this research is that developing the localization creep feed grinding with continuous dressing device and we must research more into this complex technology to discover the most efficient dressing conditions and dresser to wheel speed ratio(qd).

수면확성기의 음향특성에 관한 연구

이창헌,문종욱,박용석,최찬문,서두옥 제주대학교 해양연구소 1998 해양자원연구소연구보고 Vol.22 No.-

To obtain the fundamental data on a surface speaker made to lure fish school by pure sound, three surface speakers were made of moving coil driver units of 75W and 50W respectively. Their frequency characteristic was measured in the range of 200 - 4mHz that could be used in luring fish school. The results of the measurements in air and sea are follows. 1. The input and output wave forms of a surface speaker were similar to each other in measurement frequencies in air. Then sound pressure of a surface speaker made of 75W driver units among them was over 130dB(0dB re 20μ Pa) in the range of 300 - 400Hz maximally. 2. When the surface speaker with 75W driver units emitted the measurement frequencies at sea. Sound pressure classified by the depth of water were over 140dB at 1m and 120dB at 20m(0dB re 1μ Pa) respectively.

덕유산 국립공원 저서성대형무척추동물의 군집변동 및 생물학적 수질평가

이영미,노상은,조희욱,이종은 7개 국립대학교 환경연구논문집 공동발행 위원회 2005 공업기술연구 Vol.5 No.-

A biological assessment of water quality was carried out in Deogyusan National Park from April 2005 to August 2005. The benthic macroinvertebrates collected seasonally from 5 field sites were identified mostly up to species level. The benthic macroinvertebrates collected from the surveyed sites were composed of 105 species, 74 genera, 46 families, 12 orders, 4 classes and 3 phyla. Dominant species occurring in all the surveyed sites was white color Chironomus sp. of Diptera. The dominance index(DI) showed the highest as 0.666 at site 3 and the lowest as o.388 at site 5. The species diversity index(H') showed the highest as 3.998 at site 5 and the lowest as 2.752 at site 3. Ecological score of benthic macroinvertebrate(ESB) Showed the highest as 199 at site 5 and the lowest as 149 at site 3. All surveyed sites were Oligosaprobic that the water quality estimated by ecological score of benethic macroinvertebrate community

UHF 대역 수동형 RFID 태그 Analog Front-end 분석 및 설계

이종욱 경희-다반 ASIC 설계교육센터 2005 경희-다반 ASIC센터 논문집 Vol.6 No.-

We investigated the design trade-off in the development of UHF-band RFID tag for increased reading range. Using the quality factors of the tag antenna and tag chip as design parameters, the effects of the quality factors on the turn-on voltage of the tag chip and the backscattered power from the tag were examined. The design equations from the analysis indicate two regions of good impedances, one forproviding high tum-on voltage forthe tag chip, and the other resulting in increased radar cross section (RCS) for the antenna. An optimum quality factor which provides the best compromise of the two designs is provided. Based on the analysis, an example of the tag chip and tag antenna was designed, and the reading range test in anechoic chamber resulted in a detection distance of 5.2 m for-75 dBm reader sensitivity.

Dual-Gate GaN HEMT의 고출력 RF 특성에 대한 연구

이종욱 경희-다반 ASIC 설계교육센터 2004 경희-다반 ASIC센터 논문집 Vol.5 No.-

Dual-gate AlGaN/GaN high electron-mobility transistors (HEMTs) having a 0.35 gm gate length with 1.0 mm (8×125㎛) periphery were examined for applications requiring high power and high frequency operation. A typical device exhibited a maximum drain current density of 500 mA/mm, a device unity gain cut-off frequency (f_(τ)) of 30.5 GHz, and a maximum frequency of oscillation (f_(MAX)) of 43.7 GHz. Reduced feedback capacitance through the dual-gate cascode configuration allows a larger gate periphery for a given input capacitance, thus higher microwave power can be generated. A monolithic non-uniform distributed amplifier has been designed which offers increased efficiency and broad-band operation by removal of the drain line dummy load and dual-gate cascode gain cell arrangement.