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β-Difluoro-α-trimethylsilyl-γ-lactam 유도체의 합성
채규윤,곽경철,문재정,최장호 圓光大學校 基礎自然科學硏究所 2000 基礎科學硏究誌 Vol.18 No.1
α-위치만 선택적으로 difluoromethylene기가 도입된 α.α-difluoro-γ-trimethylsilyl-γ-lactam 유도체(6)들은 ethyl α.α-difluoro-γ-trimethylsilyl-γ-iodopentanoate(4)는 일차아민 유도체와의 반응으로부터 비교적 편리한 작용조건과 비교적 좋은 수득률로 합성하였다. The target of α.α-difluoro-γ-trimethylsilyl-γ-lactam derivatives(6) with selectively in corporated difluoromethylene on α-position were readily prepared form reaction ethyl α.α-difluoro-γ-trimethylsilyl-γ-iodopentanoate(4) and primary derivatives in moderate yields.
( Chaiyoung Lee ),( Sun Hye Shin ),( Noeul Kang ),( Yeonseok Choi ),( Hyun Kyu Cho ),( Jun Hyeok Lim ),( Hye Yun Park ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Vitamin D deficiency is prevalent in patients with chronic obstructive pulmonary disease (COPD). The relationship between vitamin D and clinical symptoms in stable COPD has not been fully investigated. We aimed to explore the association between vitamin D sufficiency and clinical symptoms in stable COPD patients. Methods We performed a cross-sectional study using data between October 2015 and March 2019 from the COPD Lung Evolution (CLUE) Registry in Samsung Medical Center. Serum 25-hydroxy (25-OH) vitamin D levels measured at diagnosis with concurrent spirometry. Vitamin D sufficiency was defined as serum level ≥ 30ng/mL of 25-OH vitamin D. Results Of the 330 COPD patients, mean age was 70.8±8.5 years and 305 (92.4%) were male. Current or ex-smokers were 296 (89.7%) and 281 (85.2%) did not have vitamin D sufficiency. Patients without vitamin D sufficiency showed higher COPD assessment test (CAT) score compared to those with vitamin D sufficiency (17.14±8.56 vs. 13.08±8.15, p = 0.002 and 80.4% vs. 63.3% for CAT ≥ 10, p =0.008). Among CAT items, the patients without vitamin D sufficiency showed higher scores in sputum (p = 0.005), chest tightness (p = 0.014), dyspnea (p = <0.001), activity (p = 0.006) and energy (p = 0.010) than those with vitamin D sufficiency. The modified Medical Research Council ≥2 was more common in patients without vitamin D sufficiency than those with vitamin D sufficiency (37.4% versus 22.4%, p = 0.044). Conclusions COPD patients without vitamin D sufficiency had worse clinical symptom than those with vitamin D sufficiency.
鄭起源,蔡奎允,李英行 圓光大學校 1993 論文集 Vol.27 No.2
새로운 축합시약인 (3-nitropyridyl) dialkyl phosphate (3a,3b)를 2-hydroxy-3-nitropyridine (1), dialkyl chlorophosphate (2a,2b) 그리고 triethylamine을 dichloromethane 용액중에서 1시간동안 상온에서 반응시켜 쉽게 얻을 수 있었다. 축합시약인 3a와 3b는 온화한 반응 조건에서 아미드와 디펩티드를 합성하는데 있어서 유용한 시약임을 알 수 있었다. A new coupling reagents,(3-nitropyridyl) diallkyl phosphate (3a,3b), were readily prepared by the reaction of 2-hydroxy-3-nitropyridine (1), dialkyl chlorophosphate (2a,2b), and triethylamine in dichloromethane at room temperature for 1h. The coupling reagents, 3a and 3b, were found to be very useful for the preparation of amides and dipeptides under mild conditions.
Synthesis of 6-Alkyloxyl-3,4-dihydro-2(1H)-quinoliones and Their Anticonvulsant Activities
Kyu-Yun Chai,Jun-Min Wang,노정래,Kyung-Chell Kwak,Hee-Cheol Kang,Chang-Soo Jun,Zhe-Shan Quan 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.11
A series of 6-alkyloxyl-3,4-dihydro-2(1H)-quinoliones (5a-5n) were synthesized through nitration, reduction, diazotization, hydrolysis and alkylation from 3,4-dihydro-2(1H)-quinolione. Their structures were characterized by IR, 1H-NMR and MS. The anticonvulsant activity was evaluated by the Maximal electroshock test (MES) and the subcutaneous pentylenetetrazole (Metrazole) test (sc-Met). The neurotoxicity was measured by the Rotarod test (Tox). The result showed that 6-hexyloxy-3,4-dihydro-2 (1H)-quinolinone (5c) was potent in anti-MES and anti-scMet test with ED50 of 24.0 mg/kg and 21.2 mg/kg, respectively, albeit its TD50 (67.6 mg/kg) revealed the high neurotoxicity. 6-Benzyloxy-3,4-dihydro-2(1H)-quinolinone (5f) was less effective against MES induced seizure with ED50 of 29.6 mg/kg, but no neurotoxicity was observed even under 300 mg/kg. Its Protective index (PI) was greater than 10 preferable to Phenytoin, Carbamazepin, Phenobarbital and Valproate.
Lee, Chai Ho,Chai, Kyu Yun,Lee, Man Koo,Chung, Bong Young 圓光大學校 基礎自然科學硏究所 1988 基礎科學硏究誌 Vol.7 No.3
Racemic N-benzylaspartic acid (4) was prepared from maleic anhydride and used to modify and develop some efficient methods for the preparation of N-benzylaspartic anhydride hydrobromide (5). Thus, successive treatment of the compound 4 with 30% HBr in acetic acid and acetic anhydride afforded the title compound 5 in 75% yield. From this compound 5. α-benzyl and α-methyl N-benzylaspartates were also prepared.
7-Perfluoroalkylperhydro-1,4-diazepine-5-one의 합성에 관한 연구
채규윤 圓光大學校 基礎自然科學硏究所 1997 基礎科學硏究誌 Vol.16 No.1
7-fluoroalkylperhydro-1,4-diazepine-5-ones were prepared by the reaction ethyl 3-prepared by the reaction ethyl 3-perfluoroal-kyl-2-iodopropanoates with excess ethylene diamine.
3-Perfluoroalkyl-1-propene의 합성
채규윤 圓光大學校 基礎自然科學硏究所 1997 基礎科學硏究誌 Vol.16 No.1
3-Perfluoroalkyl-1-propene were prepared easily by the reaction perfluoroalkyl iodide with allytrimethylsilane in presmie catalystic amount(5 mole %) pd[p(ph_3)]_4.
채규윤 圓光大學校 基礎自然科學硏究所 1997 基礎科學硏究誌 Vol.16 No.1
β-Fluoropyrrole derivatives were synthesized by the reaction ethyl-5-phenyl-2-iodo-5-oxobutanoate with excess ammonium hydroxide.
4,4-Difluoro-3-phenyl-4,5,6-trihydro-1,2-oxazine의 합성에 관한 연구
채규윤 圓光大學校 基礎自然科學硏究所 1997 基礎科學硏究誌 Vol.16 No.1
4,4-Difluoro-3-phenyl-4,5,6-trihydro-1,2-oxazine (7) and 4,4-difluoro-3-phenyl-6-trimethylsilyl-4,5,6-trkmydro-1,2-oxazine(8) were synthesized from 2,2-difluoro-1-phenyl-5-trimethylsiyl 4-iodo-1-butanone(5) in mild londition.